{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T20:27:24Z","timestamp":1781296044946,"version":"3.54.1"},"reference-count":29,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["annalsthoracicsurgery.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Annals of Thoracic Surgery"],"published-print":{"date-parts":[[2005,11]]},"DOI":"10.1016\/j.athoracsur.2005.04.054","type":"journal-article","created":{"date-parts":[[2005,10,20]],"date-time":"2005-10-20T10:20:30Z","timestamp":1129803630000},"page":"1787-1793","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Effects of Mycophenolate Mofetil on Cardiac Allograft Survival and Cardiac Allograft Vasculopathy in Miniature Swine"],"prefix":"10.1016","volume":"80","author":[{"given":"Margaret L.","family":"Schwarze","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart L.","family":"Houser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok","family":"Muniappan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James S.","family":"Allan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew T.","family":"Menard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"McMorrow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaella E.","family":"Maloney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joren C.","family":"Madsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.athoracsur.2005.04.054_bib1","first-page":"571","article-title":"Mycophenolate mofetil (RS-61443)","volume":"13","author":"Taylor","year":"1994","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.athoracsur.2005.04.054_bib2","first-page":"59","article-title":"Mycophenolic acid suppresses protein N-linked glycosylation in human monocytes and their adhesion to endothelial cells and to some substrates","volume":"24","author":"Laurent","year":"1996","journal-title":"Exp Hematol"},{"key":"10.1016\/j.athoracsur.2005.04.054_bib3","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1097\/00007890-200002150-00006","article-title":"Donor treatment with mycophenolate mofetil","volume":"69","author":"Valentin","year":"2000","journal-title":"Transplantation"},{"key":"10.1016\/j.athoracsur.2005.04.054_bib4","first-page":"754","article-title":"Effects of immunosuppressive therapy on the rat aortic allograft model","volume":"25","author":"Steele","year":"1993","journal-title":"Transplant Proc"},{"key":"10.1016\/j.athoracsur.2005.04.054_bib5","first-page":"19","article-title":"Immunosuppressive effects of the morpholinoethyl ester of mycophenolic acid (RS-61443) in rat and nonhuman primate recipients of heart allografts","volume":"23","author":"Morris","year":"1991","journal-title":"Transplant Proc"},{"key":"10.1016\/j.athoracsur.2005.04.054_bib6","first-page":"1659","article-title":"Mycophenolic acid morpholinoethylester (RS-61443) is a new immunosuppressant that prevents and halts heart allograft rejection by selective inhibition of T- and B-cell purine synthesis","volume":"22","author":"Morris","year":"1990","journal-title":"Transplant Proc"},{"key":"10.1016\/j.athoracsur.2005.04.054_bib7","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1097\/00007890-199808270-00016","article-title":"A randomized active-controlled trial of mycophenolate mofetil in heart transplant recipients","volume":"66","author":"Kobashigawa","year":"1998","journal-title":"Transplantation"},{"key":"10.1016\/j.athoracsur.2005.04.054_bib8","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S1053-2498(99)80080-1","article-title":"Three year results of the double-blind randomized multicenter trial of mycophenolate mofetil in heart transplant patients","volume":"18","author":"Keogh","year":"1999","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.athoracsur.2005.04.054_bib9","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.healun.2004.05.002","article-title":"Advances in heart and lung transplantation 2004","volume":"23","author":"Mehra","year":"2004","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.athoracsur.2005.04.054_bib10","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1016\/S0022-5223(96)70226-X","article-title":"Cardiac allograft vasculopathy in partially inbred miniature swine. I. Time course, pathology, and dependence on immune mechanisms","volume":"111","author":"Madsen","year":"1996","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"Suppl II","key":"10.1016\/j.athoracsur.2005.04.054_bib11","first-page":"41","article-title":"Cardiac allograft vasculopathy in miniature swine","volume":"1","author":"Madsen","year":"1998","journal-title":"Graft"},{"key":"10.1016\/j.athoracsur.2005.04.054_bib12","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1097\/00007890-199802150-00002","article-title":"Transplantation tolerance prevents cardiac allograft vasculopathy in major histocompatibility complex class I-disparate miniature swine","volume":"65","author":"Madsen","year":"1998","journal-title":"Transplantation"},{"key":"10.1016\/j.athoracsur.2005.04.054_bib13","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1097\/00007890-199711150-00014","article-title":"Species differences in the expression of major histocompatibility complex class II antigens on coronary artery endothelium","volume":"64","author":"Choo","year":"1997","journal-title":"Transplantation"},{"key":"10.1016\/j.athoracsur.2005.04.054_bib14","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1097\/00007890-197612000-00004","article-title":"Transplantation in miniature swine. I. Fixation of the major histocompatibility complex","volume":"22","author":"Sachs","year":"1976","journal-title":"Transplantation"},{"key":"10.1016\/j.athoracsur.2005.04.054_bib15","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1097\/00007890-198101000-00015","article-title":"Transplantation