{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T03:17:27Z","timestamp":1789269447806,"version":"build-2803163510"},"reference-count":38,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011251","name":"Northern Ontario Academic Medicine Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011251","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014588","name":"Sanofi Pasteur","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014588","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["annalsthoracicsurgery.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Annals of Thoracic Surgery"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.athoracsur.2020.07.052","type":"journal-article","created":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T11:25:01Z","timestamp":1602069901000},"page":"1923-1930","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Influenza Vaccination Blunts the Inflammatory Response in Patients Undergoing Cardiopulmonary Bypass"],"prefix":"10.1016","volume":"111","author":[{"given":"Rony","family":"Atoui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fady","family":"Ebrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Saroka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Mireau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet E.","family":"McElhaney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory M.T.","family":"Hare","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.athoracsur.2020.07.052_bib1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/sj.bjp.0707526","article-title":"Inflammatory response and cardioprotection during open heart surgery; the importance of anaesthetics","volume":"153","author":"Suleiman","year":"2008","journal-title":"Br J Pharm"},{"key":"10.1016\/j.athoracsur.2020.07.052_bib2","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1097\/00000542-200207000-00030","article-title":"The systemic inflammatory response to cardiac surgery: implications for the anesthesiologist","volume":"97","author":"Laffey","year":"2002","journal-title":"Anesthesiology"},{"key":"10.1016\/j.athoracsur.2020.07.052_bib3","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/0003-4975(93)91048-R","article-title":"Inflammatory response to cardiopulmonary bypass","volume":"55","author":"Butler","year":"1993","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.athoracsur.2020.07.052_bib4","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/S0008-6363(98)00229-6","article-title":"Acute cardiac inflammatory responses to postischemic reperfusion during cardiopulmonary bypass","volume":"41","author":"Zaher","year":"1999","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.athoracsur.2020.07.052_bib5","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.bja.2017.10.025","article-title":"Steroids in cardiac surgery: a systematic review and meta-analysis","volume":"120","author":"Dvirnik","year":"2018","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.athoracsur.2020.07.052_bib6","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.jtcvs.2018.09.017","article-title":"Effect of preoperative inhaled budesonide on pulmonary injury after cardiopulmonary bypass: a randomized pilot study","volume":"157","author":"Gao","year":"2019","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.athoracsur.2020.07.052_bib7","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1016\/S0022-5223(03)00946-2","article-title":"Antifibrinolytic therapy during cardiopulmonary bypass reduces proinflammatory cytokine levels: a randomized double-blind, placebo-controlled study of e-aminocaproic acid and aprotonin","volume":"126","author":"Greilich","year":"2003","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.athoracsur.2020.07.052_bib8","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1111\/anae.12636","article-title":"The effects of dexmedetomidine on inflammatory mediators after cardiopulmonary bypass","volume":"69","author":"Ueki","year":"2014","journal-title":"Anaesthesia"},{"key":"10.1016\/j.athoracsur.2020.07.052_bib9","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s13019-017-0582-8","article-title":"High dose statin prophylaxis in cardiopulmonary bypass related surgery: clinical utility","volume":"12","author":"Chee","year":"2017","journal-title":"J\u00a0Cardiothorac Surg"},{"key":"10.1016\/j.athoracsur.2020.07.052_bib10","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.athoracsur.2008.03.046","article-title":"High-dose insulin therapy attenuates systemic inflammatory response in coronary artery bypass grafting patients","volume":"86","author":"Albacker","year":"2008","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.athoracsur.2020.07.052_bib11","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1097\/00000542-200408000-00013","article-title":"Hemofiltration but not steroids results in earlier tracheal extubation following cardiopulmonary bypass: a prospective, randomized double-blind trial","volume":"101","author":"Oliver","year":"2004","journal-title":"Anesthesiology"},{"key":"10.1016\/j.athoracsur.2020.07.052_bib12","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/j.hrthm.2016.01.026","article-title":"The association between influenza infection, vaccination, and atrial fibrillation; a nationwide case-control study","volume":"13","author":"Chang","year":"2016","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.athoracsur.2020.07.052_bib13","doi-asserted-by":"crossref","first-page":"112697","DOI":"10.18632\/oncotarget.22352","article-title":"Influenza vaccination might reduce the risk of ischemic stroke in patients with atrial fibrillation: a population-based cohort study","volume":"8","author":"Kao","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.athoracsur.2020.07.052_bib14","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1136\/heartjnl-2016-309983","article-title":"Influenza vaccine as a coronary intervention for prevention of myocardial infarction","volume":"102","author":"MacIntyre","year":"2016","journal-title":"Heart"},{"key":"10.1016\/j.athoracsur.2020.07.052_bib15","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1159\/000493572","article-title":"Beneficial effects of vaccination on cardiovascular events: myocardial infarction, stroke, heart failure","volume":"141","author":"Fountoulaki","year":"2018","journal-title":"Cardiology"},{"key":"10.1016\/j.athoracsur.2020.07.052_bib16","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1213\/01.ane.0000215998.21739.48","article-title":"Increased interleukin-6 after cardiac surgery predicts infection","volume":"102","author":"Sander","year":"2006","journal-title":"Anesth