{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:23:20Z","timestamp":1777508600632,"version":"3.51.4"},"reference-count":30,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["annalsthoracicsurgery.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Annals of Thoracic Surgery"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.athoracsur.2017.06.036","type":"journal-article","created":{"date-parts":[[2017,9,29]],"date-time":"2017-09-29T02:46:07Z","timestamp":1506653167000},"page":"1637-1643","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Serum Biomarkers May Prognosticate Recurrence in Node-Negative, Non-Small Cell Lung Cancers Less Than 4 Centimeters"],"prefix":"10.1016","volume":"104","author":[{"given":"Christopher W.","family":"Seder","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew T.","family":"Arndt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lia","family":"Jordano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjib","family":"Basu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina L.","family":"Fhied","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selina","family":"Sayidine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary W.","family":"Chmielewski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelsey","family":"Gallo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Liptay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey A.","family":"Borgia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.athoracsur.2017.06.036_bib1","unstructured":"American Cancer Society. Cancer facts and figures\u00a02016. Available at http:\/\/www.cancer.org\/acs\/groups\/content\/@research\/documents\/document\/acspc-047079.pdf. Accessed 10\/8\/2016."},{"key":"10.1016\/j.athoracsur.2017.06.036_bib2","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1056\/NEJMoa1102873","article-title":"Reduced lung-cancer mortality with low-dose computed tomographic screening","volume":"365","author":"Aberle","year":"2011","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.athoracsur.2017.06.036_bib3","first-page":"352","article-title":"Issues with implementing a high-quality lung cancer screening program","volume":"64","author":"Mulshine","year":"2014","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.athoracsur.2017.06.036_bib4","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1016\/j.jtho.2016.06.028","article-title":"The IASLC Lung Cancer Staging Project: methodology and validation used in the development of proposals for revision of the stage classification of NSCLC in the forthcoming (eighth) edition of the TNM classification of lung cancer","volume":"11","author":"Detterbeck","year":"2016","journal-title":"J\u00a0Thorac Oncol"},{"key":"10.1016\/j.athoracsur.2017.06.036_bib5","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jtcvs.2010.08.062","article-title":"Patterns of recurrence and incidence of second primary tumors after lobectomy by means of video-assisted thoracoscopic surgery (VATS) versus thoracotomy for lung cancer","volume":"141","author":"Flores","year":"2009","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.athoracsur.2017.06.036_bib6","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.jtcvs.2006.10.043","article-title":"Advances in positron emission tomography technology have increased the need for surgical staging in non-small cell lung cancer","volume":"133","author":"Lee","year":"2007","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.athoracsur.2017.06.036_bib7","doi-asserted-by":"crossref","first-page":"3552","DOI":"10.1200\/JCO.2007.13.9030","article-title":"Lung Adjuvant Cisplatin Evaluation: a pooled analysis by the LACE collaborative group","volume":"26","author":"Pignon","year":"2008","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.athoracsur.2017.06.036_bib8","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1002\/cncr.22938","article-title":"Prognostic factors for survival of stage I non small cell lung cancer patients: a population-based analysis of 19,702 stage I patients in the California Cancer Registry from 1989 to 2003","volume":"110","author":"Ou","year":"2007","journal-title":"Cancer"},{"key":"10.1016\/j.athoracsur.2017.06.036_bib9","doi-asserted-by":"crossref","first-page":"5043","DOI":"10.1200\/JCO.2008.16.4855","article-title":"Adjuvant paclitaxel plus carboplatin compared with observation in stage IB non-small-cell lung cancer: CALGB 9633 with the Cancer and Leukemia Group B, Radiation Therapy Oncology Group, and North Central Cancer Treatment Group study groups","volume":"26","author":"Strauss","year":"2008","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.athoracsur.2017.06.036_bib10","first-page":"2033","article-title":"Meta-analysis of postoperative adjuvant chemotherapy without radiotherapy in early stage non-small cell lung cancer","volume":"8","author":"Chen","year":"2015","journal-title":"Onco Targets Ther"},{"key":"10.1016\/j.athoracsur.2017.06.036_bib11","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1097\/JTO.0b013e3181982abf","article-title":"Establishment of a multi-analyte serum biomarker panel to identify lymph node metastases in non-small cell lung cancer","volume":"4","author":"Borgia","year":"2009","journal-title":"J\u00a0Thorac Oncol"},{"key":"10.1016\/j.athoracsur.2017.06.036_bib12","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1016\/j.athoracsur.2014.06.071","article-title":"Circulating angiogenesis biomarkers are associated with disease progression in lung adenocarcinoma","volume":"98","author":"Daly","year":"2014","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.athoracsur.2017.06.036_bib13","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1097\/JTO.0b013e31827627f8","article-title":"Development and validation of a plasma biomarker panel for discerning clinical significance of indeterminate pulmonary nodules","volume":"8","author":"Daly","year":"2013","journal-title":"J\u00a0Thorac Oncol"},{"key":"10.1016\/j.athoracsur.2017.06.036_bib14","doi-asserted-by":"crossref","first-page":"3452","DOI":"10.1158\/1078-0432.CCR-09-3192","article-title":"Development of a multiplexed tumor-associated autoantibody-based blood test for the detection of non-small cell lung