{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:57:55Z","timestamp":1791118675382,"version":"4.1.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["annalsthoracicsurgery.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Annals of Thoracic Surgery"],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.1016\/j.athoracsur.2013.01.012","type":"journal-article","created":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T01:56:02Z","timestamp":1362102962000},"page":"1181-1188","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Snail Expression Is Associated With a Poor Prognosis in Malignant Pleural Mesotheliomas"],"prefix":"10.1016","volume":"95","author":[{"given":"Masashi","family":"Kobayashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-long","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Sonobe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryutaro","family":"Kikuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoto","family":"Imamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiro","family":"Kitamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shotaro","family":"Iwakiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazumi","family":"Itoi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoji","family":"Yasumizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Date","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.athoracsur.2013.01.012_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000127577","article-title":"Mesothelioma and asbestos-related pleural diseases","volume":"76","author":"Greillier","year":"2008","journal-title":"Respiration"},{"key":"10.1016\/j.athoracsur.2013.01.012_bib2","doi-asserted-by":"crossref","first-page":"444S","DOI":"10.1378\/chest.116.suppl_3.444S","article-title":"Mesothelioma clinical presentation","volume":"116","author":"Bueno","year":"1999","journal-title":"Chest"},{"key":"10.1016\/j.athoracsur.2013.01.012_bib3","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1007\/s00432-010-0834-7","article-title":"Clinical investigation of malignant mesothelioma in Japan","volume":"136","author":"Fujimoto","year":"2010","journal-title":"J Cancer Res Clin Oncol"},{"key":"10.1016\/j.athoracsur.2013.01.012_bib4","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1183\/09031936.00039510","article-title":"Trimodality therapy for malignant pleural mesothelioma: results from an EORTC phase II multicentre trial","volume":"36","author":"Schil","year":"2010","journal-title":"Eur Respir J"},{"key":"10.1016\/j.athoracsur.2013.01.012_bib5","first-page":"298","article-title":"Clinical and pathological features of three-year survivors of malignant pleural mesothelioma following extrapleural pneumonectomy","volume":"402","author":"Sugarbaker","year":"2011","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.athoracsur.2013.01.012_bib6","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1172\/JCI38019","article-title":"Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease","volume":"119","author":"Acloque","year":"2009","journal-title":"J Clin Invest"},{"key":"10.1016\/j.athoracsur.2013.01.012_bib7","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1172\/JCI39104","article-title":"The basics of epithelial-mesenchymal transition","volume":"119","author":"Kalluri","year":"2009","journal-title":"J Clin Invest"},{"key":"10.1016\/j.athoracsur.2013.01.012_bib8","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.2353\/ajpath.2009.080545","article-title":"Epithelial-mesenchymal transition: a cancer researcher's conceptual friend and foe","volume":"174","author":"Klymkowsky","year":"2009","journal-title":"Am J Pathol"},{"key":"10.1016\/j.athoracsur.2013.01.012_bib9","first-page":"75","article-title":"Epithelial-mesenchymal transition in cancer metastasis: mechanisms, markers and strategies to overcome drug resistance in the clinic","volume":"1796","author":"Voulgari","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.athoracsur.2013.01.012_bib10","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1016\/j.biocel.2007.07.011","article-title":"Epithelial-mesenchymal transition and tumour invasion","volume":"39","author":"Guarino","year":"2007","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.athoracsur.2013.01.012_bib11","doi-asserted-by":"crossref","first-page":"735","DOI":"10.18632\/aging.100209","article-title":"Epithelial-mesenchymal transition and senescence: two cancer-related processes are crossing paths","volume":"2","author":"Smit","year":"2010","journal-title":"Aging"},{"key":"10.1016\/j.athoracsur.2013.01.012_bib12","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/35000034","article-title":"The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells","volume":"2","author":"Batlle","year":"2000","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.athoracsur.2013.01.012_bib13","doi-asserted-by":"crossref","DOI":"10.1159\/000101305","article-title":"Nuclear localization signals of the E-cadherin transcriptional repressor