{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:15:39Z","timestamp":1777425339041,"version":"3.51.4"},"reference-count":25,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["annalsthoracicsurgery.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Annals of Thoracic Surgery"],"published-print":{"date-parts":[[2006,3]]},"DOI":"10.1016\/j.athoracsur.2005.09.023","type":"journal-article","created":{"date-parts":[[2006,2,19]],"date-time":"2006-02-19T07:15:17Z","timestamp":1140333317000},"page":"902-909","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Comparison of Systemic and Retrograde Delivery of Adenosine A2A Agonist for Attenuation of Spinal Cord Injury After Thoracic Aortic Cross-Clamping"],"prefix":"10.1016","volume":"81","author":[{"given":"T. Brett","family":"Reece","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David O.","family":"Okonkwo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter I.","family":"Ellman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas S.","family":"Maxey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Tache-Leon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick S.","family":"Warren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey J.","family":"Laurent","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel","family":"Linden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irving L.","family":"Kron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Curtis G.","family":"Tribble","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"Kern","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.athoracsur.2005.09.023_bib1","first-page":"269","article-title":"Thoracoabdominal aortic aneurysms","volume":"61","author":"Coselli","year":"1996","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.athoracsur.2005.09.023_bib2","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1111\/j.1540-8191.1994.tb00899.x","article-title":"Evolution of surgical techniques for aneurysms of the descending thoracic aorta","volume":"9","author":"Lawrie","year":"1994","journal-title":"J Cardiac Surg"},{"key":"10.1016\/j.athoracsur.2005.09.023_bib3","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1067\/mva.1986.avs0030389","article-title":"Thoracoabdominal aortic aneurysms","volume":"3","author":"Crawford","year":"1986","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.athoracsur.2005.09.023_bib4","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1067\/mva.2002.122024","article-title":"Cerebrospinal fluid drainage reduces paraplegia after thoracoabdominal aortic aneurysm repair","volume":"35","author":"Coselli","year":"2002","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.athoracsur.2005.09.023_bib5","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/0741-5214(92)90712-H","article-title":"Thoracoabdominal aneurysm repair","volume":"15","author":"Cox","year":"1992","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.athoracsur.2005.09.023_bib6","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1053\/S1043-0679(03)00088-1","article-title":"The role of pharmacology in spinal cord protection during thoracic aortic reconstruction","volume":"15","author":"Reece","year":"2003","journal-title":"Semin Thorac Cardiovasc Surg"},{"key":"10.1016\/j.athoracsur.2005.09.023_bib7","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1080\/140174302317282320","article-title":"Spinal cord protection during aortic cross clamping","volume":"36","author":"Winnerkvist","year":"2002","journal-title":"Scand Cardiovasc J"},{"key":"10.1016\/j.athoracsur.2005.09.023_bib8","first-page":"315","article-title":"Regional hypothermia with epidural cooling for spinal cord protection during thoracoabdominal aneurysm repair","volume":"13","author":"Cambria","year":"2000","journal-title":"Semin Vasc Surg"},{"key":"10.1016\/j.athoracsur.2005.09.023_bib9","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S1043-0679(98)70019-X","article-title":"Profound hypothermia for spinal cord protection in operations on the descending thoracic and thoracoabdominal aorta","volume":"10","author":"Rokkas","year":"1998","journal-title":"Semin Thorac Cardiovasc Surg"},{"key":"10.1016\/j.athoracsur.2005.09.023_bib10","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0741-5214(93)90594-C","article-title":"Regional adenosine attenuates postischemic spinal cord injury","volume":"18","author":"Seibel","year":"1993","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.athoracsur.2005.09.023_bib11","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/S0022-5223(00)70141-3","article-title":"Hypothermic retrograde venous perfusion with adenosine cools the spinal cord and reduces the risk of paraplegia after thoracic aortic clamping","volume":"119","author":"Ross","year":"2000","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.athoracsur.2005.09.023_bib12","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1067\/mva.2000.105003","article-title":"Retrograde venous perfusion with hypothermic saline and adenosine for protection of the ischemic