{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T14:22:13Z","timestamp":1793024533745,"version":"4.5.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["annalsthoracicsurgery.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Annals of Thoracic Surgery"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.athoracsur.2016.05.094","type":"journal-article","created":{"date-parts":[[2016,8,22]],"date-time":"2016-08-22T17:29:24Z","timestamp":1471886964000},"page":"1905-1910","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":78,"title":["Effect of Perioperative Pirfenidone Treatment in Lung Cancer Patients With Idiopathic Pulmonary Fibrosis"],"prefix":"10.1016","volume":"102","author":[{"given":"Takekazu","family":"Iwata","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigetoshi","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiki","family":"Fujiwara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironobu","family":"Wada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidemi","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Yoshino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.athoracsur.2016.05.094_bib1","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/j.athoracsur.2015.03.094","article-title":"Pulmonary resection for lung cancer in patients with idiopathic interstitial pneumonia","volume":"100","author":"Omori","year":"2015","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.athoracsur.2016.05.094_bib2","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1016\/j.athoracsur.2011.06.055","article-title":"Survival after surgery for pathologic stage IA non-small cell lung cancer associated with idiopathic pulmonary fibrosis","volume":"92","author":"Saito","year":"2011","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.athoracsur.2016.05.094_bib3","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.athoracsur.2005.09.036","article-title":"Acute exacerbation of interstitial fibrosis after pulmonary resection","volume":"82","author":"Yuksel","year":"2006","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.athoracsur.2016.05.094_bib4","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1016\/S0003-4975(03)00966-4","article-title":"Operation for lung cancer in patients with idiopathic pulmonary fibrosis: surgical contraindication?","volume":"76","author":"Fujimoto","year":"2003","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.athoracsur.2016.05.094_bib5","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.athoracsur.2011.12.010","article-title":"Acute exacerbation of usual interstitial pneumonia after resection of lung cancer","volume":"93","author":"Sugiura","year":"2012","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.athoracsur.2016.05.094_bib6","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1007\/s00595-010-4384-z","article-title":"Risk of acute exacerbation of interstitial pneumonia after pulmonary resection for lung cancer in patients with idiopathic pulmonary fibrosis based on preoperative high-resolution computed tomography","volume":"41","author":"Suzuki","year":"2011","journal-title":"Surg Today"},{"key":"10.1016\/j.athoracsur.2016.05.094_bib7","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1007\/s11748-009-0569-z","article-title":"Predictive factors for postoperative acute exacerbation of interstitial pneumonia combined with lung cancer","volume":"58","author":"Shintani","year":"2010","journal-title":"Gen Thorac Cardiovasc Surg"},{"key":"10.1016\/j.athoracsur.2016.05.094_bib8","doi-asserted-by":"crossref","first-page":"e161","DOI":"10.1093\/ejcts\/ezs147","article-title":"The importance of intraoperative fluid balance for the prevention of postoperative acute exacerbation of idiopathic pulmonary fibrosis after pulmonary resection for primary lung cancer","volume":"41","author":"Mizuno","year":"2012","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.athoracsur.2016.05.094_bib9","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1016\/j.jtcvs.2013.09.050","article-title":"Impact and predictors of acute exacerbation of interstitial lung diseases after pulmonary resection for lung cancer","volume":"147","author":"Sato","year":"2014","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.athoracsur.2016.05.094_bib10","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/s11748-014-0487-6","article-title":"A\u00a0simple risk scoring system for predicting acute exacerbation of interstitial pneumonia after pulmonary resection in lung cancer patients","volume":"63","author":"Sato","year":"2015","journal-title":"Gen Thorac Cardiovasc Surg"},{"key":"10.1016\/j.athoracsur.2016.05.094_bib11","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1007\/s11748-012-0180-6","article-title":"Surgical treatment for primary lung cancer combined with idiopathic pulmonary fibrosis","volume":"61","author":"Watanabe","year":"2013","journal-title":"Gen Thorac Cardiovasc Surg"},{"key":"10.1016\/j.athoracsur.2016.05.094_bib12","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1056\/NEJMoa1402582","article-title":"A\u00a0phase 3 trial of pirfenidone in patients with idiopathic pulmonary fibrosis","volume":"370","author":"King","year":"2014","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.athoracsur.2016.05.094_bib13","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1016\/S0140-6736(11)60405-4","article-title":"Pirfenidone in patients with idiopathic pulmonary fibrosis (CAPACITY): two randomised trials","volume":"377","author":"Noble","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.athoracsur.2016.05.094_bib14","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1164\/rccm.200404-571OC","article-title":"Double-blind, placebo-controlled trial of pirfenidone in patients with idiopathic pulmonary