{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:34:49Z","timestamp":1792085689052,"version":"4.4.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T00:00:00Z","timestamp":1689033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFA1300604"],"award-info":[{"award-number":["2021YFA1300604"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014219","name":"National Science Fund for Distinguished Young Scholars","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070466"],"award-info":[{"award-number":["82070466"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072334"],"award-info":[{"award-number":["82072334"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82230080"],"award-info":[{"award-number":["82230080"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010096","name":"Southern Medical University","doi-asserted-by":"publisher","award":["2021B023"],"award-info":[{"award-number":["2021B023"]}],"id":[{"id":"10.13039\/501100010096","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005153","name":"National Science Fund for Distinguished Young Scholars","doi-asserted-by":"publisher","award":["82025024"],"award-info":[{"award-number":["82025024"]}],"id":[{"id":"10.13039\/501100005153","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["atherosclerosis-journal.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Atherosclerosis"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.atherosclerosis.2023.06.974","type":"journal-article","created":{"date-parts":[[2023,7,7]],"date-time":"2023-07-07T20:48:10Z","timestamp":1688762890000},"page":"117183","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["LncRNA RP4-639F20.1 interacts with THRAP3 to attenuate atherosclerosis by regulating c-FOS in vascular smooth muscle cells proliferation and migration"],"prefix":"10.1016","volume":"379","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1588-4753","authenticated-orcid":false,"given":"Ruyi","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Bu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changmeng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juanjiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiumei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8342-5236","authenticated-orcid":false,"given":"Lei","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.atherosclerosis.2023.06.974_bib1","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/s41572-019-0106-z","volume":"5","author":"Libby","year":"2019","journal-title":"Atherosclerosis. Nat Rev Dis Primers."},{"issue":"8","key":"10.1016\/j.atherosclerosis.2023.06.974_bib2","doi-asserted-by":"crossref","first-page":"C7","DOI":"10.1016\/j.jacc.2005.09.068","article-title":"Pathogenesis of atherosclerosis","volume":"47","author":"Falk","year":"2006","journal-title":"J. Am. Coll. Cardiol."},{"issue":"12","key":"10.1016\/j.atherosclerosis.2023.06.974_bib3","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/s41569-019-0227-9","article-title":"Vascular smooth muscle cells in atherosclerosis","volume":"16","author":"Basatemur","year":"2019","journal-title":"Nat. Rev. Cardiol."},{"issue":"10","key":"10.1016\/j.atherosclerosis.2023.06.974_bib4","doi-asserted-by":"crossref","first-page":"6919","DOI":"10.1111\/jcmm.14576","article-title":"Long non-coding RNA SNHG16 regulates human aortic smooth muscle cell proliferation and migration via sponging miR-205 and modulating Smad2","volume":"23","author":"Lin","year":"2019","journal-title":"J. Cell Mol. Med."},{"issue":"3","key":"10.1016\/j.atherosclerosis.2023.06.974_bib5","doi-asserted-by":"crossref","first-page":"3001","DOI":"10.1002\/jcb.27070","article-title":"Long noncoding RNAs C2dat1 enhances vascular smooth muscle cell proliferation and migration by targeting MiR-34a-5p","volume":"120","author":"Wang","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.atherosclerosis.2023.06.974_bib6","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.vph.2018.10.006","article-title":"Non-coding RNAs in vascular remodeling and restenosis","volume":"114","author":"Indolfi","year":"2019","journal-title":"Vasc. Pharmacol."},{"issue":"6","key":"10.1016\/j.atherosclerosis.2023.06.974_bib7","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1016\/j.cell.2013.02.012","article-title":"Long noncoding RNAs: cellular address codes in development and disease","volume":"152","author":"Batista","year":"2013","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.atherosclerosis.2023.06.974_bib8","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1161\/CIRCRESAHA.116.302521","article-title":"Long noncoding RNAs in cardiovascular diseases","volume":"116","author":"Uchida","year":"2015","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.atherosclerosis.2023.06.974_bib9","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s12929-018-0418-4","article-title":"H19 knockdown suppresses proliferation and induces apoptosis by regulating miR-148b\/WNT\/\u03b2-catenin in ox-LDL -stimulated vascular smooth muscle cells","volume":"25","author":"Zhang","year":"2018","journal-title":"J. Biomed. Sci."