{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T01:22:48Z","timestamp":1785892968284,"version":"3.56.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81370327"],"award-info":[{"award-number":["81370327"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["annalsthoracicsurgery.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Annals of Thoracic Surgery"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.athoracsur.2020.05.156","type":"journal-article","created":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T03:10:30Z","timestamp":1595992230000},"page":"915-922","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Matrix Metalloproteinases Increase Because of Hypoperfusion in Obstructive Hypertrophic Cardiomyopathy"],"prefix":"10.1016","volume":"111","author":[{"given":"Xuanye","family":"Bi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengzhi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunhu","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiansong","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingang","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenghuan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shubin","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.athoracsur.2020.05.156_bib1","doi-asserted-by":"crossref","first-page":"238","DOI":"10.3389\/fphys.2017.00238","article-title":"Current understanding of the pathophysiology of myocardial fibrosis and its quantitative assessment in heart failure","volume":"8","author":"Liu","year":"2017","journal-title":"Front Physiol"},{"key":"10.1016\/j.athoracsur.2020.05.156_bib2","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1253\/circj.72.378","article-title":"Correlation between late gadolinium enhancement and diastolic function in hypertrophic cardiomyopathy assessed by magnetic resonance imaging","volume":"72","author":"Motoyasu","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.athoracsur.2020.05.156_bib3","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/S0735-1097(99)00492-1","article-title":"Morphology and significance of the left ventricular collagen network in young patients with hypertrophic cardiomyopathy and sudden cardiac death","volume":"35","author":"Shirani","year":"2000","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.athoracsur.2020.05.156_bib4","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.jacc.2010.05.010","article-title":"Prognostic significance of myocardial fibrosis in hypertrophic cardiomyopathy","volume":"56","author":"O\u2019Hanlon","year":"2010","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.athoracsur.2020.05.156_bib5","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.jacc.2010.05.007","article-title":"Myocardial scar visualized by cardiovascular magnetic resonance imaging predicts major adverse events in patients with hypertrophic cardiomyopathy","volume":"56","author":"Bruder","year":"2010","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.athoracsur.2020.05.156_bib6","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1161\/hh1501.094396","article-title":"Matrix metalloproteinase inhibition after myocardial infarction: a new approach to prevent heart failure?","volume":"89","author":"Creemers","year":"2001","journal-title":"Circ Res"},{"key":"10.1016\/j.athoracsur.2020.05.156_bib7","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.cardfail.2016.03.010","article-title":"Serum matrix metalloproteinases as quantitative biomarkers for myocardial fibrosis and sudden cardiac death risk stratification in patients with hypertrophic cardiomyopathy","volume":"22","author":"Munch","year":"2016","journal-title":"J\u00a0Card Fail"},{"key":"10.1016\/j.athoracsur.2020.05.156_bib8","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1152\/ajpheart.2000.278.1.H151","article-title":"Differential effects of pressure or volume overload on myocardial MMP levels and inhibitory control","volume":"278","author":"Nagatomo","year":"2000","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.athoracsur.2020.05.156_bib9","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.jacc.2009.04.072","article-title":"The case for myocardial ischemia in hypertrophic cardiomyopathy","volume":"54","author":"Maron","year":"2009","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.athoracsur.2020.05.156_bib10","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.ijcard.2007.04.003","article-title":"Myocardial capillary supply is limited in hypertrophic cardiomyopathy: a morphological analysis","volume":"126","author":"Johansson","year":"2008","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.athoracsur.2020.05.156_bib11","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1042\/cs0810703","article-title":"Abnormalities of the coronary circulation associated with left ventricular hypertrophy","volume":"81","author":"O\u2019Gorman","year":"1991","journal-title":"Clin Sci"},{"key":"10.1016\/j.athoracsur.2020.05.156_bib12","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1053\/hupa.2000.16659","article-title":"Hypertrophic cardiomyopathy and sudden death in the young: pathologic evidence of myocardial ischemia","volume":"31","author":"Basso","year":"2000","journal-title":"Hum Pathol"},{"key":"10.1016\/j.athoracsur.2020.05.156_bib13","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0735-1097(86)80181-4","article-title":"Intramural (\u201csmall vessel\u201d) coronary artery disease in hypertrophic cardiomyopathy","volume":"8","author":"Maron","year":"1986","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.athoracsur.2020.05.156_bib14","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1161\/CIRCULATIONAHA.114.009625","article-title":"Coronary microvascular rarefaction and myocardial fibrosis in heart failure with preserved ejection fraction","volume":"131","author":"Mohammed","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.athoracsur.2020.05.156_bib15","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.1007\/s00018-019-03178-2","article-title":"Metalloproteinases and their tissue inhibitors in Alzheimer\u2019s disease and other neurodegenerative disorders","volume":"76","author":"Rivera","year":"2019","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.athoracsur.2020.05.156_bib16","doi-asserted-by":"crossref","first-page":"e34177","DOI":"10.1371\/journal.pone.0034177","article-title":"A\u00a0novel intracellular isoform of matrix metalloproteinase-2 induced by oxidative stress activates innate immunity","volume":"7","author":"Lovett","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.athoracsur.2020.05.156_bib17","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/S0022-2828(05)82390-9","article-title":"Regulation of collagen degradation in the rat myocardium after infarction","volume":"27","author":"Cleutjens","year":"1995","journal-title":"J\u00a0Mol Cell