Snail","volume":"185","author":"Ko","year":"2007","journal-title":"Cells Tissues Organs"},{"key":"10.1016\/j.athoracsur.2013.01.012_bib14","doi-asserted-by":"crossref","first-page":"4769","DOI":"10.1158\/1078-0432.CCR-06-2926","article-title":"Epithelial to mesenchymal transition: expression of the regulators snail, slug, and twist in pancreatic cancer","volume":"15","author":"Hotz","year":"2007","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.athoracsur.2013.01.012_bib15","doi-asserted-by":"crossref","first-page":"39209","DOI":"10.1074\/jbc.M206400200","article-title":"Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression","volume":"277","author":"Guaita","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.athoracsur.2013.01.012_bib16","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1038\/sj.onc.1208429","article-title":"DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells","volume":"24","author":"Eger","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.athoracsur.2013.01.012_bib17","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1126\/science.2006419","article-title":"Cadherin cell adhesion receptors as amorphogenetic regulator","volume":"251","author":"Tkakechi","year":"1991","journal-title":"Science"},{"key":"10.1016\/j.athoracsur.2013.01.012_bib18","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1002\/(SICI)1097-4644(19960616)61:4<514::AID-JCB4>3.0.CO;2-R","article-title":"Cadherin-catenin complex; protein interactions and their implications for cadherin function","volume":"61","author":"Aberle","year":"1996","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.athoracsur.2013.01.012_bib19","first-page":"17","article-title":"Expression of immunoreactive E-cadherin adhesion molecules in human cancers","volume":"139","author":"Shiozaki","year":"1991","journal-title":"Am J Pathol"},{"key":"10.1016\/j.athoracsur.2013.01.012_bib20","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/(SICI)1097-0142(19960415)77:8<1605::AID-CNCR28>3.0.CO;2-2","article-title":"E-cadherin mediated adhesion system in cancer cells","volume":"77","author":"Siozaki","year":"1996","journal-title":"Cancer"},{"key":"10.1016\/j.athoracsur.2013.01.012_bib21","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1164\/ajrccm.157.4.9703099","article-title":"Reduced E-cadherin expression is associated with increased lymph node metastasis and unfavorable prognosis in non-small cell lung cancer","volume":"157","author":"Sulzer","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.athoracsur.2013.01.012_bib22","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0169-5002(98)00053-1","article-title":"Influence of E-cadherin dysfunction upon local invasion and metastasis in non small cell lung cancer","volume":"22","author":"Shibanuma","year":"1998","journal-title":"Lung Cancer"},{"key":"10.1016\/j.athoracsur.2013.01.012_bib23","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/S0003-4975(00)02545-5","article-title":"E-cadherin expression associated with differentiation and prognosis in patients with non-small cell lung cancer","volume":"71","author":"Liu","year":"2001","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.athoracsur.2013.01.012_bib24","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.4161\/cbt.3.11.1302","article-title":"Twist induces an epithelial-mesenchymal transition to facilitate tumor metastasis","volume":"3","author":"Karreth","year":"2004","journal-title":"Cancer Biol Ther"},{"key":"10.1016\/j.athoracsur.2013.01.012_bib25","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.cell.2004.06.006","article-title":"Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis","volume":"117","author":"Yang","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.athoracsur.2013.01.012_bib26","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.5858\/133.8.1317","article-title":"Guidelines for pathologic diagnosis of malignant mesothelioma: a consensus statement from the International Mesothelioma Interest Group","volume":"133","author":"Husain","year":"2009","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.athoracsur.2013.01.012_bib27","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1046\/j.1365-2559.1997.5460776.x","article-title":"Pathology of malignant mesothelioma","volume":"30","author":"Attanoos","year":"1997","journal-title":"Histopathology"},{"key":"10.1016\/j.athoracsur.2013.01.012_bib28","doi-asserted-by":"crossref","first-page":"8765","DOI":"10.1200\/JCO.2005.02.2871","article-title":"Wnt5a expression is associated with the tumor proliferation and the stromal vascular endothelial growth factor-A expression in non-small cell lung cancer","volume":"23","author":"Huang","year":"2005","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.athoracsur.2013.01.012_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-0463.2012.02931.x","article-title":"Expression of snail, twist, and Zeb1 in malignant