{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T11:30:48Z","timestamp":1791545448422,"version":"4.3.4"},"reference-count":20,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["annalsthoracicsurgery.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Annals of Thoracic Surgery"],"published-print":{"date-parts":[[2007,2]]},"DOI":"10.1016\/j.athoracsur.2006.10.091","type":"journal-article","created":{"date-parts":[[2007,1,25]],"date-time":"2007-01-25T10:04:55Z","timestamp":1169719495000},"page":"S757-S763","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":224,"title":["Early Surgical Experience With Loeys-Dietz: A New Syndrome of Aggressive Thoracic Aortic Aneurysm Disease"],"prefix":"10.1016","volume":"83","author":[{"given":"Jason A.","family":"Williams","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart L.","family":"Loeys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lois U.","family":"Nwakanma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry C.","family":"Dietz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip J.","family":"Spevak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishant D.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrien","family":"Fran\u00e7ois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"DeBacker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent L.","family":"Gott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca A.","family":"Vricella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duke E.","family":"Cameron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.athoracsur.2006.10.091_bib1","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/ng1511","article-title":"A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 and TGFBR2","volume":"37","author":"Loeys","year":"2005","journal-title":"Nat Genet"},{"key":"10.1016\/j.athoracsur.2006.10.091_bib2","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1056\/NEJMoa055695","article-title":"Aneurysm syndromes caused by mutations in the TGF-beta receptor","volume":"355","author":"Loeys","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.athoracsur.2006.10.091_bib3","doi-asserted-by":"crossref","first-page":"17058","DOI":"10.1074\/jbc.M100754200","article-title":"Identification of novel TGF-beta\/Smad gene targets in dermal fibroblasts using a combined cDNA microarray\/promoter transactivation approach","volume":"276","author":"Verrecchia","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.athoracsur.2006.10.091_bib4","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/(SICI)1096-8628(19960424)62:4<417::AID-AJMG15>3.0.CO;2-R","article-title":"Revised diagnostic criteria for the Marfan syndrome","volume":"62","author":"De Paepe","year":"1996","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.athoracsur.2006.10.091_bib5","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1002\/(SICI)1096-8628(19980319)76:3<202::AID-AJMG2>3.0.CO;2-S","article-title":"Shprintzen-Goldberg syndrome: a clinical analysis","volume":"76","author":"Greally","year":"1998","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.athoracsur.2006.10.091_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ajmg.a.10750","article-title":"TGF\u03b2\/Smad signaling system and its pathologic correlates","volume":"116A","author":"Cohen","year":"2003","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.athoracsur.2006.10.091_bib7","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1242\/jcs.00229","article-title":"Making sense of latent TGF\u03b2 activation","volume":"116","author":"Annes","year":"2003","journal-title":"J Cell Science"},{"key":"10.1016\/j.athoracsur.2006.10.091_bib8","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.tibs.2004.03.008","article-title":"New insights into TGF-\u03b2-Smad signaling","volume":"29","author":"ten Dijke","year":"2004","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.athoracsur.2006.10.091_bib9","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S1359-6101(03)00044-3","article-title":"Transforming growth factor beta in cardiovascular development and function","volume":"14","author":"Azhar","year":"2003","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.athoracsur.2006.10.091_bib10","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1242\/dev.124.13.2659","article-title":"TGFbeta2 knockout mice have multiple developmental defects that are non-overlapping with other TGFbeta knockout phenotypes","volume":"124","author":"Sanford","year":"1997","journal-title":"Development"},{"key":"10.1016\/j.athoracsur.2006.10.091_bib11","first-page":"662","article-title":"Marfan syndrome: no evidence for heterogeneity in different populations, and more precise mapping of the gene","volume":"49","author":"Kainulainen","year":"1991","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.athoracsur.2006.10.091_bib12","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/352337a0","article-title":"Marfan syndrome caused by a recurrent de novo missense mutation in the fibrillin gene","volume":"352","author":"Dietz","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.athoracsur.2006.10.091_bib13","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/ng1392","article-title":"Heterozygous TGF\u03b2R2 mutations in Marfan syndrome","volume":"36","author":"Mizuguchi","year":"2004","journal-title":"Nat Genet"},{"key":"10.1016\/j.athoracsur.2006.10.091_bib14","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/ng1116","article-title":"Dysregulation of the TGF-\u03b2 activation contributes to pathogenesis in Marfan syndrome","volume":"33","author":"Neptune","year":"2003","journal-title":"Nat Genet"},{"key":"10.1016\/j.athoracsur.2006.10.091_bib15","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1016\/S0140-6736(05)67789-6","article-title":"Marfan\u2019s syndrome","volume":"366","author":"Judge","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.athoracsur.2006.10.091_bib16","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1056\/NEJM200003093421001","article-title":"Clinical and genetic features of Ehlers-Danlos syndrome type IV, the vascular type","volume":"342","author":"Pepin","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.athoracsur.2006.10.091_bib17","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jvs.2005.03.053","article-title":"The spectrum, management and clinical outcome of Ehlers-Danlos syndrome type IV: a 30-year experience","volume":"42","author":"Oderich","year":"2005","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.athoracsur.2006.10.091_bib18","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/S0003-4975(01)03336-7","article-title":"Aortic root replacement in 271 Marfan patients: a 24-year experience","volume":"73","author":"Gott","year":"2002","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.athoracsur.2006.10.091_bib19","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1016\/S0003-4975(97)00849-7","article-title":"Cardiac operations in children with Marfan\u2019s syndrome: indications and results","volume":"64","author":"Gillinov","year":"1997","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.athoracsur.2006.10.091_bib20","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1056\/NEJM199706263362606","article-title":"Surgery of the thoracic aorta","volume":"336","author":"Kouchoukos","year":"1997","journal-title":"New Engl J Med"}],"container-title":["The Annals of Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003497506022442?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003497506022442?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T00:42:14Z","timestamp":1757724134000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003497506022442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["S0003497506022442"],"URL":"https:\/\/doi.org\/10.1016\/j.athoracsur.2006.10.091","relation":{},"ISSN":["0003-4975"],"issn-type":[{"value":"0003-4975","type":"print"}],"subject":[],"published":{"date-parts":[[2007,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early Surgical Experience With Loeys-Dietz: A New Syndrome of Aggressive Thoracic Aortic Aneurysm Disease","name":"articletitle","label":"Article Title"},{"value":"The Annals of Thoracic Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.athoracsur.2006.10.091","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}