{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T14:47:42Z","timestamp":1772462862867,"version":"3.50.1"},"reference-count":28,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["annalsthoracicsurgery.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Annals of Thoracic Surgery"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.athoracsur.2018.04.043","type":"journal-article","created":{"date-parts":[[2018,8,27]],"date-time":"2018-08-27T20:48:39Z","timestamp":1535402919000},"page":"1204-1212","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Genetic and Extracardiac Anomalies Are Associated With Inferior Single Ventricle Palliation Outcomes"],"prefix":"10.1016","volume":"106","author":[{"given":"Bahaaldin","family":"Alsoufi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Courtney","family":"McCracken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Oster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subhadra","family":"Shashidharan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirk","family":"Kanter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.athoracsur.2018.04.043_bib1","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1161\/CIRCULATIONAHA.106.183056","article-title":"Genetic basis for congenital heart defects: current knowledge: a scientific statement from the American Heart Association Congenital Cardiac Defects Committee, Council on Cardiovascular Disease in the Young: endorsed by the American Academy of Pediatrics","volume":"115","author":"Pierpont","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.athoracsur.2018.04.043_bib2","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1017\/S1047951104006043","article-title":"A\u00a0population-based study of extracardiac anomalies in children with congenital cardiac malformations","volume":"14","author":"Eskedal","year":"2004","journal-title":"Cardiol Young"},{"key":"10.1016\/j.athoracsur.2018.04.043_bib3","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.ejcts.2008.11.005","article-title":"Genetic syndromes and congenital heart defects: how is surgical management affected?","volume":"35","author":"Formigari","year":"2009","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.athoracsur.2018.04.043_bib4","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1053\/j.semtcvs.2015.10.016","article-title":"The effect of noncardiac and genetic abnormalities on outcomes following neonatal congenital heart surgery","volume":"28","author":"Alsoufi","year":"2016","journal-title":"Semin Thorac Cardiovasc Surg"},{"key":"10.1016\/j.athoracsur.2018.04.043_bib5","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1016\/j.athoracsur.2016.04.008","article-title":"Prevalence of noncardiac and genetic abnormalities in neonates undergoing cardiac operations: analysis of The Society of Thoracic Surgeons Congenital Heart Surgery Database","volume":"102","author":"Patel","year":"2016","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.athoracsur.2018.04.043_bib6","first-page":"624","article-title":"Conotruncal heart defects: impact of genetic syndromes on immediate operative mortality","volume":"5","author":"Anaclerio","year":"2004","journal-title":"Ital Heart J"},{"key":"10.1016\/j.athoracsur.2018.04.043_bib7","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1016\/j.athoracsur.2017.04.019","article-title":"The impact of 22q11.2 deletion syndrome on surgical repair outcomes of conotruncal cardiac anomalies","volume":"104","author":"Alsoufi","year":"2017","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.athoracsur.2018.04.043_bib8","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/j.1747-0803.2009.00281.x","article-title":"Do neonates with genetic abnormalities have an increased morbidity and mortality following cardiac surgery?","volume":"4","author":"Simsic","year":"2009","journal-title":"Congenit Heart Dis"},{"key":"10.1016\/j.athoracsur.2018.04.043_bib9","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.athoracsur.2015.03.106","article-title":"Impact of patient characteristics and anatomy on Norwood results for hypoplastic left heart syndrome","volume":"100","author":"Alsoufi","year":"2015","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.athoracsur.2018.04.043_bib10","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1016\/j.athoracsur.2010.02.004","article-title":"Impact of noncardiac congenital and genetic abnormalities on outcomes in hypoplastic left heart syndrome","volume":"89","author":"Patel","year":"2010","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.athoracsur.2018.04.043_bib11","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.jtcvs.2012.05.019","article-title":"Risk factors for hospital morbidity and mortality after the Norwood procedure: a report from the Pediatric Heart Network Single Ventricle Reconstruction trial","volume":"144","author":"Tabbutt","year":"2012","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.athoracsur.2018.04.043_bib12","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.jtcvs.2014.08.007","article-title":"Results of palliation with an initial pulmonary artery band in patients with single ventricle associated with unrestricted pulmonary blood flow","volume":"149","author":"Alsoufi","year":"2015","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.athoracsur.2018.04.043_bib13","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1016\/j.athoracsur.2014.12.082","article-title":"Results of palliation with an initial modified Blalock-Taussig shunt in neonates with single ventricle anomalies associated with restrictive pulmonary blood flow","volume":"99","author":"Alsoufi","year":"2015","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.athoracsur.2018.04.043_bib14","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.jtcvs.2012.01.016","article-title":"Intermediate-term mortality and cardiac transplantation in infants with single-ventricle lesions: risk factors and their interaction