{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:48:35Z","timestamp":1792633715779,"version":"4.5.0"},"reference-count":79,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82405156"],"award-info":[{"award-number":["82405156"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014717","name":"National Natural Science Foundation of China National Outstanding Youth Science Fund Project","doi-asserted-by":"publisher","award":["82022076"],"award-info":[{"award-number":["82022076"]}],"id":[{"id":"10.13039\/100014717","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["atherosclerosis-journal.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Atherosclerosis"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.atherosclerosis.2025.119136","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T11:21:27Z","timestamp":1739877687000},"page":"119136","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Genetic association of circulating lipids and lipid-lowering drug targets with vascular calcification"],"prefix":"10.1016","volume":"403","author":[{"given":"Pengfei","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengmeng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0084-863X","authenticated-orcid":false,"given":"Yue","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.atherosclerosis.2025.119136_bib1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/bs.acc.2020.02.004","article-title":"Biomarkers of vascular calcification in serum","volume":"98","author":"Roumeliotis","year":"2020","journal-title":"Adv. Clin. Chem."},{"issue":"23","key":"10.1016\/j.atherosclerosis.2025.119136_bib2","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1093\/eurheartj\/ehu163","article-title":"Medial vascular calcification revisited: review and perspectives","volume":"35","author":"Lanzer","year":"2014","journal-title":"Eur. Heart J."},{"issue":"1","key":"10.1016\/j.atherosclerosis.2025.119136_bib3","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1161\/ATVBAHA.111.235234","article-title":"Calcified atherosclerosis in different vascular beds and the risk of mortality","volume":"32","author":"Allison","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"6","key":"10.1016\/j.atherosclerosis.2025.119136_bib4","first-page":"668","article-title":"Current understanding of coronary artery calcification","volume":"12","author":"Liu","year":"2015","journal-title":"J. Geriatr. Cardiol."},{"issue":"18","key":"10.1016\/j.atherosclerosis.2025.119136_bib5","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1016\/j.jacc.2014.01.034","volume":"63","author":"G\u00e9n\u00e9reux","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.atherosclerosis.2025.119136_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2022.900579","article-title":"Intracranial arterial calcifications: potential biomarkers of stroke risk and outcome","volume":"13","author":"Fote","year":"2022","journal-title":"Front. Neurol."},{"issue":"3","key":"10.1016\/j.atherosclerosis.2025.119136_bib7","doi-asserted-by":"crossref","first-page":"275","DOI":"10.3390\/biom14030275","article-title":"Vascular calcification: molecular networking, pathological implications and translational opportunities","volume":"14","author":"Ortega","year":"2024","journal-title":"Biomolecules"},{"issue":"7","key":"10.1016\/j.atherosclerosis.2025.119136_bib8","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1161\/ATVBAHA.114.303268","article-title":"Abdominal aortic calcium, coronary artery calcium, and cardiovascular morbidity and mortality in the multi-ethnic study of atherosclerosis","volume":"34","author":"Criqui","year":"2014","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"9","key":"10.1016\/j.atherosclerosis.2025.119136_bib9","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1161\/CIRCULATIONAHA.122.062746","article-title":"Incidental coronary artery calcium: opportunistic screening of prior non-gated chest CTs to improve statin rates (NOTIFY-1 project)","volume":"147","author":"Sandhu","year":"2023","journal-title":"Circulation"},{"issue":"10","key":"10.1016\/j.atherosclerosis.2025.119136_bib10","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/j.jcmg.2018.04.015","article-title":"Effects of statins on coronary atherosclerotic plaques: the PARADIGM study","volume":"11","author":"Lee","year":"2018","journal-title":"JACC Cardiovasc. Imag."