spinal cord","volume":"32","author":"Parrino","year":"2000","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.athoracsur.2005.09.023_bib13","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1146\/annurev.pharmtox.41.1.775","article-title":"Molecular approach to adenosine receptors","volume":"41","author":"Linden","year":"2001","journal-title":"Ann Rev Pharm Tox"},{"key":"10.1016\/j.athoracsur.2005.09.023_bib14","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/S1053-2498(99)00066-2","article-title":"Selective adenosine-A2A activation reduces lung reperfusion injury following transplantation","volume":"18","author":"Ross","year":"1999","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.athoracsur.2005.09.023_bib15","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1097\/00005344-200201000-00013","article-title":"Adenosine-mediated cardioprotection in ischemic-reperfused mouse heart","volume":"39","author":"Peart","year":"2002","journal-title":"J Cardiovasc Pharm"},{"key":"10.1016\/j.athoracsur.2005.09.023_bib16","first-page":"F404","article-title":"Selective A2A adenosine receptor activation reduces ischemia-reperfusion injury in rat kidney","volume":"277","author":"Okusa","year":"1999","journal-title":"Am J Phys"},{"key":"10.1016\/j.athoracsur.2005.09.023_bib17","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1067\/mva.2001.117996","article-title":"An adenosine A2A agonist, ATL-146e, reduces paralysis and apoptosis during rabbit spinal cord reperfusion","volume":"34","author":"Cassada","year":"2001","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.athoracsur.2005.09.023_bib18","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1067\/msy.2001.115838","article-title":"Adenosine analogue reduces spinal cord reperfusion injury in a time-dependent fashion","volume":"130","author":"Cassada","year":"2001","journal-title":"Surgery"},{"key":"10.1016\/j.athoracsur.2005.09.023_bib19","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/S0003-4975(02)03793-1","article-title":"Adenosine A2A agonist reduces paralysis after spinal cord ischemia","volume":"74","author":"Cassada","year":"2002","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.athoracsur.2005.09.023_bib20","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.jtcvs.2004.08.019","article-title":"The evolution of ischemic spinal cord injury in function, cytoarchitecture, and inflammation and the effects of adenosine A2A receptor activation","volume":"128","author":"Reece","year":"2004","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.athoracsur.2005.09.023_bib21","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/j.athoracsur.2004.09.038","article-title":"Adenosine A2A receptor agonist improves cardiac dysfunction from pulmonary ischemia-reperfusion injury","volume":"79","author":"Reece","year":"2005","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.athoracsur.2005.09.023_bib22","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1016\/S0003-4975(00)01354-0","article-title":"Retrograde perfusion with a sodium channel antagonist provides ischemic spinal cord protection","volume":"69","author":"Gangemi","year":"2000","journal-title":"Ann Thorac Surg"},{"issue":"Suppl","key":"10.1016\/j.athoracsur.2005.09.023_bib23","first-page":"30","article-title":"Spinal cord protection by adenosine A2A receptor activation during ischemia\/reperfusion parallels MAP-2 preservation","volume":"197","author":"Reece","year":"2003","journal-title":"J Am College Surg"},{"key":"10.1016\/j.athoracsur.2005.09.023_bib24","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/S0003-4975(97)00903-X","article-title":"Neuronal cell death in the ischemic spinal cord","volume":"64","author":"Kanellopoulos","year":"1997","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.athoracsur.2005.09.023_bib25","first-page":"839","article-title":"Spinal cord protection by papaverine and intrathecal cooling during aortic crossclamping","volume":"39","author":"Sun","year":"1998","journal-title":"J Cardiovasc Surg"}],"container-title":["The Annals of Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003497505016243?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003497505016243?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T00:35:46Z","timestamp":1757723746000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003497505016243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,3]]}},"alternative-id":["S0003497505016243"],"URL":"https:\/\/doi.org\/10.1016\/j.athoracsur.2005.09.023","relation":{},"ISSN":["0003-4975"],"issn-type":[{"value":"0003-4975","type":"print"}],"subject":[],"published":{"date-parts":[[2006,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparison of Systemic and Retrograde Delivery of Adenosine A2A Agonist for Attenuation of Spinal Cord Injury After Thoracic Aortic Cross-Clamping","name":"articletitle","label":"Article Title"},{"value":"The Annals of Thoracic Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.athoracsur.2005.09.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}