{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T11:18:03Z","timestamp":1779103083277,"version":"3.51.4"},"reference-count":34,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["annalsthoracicsurgery.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Annals of Thoracic Surgery"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.athoracsur.2018.09.031","type":"journal-article","created":{"date-parts":[[2018,11,2]],"date-time":"2018-11-02T13:55:38Z","timestamp":1541166938000},"page":"733-739","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Pretreatment With Diazoxide Attenuates Spinal Cord Ischemia-Reperfusion Injury Through Signaling Transducer and Activator of Transcription 3 Pathway"],"prefix":"10.1016","volume":"107","author":[{"given":"Katsuhiro","family":"Yamanaka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Eldeiry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Aftab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas J.","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gavriel","family":"Roda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianzhong","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Weyant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Joseph C.","family":"Cleveland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Fullerton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. Brett","family":"Reece","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.athoracsur.2018.09.031_bib1","article-title":"Japanese perspective in surgery for thoracoabdominal aortic aneurysms","author":"Shiiya","year":"2017","journal-title":"Gen Thorac Cardiovasc Surg"},{"key":"10.1016\/j.athoracsur.2018.09.031_bib2","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/j.jtcvs.2015.12.050","article-title":"Outcomes of 3309 thoracoabdominal aortic aneurysm repairs","volume":"151","author":"Coselli","year":"2016","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.athoracsur.2018.09.031_bib3","doi-asserted-by":"crossref","first-page":"S856","DOI":"10.1016\/j.athoracsur.2006.10.096","article-title":"Thoracoabdominal aneurysm repair: a 20-year perspective","volume":"83","author":"Conrad","year":"2007","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.athoracsur.2018.09.031_bib4","first-page":"111","article-title":"STAT transcription in the ischemic heart","volume":"1","author":"Knight","year":"2012","journal-title":"JAKSTAT"},{"key":"10.1016\/j.athoracsur.2018.09.031_bib5","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.neulet.2017.10.037","article-title":"JAK2\/STAT3 pathway is involved in the protective effects of epidermal growth factor receptor activation against cerebral ischemia\/reperfusion injury in rats","volume":"662","author":"Tang","year":"2018","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.athoracsur.2018.09.031_bib6","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s00395-016-0543-8","article-title":"Understanding STAT3 signaling in cardiac ischemia","volume":"111","author":"O\u2019Sullivan","year":"2016","journal-title":"Basic Res Cardiol"},{"key":"10.1016\/j.athoracsur.2018.09.031_bib7","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.surg.2006.04.010","article-title":"Interleukin-6 and STAT3 protect the liver from hepatic ischemia and reperfusion injury during ischemic preconditioning","volume":"140","author":"Matsumoto","year":"2006","journal-title":"Surgery"},{"key":"10.1016\/j.athoracsur.2018.09.031_bib8","first-page":"4609502","article-title":"Endothelial STAT3 modulates protective mechanisms in a mouse ischemia-reperfusion model of acute kidney injury","volume":"2017","author":"Dube","year":"2017","journal-title":"J\u00a0Immunol Res"},{"key":"10.1016\/j.athoracsur.2018.09.031_bib9","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.athoracsur.2015.01.027","article-title":"Spinal cord ischemia-reperfusion injury induces erythropoietin receptor expression","volume":"100","author":"Foley","year":"2015","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.athoracsur.2018.09.031_bib10","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1161\/01.CIR.74.5.1124","article-title":"Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium","volume":"74","author":"Murry","year":"1986","journal-title":"Circulation"},{"key":"10.1016\/j.athoracsur.2018.09.031_bib11","doi-asserted-by":"crossref","first-page":"H2350","DOI":"10.1152\/ajpheart.2000.279.5.H2350","article-title":"Differential