},{"issue":"9","key":"10.1016\/j.atherosclerosis.2025.119136_bib11","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1161\/01.CIR.0000027567.49283.FF","article-title":"Influence of lipid-lowering therapy on the progression of coronary artery calcification: a prospective evaluation","volume":"106","author":"Achenbach","year":"2002","journal-title":"Circulation"},{"issue":"8","key":"10.1016\/j.atherosclerosis.2025.119136_bib12","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1161\/01.RES.0000218859.90970.8d","article-title":"Statins protect human aortic smooth muscle cells from inorganic phosphate-induced calcification by restoring Gas6-axl survival pathway","volume":"98","author":"Son","year":"2006","journal-title":"Circ. Res."},{"key":"10.1016\/j.atherosclerosis.2025.119136_bib13","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41514-018-0026-2","article-title":"The annual rate of coronary artery calcification with combination therapy with a PCSK9 inhibitor and a statin is lower than that with statin monotherapy","volume":"4","author":"Ikegami","year":"2018","journal-title":"NPJ Aging Mech. Dis."},{"key":"10.1016\/j.atherosclerosis.2025.119136_bib14","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.atherosclerosis.2016.08.038","article-title":"PCSK9 and lipoprotein (a) levels are two predictors of coronary artery calcification in asymptomatic patients with familial hypercholesterolemia","volume":"254","author":"Alonso","year":"2016","journal-title":"Atherosclerosis"},{"issue":"12","key":"10.1016\/j.atherosclerosis.2025.119136_bib15","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1161\/01.CIR.0000159263.50305.BD","article-title":"Lipoprotein(a) and apolipoprotein(a) isoforms: No association with coronary artery calcification in the dallas heart study","volume":"111","author":"Guerra","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.atherosclerosis.2025.119136_bib16","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12881-020-01003-3","article-title":"Association between lipoprotein(a) (lp(a)) levels and lp(a) genetic variants with coronary artery calcification","volume":"21","author":"Pechlivanis","year":"2020","journal-title":"BMC Med. Genet."},{"issue":"1","key":"10.1016\/j.atherosclerosis.2025.119136_bib17","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ejim.2012.08.014","article-title":"Lipoprotein (a) is independently correlated with coronary artery calcification","volume":"24","author":"Greif","year":"2013","journal-title":"Eur. J. Intern. Med."},{"key":"10.1016\/j.atherosclerosis.2025.119136_bib18","doi-asserted-by":"crossref","DOI":"10.5551\/jat.64600","article-title":"The risk of coronary artery calcification according to different lipid parameters and average lipid parameters","author":"Yoo","year":"2024","journal-title":"J. Atherosclerosis Thromb."},{"issue":"2","key":"10.1016\/j.atherosclerosis.2025.119136_bib19","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.atherosclerosis.2013.04.015","article-title":"Gender-specific association of coronary artery calcium and lipoprotein parameters: the heinz nixdorf recall study","volume":"229","author":"Erbel","year":"2013","journal-title":"Atherosclerosis"},{"issue":"1","key":"10.1016\/j.atherosclerosis.2025.119136_bib20","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jacl.2019.11.005","article-title":"Apolipoprotein B discordance with low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol in relation to coronary artery calcification in the multi-ethnic study of atherosclerosis (MESA)","volume":"14","author":"Cao","year":"2020","journal-title":"J. Clin. Lipidol."},{"issue":"22","key":"10.1016\/j.atherosclerosis.2025.119136_bib21","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1001\/jama.2009.812","article-title":"Mendelian randomization: Nature's randomized trial in the post\u2013genome era","volume":"301","author":"Thanassoulis","year":"2009","journal-title":"JAMA"},{"issue":"8","key":"10.1016\/j.atherosclerosis.2025.119136_bib22","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1002\/sim.3034","article-title":"Mendelian randomization: using genes as instruments for making causal inferences in epidemiology","volume":"27","author":"Lawlor","year":"2008","journal-title":"Stat. Med."},{"issue":"42","key":"10.1016\/j.atherosclerosis.2025.119136_bib23","doi-asserted-by":"crossref","first-page":"4447","DOI":"10.1093\/eurheartj\/ehac394","article-title":"From the garden to the clinic: how mendelian randomization is shaping up atherosclerotic cardiovascular disease prevention strategies","volume":"43","author":"Arsenault","year":"2022","journal-title":"Eur. Heart J."},{"issue":"1","key":"10.1016\/j.atherosclerosis.2025.119136_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ije\/dyg070","article-title":"Mendelian randomization\u2019: can genetic epidemiology contribute to understanding environmental determinants of disease?","volume":"32","author":"Smith","year":"2003","journal-title":"Int. J. Epidemiol."