cancer","volume":"16","author":"Farlow","year":"2010","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.athoracsur.2017.06.036_bib15","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1038\/sj.bjc.6605865","article-title":"A\u00a0multi-analyte serum test for the detection of non-small cell lung cancer","volume":"103","author":"Farlow","year":"2010","journal-title":"Br J Cancer"},{"key":"10.1016\/j.athoracsur.2017.06.036_bib16","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/j.jtcvs.2012.08.033","article-title":"Development of a serum biomarker panel predicting recurrence in stage I non-small cell lung cancer patients","volume":"144","author":"Rinewalt","year":"2012","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.athoracsur.2017.06.036_bib17","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.athoracsur.2015.04.018","article-title":"Angiogenesis biomarkers may be useful in the management of patients with indeterminate pulmonary nodules","volume":"100","author":"Seder","year":"2015","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.athoracsur.2017.06.036_bib18","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.jtcvs.2014.08.085","article-title":"Value of circulating insulin-like growth factor-associated proteins for the detection of stage I non-small cell lung cancer","volume":"149","author":"Kubasiak","year":"2015","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.athoracsur.2017.06.036_bib19","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/ijc.25644","article-title":"Enhancement of a multianalyte serum biomarker panel to identify lymph node metastases in non-small cell lung cancer with circulating autoantibody biomarkers","volume":"129","author":"Patel","year":"2010","journal-title":"Int J Cancer"},{"key":"10.1016\/j.athoracsur.2017.06.036_bib20","doi-asserted-by":"crossref","first-page":"7553","DOI":"10.1200\/jco.2010.28.15_suppl.7553","article-title":"Insulin-like growth factor binding proteins related to progression-free survival (PFS) and overall survival (OS) in advanced non-small cell lung cancer (NSCLC) patients treated with chemotherapy","volume":"28","author":"Karmali","year":"2010","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.athoracsur.2017.06.036_bib21","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1016\/j.athoracsur.2011.06.058","article-title":"Biomarkers of the insulin-like growth factor pathway predict progression and outcome in lung cancer","volume":"92","author":"Shersher","year":"2011","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.athoracsur.2017.06.036_bib22","first-page":"19014","article-title":"Value of serum marker HE4 in pulmonary carcinoma diagnosis","volume":"8","author":"Tang","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"10.1016\/j.athoracsur.2017.06.036_bib23","doi-asserted-by":"crossref","first-page":"187","DOI":"10.15430\/JCP.2016.21.3.187","article-title":"Diagnostic value of combining tumor and inflammatory markers in lung cancer","volume":"21","author":"Yoon","year":"2016","journal-title":"J\u00a0Cancer Prev"},{"key":"10.1016\/j.athoracsur.2017.06.036_bib24","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.cca.2016.02.002","article-title":"Serum human epididymis protein 4 (HE4) may be a better tumor marker in early lung cancer","volume":"455","author":"Zeng","year":"2016","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.athoracsur.2017.06.036_bib25","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s12094-015-1375-y","article-title":"Serum human epididymis protein 4 is associated with the treatment response of concurrent chemoradiotherapy and prognosis in patients with locally advanced non-small cell lung cancer","volume":"18","author":"Lan","year":"2015","journal-title":"Clin Transl Oncol"},{"key":"10.1016\/j.athoracsur.2017.06.036_bib26","first-page":"5568","article-title":"Expression level of serum human epididymis 4 and its prognostic significance in human non-small cell lung cancer","volume":"7","author":"Jiang","year":"2014","journal-title":"Int J Clin Exp Med"},{"key":"10.1016\/j.athoracsur.2017.06.036_bib27","doi-asserted-by":"crossref","first-page":"e0128836","DOI":"10.1371\/journal.pone.0128836","article-title":"Serum HE4: an independent prognostic factor in non-small cell lung cancer","volume":"10","author":"Lamy","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1016\/j.athoracsur.2017.06.036_bib28","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1007\/s13277-012-0499-8","article-title":"Serum level of HE4 is closely associated with pulmonary adenocarcinoma progression","volume":"33","author":"Yamashita","year":"2012","journal-title":"Tumour Biol"},{"issue":"Supplement 4","key":"10.1016\/j.athoracsur.2017.06.036_bib29","first-page":"284","article-title":"Insulin-like growth factor 1 receptor (IGF-1R) and outcome measures in advanced non-small cell lung cancer (NSCLC) patients treated with gefitinib","volume":"3","author":"Fidler","year":"2008","journal-title":"J\u00a0Thorac Oncol"},{"key":"10.1016\/j.athoracsur.2017.06.036_bib30","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1186\/1477-7819-11-228","article-title":"Beta-HCG secretion by a pulmonary adenocarcinoma","volume":"11","author":"Vicier","year":"2013","journal-title":"World J Surg Oncol"}],"container-title":["The Annals of Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003497517309189?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003497517309189?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T03:50:15Z","timestamp":1757735415000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003497517309189"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["S0003497517309189"],"URL":"https:\/\/doi.org\/10.1016\/j.athoracsur.2017.06.036","relation":{},"ISSN":["0003-4975"],"issn-type":[{"value":"0003-4975","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serum Biomarkers May Prognosticate Recurrence in Node-Negative, Non-Small Cell Lung Cancers Less Than 4 Centimeters","name":"articletitle","label":"Article Title"},{"value":"The Annals of Thoracic Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.athoracsur.2017.06.036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 by The Society of Thoracic Surgeons Published by Elsevier","name":"copyright","label":"Copyright"}]}}