{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:48:36Z","timestamp":1791474516465,"version":"4.3.4"},"reference-count":35,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["annalsthoracicsurgery.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Annals of Thoracic Surgery"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.athoracsur.2016.05.110","type":"journal-article","created":{"date-parts":[[2016,10,20]],"date-time":"2016-10-20T09:01:49Z","timestamp":1476954109000},"page":"1747-1755","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":76,"title":["Endosonography Versus Mediastinoscopy in Mediastinal Staging of Lung Cancer: Systematic Review and Meta-Analysis"],"prefix":"10.1016","volume":"102","author":[{"given":"Inderpaul Singh","family":"Sehgal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahajal","family":"Dhooria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashutosh Nath","family":"Aggarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Digambar","family":"Behera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritesh","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.athoracsur.2016.05.110_bib1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.6004\/jnccn.2016.0031","article-title":"NCCN guidelines insights: non-small cell lung cancer, version 4.2016","volume":"14","author":"Ettinger","year":"2016","journal-title":"J\u00a0Natl Compr Canc Netw"},{"key":"10.1016\/j.athoracsur.2016.05.110_bib2","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1093\/annonc\/mdv187","article-title":"2nd esmo consensus conference in lung cancer: locally advanced stage III non-small-cell lung cancer","volume":"26","author":"Eberhardt","year":"2015","journal-title":"Ann Oncol"},{"key":"10.1016\/j.athoracsur.2016.05.110_bib3","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1378\/chest.12-2377","article-title":"Executive summary: diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines","volume":"143","author":"Detterbeck","year":"2013","journal-title":"Chest"},{"key":"10.1016\/j.athoracsur.2016.05.110_bib4","doi-asserted-by":"crossref","first-page":"137","DOI":"10.4997\/JRCPE.2013.211","article-title":"Is there still a role for mediastinoscopy as the first mediastinal staging procedure in lung cancer?","volume":"43","author":"Waller","year":"2013","journal-title":"J\u00a0R Coll Physicians Edinb"},{"key":"10.1016\/j.athoracsur.2016.05.110_bib5","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1093\/annonc\/mdu089","article-title":"2nd ESMO Consensus Conference on Lung Cancer: early-stage non-small-cell lung cancer consensus on diagnosis, treatment and follow-up","volume":"25","author":"Vansteenkiste","year":"2014","journal-title":"Ann Oncol"},{"key":"10.1016\/j.athoracsur.2016.05.110_bib6","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1007\/s00408-015-9761-3","article-title":"Comparison of endobronchial ultrasound-guided fine needle aspiration and video-assisted mediastinoscopy for mediastinal staging of lung cancer","volume":"193","author":"Ge","year":"2015","journal-title":"Lung"},{"key":"10.1016\/j.athoracsur.2016.05.110_bib7","doi-asserted-by":"crossref","first-page":"W65","DOI":"10.7326\/0003-4819-151-4-200908180-00136","article-title":"The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration","volume":"151","author":"Liberati","year":"2009","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.athoracsur.2016.05.110_bib8","series-title":"Standard Quality Assessment Criteria for Evaluating Primary Research Papers From a\u00a0Variety of Fields","author":"Kmet","year":"2004"},{"key":"10.1016\/j.athoracsur.2016.05.110_bib9","series-title":"Cochrane Handbook for Systematic Reviews of Diagnostic Test Accuracy Version","author":"Macaskill","year":"2010"},{"key":"10.1016\/j.athoracsur.2016.05.110_bib10","series-title":"Cochrane Reviewers\u2019 Handbook 422","first-page":"68","article-title":"Analysing and presenting results","author":"Deeks","year":"2004"},{"key":"10.1016\/j.athoracsur.2016.05.110_bib11","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0197-2456(86)90034-6","article-title":"Analysis of data from multiclinic trials","volume":"7","author":"Fleiss","year":"1986","journal-title":"Control Clin Trials"},{"key":"10.1016\/j.athoracsur.2016.05.110_bib12","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1214\/ss\/1177011363","article-title":"An approach to assessing