},{"issue":"2","key":"10.1016\/j.atherosclerosis.2025.119136_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1003898","article-title":"The evolution of mendelian randomization for investigating drug effects","volume":"19","author":"Gill","year":"2022","journal-title":"PLoS Med."},{"key":"10.1016\/j.atherosclerosis.2025.119136_bib26","first-page":"n2233","article-title":"Strengthening the reporting of observational studies in epidemiology using mendelian randomisation (STROBE-MR): explanation and elaboration","volume":"375","author":"Skrivankova","year":"2021","journal-title":"BMJ (Practice Obs. Ed.)"},{"issue":"3","key":"10.1016\/j.atherosclerosis.2025.119136_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1003062","article-title":"Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: a multivariable mendelian randomisation analysis","volume":"17","author":"Richardson","year":"2020","journal-title":"PLoS Med."},{"issue":"42","key":"10.1016\/j.atherosclerosis.2025.119136_bib28","doi-asserted-by":"crossref","first-page":"4324","DOI":"10.1093\/eurheartj\/ehab432","article-title":"Remnant cholesterol predicts cardiovascular disease beyond LDL and ApoB: a primary prevention study","volume":"42","author":"Quispe","year":"2021","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.atherosclerosis.2025.119136_bib29","article-title":"2023 Chinese guideline for lipid management","volume":"14","author":"Li","year":"2023","journal-title":"Front. Pharmacol."},{"issue":"6","key":"10.1016\/j.atherosclerosis.2025.119136_bib30","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1007\/s40265-024-02046-z","article-title":"Therapeutic potential of lipoprotein(a) inhibitors","volume":"84","author":"Nicholls","year":"2024","journal-title":"Drugs"},{"issue":"11","key":"10.1016\/j.atherosclerosis.2025.119136_bib31","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1038\/ng.2797","article-title":"Discovery and refinement of loci associated with lipid levels","volume":"45","author":"Willer","year":"2013","journal-title":"Nat. Genet."},{"issue":"7","key":"10.1016\/j.atherosclerosis.2025.119136_bib32","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.jacc.2022.05.041","article-title":"Mendelian randomization study of PCSK9 and HMG-CoA reductase inhibition and cognitive function","volume":"80","author":"Rosoff","year":"2022","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.atherosclerosis.2025.119136_bib33","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.73873","article-title":"Association of lipid-lowering drugs with COVID-19 outcomes from a mendelian randomization study","volume":"10","author":"Huang","year":"2021","journal-title":"eLife"},{"issue":"1","key":"10.1016\/j.atherosclerosis.2025.119136_bib34","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1186\/s12967-024-05097-8","article-title":"Statins as a risk factor for diabetic retinopathy: a mendelian randomization and cross-sectional observational study","volume":"22","author":"Chen","year":"2024","journal-title":"J. Transl. Med."},{"issue":"1","key":"10.1016\/j.atherosclerosis.2025.119136_bib35","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/gepi.22506","article-title":"Statistical methods for cis\u2010Mendelian randomization with two\u2010sample summary\u2010level data","volume":"47","author":"Gkatzionis","year":"2023","journal-title":"Genet. Epidemiol."},{"issue":"1","key":"10.1016\/j.atherosclerosis.2025.119136_bib36","doi-asserted-by":"crossref","first-page":"3255","DOI":"10.1038\/s41467-020-16969-0","article-title":"Genetic drug target validation using Mendelian randomisation","volume":"11","author":"Schmidt","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.atherosclerosis.2025.119136_bib37","doi-asserted-by":"crossref","first-page":"16","DOI":"10.12688\/wellcomeopenres.16544.1","article-title":"Mendelian randomization for studying the effects of perturbing drug targets","volume":"6","author":"Gill","year":"2021","journal-title":"Wellcome Open Res."},{"issue":"9","key":"10.1016\/j.atherosclerosis.2025.119136_bib38","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1038\/s41588-021-00913-z","article-title":"Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression","volume":"53","author":"V\u00f5sa","year":"2021","journal-title":"Nat. Genet."},{"issue":"6509","key":"10.1016\/j.atherosclerosis.2025.119136_bib39","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1126\/science.aaz1776","article-title":"The GTEx consortium atlas of genetic regulatory effects across human tissues","volume":"369","author":"Consortium","year":"2020","journal-title":"Science (New York, N.Y.)"},{"issue":"10","key":"10.1016\/j.atherosclerosis.2025.119136_bib40","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1038\/s41588-023-01518-4","article-title":"Multi-ancestry genome-wide study identifies effector genes and druggable pathways for coronary artery calcification","volume":"55","author":"Kavousi","year":"2023","journal-title":"Nat. Genet."