{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T19:27:31Z","timestamp":1789846051049,"version":"4.0.1"},"reference-count":26,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["annalsthoracicsurgery.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Annals of Thoracic Surgery"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1016\/j.athoracsur.2015.02.094","type":"journal-article","created":{"date-parts":[[2015,6,12]],"date-time":"2015-06-12T09:19:31Z","timestamp":1434100771000},"page":"535-541","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":102,"title":["Stroke After Left Ventricular Assist Device Implantation: Outcomes in the Continuous-Flow Era"],"prefix":"10.1016","volume":"100","author":[{"given":"Laura","family":"Harvey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Holley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samit S.","family":"Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Eckman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Cogswell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjit","family":"John","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.athoracsur.2015.02.094_bib1","first-page":"e46","article-title":"Heart disease and stroke statistics\u20142010 update: a report from the American Heart Association","volume":"121","author":"Lloyd-Jones","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.athoracsur.2015.02.094_bib2","first-page":"407","article-title":"An overview of approved and investigational left ventricular assist devices","volume":"17","author":"Marcel","year":"2004","journal-title":"Proc (Bayl Univ Med Cent)"},{"key":"10.1016\/j.athoracsur.2015.02.094_bib3","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1056\/NEJMoa012175","article-title":"Randomized Evaluation of Mechanical Assistance for the Treatment of Congestive Heart Failure (REMATCH) Study Group. Long-term use of a left ventricular assist device for end-stage heart failure","volume":"345","author":"Rose","year":"2001","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.athoracsur.2015.02.094_bib4","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/j.athoracsur.2008.06.030","article-title":"Improved survival and decreasing incidence of adverse events with the HeartMate II left ventricular assist device as bridge-to-transplant therapy","volume":"86","author":"John","year":"2008","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.athoracsur.2015.02.094_bib5","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/j.athoracsur.2009.06.095","article-title":"Activation of endothelial and coagulation systems in left ventricular assist device recipients","volume":"88","author":"John","year":"2009","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.athoracsur.2015.02.094_bib6","doi-asserted-by":"crossref","first-page":"3038","DOI":"10.1161\/CIRCULATIONAHA.111.040246","article-title":"Bleeding and thrombosis in patients with continuous-flow ventricular assist devices","volume":"125","author":"Eckman","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.athoracsur.2015.02.094_bib7","doi-asserted-by":"crossref","first-page":"91","DOI":"10.4037\/NCI.0b013e31824124d0","article-title":"Anticoagulation and bleeding in patients with ventricular assist devices: walking the tightrope","volume":"23","author":"Kurien","year":"2012","journal-title":"AACN Adv Crit Care"},{"key":"10.1016\/j.athoracsur.2015.02.094_bib8","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.healun.2009.05.018","article-title":"Low thromboembolism and pump thrombosis with the HeartMate II left ventricular assist device: analysis of outpatient anti-coagulation","volume":"28","author":"Boyle","year":"2009","journal-title":"J\u00a0Heart Lung Transplant"},{"key":"10.1016\/j.athoracsur.2015.02.094_bib9","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1056\/NEJMoa1313385","article-title":"Unexpected abrupt increase in left ventricular assist device thrombosis","volume":"370","author":"Starling","year":"2014","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.athoracsur.2015.02.094_bib10","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.healun.2013.12.001","article-title":"An analysis of pump thrombus events in patients in the HeartWare ADVANCE bridge to transplant and continued access protocol trial","volume":"33","author":"Najjar","year":"2014","journal-title":"J\u00a0Heart Lung Transplant"},{"issue":"3 Suppl","key":"10.1016\/j.athoracsur.2015.02.094_bib11","doi-asserted-by":"crossref","first-page":"S116","DOI":"10.1016\/S0003-4975(00)02639-4","article-title":"HeartMate II left ventricular assist system: from concept to first clinical use","volume":"71","author":"Griffith","year":"2001","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.athoracsur.2015.02.094_bib12","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1161\/CIRCHEARTFAILURE.112.000186","article-title":"Validity and reliability of a novel slow cuff-deflation system for noninvasive blood pressure monitoring in patients with continuous-flow left ventricular assist device","volume":"6","author":"Lanier","year":"2013","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.athoracsur.2015.02.094_bib13","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.healun.2012.09.013","article-title":"The 2013 International Society for Heart and Lung Transplantation Guidelines for mechanical circulatory support: executive