},{"issue":"12","key":"10.1016\/j.atherosclerosis.2023.06.974_bib10","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1038\/s41419-020-03263-6","article-title":"LncRNA kcnq1ot1 promotes lipid accumulation and accelerates atherosclerosis via functioning as a ceRNA through the miR-452-3p\/HDAC3\/ABCA1 axis","volume":"11","author":"Yu","year":"2020","journal-title":"Cell Death Dis."},{"issue":"21","key":"10.1016\/j.atherosclerosis.2023.06.974_bib11","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.140627","article-title":"LncRNA VINAS regulates atherosclerosis by modulating NF-\u03baB and MAPK signaling","volume":"5","author":"Simion","year":"2020","journal-title":"JCI Insight"},{"issue":"12","key":"10.1016\/j.atherosclerosis.2023.06.974_bib12","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1152\/physiolgenomics.00077.2019","article-title":"Microarray profiling analysis and validation of novel long noncoding RNAs and mRNAs as potential biomarkers and their functions in atherosclerosis","volume":"51","author":"Bai","year":"2019","journal-title":"Physiol. Genom."},{"issue":"10","key":"10.1016\/j.atherosclerosis.2023.06.974_bib13","first-page":"3440","article-title":"TRAP150 activates pre-mRNA splicing and promotes nuclear mRNA degradation","volume":"38","author":"Lee Km","year":"2010","journal-title":"Nucleic Acids Res."},{"issue":"5","key":"10.1016\/j.atherosclerosis.2023.06.974_bib14","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1210\/me.2012-1332","article-title":"THRAP3 interacts with HELZ2 and plays a novel role in adipocyte differentiation","volume":"27","author":"Katano-Toki","year":"2013","journal-title":"Mol. Endocrinol."},{"issue":"12","key":"10.1016\/j.atherosclerosis.2023.06.974_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2020.101857","article-title":"Super-enhancer LncRNA LINC00162 promotes progression of bladder cancer","volume":"23","author":"Wang","year":"2020","journal-title":"iScience"},{"issue":"12","key":"10.1016\/j.atherosclerosis.2023.06.974_bib16","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1016\/j.febslet.2013.04.033","article-title":"Rhomboid domain containing 1 inhibits cell apoptosis by upregulating AP-1 activity and its downstream target Bcl-3","volume":"587","author":"Ren","year":"2013","journal-title":"FEBS Lett."},{"issue":"16","key":"10.1016\/j.atherosclerosis.2023.06.974_bib17","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1016\/j.ejca.2005.08.008","article-title":"The Fos family of transcription factors and their role in tumourigenesis","volume":"41","author":"Milde-Langosch","year":"2005","journal-title":"Eur. J. Cancer"},{"issue":"8","key":"10.1016\/j.atherosclerosis.2023.06.974_bib18","first-page":"7232","article-title":"LncRNA XIST promotes myocardial infarction by regulating FOS through targeting miR-101a-3p","volume":"12","author":"Lin","year":"2020","journal-title":"Aging(Albany NY)"},{"issue":"6","key":"10.1016\/j.atherosclerosis.2023.06.974_bib19","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/s41419-020-2617-7","article-title":"The lncRNA RUNX1-IT1 regulates C-FOS transcription by interacting with RUNX1 in the process of pancreatic cancer proliferation, migration and invasion","volume":"11","author":"Liu","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.atherosclerosis.2023.06.974_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110290","article-title":"MicroRNA miR-29c-3p modulates FOS expression to repress EMT and cell proliferation while induces apoptosis in TGF-\u03b22-treated lens epithelial cells regulated by lncRNA KCNQ1OT1","volume":"129","author":"Yao","year":"2020","journal-title":"Biomed. Pharmacother."},{"issue":"6","key":"10.1016\/j.atherosclerosis.2023.06.974_bib21","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s10735-010-9298-y","article-title":"Immunohistochemical and transcriptional expression of matrix metalloproteinases in full-term human umbilical cord and human umbilical vein endothelial cells","volume":"41","author":"Mauro","year":"2010","journal-title":"J. Mol. Histol."},{"issue":"1","key":"10.1016\/j.atherosclerosis.2023.06.974_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2022.113267","article-title":"MCPIP1 promotes cell proliferation, migration and angiogenesis of glioma via VEGFA-mediated ERK pathway","volume":"418","author":"Wang","year":"2022","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.atherosclerosis.2023.06.974_bib23","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.atherosclerosis.2018.09.022","article-title":"Matrix metalloproteinase-10 deficiency delays atherosclerosis progression and plaque calcification","volume":"278","author":"Purroy","year":"2018","journal-title":"Atherosclerosis"},{"issue":"4","key":"10.1016\/j.atherosclerosis.2023.06.974_bib24","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1097\/FJC.0000000000001203","article-title":"Circular RNA circ_0002984 promotes cell proliferation and migration by regulating miR-181b-5p\/vascular endothelial growth factor Axis and PI3K-AKT signaling pathway in oxidized low-density lipoprotein-treated vascular smooth muscle cells","volume":"79","author":"Wang","year":"2022","journal-title":"J. Cardiovasc. Pharmacol."