Cardiol"},{"key":"10.1016\/j.athoracsur.2020.05.156_bib18","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0008-6363(00)00029-8","article-title":"Evolution of matrix metalloprotease and tissue inhibitor expression during heart failure progression in the infarcted rat","volume":"46","author":"Peterson","year":"2000","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.athoracsur.2020.05.156_bib19","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.nuclcard.2006.05.018","article-title":"Regional heterogeneity of resting perfusion in hypertrophic cardiomyopathy is related to delayed contrast enhancement but not to systolic function: a PET and MRI study","volume":"13","author":"Knaapen","year":"2006","journal-title":"J\u00a0Nucl Cardiol"},{"key":"10.1016\/j.athoracsur.2020.05.156_bib20","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1161\/CIRCULATIONAHA.106.657023","article-title":"Evidence for microvascular dysfunction in hypertrophic cardiomyopathy","volume":"115","author":"Petersen","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.athoracsur.2020.05.156_bib21","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.2967\/jnumed.107.050138","article-title":"Spatial relationship between coronary microvascular dysfunction and delayed contrast enhancement in patients with hypertrophic cardiomyopathy","volume":"49","author":"Sotgia","year":"2008","journal-title":"J\u00a0Nucl Med"},{"key":"10.1016\/j.athoracsur.2020.05.156_bib22","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1056\/NEJMoa1002659","article-title":"Myocardial fibrosis as an early manifestation of hypertrophic cardiomyopathy","volume":"363","author":"Ho","year":"2010","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.athoracsur.2020.05.156_bib23","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1161\/CIRCULATIONAHA.107.755777","article-title":"Severe heart failure and early mortality in a double-mutation mouse model of familial hypertrophic cardiomyopathy","volume":"117","author":"Tsoutsman","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.athoracsur.2020.05.156_bib24","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.jacc.2015.10.063","article-title":"Myocardial collagen cross-linking is associated with heart failure hospitalization in patients with hypertensive heart failure","volume":"67","author":"Lopez","year":"2016","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.athoracsur.2020.05.156_bib25","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1161\/CIRCULATIONAHA.109.912774","article-title":"Circulating biomarkers of collagen metabolism in cardiac diseases","volume":"121","author":"L\u00f3pez","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.athoracsur.2020.05.156_bib26","doi-asserted-by":"crossref","first-page":"272","DOI":"10.5507\/bp.2013.091","article-title":"Predictive value of serum collagen biomarkers on the outcome of acute myocardial infarction treated with percutaneous coronary intervention","volume":"159","author":"Gao","year":"2015","journal-title":"Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub"},{"key":"10.1016\/j.athoracsur.2020.05.156_bib27","doi-asserted-by":"crossref","first-page":"6103","DOI":"10.1038\/s41598-019-42468-4","article-title":"Low fibrosis biomarker levels predict cardiac resynchronization therapy response","volume":"9","author":"Massoulli\u00e9","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.athoracsur.2020.05.156_bib28","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.advms.2017.10.004","article-title":"Prognostic value of fibrosis-related markers in dilated cardiomyopathy: a link between osteopontin and cardiovascular events","volume":"63","author":"Rubi\u015b","year":"2018","journal-title":"Adv Med Sci"},{"key":"10.1016\/j.athoracsur.2020.05.156_bib29","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1093\/ehjci\/jey135","article-title":"Progression of myocardial fibrosis in hypertrophic cardiomyopathy: mechanisms and clinical implications","volume":"20","author":"Raman","year":"2019","journal-title":"Eur Heart J Cardiovasc Imag"},{"key":"10.1016\/j.athoracsur.2020.05.156_bib30","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s10554-017-1263-3","article-title":"CMR assessment and clinical outcomes of hypertrophic cardiomyopathy with or without ventricular remodeling in the end-stage phase","volume":"34","author":"Cheng","year":"2018","journal-title":"Int J Cardiovasc Imag"},{"key":"10.1016\/j.athoracsur.2020.05.156_bib31","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.ijcard.2017.07.087","article-title":"Prognostic implications of global myocardial mechanics in hypertrophic cardiomyopathy by cardiovascular magnetic\u00a0resonance feature tracking. Relations to left ventricular hypertrophy and fibrosis","volume":"249","author":"Hinojar","year":"2017","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.athoracsur.2020.05.156_bib32","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1253\/circj.CJ-09-1013","article-title":"Impact of metalloproteinases on left ventricular remodeling and heart failure events in patients with hypertrophic cardiomyopathy","volume":"74","author":"Kitaoka","year":"2010","journal-title":"Circ J"},{"key":"10.1016\/j.athoracsur.2020.05.156_bib33","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1253\/circj.68.355","article-title":"Increased circulating matrix\u00a0metalloproteinase-2 in patients with hypertrophic cardiomyopathy with systolic dysfunction","volume":"68","author":"Noji","year":"2004","journal-title":"Circ J"},{"key":"10.1016\/j.athoracsur.2020.05.156_bib34","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1161\/01.HYP.0000024573.17293.23","article-title":"TIMP-1: a marker of left ventricular diastolic dysfunction and fibrosis in hypertension","volume":"40","author":"Lindsay","year":"2002","journal-title":"Hypertension"}],"container-title":["The Annals of Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003497520312121?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003497520312121?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T04:07:16Z","timestamp":1757736436000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003497520312121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["S0003497520312121"],"URL":"https:\/\/doi.org\/10.1016\/j.athoracsur.2020.05.156","relation":{},"ISSN":["0003-4975"],"issn-type":[{"value":"0003-4975","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Matrix Metalloproteinases Increase Because of Hypoperfusion in Obstructive Hypertrophic Cardiomyopathy","name":"articletitle","label":"Article Title"},{"value":"The Annals of Thoracic Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.athoracsur.2020.05.156","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 by The Society of Thoracic Surgeons Published by Elsevier","name":"copyright","label":"Copyright"}]}}