publication bias prior to performing a meta-analysis","volume":"7","author":"Dear","year":"1992","journal-title":"Stat Sci"},{"key":"10.1016\/j.athoracsur.2016.05.110_bib13","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ"},{"key":"10.1016\/j.athoracsur.2016.05.110_bib14","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.2307\/2533446","article-title":"Operating characteristics of a rank correlation test for publication bias","volume":"50","author":"Begg","year":"1994","journal-title":"Biometrics"},{"key":"10.1016\/j.athoracsur.2016.05.110_bib15","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1001\/jama.294.8.931","article-title":"Endoscopic ultrasound added to mediastinoscopy for preoperative staging of patients with lung cancer","volume":"294","author":"Annema","year":"2005","journal-title":"JAMA"},{"key":"10.1016\/j.athoracsur.2016.05.110_bib16","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.lungcan.2004.10.002","article-title":"Endoscopic ultrasound guided biopsy versus mediastinoscopy for analysis of paratracheal and subcarinal lymph nodes in lung cancer staging","volume":"48","author":"Larsen","year":"2005","journal-title":"Lung Cancer"},{"key":"10.1016\/j.athoracsur.2016.05.110_bib17","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1097\/JTO.0b013e3181753b5e","article-title":"Diagnosis of mediastinal adenopathy-real-time endobronchial ultrasound guided needle aspiration versus mediastinoscopy","volume":"3","author":"Ernst","year":"2008","journal-title":"J\u00a0Thorac Oncol"},{"key":"10.1016\/j.athoracsur.2016.05.110_bib18","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1164\/rccm.200708-1241OC","article-title":"Endoscopic ultrasound reduces surgical mediastinal staging in lung cancer: a randomized trial","volume":"177","author":"Tournoy","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.athoracsur.2016.05.110_bib19","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1001\/jama.2010.1705","article-title":"Mediastinoscopy vs endosonography for mediastinal nodal staging of lung cancer: a randomized trial","volume":"304","author":"Annema","year":"2010","journal-title":"JAMA"},{"key":"10.1016\/j.athoracsur.2016.05.110_bib20","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1016\/j.jtcvs.2011.08.037","article-title":"A\u00a0prospective controlled trial of endobronchial ultrasound-guided transbronchial needle aspiration compared with mediastinoscopy for mediastinal lymph node staging of lung cancer","volume":"142","author":"Yasufuku","year":"2011","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.athoracsur.2016.05.110_bib21","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/1749-8090-7-51","article-title":"Endobronchial ultrasound guided fine needle aspiration versus transcervical mediastinoscopy in nodal staging of non small cell lung cancer: a prospective comparison study","volume":"7","author":"Zhang","year":"2012","journal-title":"J\u00a0Cardiothorac Surg"},{"key":"10.1016\/j.athoracsur.2016.05.110_bib22","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1378\/chest.13-2349","article-title":"Endosonographic mediastinal lymph node staging of lung cancer","volume":"146","author":"Liberman","year":"2014","journal-title":"Chest"},{"key":"10.1016\/j.athoracsur.2016.05.110_bib23","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1097\/JTO.0000000000000388","article-title":"Endobronchial ultrasound versus mediastinoscopy for mediastinal nodal staging of non-small-cell lung cancer","volume":"10","author":"Um","year":"2015","journal-title":"J\u00a0Thorac Oncol"},{"key":"10.1016\/j.athoracsur.2016.05.110_bib24","doi-asserted-by":"crossref","first-page":"599","DOI":"10.6004\/jnccn.2012.0062","article-title":"The management of patients with stage IIIA non-small cell lung cancer with N2\u00a0mediastinal node involvement","volume":"10","author":"Martins","year":"2012","journal-title":"J\u00a0Natl Compr Canc Netw"},{"key":"10.1016\/j.athoracsur.2016.05.110_bib25","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1378\/chest.06-1437","article-title":"Endoscopic ultrasound-guided fine-needle aspiration for non-small cell lung cancer staging: a systematic review and metaanalysis","volume":"131","author":"Micames","year":"2007","journal-title":"Chest"},{"key":"10.1016\/j.athoracsur.2016.05.110_bib26","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1136\/thx.2008.109868","article-title":"Test