},{"issue":"Oct","key":"10.1016\/j.atherosclerosis.2025.119136_bib41","article-title":"Calcification of the abdominal aorta is an under-appreciated cardiovascular disease risk factor in the general population","volume":"9","author":"Sethi","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"issue":"19","key":"10.1016\/j.atherosclerosis.2025.119136_bib42","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1001\/jama.2017.17219","article-title":"Mendelian randomization","volume":"318","author":"Emdin","year":"2017","journal-title":"JAMA"},{"issue":"5","key":"10.1016\/j.atherosclerosis.2025.119136_bib43","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/ng.3538","article-title":"Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets","volume":"48","author":"Zhu","year":"2016","journal-title":"Nat. Genet."},{"issue":"5","key":"10.1016\/j.atherosclerosis.2025.119136_bib44","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004383","article-title":"Bayesian test for colocalisation between pairs of genetic association studies using summary statistics","volume":"10","author":"Giambartolomei","year":"2014","journal-title":"PLoS Genet."},{"issue":"1","key":"10.1016\/j.atherosclerosis.2025.119136_bib45","doi-asserted-by":"crossref","first-page":"7342","DOI":"10.1038\/s41467-021-26280-1","article-title":"Finding genetically-supported drug targets for Parkinson's disease using mendelian randomization of the druggable genome","volume":"12","author":"Storm","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.atherosclerosis.2025.119136_bib46","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/4461311","article-title":"Epidemiological research advances in vascular calcification in diabetes","volume":"2021","author":"Yao","year":"2021","journal-title":"J. Diabetes Res."},{"issue":"2","key":"10.1016\/j.atherosclerosis.2025.119136_bib47","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1093\/ckj\/sfu017","article-title":"Cardiovascular risk markers associated with arterial calcification in patients with chronic kidney disease stages 3 and 4","volume":"7","author":"Kiu Weber","year":"2014","journal-title":"Clin. Kidney J."},{"issue":"8","key":"10.1016\/j.atherosclerosis.2025.119136_bib48","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1111\/j.1476-5381.2008.00108.x","article-title":"Vascular calcification and secondary hyperparathyroidism of severe chronic kidney disease and its relation to serum phosphate and calcium levels","volume":"156","author":"Terai","year":"2009","journal-title":"Br. J. Pharmacol."},{"issue":"9","key":"10.1016\/j.atherosclerosis.2025.119136_bib49","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.3390\/genes13091541","article-title":"TwoStepCisMR: a novel method and R package for attenuating bias in cis-mendelian randomization analyses","volume":"13","author":"Woolf","year":"2022","journal-title":"Genes"},{"issue":"10","key":"10.1016\/j.atherosclerosis.2025.119136_bib50","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1038\/ng.3396","article-title":"A comprehensive 1,000 genomes-based genome-wide association meta-analysis of coronary artery disease","volume":"47","author":"Nikpay","year":"2015","journal-title":"Nat. Genet."},{"issue":"7","key":"10.1016\/j.atherosclerosis.2025.119136_bib51","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1002\/gepi.21998","article-title":"Bias due to participant overlap in two\u2010sample mendelian randomization","volume":"40","author":"Burgess","year":"2016","journal-title":"Genet. Epidemiol."},{"issue":"1","key":"10.1016\/j.atherosclerosis.2025.119136_bib52","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.tpb.2008.05.006","article-title":"Mathematical properties of the r2 measure of linkage disequilibrium","volume":"74","author":"VanLiere","year":"2008","journal-title":"Theor. Popul. Biol."},{"issue":"17","key":"10.1016\/j.atherosclerosis.2025.119136_bib53","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1016\/j.jacc.2014.01.017","article-title":"Coronary artery calcification: pathogenesis and prognostic implications","volume":"63","author":"Madhavan","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"issue":"6","key":"10.1016\/j.atherosclerosis.2025.119136_bib54","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.2215\/CJN.02120508","article-title":"Media calcification and intima calcification are distinct entities in chronic kidney disease","volume":"3","author":"Amann","year":"2008","journal-title":"Clin. J. Am. Soc. Nephrol."