{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:11:34Z","timestamp":1792120294044,"version":"4.4.0"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,7]],"date-time":"2024-04-07T00:00:00Z","timestamp":1712448000000},"content-version":"am","delay-in-days":372,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["20314864"],"award-info":[{"award-number":["20314864"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["22672854"],"award-info":[{"award-number":["22672854"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20H03927"],"award-info":[{"award-number":["20H03927"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21H03179"],"award-info":[{"award-number":["21H03179"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22H03330"],"award-info":[{"award-number":["22H03330"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["atherosclerosis-journal.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Atherosclerosis"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1016\/j.atherosclerosis.2023.03.005","type":"journal-article","created":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T21:36:24Z","timestamp":1679002584000},"page":"61-66","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Attainment of the low-density lipoprotein cholesterol treatment target and prognosis of heterozygous familial hypercholesterolemia"],"prefix":"10.1016","volume":"371","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3357-1809","authenticated-orcid":false,"given":"Hayato","family":"Tada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Nomura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Nohara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soichiro","family":"Usui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Sakata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenshi","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noboru","family":"Fujino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Takamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masa-aki","family":"Kawashiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.atherosclerosis.2023.03.005_bib1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.5551\/jat.RV16008","article-title":"Half a century tales of familial hypercholesterolemia (FH) in Japan","volume":"24","author":"Mabuchi","year":"2017","journal-title":"J. Atherosclerosis Thromb."},{"key":"10.1016\/j.atherosclerosis.2023.03.005_bib2","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1016\/j.jacc.2021.09.004","article-title":"Familial hypercholesterolemia: JACC focus seminar 4\/4","volume":"78","author":"Brandts","year":"2021","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.atherosclerosis.2023.03.005_bib3","doi-asserted-by":"crossref","first-page":"665","DOI":"10.5551\/jat.RV17050","article-title":"Homozygous familial hypercholesterolemia","volume":"28","author":"Nohara","year":"2021","journal-title":"J. Atherosclerosis Thromb."},{"key":"10.1016\/j.atherosclerosis.2023.03.005_bib4","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1161\/CIR.0000000000000297","volume":"132","author":"Gidding","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2023.03.005_bib5","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.jacl.2014.01.002","article-title":"Integrated guidance on the care of familial hypercholesterolemia from the International FH Foundation","volume":"8","author":"Watts","year":"2014","journal-title":"J Clin Lipidol"},{"key":"10.1016\/j.atherosclerosis.2023.03.005_bib6","unstructured":"National Institute for Health and Care Excellence. Familial hypercholesterolaemia: identification and management. Guidance and guidelines. ProMED-mail website. https:\/\/www.nice.org.uk\/guidance\/cg71. Accessed October 14, 2022."},{"key":"10.1016\/j.atherosclerosis.2023.03.005_bib7","doi-asserted-by":"crossref","first-page":"751","DOI":"10.5551\/jat.CR003","article-title":"Working group by Japan Atherosclerosis society for making guidance of familial hypercholesterolemia. Guidelines for diagnosis and treatment of familial hypercholesterolemia","volume":"25","author":"Harada-Shiba","year":"2018","journal-title":"J. Atherosclerosis Thromb."},{"key":"10.1016\/j.atherosclerosis.2023.03.005_bib8","doi-asserted-by":"crossref","first-page":"539","DOI":"10.5551\/jat.CR002","article-title":"Joint working group by Japan pediatric society and Japan Atherosclerosis society for making guidance of pediatric familial hypercholesterolemia. Guidance for pediatric familial hypercholesterolemia 2017","volume":"25","author":"Harada-Shiba","year":"2018","journal-title":"J. Atherosclerosis Thromb."},{"key":"10.1016\/j.atherosclerosis.2023.03.005_bib9","doi-asserted-by":"crossref","first-page":"608","DOI":"10.5551\/jat.62764","article-title":"Effectiveness and safety of lipid-lowering drug treatments in Japanese patients with familial hypercholesterolemia: familial hypercholesterolemia expert forum (FAME) study","volume":"29","author":"Yamashita","year":"2022","journal-title":"J. Atherosclerosis Thromb."},{"key":"10.1016\/j.atherosclerosis.2023.03.005_bib10","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.atherosclerosis.2019.08.007","article-title":"Longitudinal low density lipoprotein cholesterol goal achievement and cardiovascular outcomes among adult patients with familial hypercholesterolemia: the CASCADE FH registry","volume":"289","author":"Duell","year":"2019","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2023.03.005_bib11","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1111\/jdi.13306","article-title":"Japanese clinical practice guideline for diabetes 2019","volume":"11","author":"Araki","year":"2020","journal-title":"J Diabetes Investig"},{"key":"10.1016\/j.atherosclerosis.2023.03.005_bib12","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1253\/circj.CJ-21-0193","article-title":"Effect of cumulative exposure to low-density lipoprotein-cholesterol on cardiovascular events in patients with familial hypercholesterolemia","volume":"85","author":"Tada","year":"2021","journal-title":"Circ. J."