mesothelioma","volume":"121","author":"Merikallio","year":"2013","journal-title":"APMIS"},{"key":"10.1016\/j.athoracsur.2013.01.012_bib30","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1183\/09031936.00000811","article-title":"Predicting survival in malignant mesothelioma","volume":"38","author":"Musk","year":"2011","journal-title":"Eur Respir J"},{"key":"10.1016\/j.athoracsur.2013.01.012_bib31","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.lungcan.2009.12.010","article-title":"Snail nuclear expression parallels higher malignancy potential in neuroendocrine lung tumors","volume":"69","author":"Galv\u00e1n","year":"2010","journal-title":"Lung Cancer"},{"key":"10.1016\/j.athoracsur.2013.01.012_bib32","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.ejcts.2009.08.027","article-title":"Prognostic significance of epithelial-mesenchymal transition in malignant pleural mesothelioma","volume":"37","author":"Schramm","year":"2010","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.athoracsur.2013.01.012_bib33","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/modpathol.2011.144","article-title":"Epithelial-mesenchymal transition in malignant mesothelioma","volume":"25","author":"Fassina","year":"2012","journal-title":"Mod Pathol"},{"key":"10.1016\/j.athoracsur.2013.01.012_bib34","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.lungcan.2006.08.010","article-title":"Expression of Snail, Slug and Sip1 in malignant mesothelioma effusions is associated with matrix metalloproteinase, but not with cadherin expression","volume":"54","author":"Sivertsen","year":"2006","journal-title":"Lung Cancer"},{"key":"10.1016\/j.athoracsur.2013.01.012_bib35","doi-asserted-by":"crossref","first-page":"11740","DOI":"10.1074\/jbc.M413878200","article-title":"Wnt-dependent regulation of the E-cadherin repressor snail","volume":"280","author":"Yook","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.athoracsur.2013.01.012_bib36","doi-asserted-by":"crossref","first-page":"5075","DOI":"10.1038\/onc.2008.140","article-title":"Snail promotes Wnt target gene expression and interacts with beta-catenin","volume":"27","author":"Stemmer","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.athoracsur.2013.01.012_bib37","doi-asserted-by":"crossref","first-page":"21113","DOI":"10.1074\/jbc.M211304200","article-title":"Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions","volume":"278","author":"Peinado","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.athoracsur.2013.01.012_bib38","doi-asserted-by":"crossref","first-page":"7345","DOI":"10.1038\/sj.onc.1207990","article-title":"Regulation of Snail transcription during epithelial to mesenchymal transition of tumor cells","volume":"23","author":"Barber\u00e0","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.athoracsur.2013.01.012_bib39","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1126\/science.281.5382.1509","article-title":"Identification of c-MYC as a target of the APC pathway","volume":"281","author":"He","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.athoracsur.2013.01.012_bib40","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/nrc3090","article-title":"Cyclin D as a therapeutic target in cancer","volume":"11","author":"Musgrove","year":"2011","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.athoracsur.2013.01.012_bib41","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0140-6736(03)13910-4","article-title":"Survivin and molecular pathogenesis of colorectal cancer","volume":"362","author":"Kim","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.athoracsur.2013.01.012_bib42","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1006\/excr.1999.4686","article-title":"Function of the c-Myc oncogenic transcription factor","volume":"253","author":"Dang","year":"1999","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.athoracsur.2013.01.012_bib43","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1023\/A:1013556727182","article-title":"Expression of survivin mRNA and protein in gastric cancer cell line (MKN-45) during cisplatin treatment","volume":"7","author":"Ikeguchi","year":"2002","journal-title":"Apoptosis"}],"container-title":["The Annals of Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003497513001161?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003497513001161?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T02:30:25Z","timestamp":1757730625000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003497513001161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["S0003497513001161"],"URL":"https:\/\/doi.org\/10.1016\/j.athoracsur.2013.01.012","relation":{},"ISSN":["0003-4975"],"issn-type":[{"value":"0003-4975","type":"print"}],"subject":[],"published":{"date-parts":[[2013,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Snail Expression Is Associated With a Poor Prognosis in Malignant Pleural Mesotheliomas","name":"articletitle","label":"Article Title"},{"value":"The Annals of Thoracic Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.athoracsur.2013.01.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}