role of K(ATP) channels in late preconditioning against myocardial stunning and infarction in rabbits","volume":"279","author":"Takano","year":"2000","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.athoracsur.2018.09.031_bib12","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.pharmthera.2013.06.007","article-title":"Multiplicity of effectors of the cardioprotective agent, diazoxide","volume":"140","author":"Coetzee","year":"2013","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.athoracsur.2018.09.031_bib13","doi-asserted-by":"crossref","first-page":"427","DOI":"10.3389\/fnins.2017.00427","article-title":"Molecular bases of brain preconditioning","volume":"11","author":"Deryagin","year":"2017","journal-title":"Front Neurosci"},{"key":"10.1016\/j.athoracsur.2018.09.031_bib14","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1016\/j.jtcvs.2017.12.132","article-title":"Optimized induction of beta common receptor subunit enhances the neuroprotective function of erythropoietin against spinal cord ischemia and reperfusion injury","volume":"155","author":"Yamanaka","year":"2018","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.athoracsur.2018.09.031_bib15","first-page":"50910","article-title":"Reproducable paraplegia by thoracic aortic occlusion in a murine model of spinal cord ischemia-reperfusion","volume":"85","author":"Bell","year":"2014","journal-title":"J\u00a0Vis Exp"},{"key":"10.1016\/j.athoracsur.2018.09.031_bib16","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.jss.2010.12.025","article-title":"Ischemic dose-response in the spinal cord: both immediate and delayed paraplegia","volume":"174","author":"Smith","year":"2012","journal-title":"J\u00a0Surg Res"},{"issue":"11 Suppl 1","key":"10.1016\/j.athoracsur.2018.09.031_bib17","first-page":"S110","article-title":"The evolution of chemokine release supports a bimodal mechanism of spinal cord ischemia and reperfusion injury","volume":"126","author":"Smith","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.athoracsur.2018.09.031_bib18","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.pharmthera.2008.08.002","article-title":"The myocardial JAK\/STAT pathway: from protection to failure","volume":"120","author":"Boengler","year":"2008","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.athoracsur.2018.09.031_bib19","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1186\/ar1197","article-title":"Signaling by STATs","volume":"6","author":"Ivashkiv","year":"2004","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.athoracsur.2018.09.031_bib20","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0092-8674(95)90311-9","article-title":"Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation","volume":"82","author":"Wen","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.athoracsur.2018.09.031_bib21","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1111\/ejn.12412","article-title":"Neuronal activity-dependent STAT3 localization to nucleus is dependent on Tyr-705 and Ser-727 phosphorylation in rat hippocampal neurons","volume":"39","author":"Murase","year":"2014","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.athoracsur.2018.09.031_bib22","doi-asserted-by":"crossref","first-page":"6508","DOI":"10.1128\/MCB.17.11.6508","article-title":"STAT3 serine phosphorylation by ERK-dependent and-independent pathways negatively modulates its tyrosine phosphorylation","volume":"17","author":"Chung","year":"1997","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.athoracsur.2018.09.031_bib23","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/sj.cr.7290213","article-title":"ERK1\/2 contributes negative regulation to STAT3 activity in HSS-transfected HepG2 cells","volume":"14","author":"Tian","year":"2004","journal-title":"Cell Res"},{"key":"10.1016\/j.athoracsur.2018.09.031_bib24","doi-asserted-by":"crossref","first-page":"12917","DOI":"10.18632\/oncotarget.7338","article-title":"A\u00a0novel small molecule STAT3 inhibitor, LY5, inhibits cell viability, colony formation, and migration of colon and liver cancer cells","volume":"7","author":"Zhao","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.athoracsur.2018.09.031_bib25","doi-asserted-by":"crossref","first-page":"e0181885","DOI":"10.1371\/journal.pone.0181885","article-title":"Target