{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:44:37Z","timestamp":1790887477296,"version":"4.1.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["annalsthoracicsurgery.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Annals of Thoracic Surgery"],"published-print":{"date-parts":[[2007,4]]},"DOI":"10.1016\/j.athoracsur.2006.10.065","type":"journal-article","created":{"date-parts":[[2007,3,24]],"date-time":"2007-03-24T07:05:45Z","timestamp":1174719945000},"page":"1374-1380","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":89,"title":["Simvastatin Increases Neutrophil Apoptosis and Reduces Inflammatory Reaction After Coronary Surgery"],"prefix":"10.1016","volume":"83","author":[{"given":"Massimo","family":"Chello","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amedeo","family":"Anselmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiano","family":"Spadaccio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Patti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Costanza","family":"Goffredo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Germano","family":"Di Sciascio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvio","family":"Covino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.athoracsur.2006.10.065_bib1","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/S1010-7940(01)01099-5","article-title":"Cardiopulmonary bypass induces inflammation: pathophysiology and treatment","volume":"21","author":"Paparella","year":"2002","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.athoracsur.2006.10.065_bib2","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1046\/j.1525-1594.2000.06381.x","article-title":"Enhanced responsiveness of circulatory neutrophils after cardiopulmonary bypass: increased aggregability and superoxide producing capacity","volume":"24","author":"Kawahito","year":"2000","journal-title":"Artif Organs"},{"key":"10.1016\/j.athoracsur.2006.10.065_bib3","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S0014-5793(00)02324-3","article-title":"Molecular control of neutrophil apoptosis","volume":"487","author":"Akgul","year":"2001","journal-title":"FEBS Lett"},{"key":"10.1016\/j.athoracsur.2006.10.065_bib4","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S1074-7613(00)80428-8","article-title":"ICE family proteases: mediators of all apoptotic cell death","volume":"4","author":"Hankart","year":"1996","journal-title":"Immunity"},{"key":"10.1016\/j.athoracsur.2006.10.065_bib5","doi-asserted-by":"crossref","first-page":"3289","DOI":"10.4049\/jimmunol.155.7.3289","article-title":"Regulation of apoptosis in neutrophils\u2014Fas track to death?","volume":"155","author":"Liles","year":"1995","journal-title":"J Immunol"},{"key":"10.1016\/j.athoracsur.2006.10.065_bib6","doi-asserted-by":"crossref","first-page":"4309","DOI":"10.1074\/jbc.274.7.4309","article-title":"TNF-kappa activation is a critical regulator of human granulocyte apoptosis in vitro","volume":"274","author":"Ward","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.athoracsur.2006.10.065_bib7","doi-asserted-by":"crossref","first-page":"5123","DOI":"10.4049\/jimmunol.150.11.5124","article-title":"Impairment of function in aging neutrophils is associated with apoptosis","volume":"150","author":"Whyte","year":"1993","journal-title":"J Immunol"},{"key":"10.1016\/j.athoracsur.2006.10.065_bib8","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.ejcts.2003.12.003","article-title":"Myocardial ischemia, stunning, inflammation and apoptosis during cardiac surgery: a review of evidence","volume":"25","author":"Anselmi","year":"2004","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.athoracsur.2006.10.065_bib9","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1161\/01.RES.83.5.490","article-title":"3-Hydroxy-3-methylglutaryl coenzyme a reductase and isoprenylation inhibitors induce apoptosis of vascular smooth muscle cells in culture","volume":"83","author":"Guijarro","year":"1998","journal-title":"Circ Res"},{"key":"10.1016\/j.athoracsur.2006.10.065_bib10","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0021-9150(03)00301-0","article-title":"All hydrophobic HMG-CoA reductase inhibitors (statins) induce apoptotic death in rat pulmonary vein endothelial cells","volume":"170","author":"Kaneta","year":"2003","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.athoracsur.2006.10.065_bib11","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0021-9150(01)00613-X","article-title":"3-Hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitors, atorvastatin and simvastatin, induce apoptosis of vascular smooth muscle cells by downregulation Bcl-2 expression and Rho A prenylation","volume":"161","author":"Blanco-Colio","year":"2002","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.athoracsur.2006.10.065_bib12","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0021-9150(00)00764-4","article-title":"Induction of apoptosis and inhibition of migration of inflammatory and vascular wall cells by