{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T10:20:43Z","timestamp":1789381243035,"version":"build-2803163510"},"reference-count":30,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["annalsthoracicsurgery.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Annals of Thoracic Surgery"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.athoracsur.2019.07.093","type":"journal-article","created":{"date-parts":[[2019,9,14]],"date-time":"2019-09-14T01:49:22Z","timestamp":1568425762000},"page":"1142-1149","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Intramyocardial Bone Marrow Stem Cells in Patients Undergoing Cardiac Surgical Revascularization"],"prefix":"10.1016","volume":"109","author":[{"given":"Joshua L.","family":"Chan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin G.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela G.","family":"Robey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David F.","family":"Stroncek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew E.","family":"Arai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vandana","family":"Sachdev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith A.","family":"Horvath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.athoracsur.2019.07.093_bib1","first-page":"9404057","article-title":"Cell therapies in cardiomyopathy: current status of clinical trials","volume":"2017","author":"Hao","year":"2017","journal-title":"Anal Cell Pathol (Amst)"},{"key":"10.1016\/j.athoracsur.2019.07.093_bib2","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1002\/jcb.22164","article-title":"Prospects for pluripotent stem cell-derived cardiomyocytes in cardiac cell therapy and as disease models","volume":"107","author":"Freund","year":"2009","journal-title":"J\u00a0Cell Biochem"},{"key":"10.1016\/j.athoracsur.2019.07.093_bib3","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1161\/01.CIR.0000095788.78169.AF","article-title":"Infarct remodeling after intracoronary progenitor cell treatment in patients with acute myocardial infarction (TOPCARE-AMI): mechanistic insights from serial contrast-enhanced magnetic resonance imaging","volume":"108","author":"Britten","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.athoracsur.2019.07.093_bib4","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1016\/j.jacc.2004.08.014","article-title":"Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction: final one-year results of the TOPCARE-AMI trial","volume":"44","author":"Schachinger","year":"2004","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.athoracsur.2019.07.093_bib5","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1016\/j.jacc.2005.01.069","article-title":"Regeneration of human infarcted heart muscle by intracoronary autologous bone marrow cell transplantation in chronic coronary artery disease: the IACT study","volume":"46","author":"Strauer","year":"2005","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.athoracsur.2019.07.093_bib6","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1161\/01.CIR.0000034046.87607.1C","article-title":"Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans","volume":"106","author":"Strauer","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.athoracsur.2019.07.093_bib7","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1161\/01.CIR.0000070596.30552.8B","article-title":"Transendocardial, autologous bone marrow cell transplantation for severe, chronic ischemic heart failure","volume":"107","author":"Perin","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.athoracsur.2019.07.093_bib8","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.amjcard.2004.03.034","article-title":"Effect on left ventricular function of intracoronary transplantation of autologous bone marrow mesenchymal stem cell in patients with acute myocardial infarction","volume":"94","author":"Chen","year":"2004","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.athoracsur.2019.07.093_bib9","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1016\/S0735-1097(03)00328-0","article-title":"Catheter-based autologous bone marrow myocardial injection in no-option patients with advanced coronary artery disease: a feasibility study","volume":"41","author":"Fuchs","year":"2003","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.athoracsur.2019.07.093_bib10","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1016\/j.jacc.2009.06.055","article-title":"A\u00a0randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction","volume":"54","author":"Hare","year":"2009","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.athoracsur.2019.07.093_bib11","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1161\/CIRCRESAHA.114.303180","volume":"114","author":"Karantalis","year":"2014","journal-title":"Circ Res"},{"key":"10.1016\/j.athoracsur.2019.07.093_bib12","doi-asserted-by":"crossref","first-page":"547902","DOI":"10.1155\/2013\/547902","article-title":"Current stem cell delivery methods for myocardial repair","volume":"2013","author":"Sheng","year":"2013","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.athoracsur.2019.07.093_bib13","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.jacc.2014.06.1175","article-title":"Translating stem cell research to cardiac disease therapies: pitfalls and prospects for improvement","volume":"64","author":"Rosen","year":"2014","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.athoracsur.2019.07.093_bib14","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/cdd.2013.158","article-title":"Immunobiology of mesenchymal stem cells","volume":"21","author":"Ma","year":"2014","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.athoracsur.2019.07.093_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0129164","article-title":"Paracrine action of