{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T02:30:20Z","timestamp":1793673020711,"version":"4.5.1"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T00:00:00Z","timestamp":1677196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013093","name":"Science and Technology Planning Project of Shenzhen Municipality","doi-asserted-by":"publisher","award":["JCYJ20180306173433984"],"award-info":[{"award-number":["JCYJ20180306173433984"]}],"id":[{"id":"10.13039\/501100013093","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["atherosclerosis-journal.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Atherosclerosis"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.atherosclerosis.2023.02.008","type":"journal-article","created":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T21:44:42Z","timestamp":1677102282000},"page":"17-26","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["CD40-targeting magnetic nanoparticles for MRI\/optical dual-modality molecular imaging of vulnerable atherosclerotic plaques"],"prefix":"10.1016","volume":"369","author":[{"given":"Qimin","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guifu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fensheng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousheng","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxia","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.atherosclerosis.2023.02.008_bib1","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.jacc.2012.11.002","article-title":"The worldwide environment of cardiovascular disease: prevalence, diagnosis, therapy, and policy issues: a report from the American College of Cardiology","volume":"60","author":"Laslett","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.atherosclerosis.2023.02.008_bib2","author":"Cardiovascular Diseases (CVDs)"},{"key":"10.1016\/j.atherosclerosis.2023.02.008_bib3","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.hlc.2013.03.001","article-title":"Pathophysiology of atherosclerosis plaque progression","volume":"22","author":"Sakakura","year":"2013","journal-title":"Heart Lung Circ."},{"key":"10.1016\/j.atherosclerosis.2023.02.008_bib4","doi-asserted-by":"crossref","first-page":"8040","DOI":"10.1039\/D0NR00599A","article-title":"Recent advances in molecular imaging of atherosclerotic plaques and thrombosis","volume":"12","author":"Qiao","year":"2020","journal-title":"Nanoscale"},{"key":"10.1016\/j.atherosclerosis.2023.02.008_bib5","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1093\/eurheartj\/ehs067","article-title":"Non-invasive anatomic and functional imaging of vascular inflammation and unstable plaque","volume":"33","author":"Camici","year":"2012","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.atherosclerosis.2023.02.008_bib6","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1161\/ATVBAHA.116.306483","article-title":"Molecular imaging of atherothrombotic diseases: seeing is believing","volume":"37","author":"Wang","year":"2017","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.atherosclerosis.2023.02.008_bib7","doi-asserted-by":"crossref","first-page":"7681","DOI":"10.2147\/IJN.S142385","article-title":"A review of molecular imaging of atherosclerosis and the potential application of dendrimer in imaging of plaque","volume":"12","author":"Anwaier","year":"2017","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.atherosclerosis.2023.02.008_bib8","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.692915","article-title":"Molecular imaging and non-molecular imaging of atherosclerotic plaque thrombosis","volume":"8","author":"Guo","year":"2021","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.atherosclerosis.2023.02.008_bib9","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1471-2342-10-27","article-title":"MRI plaque imaging reveals high-risk carotid plaques especially in diabetic patients irrespective of the degree of stenosis","volume":"10","author":"Esposito","year":"2010","journal-title":"BMC Med. Imag."},{"key":"10.1016\/j.atherosclerosis.2023.02.008_bib10","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1021\/ar800045c","article-title":"Synergistically integrated nanoparticles as multimodal probes for nanobiotechnology","volume":"41","author":"Cheon","year":"2008","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.atherosclerosis.2023.02.008_bib11","doi-asserted-by":"crossref","first-page":"4501","DOI":"10.1039\/C4CS00345D","article-title":"Recent advances in magnetic nanoparticle-based multi-modal imaging","volume":"44","author":"Shin","year":"2015","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.atherosclerosis.2023.02.008_bib12","doi-asserted-by":"crossref","first-page":"323","DOI":"10.2174\/1570161118666200318104434","article-title":"Inflammatory markers in cardiovascular disease; lessons learned and future perspectives","volume":"19","author":"Patoulias","year":"2021","journal-title":"Curr. Vasc. Pharmacol."