performance of endobronchial ultrasound and transbronchial needle aspiration biopsy for mediastinal staging in patients with lung cancer: systematic review and meta-analysis","volume":"64","author":"Adams","year":"2009","journal-title":"Thorax"},{"key":"10.1016\/j.athoracsur.2016.05.110_bib27","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/j.ejca.2008.11.043","article-title":"Endobronchial ultrasound-guided transbronchial needle aspiration for staging of lung cancer: a systematic review and meta-analysis","volume":"45","author":"Gu","year":"2009","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.athoracsur.2016.05.110_bib28","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1016\/j.ejca.2013.02.008","article-title":"Combined endobronchial and endoscopic ultrasound-guided fine needle aspiration for mediastinal lymph node staging of lung cancer: a meta-analysis","volume":"49","author":"Zhang","year":"2013","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.athoracsur.2016.05.110_bib29","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.ejcts.2007.10.021","article-title":"Does video-mediastinoscopy improve the results of conventional mediastinoscopy?","volume":"33","author":"Leschber","year":"2008","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.athoracsur.2016.05.110_bib30","first-page":"225","article-title":"Preoperative mediastinal lymph node staging for non-small cell lung cancer: 2014 update of the 2007 ests guidelines","volume":"3","author":"De Leyn","year":"2014","journal-title":"Transl Lung Cancer Res"},{"key":"10.1016\/j.athoracsur.2016.05.110_bib31","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1164\/rccm.201409-1615OC","article-title":"Randomized trial\u00a0of endobronchial ultrasound-guided transbronchial needle aspiration under general anesthesia versus moderate sedation","volume":"191","author":"Casal","year":"2015","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.athoracsur.2016.05.110_bib32","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/j.1759-7714.2011.00106.x","article-title":"Endobronchial ultrasound (EBUS) with tranbronchial needle aspiration (TBNA) versus mediastinoscopy for mediastinal staging in non-small cell lung cancer (NSCLC) thoracic cancer","volume":"3","author":"Nasir","year":"2012","journal-title":"Thoracic Cancer"},{"key":"10.1016\/j.athoracsur.2016.05.110_bib33","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1093\/icvts\/ivt302","article-title":"Mediastinal staging in daily practice: endosonography, followed by cervical mediastinoscopy. Do we really need both?","volume":"17","author":"Verhagen","year":"2013","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"10.1016\/j.athoracsur.2016.05.110_bib34","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.4187\/respcare.03779","article-title":"Utility and safety of endoscopic ultrasound with bronchoscope-guided fine-needle aspiration in mediastinal lymph node sampling: Systematic review and meta-analysis","volume":"60","author":"Dhooria","year":"2015","journal-title":"Respir Care"},{"key":"10.1016\/j.athoracsur.2016.05.110_bib35","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.lungcan.2005.05.029","article-title":"Accuracy of mediastinoscopy compared to\u00a0endoscopic ultrasound with fine needle aspiration (EUS-FNA)","volume":"50","author":"Van Schil","year":"2005","journal-title":"Lung Cancer"}],"container-title":["The Annals of Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003497516306191?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003497516306191?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T03:40:29Z","timestamp":1757734829000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003497516306191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["S0003497516306191"],"URL":"https:\/\/doi.org\/10.1016\/j.athoracsur.2016.05.110","relation":{},"ISSN":["0003-4975"],"issn-type":[{"value":"0003-4975","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Endosonography Versus Mediastinoscopy in Mediastinal Staging of Lung Cancer: Systematic Review and Meta-Analysis","name":"articletitle","label":"Article Title"},{"value":"The Annals of Thoracic Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.athoracsur.2016.05.110","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 by The Society of Thoracic Surgeons Published by Elsevier","name":"copyright","label":"Copyright"}]}}