mesenchymal stem cells revealed by single cell gene profiling in infarcted murine hearts","volume":"10","author":"Yao","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.athoracsur.2019.07.093_bib16","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1016\/j.athoracsur.2011.01.021","article-title":"Marrow stromal cells differentiate into vasculature after allogeneic transplantation into ischemic myocardium","volume":"91","author":"Zhou","year":"2011","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.athoracsur.2019.07.093_bib17","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.bbrc.2009.10.074","article-title":"Direct injection of autologous mesenchymal stromal cells improves myocardial function","volume":"390","author":"Zhou","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.athoracsur.2019.07.093_bib18","first-page":"43","article-title":"Transplantation of autologous bone marrow derived mesenchymal stem cells trans-epicardially in patients undergoing coronary bypass surgery","volume":"62","author":"Viswanathan","year":"2010","journal-title":"Indian Heart J"},{"key":"10.1016\/j.athoracsur.2019.07.093_bib19","doi-asserted-by":"crossref","first-page":"10849","DOI":"10.1158\/0008-5472.CAN-06-2146","article-title":"Spontaneous transformation of cultured mouse bone marrow-derived stromal cells","volume":"66","author":"Zhou","year":"2006","journal-title":"Cancer Res"},{"key":"10.1016\/j.athoracsur.2019.07.093_bib20","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1093\/eurheartj\/ehv529","article-title":"Myocardial strain imaging: how useful is it in clinical decision making?","volume":"37","author":"Smiseth","year":"2016","journal-title":"Eur Heart J"},{"key":"10.1016\/j.athoracsur.2019.07.093_bib21","doi-asserted-by":"crossref","first-page":"187","DOI":"10.14797\/mdcj-9-4-187","article-title":"Stem cell therapy for heart failure","volume":"9","author":"Michler","year":"2013","journal-title":"Methodist Debakey Cardiovasc J"},{"key":"10.1016\/j.athoracsur.2019.07.093_bib22","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1126\/science.284.5411.143","article-title":"Multilineage potential of adult human mesenchymal stem cells","volume":"284","author":"Pittenger","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.athoracsur.2019.07.093_bib23","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1126\/science.275.5302.964","article-title":"Isolation of putative progenitor endothelial cells for angiogenesis","volume":"275","author":"Asahara","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.athoracsur.2019.07.093_bib24","doi-asserted-by":"crossref","first-page":"11474","DOI":"10.1073\/pnas.0504388102","article-title":"Cardiac repair with intramyocardial injection of allogeneic mesenchymal stem cells after myocardial infarction","volume":"102","author":"Amado","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.athoracsur.2019.07.093_bib25","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1007\/s11897-007-0013-6","article-title":"The role of stem cells in the post-MI patient","volume":"4","author":"Meyer","year":"2007","journal-title":"Curr Heart Fail Rep"},{"key":"10.1016\/j.athoracsur.2019.07.093_bib26","doi-asserted-by":"crossref","first-page":"2978","DOI":"10.1093\/eurheartj\/ehp374","article-title":"Intracoronary bone marrow cell transfer after myocardial infarction: 5-year follow-up from the randomized-controlled boost trial","volume":"30","author":"Meyer","year":"2009","journal-title":"Eur Heart J"},{"key":"10.1016\/j.athoracsur.2019.07.093_bib27","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1161\/CIRCULATIONAHA.108.777102","article-title":"Pilot trial on determinants of progenitor cell recruitment to the infarcted human myocardium","volume":"118","author":"Schachinger","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.athoracsur.2019.07.093_bib28","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1161\/CIRCULATIONAHA.107.734103","article-title":"The myoblast autologous grafting in ischemic cardiomyopathy (MAGIC) trial: first randomized placebo-controlled study of myoblast transplantation","volume":"117","author":"Menasche","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.athoracsur.2019.07.093_bib29","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1093\/eurheartj\/ehr018","article-title":"Stem and progenitor cell-based therapy in ischaemic heart disease: promise, uncertainties, and challenges","volume":"32","author":"Tongers","year":"2011","journal-title":"Eur Heart J"},{"key":"10.1016\/j.athoracsur.2019.07.093_bib30","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1161\/CIRCRESAHA.109.208991","article-title":"Assessment and optimization of cell engraftment after transplantation into the heart","volume":"106","author":"Terrovitis","year":"2010","journal-title":"Circ Res"}],"container-title":["The Annals of Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003497519313943?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003497519313943?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T04:02:54Z","timestamp":1757736174000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003497519313943"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["S0003497519313943"],"URL":"https:\/\/doi.org\/10.1016\/j.athoracsur.2019.07.093","relation":{},"ISSN":["0003-4975"],"issn-type":[{"value":"0003-4975","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intramyocardial Bone Marrow Stem Cells in Patients Undergoing Cardiac Surgical Revascularization","name":"articletitle","label":"Article Title"},{"value":"The Annals of Thoracic Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.athoracsur.2019.07.093","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 by The Society of Thoracic Surgeons Published by Elsevier","name":"copyright","label":"Copyright"}]}}