{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T01:07:11Z","timestamp":1783386431907,"version":"3.54.6"},"reference-count":27,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["annalsthoracicsurgery.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Annals of Thoracic Surgery"],"published-print":{"date-parts":[[2008,2]]},"DOI":"10.1016\/j.athoracsur.2007.10.098","type":"journal-article","created":{"date-parts":[[2008,1,26]],"date-time":"2008-01-26T20:31:41Z","timestamp":1201379501000},"page":"365-367","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Multimodality Therapy for Locally Advanced Thymomas: State of the Art or Investigational Therapy?"],"prefix":"10.1016","volume":"85","author":[{"given":"James","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory J.","family":"Riely","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth E.","family":"Rosenzweig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie W.","family":"Rusch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.athoracsur.2007.10.098_bib1","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1002\/1097-0142(19811201)48:11<2485::AID-CNCR2820481123>3.0.CO;2-R","article-title":"Follow-up study of thymomas with special reference to their clinical stages","volume":"48","author":"Masaoka","year":"1981","journal-title":"Cancer"},{"key":"10.1016\/j.athoracsur.2007.10.098_bib2","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/j.jtcvs.2005.07.026","article-title":"Predictors of recurrence in thymic tumors: importance of invasion, World Health organization histology, and size","volume":"130","author":"Wright","year":"2005","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.athoracsur.2007.10.098_bib3","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.athoracsur.2007.08.051","article-title":"Induction chemoradiotherapy followed by resection for locally advanced Masaoka stage III and IVA thymic tumors","volume":"85","author":"Wright","year":"2008","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.athoracsur.2007.10.098_bib4","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S0022-5223(19)34092-9","article-title":"Chemotherapy and operation for invasive thymoma","volume":"106","author":"Rea","year":"1993","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.athoracsur.2007.10.098_bib5","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1016\/S0003-4975(03)01020-8","article-title":"Long-term outcome after multimodality treatment for stage III thymic tumors","volume":"76","author":"Venuta","year":"2003","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.athoracsur.2007.10.098_bib6","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1016\/j.athoracsur.2004.12.047","article-title":"Advanced stage thymomas and thymic carcinomas: results of multimodality treatments","volume":"79","author":"Lucchi","year":"2005","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.athoracsur.2007.10.098_bib7","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.lungcan.2003.09.022","article-title":"Multimodal management of stages III-IVa malignant thymoma","volume":"44","author":"Bretti","year":"2004","journal-title":"Lung Cancer"},{"key":"10.1016\/j.athoracsur.2007.10.098_bib8","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.lungcan.2003.12.010","article-title":"Phase II study of multidisciplinary approach with induction chemotherapy, followed by surgical resection, radiation therapy, and consolidation chemotherapy for unresectable malignant thymomas: final report","volume":"44","author":"Kim","year":"2004","journal-title":"Lung Cancer"},{"key":"10.1016\/j.athoracsur.2007.10.098_bib9","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1200\/JCO.1995.13.8.1880","article-title":"Concurrent cisplatin\/etoposide plus chest radiotherapy followed by surgery for stages IIIA (N2) and IIIB non-small cell lung cancer: mature results of Southwest Oncology Group Phase II study 8805","volume":"13","author":"Albain","year":"1995","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.athoracsur.2007.10.098_bib10","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1200\/JCO.2006.08.2826","article-title":"Induction chemoradiation and surgical resection for superior sulcus non-small cell lung carcinomas: long-term results of Southwest Oncology Group trial 9416 (Intergroup trial 0160)","volume":"25","author":"Rusch","year":"2007","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.athoracsur.2007.10.098_bib11","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/0003-4975(95)00983-3","article-title":"Surgical treatment for invasive thymoma, especially when the superior vena cava is invaded","volume":"61","author":"Yagi","year":"1996","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.athoracsur.2007.10.098_bib12","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/j.athoracsur.2006.05.028","article-title":"Pleuropneumonectomy for the treatment of Masaoka stage IV thymoma","volume":"82","author":"Wright","year":"2006","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.athoracsur.2007.10.098_bib13","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1016\/j.jtcvs.2007.07.049","article-title":"Feasbility of multimodality therapy including extended resections in