},{"issue":"18","key":"10.1016\/j.atherosclerosis.2023.06.974_bib25","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1101\/gad.223339.113","article-title":"Inflammation-mediated skin tumorigenesis induced by epidermal c-Fos","volume":"27","author":"Briso","year":"2013","journal-title":"Genes Dev."},{"issue":"6","key":"10.1016\/j.atherosclerosis.2023.06.974_bib26","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1038\/ki.2013.217","article-title":"The proto-oncogene c-Fos transcriptionally regulates VEGF production during peritoneal inflammation","volume":"84","author":"Catar","year":"2013","journal-title":"Kidney Int."},{"issue":"5","key":"10.1016\/j.atherosclerosis.2023.06.974_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0097549","article-title":"The LIM domain protein nTRIP6 recruits the mediator complex to AP-1-regulated promoters","volume":"9","author":"Diefenbacher","year":"2014","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.atherosclerosis.2023.06.974_bib28","first-page":"257","article-title":"The serum concentration of C-FOS protein increased in patients with acute intracerebral hemorrhage","volume":"12","author":"CL","year":"2012","journal-title":"Journal of Neuroscience and Mental Health"},{"issue":"9867","key":"10.1016\/j.atherosclerosis.2023.06.974_bib29","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0140-6736(13)60141-5","article-title":"Coronary artery bypass graft surgery versus percutaneous coronary intervention in patients with three-vessel disease and left main coronary disease: 5-year follow-up of the randomised, clinical SYNTAX trial","volume":"381","author":"Mohr","year":"2013","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.atherosclerosis.2023.06.974_bib30","first-page":"219","article-title":"The SYNTAX Score: an angiographic tool grading the complexity of coronary artery disease","volume":"1","author":"Sianos","year":"2005","journal-title":"EuroIntervention"},{"issue":"12","key":"10.1016\/j.atherosclerosis.2023.06.974_bib31","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1093\/cvr\/cvz203","article-title":"Non-coding RNAs in cardiovascular cell biology and atherosclerosis","volume":"115","author":"Fasolo","year":"2019","journal-title":"Cardiovasc. Res."},{"issue":"6","key":"10.1016\/j.atherosclerosis.2023.06.974_bib32","doi-asserted-by":"crossref","first-page":"591","DOI":"10.17219\/acem\/133496","article-title":"Silencing of lncRNA SNHG12 inhibits proliferation and migration of vascular smooth muscle cells via targeting miR-766-5p\/EIF5A axis","volume":"30","author":"Liu","year":"2021","journal-title":"Adv. Clin. Exp. Med."},{"issue":"4","key":"10.1016\/j.atherosclerosis.2023.06.974_bib33","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1007\/s11239-020-02314-1","article-title":"LncRNA BANCR induced vascular smooth muscle cell proliferation by downregulating miR-34c methylation in atherosclerosis","volume":"51","author":"Jiang","year":"2021","journal-title":"J. Thromb. Thrombolysis"},{"issue":"6","key":"10.1016\/j.atherosclerosis.2023.06.974_bib34","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.3892\/etm.2021.10874","article-title":"lncRNA RP11-531A24.3 inhibits the migration and proliferation of vascular smooth muscle cells by downregulating ANXA2 expression","volume":"22","author":"Wu","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.atherosclerosis.2023.06.974_bib35","doi-asserted-by":"crossref","first-page":"838","DOI":"10.3389\/fimmu.2019.00838","article-title":"A novel lncRNA regulates the toll-like receptor signaling pathway and related immune function by stabilizing FOS mRNA as a competitive endogenous RNA","volume":"10","author":"Fan","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.atherosclerosis.2023.06.974_bib36","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.preghy.2020.05.001","article-title":"LncRNA MALAT1 affects the migration and invasion of trophoblast cells by regulating FOS expression in early-onset preeclampsia","volume":"21","author":"Li","year":"2020","journal-title":"Pregnancy Hypertens"},{"key":"10.1016\/j.atherosclerosis.2023.06.974_bib37","article-title":"LNCcation: lncRNA localization and function","volume":"2","author":"Bridges","year":"2021","journal-title":"J. Cell Biol."}],"container-title":["Atherosclerosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915023050773?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915023050773?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T16:27:54Z","timestamp":1762187274000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021915023050773"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":37,"alternative-id":["S0021915023050773"],"URL":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2023.06.974","relation":{},"ISSN":["0021-9150"],"issn-type":[{"value":"0021-9150","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"LncRNA RP4-639F20.1 interacts with THRAP3 to attenuate atherosclerosis by regulating c-FOS in vascular smooth muscle cells proliferation and migration","name":"articletitle","label":"Article Title"},{"value":"Atherosclerosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2023.06.974","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"117183"}}