in miniature swine: VIII. recombination within the major histocompatibility complex of miniature swine","volume":"31","author":"Pennington","year":"1981","journal-title":"Transplantation"},{"key":"10.1016\/j.athoracsur.2005.04.054_bib16","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1097\/00007890-197907000-00006","article-title":"Transplantation in miniature swine. VII. Evidence for cellular immune mechanisms in hyperacute rejection of renal allografts","volume":"28","author":"Kirkman","year":"1979","journal-title":"Transplantation"},{"key":"10.1016\/j.athoracsur.2005.04.054_bib17","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1399-0039.1978.tb01301.x","article-title":"Transplantation in miniature swine. III: effects of MSLA and A-O blood group matching on skin allograft survival","volume":"12","author":"Leight","year":"1978","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.athoracsur.2005.04.054_bib18","first-page":"587","article-title":"A working formulation for the standardization of nomenclature in the diagnosis of heart and lung rejection","volume":"9","author":"Billingham","year":"1990","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.athoracsur.2005.04.054_bib19","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1097\/00007890-198101000-00010","article-title":"Pathogenesis and prevention of graft arteriosclerosis in an experimental heart transplant model","volume":"31","author":"Lurie","year":"1981","journal-title":"Transplantation"},{"key":"10.1016\/j.athoracsur.2005.04.054_bib20","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/S1053-2498(03)00065-2","article-title":"Histomorphometric comparison of cardiac allograft vasculopathy in miniature swine","volume":"23","author":"Houser","year":"2004","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.athoracsur.2005.04.054_bib21","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/0966-3274(95)80021-2","article-title":"Mycophenolate mofetil (MMF, RS-61443) inhibits inflammation and smooth muscle cell proliferation in rat aortic allografts","volume":"3","author":"Raisanen-Sokolowski","year":"1995","journal-title":"Transplant Immunology"},{"key":"10.1016\/j.athoracsur.2005.04.054_bib22","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1097\/01.TP.0000127592.13707.B6","article-title":"Mycophenolate mofetil prevents transplant arteriosclerosis by direct inhibition of vascular smooth muscle cell proliferation","volume":"77","author":"Shimizu","year":"2004","journal-title":"Transplantation"},{"key":"10.1016\/j.athoracsur.2005.04.054_bib23","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1111\/j.1399-0012.2004.00203.x","article-title":"Mycophenolates in transplantation","volume":"18","author":"Sollinger","year":"2004","journal-title":"Clin Transplant"},{"key":"10.1016\/j.athoracsur.2005.04.054_bib24","doi-asserted-by":"crossref","first-page":"570S","DOI":"10.1016\/j.transproceed.2004.01.020","article-title":"The antagonism of calcineurin inhibitors and costimulatory blockers","volume":"36","author":"Izawa","year":"2004","journal-title":"Transplant Proc"},{"key":"10.1016\/j.athoracsur.2005.04.054_bib25","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1172\/JCI119564","article-title":"Interferon-gamma deficiency prevents coronary arteriosclerosis but not myocardial rejection in transplanted mouse hearts","volume":"100","author":"Nagano","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1016\/j.athoracsur.2005.04.054_bib26","first-page":"359","article-title":"Reduced transplant arteriosclerosis in murine cardiac allografts placed in interferon-gamma knockout recipients","volume":"152","author":"Raisanen-Sokolowski","year":"1998","journal-title":"Am J Pathol"},{"key":"10.1016\/j.athoracsur.2005.04.054_bib27","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s00281-003-0139-x","article-title":"Humoral rejection of human organ transplants","volume":"25","author":"Michaels","year":"2003","journal-title":"Springer Semin Immunopathol"},{"key":"10.1016\/j.athoracsur.2005.04.054_bib28","first-page":"26","article-title":"Vascular rejection of human cardiac allografts and the role of humoral immunity in chronic allograft rejection","volume":"23","author":"Hammond","year":"1991","journal-title":"Transplant Proc"},{"key":"10.1016\/j.athoracsur.2005.04.054_bib29","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1097\/00007890-199712150-00005","article-title":"Alloantibody- and T cell-mediated immunity in the pathogenesis of transplant arteriosclerosis","volume":"64","author":"Russell","year":"1997","journal-title":"Transplantation"}],"container-title":["The Annals of Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000349750500754X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000349750500754X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T00:34:37Z","timestamp":1757723677000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000349750500754X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2005,11]]}},"alternative-id":["S000349750500754X"],"URL":"https:\/\/doi.org\/10.1016\/j.athoracsur.2005.04.054","relation":{},"ISSN":["0003-4975"],"issn-type":[{"value":"0003-4975","type":"print"}],"subject":[],"published":{"date-parts":[[2005,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of Mycophenolate Mofetil on Cardiac Allograft Survival and Cardiac Allograft Vasculopathy in Miniature Swine","name":"articletitle","label":"Article Title"},{"value":"The Annals of Thoracic Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.athoracsur.2005.04.054","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}