},{"issue":"6090","key":"10.1016\/j.atherosclerosis.2025.119136_bib55","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1038\/323734a0","article-title":"Complete protein sequence and identification of structural domains of human apolipoprotein B","volume":"323","author":"Knott","year":"1986","journal-title":"Nature"},{"key":"10.1016\/j.atherosclerosis.2025.119136_bib56","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1146\/annurev-pharmtox-031023-100609","article-title":"LP(a): structure, genetics, associated cardiovascular risk, and emerging therapeutics","volume":"64","author":"Tasdighi","year":"2024","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"issue":"1","key":"10.1016\/j.atherosclerosis.2025.119136_bib57","first-page":"76","article-title":"Lipoprotein (a): structure, pathophysiology and clinical implications","volume":"103","author":"Maranh\u00e3o","year":"2014","journal-title":"Arq. Bras. Cardiol."},{"issue":"39","key":"10.1016\/j.atherosclerosis.2025.119136_bib58","doi-asserted-by":"crossref","first-page":"3925","DOI":"10.1093\/eurheartj\/ehac361","article-title":"Lipoprotein(a) in atherosclerotic cardiovascular disease and aortic stenosis: a European Atherosclerosis Society consensus statement","volume":"43","author":"Kronenberg","year":"2022","journal-title":"Eur. Heart J."},{"issue":"2","key":"10.1016\/j.atherosclerosis.2025.119136_bib59","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0022-2275(20)33367-8","article-title":"Presecretory degradation of apolipoprotein[a] is mediated by the proteasome pathway","volume":"40","author":"White","year":"1999","journal-title":"JLR (J. Lipid Res.)"},{"key":"10.1016\/j.atherosclerosis.2025.119136_bib60","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.118.011781","article-title":"Lipoprotein(a) particle production as a determinant of plasma lipoprotein(a) concentration across varying apolipoprotein(a) isoform sizes and background cholesterol\u2010lowering therapy","author":"Chan","year":"2019","journal-title":"J. Am. Heart Assoc."},{"issue":"39","key":"10.1016\/j.atherosclerosis.2025.119136_bib61","doi-asserted-by":"crossref","first-page":"3960","DOI":"10.1093\/eurheartj\/ehac377","article-title":"Lipoprotein(a) is associated with the onset but not the progression of aortic valve calcification","volume":"43","author":"Kaiser","year":"2022","journal-title":"Eur. Heart J."},{"issue":"8","key":"10.1016\/j.atherosclerosis.2025.119136_bib62","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1093\/cvr\/cvad062","article-title":"Lipoprotein(a) and calcific aortic valve disease initiation and progression: a systematic review and meta-analysis","volume":"119","author":"Pantelidis","year":"2023","journal-title":"Cardiovasc. Res."},{"issue":"1","key":"10.1016\/j.atherosclerosis.2025.119136_bib63","first-page":"77","article-title":"Lipoprotein(a) and calcific aortic valve disease: current evidence and future directions","volume":"27","author":"Lan","year":"2024","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"issue":"10057","key":"10.1016\/j.atherosclerosis.2025.119136_bib64","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1016\/S0140-6736(16)31009-1","article-title":"Antisense oligonucleotides targeting apolipoprotein(a) in people with raised lipoprotein(a): two randomised, double-blind, placebo-controlled, dose-ranging trials","volume":"388","author":"Viney","year":"2016","journal-title":"Lancet"},{"issue":"10002","key":"10.1016\/j.atherosclerosis.2025.119136_bib65","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1016\/S0140-6736(15)61252-1","article-title":"Antisense therapy targeting apolipoprotein(a): a randomised, double-blind, placebo-controlled phase 1 study","volume":"386","author":"Tsimikas","year":"2015","journal-title":"Lancet"},{"issue":"19\u201320","key":"10.1016\/j.atherosclerosis.2025.119136_bib66","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1016\/j.cca.2011.05.036","article-title":"Lipoprotein(a)-cholesterol: a significant component of serum cholesterol","volume":"412","author":"Kinpara","year":"2011","journal-title":"Clin. Chim. Acta; Int. J. Clin. Chem."},{"issue":"11","key":"10.1016\/j.atherosclerosis.2025.119136_bib67","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/j.jacc.2021.12.032","article-title":"Effect of pelacarsen on lipoprotein(a) cholesterol and corrected low-density lipoprotein cholesterol","volume":"79","author":"Yeang","year":"2022","journal-title":"J. Am. Coll. Cardiol."},{"issue":"1","key":"10.1016\/j.atherosclerosis.2025.119136_bib68","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/s41591-021-01634-w","article-title":"Preclinical development and phase 1 trial of a novel siRNA targeting lipoprotein(a)","volume":"28","author":"Koren","year":"2022","journal-title":"Nat. Med."