stage IVA thymoma","volume":"134","author":"Huang","year":"2007","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.athoracsur.2007.10.098_bib14","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0022-5223(97)70399-4","article-title":"Recurrence of thymoma: analysis of clinicopathologic features, treatment and outcome","volume":"113","author":"Ruffini","year":"1997","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.athoracsur.2007.10.098_bib15","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0022-5223(96)70265-9","article-title":"Prognostic factors and long-term results after thymoma resection: a series of 307 patients","volume":"112","author":"Regnard","year":"1996","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.athoracsur.2007.10.098_bib16","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1067\/mtc.2001.116560","article-title":"A phase II trial of surgical resection and adjuvant high dose hemithoracic radiation for malignant pleural mesothelioma","volume":"122","author":"Rusch","year":"2001","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.athoracsur.2007.10.098_bib17","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s00432-001-0319-9","article-title":"Epidermal growth factor expression in invasive thymoma","volume":"128","author":"Henley","year":"2002","journal-title":"J Cancer Res Clin Oncol"},{"key":"10.1016\/j.athoracsur.2007.10.098_bib18","doi-asserted-by":"crossref","first-page":"757","DOI":"10.2741\/2098","article-title":"Cetuximab is an active treatment of metastatic and chemorefractory thymoma","volume":"12","author":"Palmieri","year":"2007","journal-title":"Front Biosci"},{"key":"10.1016\/j.athoracsur.2007.10.098_bib19","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S1470-2045(07)70141-9","article-title":"Response of thymoma to cetuximab","volume":"8","author":"Farina","year":"2007","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.athoracsur.2007.10.098_bib20","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.lungcan.2006.01.009","article-title":"Thymic carcinoma with epidermal growth factor receptor gene mutations","volume":"52","author":"Yamaguchi","year":"2006","journal-title":"Lung Cancer"},{"key":"10.1016\/j.athoracsur.2007.10.098_bib21","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1007\/s00432-004-0545-z","article-title":"Tyrosine kinase receptor expression in thymomas","volume":"130","author":"Henley","year":"2004","journal-title":"J Cancer Res Clin Oncol"},{"key":"10.1016\/j.athoracsur.2007.10.098_bib22","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1002\/path.1514","article-title":"KIT (CD117) is frequently overexpressed in thymic carcinomas but is absent in thymomas","volume":"202","author":"Pan","year":"2004","journal-title":"J Pathol"},{"key":"10.1016\/j.athoracsur.2007.10.098_bib23","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1378\/chest.128.1.140","article-title":"Immunohistochemical KIT (CD117) expression in thymic epithelial tumors","volume":"128","author":"Nakagawa","year":"2005","journal-title":"Chest"},{"key":"10.1016\/j.athoracsur.2007.10.098_bib24","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.1056\/NEJM200406173502523","article-title":"Thymic carcinoma with overexpression of mutated KIT and the response to Imatinib","volume":"350","author":"Str\u00f6bel","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.athoracsur.2007.10.098_bib25","doi-asserted-by":"crossref","first-page":"e56","DOI":"10.1200\/JCO.2006.08.8963","article-title":"Dasatanib induces a response in malignant thymoma","volume":"24","author":"Chuah","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.athoracsur.2007.10.098_bib26","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1002\/ijc.22078","article-title":"COX-2 upregulation in thymomas and thymic carcinomas","volume":"119","author":"Rieker","year":"2006","journal-title":"Int J Cancer"},{"key":"10.1016\/j.athoracsur.2007.10.098_bib27","series-title":"Pathology and genetics: tumours of the lung, pleura, thymus and heart (WHO classification of tumours)","first-page":"196","article-title":"Combined thymic epithelial tumours","author":"M\u00fcller-Hermelink","year":"2004"}],"container-title":["The Annals of Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003497507022539?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003497507022539?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T00:44:41Z","timestamp":1757724281000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003497507022539"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,2]]}},"alternative-id":["S0003497507022539"],"URL":"https:\/\/doi.org\/10.1016\/j.athoracsur.2007.10.098","relation":{},"ISSN":["0003-4975"],"issn-type":[{"value":"0003-4975","type":"print"}],"subject":[],"published":{"date-parts":[[2008,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multimodality Therapy for Locally Advanced Thymomas: State of the Art or Investigational Therapy?","name":"articletitle","label":"Article Title"},{"value":"The Annals of Thoracic Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.athoracsur.2007.10.098","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.athoracsur.2007.08.051","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}