{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T07:39:56Z","timestamp":1776843596890,"version":"3.51.2"},"reference-count":11,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2004,8,1]],"date-time":"2004-08-01T00:00:00Z","timestamp":1091318400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,8,1]],"date-time":"2004-08-01T00:00:00Z","timestamp":1091318400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["annalsthoracicsurgery.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Annals of Thoracic Surgery"],"published-print":{"date-parts":[[2004,8]]},"DOI":"10.1016\/j.athoracsur.2003.09.032","type":"journal-article","created":{"date-parts":[[2004,7,27]],"date-time":"2004-07-27T17:39:26Z","timestamp":1090949966000},"page":"673-678","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Novel treatment strategy for leg and sternal wound complications after coronary artery bypass graft surgery: Bioengineered Apligraf"],"prefix":"10.1016","volume":"78","author":[{"given":"David E","family":"Allie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris J","family":"Hebert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitchell D","family":"Lirtzman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles H","family":"Wyatt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.Antoine","family":"Keller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stella M","family":"Souther","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam A","family":"Allie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena V","family":"Mitran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig M","family":"Walker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.athoracsur.2003.09.032_BIB1","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1093\/clinids\/22.3.424","article-title":"The epidemiology of chest and leg wound infections following cardiothoracic surgery","volume":"22","author":"L'Ecuyer","year":"1996","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.athoracsur.2003.09.032_BIB2","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/0003-4975(95)01035-1","article-title":"Postoperative mediastinitis","volume":"61","author":"El Oakley","year":"1996","journal-title":"Ann Thorac Surg"},{"issue":"Suppl A","key":"10.1016\/j.athoracsur.2003.09.032_BIB3","first-page":"20","article-title":"The safety and efficacy of Apligraf (Apligraf) in the treatment of venous leg ulcers","volume":"12","author":"Atillasoy","year":"2000","journal-title":"Wounds"},{"key":"10.1016\/j.athoracsur.2003.09.032_BIB4","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1001\/archderm.134.3.293","article-title":"Rapid healing of venous ulcers and lack of clinical rejection with an allogenic cultured human skin equivalent","volume":"134","author":"Falanga","year":"1998","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.athoracsur.2003.09.032_BIB5","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/0142-9612(96)85569-4","article-title":"Cultured skin as a \u201csmart material\u201d for healing wounds","volume":"17","author":"Sabolinski","year":"1996","journal-title":"Biomaterials"},{"issue":"Suppl A","key":"10.1016\/j.athoracsur.2003.09.032_BIB6","first-page":"27","article-title":"Graftskin (Apligraf) in the treatment of venous leg ulcer","volume":"12","author":"Moneta","year":"2000","journal-title":"Wounds"},{"key":"10.1016\/j.athoracsur.2003.09.032_BIB7","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1111\/j.1346-8138.1998.tb02510.x","article-title":"Apligraf treatment of venous ulcers and other chronic wounds","volume":"25","author":"Falanga","year":"1998","journal-title":"J Dermatol"},{"issue":"Suppl A","key":"10.1016\/j.athoracsur.2003.09.032_BIB8","first-page":"12","article-title":"Growth factor expression, healing, and structural characteristics of Graftskin (Apligraf)","volume":"12","author":"Milstone","year":"2000","journal-title":"Wounds"},{"key":"10.1016\/j.athoracsur.2003.09.032_BIB9","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/43088","article-title":"A peptide antibiotic from the human skin","volume":"387","author":"Harder","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.athoracsur.2003.09.032_BIB10","doi-asserted-by":"crossref","first-page":"439","DOI":"10.2165\/00063030-200216060-00005","article-title":"Bilayered bioengineered skin substitute (Apligraf). A review of its use in the treatment of venous leg ulcers and diabetic foot ulcers","volume":"16","author":"Curran","year":"2002","journal-title":"Biodrugs"},{"key":"10.1016\/j.athoracsur.2003.09.032_BIB11","first-page":"81","article-title":"Clinical and economic outcomes with Graftskin for hard-to-heal venous leg ulcers. A single-center experience","volume":"28","author":"Kirsner","year":"2002","journal-title":"Dermatol Surg"}],"container-title":["The Annals of Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003497503018769?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003497503018769?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T00:27:13Z","timestamp":1757723233000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003497503018769"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,8]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,8]]}},"alternative-id":["S0003497503018769"],"URL":"https:\/\/doi.org\/10.1016\/j.athoracsur.2003.09.032","relation":{},"ISSN":["0003-4975"],"issn-type":[{"value":"0003-4975","type":"print"}],"subject":[],"published":{"date-parts":[[2004,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel treatment strategy for leg and sternal wound complications after coronary artery bypass graft surgery: Bioengineered Apligraf","name":"articletitle","label":"Article Title"},{"value":"The Annals of Thoracic Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.athoracsur.2003.09.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}