cerivastatin","volume":"158","author":"Kaneider","year":"2001","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.athoracsur.2006.10.065_bib13","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0003-4975(01)03055-7","article-title":"Inhibition of neutrophil apoptosis after coronary bypass operation with cardiopulmonary bypass","volume":"73","author":"Chello","year":"2002","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.athoracsur.2006.10.065_bib14","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1067\/mtc.2003.177","article-title":"Pretreatment with statins enhances myocardial protection during coronary revascularization","volume":"125","author":"Lazar","year":"2003","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.athoracsur.2006.10.065_bib15","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1097\/00005344-199603000-00015","article-title":"Reduction by indobufen of neutrophil activation in peripheral arterial occlusive disease","volume":"27","author":"Chello","year":"1996","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.athoracsur.2006.10.065_bib16","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1001\/archsurg.1997.01430360009002","article-title":"Dysregulated expression of neutrophil apoptosis in the systemic inflammatory response syndrome","volume":"132","author":"Jimenez","year":"1997","journal-title":"Arch Surg"},{"key":"10.1016\/j.athoracsur.2006.10.065_bib17","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0039-6060(99)70094-2","article-title":"Inhibition of neutrophil apoptosis after elective surgery","volume":"126","author":"Fanning","year":"1999","journal-title":"Surgery"},{"key":"10.1016\/j.athoracsur.2006.10.065_bib18","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1136\/heart.89.5.538","article-title":"Simvastatin attenuates leucocyte-endothelial interactions after coronary revascularisation with cardiopulmonary bypass","volume":"89","author":"Chello","year":"2003","journal-title":"Heart"},{"key":"10.1016\/j.athoracsur.2006.10.065_bib19","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1097\/01.CCM.0000201407.89977.EA","article-title":"Effects of atorvastatin on systemic inflammatory response after coronary bypass surgery","volume":"34","author":"Chello","year":"2006","journal-title":"Crit Care Med"},{"key":"10.1016\/j.athoracsur.2006.10.065_bib20","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1067\/msy.2001.109060","article-title":"Cytokine-modulated inhibition of neutrophil apoptosis at local site augments exudative neutrophil functions and reflects inflammatory response after surgery","volume":"129","author":"Matsuda","year":"2001","journal-title":"Surgery"},{"key":"10.1016\/j.athoracsur.2006.10.065_bib21","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1056\/NEJM199610033351401","article-title":"The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels","volume":"335","author":"Sacks","year":"1996","journal-title":"N Engl J Med"},{"key":"10.1016\/j.athoracsur.2006.10.065_bib22","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/S0140-6736(96)90217-2","article-title":"Inhibition of the mevalonate pathway: benefits beyond cholesterol reduction?","volume":"347","author":"Massy","year":"1996","journal-title":"Lancet"},{"key":"10.1016\/j.athoracsur.2006.10.065_bib23","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1007\/s00380-005-0868-y","article-title":"Effects of simvastatin on cardio hemodynamic responses to ischemia-reperfusion in isolated rat hearts","volume":"21","author":"Zheng","year":"2006","journal-title":"Heart Vess"},{"key":"10.1016\/j.athoracsur.2006.10.065_bib24","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1084\/jem.184.2.429","article-title":"Differential expression of Fas (CD95) and Fas ligand on normal human phagocytes: implications for the regulation of apoptosis in neutrophils","volume":"184","author":"Liles","year":"1996","journal-title":"J Exp Med"},{"key":"10.1016\/j.athoracsur.2006.10.065_bib25","first-page":"2350","article-title":"Apoptosis: a different type of cell death","volume":"6","author":"Gerschenson","year":"1999","journal-title":"FASEB J"}],"container-title":["The Annals of Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003497506020947?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003497506020947?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T00:41:56Z","timestamp":1757724116000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003497506020947"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,4]]}},"alternative-id":["S0003497506020947"],"URL":"https:\/\/doi.org\/10.1016\/j.athoracsur.2006.10.065","relation":{},"ISSN":["0003-4975"],"issn-type":[{"value":"0003-4975","type":"print"}],"subject":[],"published":{"date-parts":[[2007,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Simvastatin Increases Neutrophil Apoptosis and Reduces Inflammatory Reaction After Coronary Surgery","name":"articletitle","label":"Article Title"},{"value":"The Annals of Thoracic Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.athoracsur.2006.10.065","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}