fibrosis","volume":"171","author":"Azuma","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.athoracsur.2016.05.094_bib15","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1183\/09031936.00005209","article-title":"Pirfenidone in idiopathic pulmonary fibrosis","volume":"35","author":"Taniguchi","year":"2010","journal-title":"Eur Respir J"},{"key":"10.1016\/j.athoracsur.2016.05.094_bib16","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1007\/s00595-014-1071-5","article-title":"Experience with perioperative pirfenidone for lung cancer surgery in patients with idiopathic pulmonary fibrosis","volume":"45","author":"Iwata","year":"2015","journal-title":"Surg Today"},{"key":"10.1016\/j.athoracsur.2016.05.094_bib17","doi-asserted-by":"crossref","first-page":"395A","DOI":"10.1378\/chest.2228629","article-title":"Effect of perioperative pirfenidone treatment in lung cancer patients with idiopathic pulmonary fibrosis (West Japan Oncology Group 6711L): a phase II study","volume":"148","author":"Iwata","year":"2015","journal-title":"Chest"},{"key":"10.1016\/j.athoracsur.2016.05.094_bib18","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1164\/rccm.2009-040GL","article-title":"An official ATS\/ERS\/JRS\/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management","volume":"183","author":"Raghu","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.athoracsur.2016.05.094_bib19","series-title":"Idiopathic Interstitial Pneumonias: Diagnosis and Treatment","first-page":"67","year":"2011"},{"key":"10.1016\/j.athoracsur.2016.05.094_bib20","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1164\/rccm.200703-463PP","article-title":"Acute exacerbations of idiopathic pulmonary fibrosis","volume":"176","author":"Collard","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.athoracsur.2016.05.094_bib21","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/bmt.2012.244","article-title":"Investigation of the freely available easy-to-use software 'EZR' for medical statistics","volume":"48","author":"Kanda","year":"2013","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.athoracsur.2016.05.094_bib22","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1007\/s11748-015-0590-3","article-title":"Thoracic and cardiovascular surgery in Japan during 2013: Annual report by the Japanese Association for Thoracic Surgery","volume":"63","author":"Masuda","year":"2015","journal-title":"Gen Thorac Cardiovasc Surg"},{"key":"10.1016\/j.athoracsur.2016.05.094_bib23","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1378\/chest.07-0299","article-title":"Acute exacerbation of idiopathic pulmonary fibrosis","volume":"132","author":"Hyzy","year":"2007","journal-title":"Chest"},{"key":"10.1016\/j.athoracsur.2016.05.094_bib24","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1016\/S0022-5223(03)00028-X","article-title":"Pulmonary fibrosis and lung cancer: risk and benefit analysis of pulmonary resection","volume":"125","author":"Kumar","year":"2003","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.athoracsur.2016.05.094_bib25","unstructured":"Yoshimura K, Miyamoto A, Uruga H, Morokawa N, Beika Y, Kishi K. A nation-wide survey on prophylaxis for acute exacerbation of idiopathic pulmonary fibrosis following lung surgery for associated lung cancer. The Annual Report by Study Group of Ministry of Health and Welfare for Diffuse Lung Disease. Diffuse Lung Diseases Research Group from the Ministry of Health, Labour and Welfare of Japanese Government 2008. 2009;77\u201381."},{"key":"10.1016\/j.athoracsur.2016.05.094_bib26","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1093\/icvts\/ivr029","article-title":"Post-operative acute exacerbation of pulmonary fibrosis in lung cancer patients undergoing lung resection","volume":"14","author":"Yano","year":"2012","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"10.1016\/j.athoracsur.2016.05.094_bib27","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0022-3565(24)35110-9","article-title":"Effects of pirfenidone on transforming growth factor-beta gene expression at the transcriptional level in bleomycin hamster model of lung fibrosis","volume":"291","author":"Iyer","year":"1999","journal-title":"J\u00a0Pharmacol Exp Ther"},{"key":"10.1016\/j.athoracsur.2016.05.094_bib28","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jtcvs.2014.08.086","article-title":"Long-term results and predictors of survival after surgical resection of patients with lung cancer and interstitial lung diseases","volume":"149","author":"Sato","year":"2015","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.athoracsur.2016.05.094_bib29","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/S0022-5223(03)00791-8","article-title":"Impact of interstitial lung disease on surgical morbidity and mortality for lung cancer: analyses of short-term and long-term outcomes","volume":"126","author":"Chiyo","year":"2003","journal-title":"J\u00a0Thorac Cardiovasc Surg"}],"container-title":["The Annals of Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003497516306014?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003497516306014?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T03:39:50Z","timestamp":1757734790000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003497516306014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["S0003497516306014"],"URL":"https:\/\/doi.org\/10.1016\/j.athoracsur.2016.05.094","relation":{},"ISSN":["0003-4975"],"issn-type":[{"value":"0003-4975","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of Perioperative Pirfenidone Treatment in Lung Cancer Patients With Idiopathic Pulmonary Fibrosis","name":"articletitle","label":"Article Title"},{"value":"The Annals of Thoracic Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.athoracsur.2016.05.094","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 by The Society of Thoracic Surgeons Published by Elsevier","name":"copyright","label":"Copyright"}]}}