},{"key":"10.1016\/j.atherosclerosis.2023.02.008_bib13","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.jacc.2009.03.076","article-title":"The CD40\/CD40 ligand system: linking inflammation with atherothrombosis","volume":"54","author":"Antoniades","year":"2009","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.atherosclerosis.2023.02.008_bib14","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/28204","article-title":"Reduction of atherosclerosis in mice by inhibition of CD40 signalling","volume":"394","author":"Mach","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.atherosclerosis.2023.02.008_bib15","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1161\/hh2401.101272","article-title":"CD40 signaling and plaque instability","volume":"89","author":"Schonbeck","year":"2001","journal-title":"Circ. Res."},{"key":"10.1016\/j.atherosclerosis.2023.02.008_bib16","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.1161\/01.CIR.0000043029.52803.7B","article-title":"Oxidized low-density lipoprotein augments and 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors limit CD40 and CD40L expression in human vascular cells","volume":"106","author":"Schonbeck","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2023.02.008_bib17","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.jacc.2017.11.055","article-title":"Targeting CD40-induced TRAF6 signaling in macrophages reduces atherosclerosis","volume":"71","author":"Seijkens","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.atherosclerosis.2023.02.008_bib18","doi-asserted-by":"crossref","first-page":"5398","DOI":"10.1021\/nn101000e","article-title":"Fluorescent, superparamagnetic nanospheres for drug storage, targeting, and imaging: a multifunctional nanocarrier system for cancer diagnosis and treatment","volume":"4","author":"Cho","year":"2010","journal-title":"ACS Nano"},{"key":"10.1016\/j.atherosclerosis.2023.02.008_bib19","doi-asserted-by":"crossref","first-page":"506","DOI":"10.7150\/thno.49812","article-title":"Highly sensitive magnetic particle imaging of vulnerable atherosclerotic plaque with active myeloperoxidase-targeted nanoparticles","volume":"11","author":"Tong","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.atherosclerosis.2023.02.008_bib20","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1161\/CIRCULATIONAHA.117.029870","article-title":"Acute coronary syndromes: the way forward from mechanisms to precision treatment","volume":"136","author":"Crea","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2023.02.008_bib21","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.jacc.2018.05.027","article-title":"Coronary calcium score and cardiovascular risk","volume":"72","author":"Greenland","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.atherosclerosis.2023.02.008_bib22","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1161\/01.cir.0000437738.63853.7a","article-title":"2013 ACC\/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines","volume":"129","author":"Stone","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2023.02.008_bib23","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1161\/CIRCRESAHA.120.315890","article-title":"The molecular basis of predicting atherosclerotic cardiovascular disease risk","volume":"128","author":"Nayor","year":"2021","journal-title":"Circ. Res."},{"key":"10.1016\/j.atherosclerosis.2023.02.008_bib24","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/s41551-018-0221-2","article-title":"Efficacy and safety assessment of a TRAF6-targeted nanoimmunotherapy in atherosclerotic mice and non-human primates","volume":"2","author":"Lameijer","year":"2018","journal-title":"Nat Biomed Eng"},{"key":"10.1016\/j.atherosclerosis.2023.02.008_bib25","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1084\/jem.20091293","article-title":"Deficient CD40-TRAF6 signaling in leukocytes prevents atherosclerosis by skewing the immune response toward an antiinflammatory profile","volume":"207","author":"Lutgens","year":"2010","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.atherosclerosis.2023.02.008_bib26","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1055\/a-1397-1858","article-title":"Deficiency of endothelial CD40 induces a stable plaque phenotype and limits inflammatory cell recruitment to atherosclerotic lesions in mice","volume":"121","author":"Gissler","year":"2021","journal-title":"Thromb. Haemostasis"},{"key":"10.1016\/j.atherosclerosis.2023.02.008_bib27","article-title":"Rolling ball sifting algorithm for the augmented visual inspection of carotid bruit auscultation","volume":"6","author":"Huang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.atherosclerosis.2023.02.008_bib28","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1148\/radiol.2441051769","article-title":"The vulnerable, or high-risk, atherosclerotic plaque: noninvasive MR imaging for characterization and assessment","volume":"244","author":"Saam","year":"2007","journal-title":"Radiology"},{"key":"10.1016\/j.atherosclerosis.2023.02.008_bib29","first-page":"641","article-title":"Analysis of in situ and ex vivo alphaVbeta3 integrin expression during experimental carotid atherogenesis","volume":"7","author":"Yao","year":"2012","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.atherosclerosis.2023.02.008_bib30","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1093\/joneph\/21.3.324","article-title":"Gadolinium-associated nephrogenic systemic fibrosis: the need for nephrologists' awareness","volume":"21","author":"Canavese","year":"2008","journal-title":"J. Nephrol."