specificity, in\u00a0vivo pharmacokinetics, and efficacy of the putative STAT3 inhibitor LY5 in osteosarcoma, Ewing\u2019s sarcoma, and rhabdomyosarcoma","volume":"12","author":"Yu","year":"2017","journal-title":"PloS One"},{"key":"10.1016\/j.athoracsur.2018.09.031_bib26","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/onc.2016.235","article-title":"CD133(+) brain tumor-initiating cells are dependent on STAT3 signaling to drive medulloblastoma recurrence","volume":"36","author":"Garg","year":"2017","journal-title":"Oncogene"},{"key":"10.1016\/j.athoracsur.2018.09.031_bib27","doi-asserted-by":"crossref","first-page":"4402","DOI":"10.1021\/jm400080c","article-title":"Discovery of novel STAT3 small molecule inhibitors via in silico site-directed fragment-based drug design","volume":"56","author":"Yu","year":"2013","journal-title":"J\u00a0Med Chem"},{"key":"10.1016\/j.athoracsur.2018.09.031_bib28","doi-asserted-by":"crossref","first-page":"3418","DOI":"10.1074\/jbc.M114.616748","article-title":"A\u00a0novel small molecular STAT3 inhibitor, LY5, inhibits cell viability, cell migration, and angiogenesis in medulloblastoma cells","volume":"290","author":"Xiao","year":"2015","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.athoracsur.2018.09.031_bib29","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.yjmcc.2011.01.002","article-title":"A\u00a0murine model of inducible, cardiac-specific deletion of STAT3: its use to determine the role of STAT3 in the upregulation of cardioprotective proteins by ischemic preconditioning","volume":"50","author":"Bolli","year":"2011","journal-title":"J\u00a0Mol Cell Cardiol"},{"key":"10.1016\/j.athoracsur.2018.09.031_bib30","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0022-2828(03)00043-9","article-title":"The mitochondrial permeability transition pore: its fundamental role in mediating cell death during ischaemia and reperfusion","volume":"35","author":"Hausenloy","year":"2003","journal-title":"J\u00a0Mol Cell Cardiol"},{"key":"10.1016\/j.athoracsur.2018.09.031_bib31","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s00395-011-0152-5","article-title":"STAT3alpha interacts with nuclear GSK3beta and cytoplasmic RISK pathway and stabilizes rhythm in the anoxic-reoxygenated embryonic heart","volume":"106","author":"Pedretti","year":"2011","journal-title":"Basic Res Cardiol"},{"key":"10.1016\/j.athoracsur.2018.09.031_bib32","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1007\/s12035-010-8102-z","article-title":"Reperfusion and neurovascular dysfunction in stroke: from basic mechanisms to potential strategies for neuroprotection","volume":"41","author":"Jung","year":"2010","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.athoracsur.2018.09.031_bib33","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jneuroim.2010.01.016","article-title":"Effect of carbamylated erythropoietin on major histocompatibility complex expression and neural differentiation of human neural stem cells","volume":"221","author":"Fu","year":"2010","journal-title":"J\u00a0Neuroimmunol"},{"key":"10.1016\/j.athoracsur.2018.09.031_bib34","doi-asserted-by":"crossref","first-page":"486","DOI":"10.2119\/molmed.2011.00414","article-title":"The receptor that tames the innate immune response","volume":"18","author":"Brines","year":"2012","journal-title":"Mol Med"}],"container-title":["The Annals of Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003497518315492?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003497518315492?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T03:57:23Z","timestamp":1757735843000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003497518315492"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["S0003497518315492"],"URL":"https:\/\/doi.org\/10.1016\/j.athoracsur.2018.09.031","relation":{},"ISSN":["0003-4975"],"issn-type":[{"value":"0003-4975","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pretreatment With Diazoxide Attenuates Spinal Cord Ischemia-Reperfusion Injury Through Signaling Transducer and Activator of Transcription 3 Pathway","name":"articletitle","label":"Article Title"},{"value":"The Annals of Thoracic Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.athoracsur.2018.09.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 by The Society of Thoracic Surgeons Published by Elsevier","name":"copyright","label":"Copyright"}]}}