},{"key":"10.1016\/j.atherosclerosis.2023.03.005_bib13","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S0021-9150(00)00371-3","article-title":"The rebound of lipoproteins after LDL-apheresis. Kinetics and estimation of mean lipoprotein levels","volume":"152","author":"Kroon","year":"2000","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2023.03.005_bib14","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1016\/j.jacl.2018.08.006","article-title":"Oligogenic familial hypercholesterolemia, LDL cholesterol, and coronary artery disease","volume":"12","author":"Tada","year":"2018","journal-title":"J Clin Lipidol"},{"key":"10.1016\/j.atherosclerosis.2023.03.005_bib15","doi-asserted-by":"crossref","DOI":"10.1038\/hgv.2016.25","article-title":"Challenges in detecting genomic copy number aberrations using next-generation sequencing data and the eXome Hidden Markov Model: a clinical exome-first diagnostic approach","volume":"3","author":"Yamamoto","year":"2016","journal-title":"Hum Genome Var"},{"key":"10.1016\/j.atherosclerosis.2023.03.005_bib16","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"ACMG laboratory quality assurance committee. Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of medical genetics and Genomics and the association for molecular pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet. Med."},{"key":"10.1016\/j.atherosclerosis.2023.03.005_bib17","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.atherosclerosis.2018.08.014","article-title":"The effects of 3-year statin therapy and the achievement of LDL cholesterol target values in familial hypercholesterolemia patients: an experience from Serbia","volume":"277","author":"Lali\u0107","year":"2018","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2023.03.005_bib18","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.atherosclerosis.2018.06.820","article-title":"LDL-cholesterol target achievement in patients with heterozygous familial hypercholesterolemia at Groote Schuur Hospital: minority at target despite large reductions in LDL-C","volume":"277","author":"van Delden","year":"2018","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.atherosclerosis.2023.03.005_bib19","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.ijcard.2021.10.024","article-title":"LDL cholesterol target achievement in heterozygous familial hypercholesterolemia patients according to 2019 ESC\/EAS lipid guidelines: implications for newer lipid-lowering treatments","volume":"345","author":"Rizos","year":"2021","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.atherosclerosis.2023.03.005_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajpc.2022.100393","article-title":"The burden of severe hypercholesterolemia and familial hypercholesterolemia in a population-based setting in the US","volume":"12","author":"Saadatagah","year":"2022","journal-title":"Am J Prev Cardiol"},{"key":"10.1016\/j.atherosclerosis.2023.03.005_bib21","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.jacl.2020.12.012","article-title":"Prognostic impact of cascade screening for familial hypercholesterolemia on cardiovascular events","volume":"15","author":"Tada","year":"2021","journal-title":"J Clin Lipidol"},{"key":"10.1016\/j.atherosclerosis.2023.03.005_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajpc.2022.100434","article-title":"Early diagnosis and treatments in childhood are associated with better prognosis in patients with familial hypercholesterolemia","volume":"12","author":"Tada","year":"2022","journal-title":"Am J Prev Cardiol"},{"key":"10.1016\/j.atherosclerosis.2023.03.005_bib23","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1056\/NEJMoa1615664","article-title":"FOURIER steering committee and investigators. Evolocumab and clinical outcomes in patients with cardiovascular disease","volume":"376","author":"Sabatine","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.atherosclerosis.2023.03.005_bib24","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1056\/NEJMoa1801174","article-title":"Zeiher AM; ODYSSEY OUTCOMES committees and investigators. Alirocumab and cardiovascular outcomes after acute coronary syndrome","volume":"379","author":"Schwartz","year":"2018","journal-title":"N. Engl. J. Med."}],"container-title":["Atherosclerosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002191502300103X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002191502300103X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:51:26Z","timestamp":1758156686000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002191502300103X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":24,"alternative-id":["S002191502300103X"],"URL":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2023.03.005","relation":{},"ISSN":["0021-9150"],"issn-type":[{"value":"0021-9150","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Attainment of the low-density lipoprotein cholesterol treatment target and prognosis of heterozygous familial hypercholesterolemia","name":"articletitle","label":"Article Title"},{"value":"Atherosclerosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2023.03.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}