with shunt type","volume":"144","author":"Tweddell","year":"2012","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.athoracsur.2018.04.043_bib15","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.athoracsur.2016.04.054","article-title":"The impact of dominant ventricle morphology on palliation outcomes of single ventricle anomalies","volume":"102","author":"Alsoufi","year":"2016","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.athoracsur.2018.04.043_bib16","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/j.athoracsur.2015.05.037","article-title":"Influence of morphology and initial surgical strategy on survival of infants with tricuspid atresia","volume":"100","author":"Alsoufi","year":"2015","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.athoracsur.2018.04.043_bib17","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1016\/j.athoracsur.2017.04.031","article-title":"Current results of single ventricle palliation of patients with double inlet left ventricle","volume":"104","author":"Alsoufi","year":"2017","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.athoracsur.2018.04.043_bib18","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1177\/2150135110397670","article-title":"Heterotaxy: lessons learned about patterns of practice and outcomes from the congenital heart surgery database of The Society of Thoracic Surgeons","volume":"2","author":"Jacobs","year":"2011","journal-title":"World J Pediatr Congenit Heart Surg"},{"key":"10.1016\/j.athoracsur.2018.04.043_bib19","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1016\/j.jtcvs.2016.01.054","article-title":"Outcomes of multistage palliation of infants with functional single ventricle and heterotaxy syndrome","volume":"151","author":"Alsoufi","year":"2016","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.athoracsur.2018.04.043_bib20","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/j.jtcvs.2013.06.018","article-title":"Increased postoperative respiratory complications in heterotaxy congenital heart disease patients with respiratory ciliary dysfunction","volume":"147","author":"Harden","year":"2014","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.athoracsur.2018.04.043_bib21","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1016\/j.athoracsur.2015.11.047","article-title":"Survival in children with Down syndrome undergoing single-ventricle palliation","volume":"101","author":"Colquitt","year":"2016","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.athoracsur.2018.04.043_bib22","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1016\/j.jtcvs.2013.02.017","article-title":"Outcome of univentricular repair in patients with Down syndrome","volume":"146","author":"Furukawa","year":"2013","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.athoracsur.2018.04.043_bib23","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1016\/j.jtcvs.2014.07.047","article-title":"Low-weight infants are at increased mortality risk after palliative or corrective cardiac surgery","volume":"148","author":"Alsoufi","year":"2014","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.athoracsur.2018.04.043_bib24","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.jtcvs.2007.09.068","article-title":"Cardiac surgery in infants with low birth weight is associated with increased mortality: analysis of The Society of Thoracic Surgeons Congenital Heart database","volume":"135","author":"Curzon","year":"2008","journal-title":"J\u00a0Thoracic Cardiovasc Surg"},{"key":"10.1016\/j.athoracsur.2018.04.043_bib25","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1016\/j.jtcvs.2014.07.031","article-title":"Outcomes of cardiac surgery in patients weighing <2.5 kg: affect of patient-dependent and -independent variables","volume":"148","author":"Kalfa","year":"2014","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.athoracsur.2018.04.043_bib26","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.athoracsur.2014.09.036","article-title":"Single ventricle palliation in low weight patients is associated with worse early and midterm outcomes","volume":"99","author":"Alsoufi","year":"2015","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.athoracsur.2018.04.043_bib27","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1016\/j.athoracsur.2013.12.037","article-title":"Procedure-based complications to guide informed consent: analysis of Society of Thoracic Surgeons-Congenital Heart Surgery Database","volume":"97","author":"Mavroudis","year":"2014","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.athoracsur.2018.04.043_bib28","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1093\/ejcts\/ezs026","article-title":"Initial application in the EACTS and STS Congenital Heart Surgery Databases of an empirically derived methodology of complexity adjustment to evaluate surgical case mix and results","volume":"42","author":"Jacobs","year":"2012","journal-title":"Eur J Cardiothorac Surg"}],"container-title":["The Annals of Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003497518306726?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003497518306726?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T03:56:05Z","timestamp":1757735765000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003497518306726"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["S0003497518306726"],"URL":"https:\/\/doi.org\/10.1016\/j.athoracsur.2018.04.043","relation":{},"ISSN":["0003-4975"],"issn-type":[{"value":"0003-4975","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic and Extracardiac Anomalies Are Associated With Inferior Single Ventricle Palliation Outcomes","name":"articletitle","label":"Article Title"},{"value":"The Annals of Thoracic Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.athoracsur.2018.04.043","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 by The Society of Thoracic Surgeons Published by Elsevier","name":"copyright","label":"Copyright"}]}}