},{"issue":"18","key":"10.1016\/j.atherosclerosis.2025.119136_bib69","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1001\/jama.2024.4504","article-title":"Single ascending and multiple-dose trial of zerlasiran, a short interfering RNA targeting lipoprotein(a): a randomized clinical trial","volume":"331","author":"Nissen","year":"2024","journal-title":"JAMA"},{"issue":"9","key":"10.1016\/j.atherosclerosis.2025.119136_bib70","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1161\/ATVBAHA.116.307311","article-title":"Functional variant in the SLC22A3-LPAL2-LPA gene cluster contributes to the severity of coronary artery disease","volume":"36","author":"Wang","year":"2016","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"2","key":"10.1016\/j.atherosclerosis.2025.119136_bib71","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1161\/ATVBAHA.116.306256","article-title":"Pathology of human coronary and carotid artery atherosclerosis and vascular calcification in diabetes mellitus","volume":"37","author":"Yahagi","year":"2017","journal-title":"ATVB"},{"issue":"6","key":"10.1016\/j.atherosclerosis.2025.119136_bib72","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1001\/jamacardio.2017.0363","article-title":"Coronary artery calcification and risk of cardiovascular disease and death among patients with chronic kidney disease","volume":"2","author":"Chen","year":"2017","journal-title":"JAMA Cardiol."},{"issue":"3","key":"10.1016\/j.atherosclerosis.2025.119136_bib73","doi-asserted-by":"crossref","first-page":"673","DOI":"10.14336\/AD.2021.1024","article-title":"Vascular calcification in chronic kidney disease: an update and perspective","volume":"13","author":"Ren","year":"2022","journal-title":"Aging Dis."},{"issue":"4","key":"10.1016\/j.atherosclerosis.2025.119136_bib74","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCGEN.120.003258","article-title":"Multiethnic genome-wide association study of subclinical atherosclerosis in individuals with type 2 diabetes","volume":"14","author":"Lu","year":"2021","journal-title":"Circ. Genom. Precis. Med."},{"issue":"1","key":"10.1016\/j.atherosclerosis.2025.119136_bib75","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1161\/ATVBAHA.123.320138","article-title":"Assessment of subclinical atherosclerosis in asymptomatic people in vivo: measurements suitable for biomarker and mendelian randomization studies","volume":"44","author":"Garg","year":"2024","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"1","key":"10.1016\/j.atherosclerosis.2025.119136_bib76","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-15739-w","article-title":"Vascular calcification in different arterial beds in ex vivo ring culture and in vivo rat model","volume":"12","author":"Muyor","year":"2022","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.atherosclerosis.2025.119136_bib77","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1161\/CIRCGENETICS.116.001572","article-title":"Multiethnic exome-wide association study of subclinical atherosclerosis","volume":"9","author":"Natarajan","year":"2016","journal-title":"Circ. Cardiovasc. Genet."},{"issue":"10","key":"10.1016\/j.atherosclerosis.2025.119136_bib78","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1161\/01.CIR.0000157730.94423.4B","article-title":"Ethnic differences in coronary calcification","volume":"111","author":"Bild","year":"2005","journal-title":"Circulation"},{"issue":"7","key":"10.1016\/j.atherosclerosis.2025.119136_bib79","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.scib.2024.02.003","article-title":"Single-cell profile reveals the landscape of cardiac immunity and identifies a cardio-protective ym-1hi neutrophil in myocardial ischemia-reperfusion injury","volume":"69","author":"Dong","year":"2024","journal-title":"Sci Bull. (Beijing)"}],"container-title":["Atherosclerosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915025000334?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021915025000334?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T16:28:49Z","timestamp":1762187329000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021915025000334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":79,"alternative-id":["S0021915025000334"],"URL":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2025.119136","relation":{},"ISSN":["0021-9150"],"issn-type":[{"value":"0021-9150","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic association of circulating lipids and lipid-lowering drug targets with vascular calcification","name":"articletitle","label":"Article Title"},{"value":"Atherosclerosis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.atherosclerosis.2025.119136","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"119136"}}