},{"key":"10.1016\/j.atherosclerosis.2023.02.008_bib31","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.cis.2013.06.007","article-title":"Superparamagnetic iron oxide based nanoprobes for imaging and theranostics","volume":"199\u2013200","author":"Lam","year":"2013","journal-title":"Adv. Colloid Interface Sci."},{"key":"10.1016\/j.atherosclerosis.2023.02.008_bib32","doi-asserted-by":"crossref","first-page":"6097","DOI":"10.2147\/IJN.S321984","article-title":"Superparamagnetic iron oxide nanoparticles: cytotoxicity, metabolism, and cellular behavior in biomedicine applications","volume":"16","author":"Wei","year":"2021","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.atherosclerosis.2023.02.008_bib33","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.jconrel.2013.07.019","article-title":"Long term biotransformation and toxicity of dimercaptosuccinic acid-coated magnetic nanoparticles support their use in biomedical applications","volume":"171","author":"Mejias","year":"2013","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.atherosclerosis.2023.02.008_bib34","doi-asserted-by":"crossref","DOI":"10.1109\/LMAG.2016.2535414","article-title":"Dose-Response bioconversion and toxicity analysis of magnetite nanoparticles","volume":"7","author":"Ruiz","year":"2016","journal-title":"IEEE MAGN LETT"},{"key":"10.1016\/j.atherosclerosis.2023.02.008_bib35","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1016\/j.jacc.2009.03.018","article-title":"The ATHEROMA (Atorvastatin Therapy: effects on Reduction of Macrophage Activity) Study. Evaluation using ultrasmall superparamagnetic iron oxide-enhanced magnetic resonance imaging in carotid disease","volume":"53","author":"Tang","year":"2009","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.atherosclerosis.2023.02.008_bib36","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1093\/cvr\/cvaa047","article-title":"The choice of targets and ligands for site-specific delivery of nanomedicine to atherosclerosis","volume":"116","author":"Zia","year":"2020","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.atherosclerosis.2023.02.008_bib37","doi-asserted-by":"crossref","DOI":"10.3791\/3482","article-title":"Labeling stem cells with ferumoxytol, an FDA-approved iron oxide nanoparticle","author":"Castaneda","year":"2011","journal-title":"JoVE"},{"key":"10.1016\/j.atherosclerosis.2023.02.008_bib38","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1063\/1.1496124","article-title":"Structural and magnetic transformation of monodispersed iron oxide particles in a reducing atmosphere","volume":"92","author":"Varanda","year":"2002","journal-title":"J. Appl. Phys."},{"key":"10.1016\/j.atherosclerosis.2023.02.008_bib39","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.addr.2010.05.006","article-title":"Superparamagnetic iron oxide nanoparticles (SPIONs): development, surface modification and applications in chemotherapy","volume":"63","author":"Mahmoudi","year":"2011","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.atherosclerosis.2023.02.008_bib40","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/j.addr.2008.03.018","article-title":"Magnetic nanoparticles in MR imaging and drug delivery","volume":"60","author":"Sun","year":"2008","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.atherosclerosis.2023.02.008_bib41","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1080\/21691401.2019.1699823","article-title":"Construction of dual nanomedicines for the imaging and alleviation of atherosclerosis","volume":"48","author":"Zhang","year":"2020","journal-title":"Artif. Cell Nanomed. Biotechnol."}],"container-title":["Atherosclerosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915023000849?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915023000849?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:48:33Z","timestamp":1777384113000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021915023000849"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":41,"alternative-id":["S0021915023000849"],"URL":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2023.02.008","relation":{},"ISSN":["0021-9150"],"issn-type":[{"value":"0021-9150","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CD40-targeting magnetic nanoparticles for MRI\/optical dual-modality molecular imaging of vulnerable atherosclerotic plaques","name":"articletitle","label":"Article Title"},{"value":"Atherosclerosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2023.02.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}