summary","volume":"32","author":"Feldman","year":"2013","journal-title":"J\u00a0Heart Lung Transplant"},{"issue":"4 Suppl","key":"10.1016\/j.athoracsur.2015.02.094_bib14","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.healun.2010.01.011","article-title":"Clinical management of continuous-flow left ventricular assist devices in advanced heart failure","volume":"29","author":"Slaughter","year":"2010","journal-title":"J\u00a0Heart Lung Transplant"},{"key":"10.1016\/j.athoracsur.2015.02.094_bib15","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.jacc.2013.08.1656","article-title":"Pre-operative risk factors of bleeding and stroke during left ventricular assist device support: an analysis of more than 900 HeartMate II outpatients","volume":"63","author":"Boyle","year":"2014","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.athoracsur.2015.02.094_bib16","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1097\/MAT.0000000000000074","article-title":"Stroke while on long-term left ventricular assist device support: incidence, outcome, and predictors","volume":"60","author":"Morgan","year":"2014","journal-title":"ASAIO J"},{"key":"10.1016\/j.athoracsur.2015.02.094_bib17","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1016\/j.athoracsur.2014.02.041","article-title":"Hemolysis, pump thrombus, and neurologic events in continuous-flow left ventricular assist device recipients","volume":"97","author":"Whitson","year":"2014","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.athoracsur.2015.02.094_bib18","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1161\/CIRCHEARTFAILURE.109.877597","article-title":"Acquired von Willebrand syndrome in patients with an axial flow left ventricular assist device","volume":"3","author":"Meyer","year":"2010","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.athoracsur.2015.02.094_bib19","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1016\/j.jtcvs.2007.12.077","article-title":"Low thromboembolic risk for patients with the HeartMate II left ventricular assist device","volume":"136","author":"John","year":"2008","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.athoracsur.2015.02.094_bib20","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1093\/ejcts\/ezr312","article-title":"Low stroke rate and few thrombo-embolic events after HeartMate II implantation under mild anticoagulation","volume":"42","author":"Menon","year":"2012","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.athoracsur.2015.02.094_bib21","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1212\/WNL.54.2.288","article-title":"Stroke in patients with heart failure and reduced left ventricular ejection fraction","volume":"54","author":"Pullicino","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.athoracsur.2015.02.094_bib22","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1097\/MAT.0b013e318260c6a6","article-title":"Are blood stream infections associated with an increased risk of hemorrhagic stroke in patients with a left ventricular assist device?","volume":"58","author":"Aggarwal","year":"2012","journal-title":"ASAIO J"},{"key":"10.1016\/j.athoracsur.2015.02.094_bib23","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1161\/STROKEAHA.111.639682","article-title":"Asymmetric pattern of cerebrovascular lesions in patients after left ventricular assist device implantation","volume":"43","author":"Kato","year":"2012","journal-title":"Stroke"},{"key":"10.1016\/j.athoracsur.2015.02.094_bib24","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1016\/j.athoracsur.2011.06.081","article-title":"Lessons learned from experience with over 100 consecutive HeartMate II left ventricular assist devices","volume":"92","author":"John","year":"2011","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.athoracsur.2015.02.094_bib25","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.athoracsur.2013.07.069","article-title":"Blood pressure control in continuous flow left ventricular assist devices: efficacy and impact on adverse events","volume":"97","author":"Lampert","year":"2014","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.athoracsur.2015.02.094_bib26","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.healun.2010.02.003","article-title":"Post-operative heparin may not be required for transitioning patients with a HeartMate II left ventricular assist system to long-term warfarin therapy","volume":"29","author":"Slaughter","year":"2010","journal-title":"J\u00a0Heart Lung Transplant"}],"container-title":["The Annals of Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003497515003677?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003497515003677?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T03:18:36Z","timestamp":1757733516000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003497515003677"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["S0003497515003677"],"URL":"https:\/\/doi.org\/10.1016\/j.athoracsur.2015.02.094","relation":{},"ISSN":["0003-4975"],"issn-type":[{"value":"0003-4975","type":"print"}],"subject":[],"published":{"date-parts":[[2015,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Stroke After Left Ventricular Assist Device Implantation: Outcomes in the Continuous-Flow Era","name":"articletitle","label":"Article Title"},{"value":"The Annals of Thoracic Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.athoracsur.2015.02.094","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}