Analg"},{"issue":"S1","key":"10.1016\/j.athoracsur.2020.07.052_bib17","doi-asserted-by":"crossref","first-page":"S107","DOI":"10.1016\/S1010-7940(99)00200-6","article-title":"Cytokines in myocardial injury: impact on cardiac surgical approach","volume":"16","author":"Wan","year":"1999","journal-title":"Eur J Cardiothoracic Surg"},{"key":"10.1016\/j.athoracsur.2020.07.052_bib18","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1097\/00000542-200106000-00030","article-title":"Pathophysiology, clinical manifestations, and prevention of ischemia-reperfusion injury","volume":"94","author":"Collard","year":"2001","journal-title":"Anesthesiology"},{"key":"10.1016\/j.athoracsur.2020.07.052_bib19","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/S0003-4975(99)00315-X","article-title":"Avoiding cardiopulmonary bypass in multivessel CABG reduces cytokine response and myocardial injury","volume":"68","author":"Wan","year":"1999","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.athoracsur.2020.07.052_bib20","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/S0003-4975(00)01152-8","article-title":"Inflammatory response after coronary revascularization with or without cardiopulmonary bypass","volume":"69","author":"Ascione","year":"2000","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.athoracsur.2020.07.052_bib21","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1093\/aje\/152.7.674","article-title":"Influenza vaccination and the risk of primary cardiac arrest","volume":"152","author":"Siscovick","year":"2000","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.athoracsur.2020.07.052_bib22","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ehj.2003.10.018","article-title":"Flu vaccination in acute coronary syndromes and planned percutaneous coronary interventions (FLUVACS) Study","volume":"25","author":"Gurfinkel","year":"2004","journal-title":"Eur Heart J"},{"key":"10.1016\/j.athoracsur.2020.07.052_bib23","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1093\/eurheartj\/ehm581","article-title":"Influenza vaccination in secondary prevention from coronary ischaemic events in coronary artery disease: FLUCAD study","volume":"29","author":"Ciszewski","year":"2008","journal-title":"Eur Heart J"},{"key":"10.1016\/j.athoracsur.2020.07.052_bib24","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1093\/eurheartj\/ehr004","article-title":"Influenza vaccination reduces cardiovascular events in patients with acute coronary syndrome","volume":"32","author":"Phrommintikul","year":"2011","journal-title":"Eur Heart J"},{"key":"10.1016\/j.athoracsur.2020.07.052_bib25","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1001\/jama.2013.279206","article-title":"Association between influenza vaccination and cardiovascular outcomes in high-risk patients: a meta-analysis","volume":"310","author":"Udell","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.athoracsur.2020.07.052_bib26","first-page":"CD005050","article-title":"Influenza vaccines for preventing cardiovascular disease","volume":"201","author":"Clar","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.athoracsur.2020.07.052_bib27","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1161\/CIRCULATIONAHA.106.178242","article-title":"Influenza vaccination as secondary prevention for cardiovascular disease: a science advisory from the American Heart Association\/American College of Cardiology","volume":"114","author":"Davis","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.athoracsur.2020.07.052_bib28","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1093\/eurheartj\/ehw106","article-title":"2016 European Guidelines on cardiovascular disease prevention in clinical practice: The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice","volume":"37","author":"Piepoli","year":"2016","journal-title":"Eur Heart J"},{"key":"10.1016\/j.athoracsur.2020.07.052_bib29","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.vaccine.2017.11.078","article-title":"Cardioprotective effect of influenza and pneumococcal vaccination in patients with cardiovascular diseases","volume":"36","author":"Ciszewski","year":"2018","journal-title":"Vaccine"},{"key":"10.1016\/j.athoracsur.2020.07.052_bib30","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.atherosclerosis.2011.03.019","article-title":"Influenza vaccination promotes stable atherosclerotic plaques in apoE knockout mice","volume":"217","author":"Bermudez-Fajardo","year":"2011","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.athoracsur.2020.07.052_bib31","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1161\/01.CIR.0000048190.68071.2B","article-title":"Influenza infection exerts prominent inflammatory and thrombotic effects on the atherosclerotic plaques of apolipoprotein E-deficient mice","volume":"107","author":"Naghavi","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.athoracsur.2020.07.052_bib32","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1159\/000478017","article-title":"Effect of influenza vaccination on risk of stroke: a systemic review and meta-analysis","volume":"48","author":"Lee","year":"2017","journal-title":"Neuroepidemiology"},{"key":"10.1016\/j.athoracsur.2020.07.052_bib33","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1161\/CIRCULATIONAHA.118.036788","article-title":"Influenza vaccine in heart failure","volume":"139","author":"Modin","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.athoracsur.2020.07.052_bib34","first-page":"194","article-title":"Can vaccinations improve heart failure outcomes?","volume":"5","author":"Bhatt","year":"2017","journal-title":"JACC: Heart Failure"},{"key":"10.1016\/j.athoracsur.2020.07.052_bib35","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1016\/j.jacc.2012.04.063","article-title":"Inflammation in atrial fibrillation","volume":"60","author":"Guo","year":"2012","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.athoracsur.2020.07.052_bib36","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.hrthm.2009.12.009","article-title":"Role of inflammation antioxidative stress in atrial fibrillation","volume":"7","author":"Li","year":"2010","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.athoracsur.2020.07.052_bib37","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.ijcard.2016.12.074","article-title":"Influenza vaccination reduces hemorrhagic stroke risk in patients with atrial fibrillation: a population-based cohort study","volume":"232","author":"Liu","year":"2017","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.athoracsur.2020.07.052_bib38","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1056\/NEJMe1914378","article-title":"Inflammation as a treatment target after acute myocardial infarction","volume":"381","author":"Newby","year":"2019","journal-title":"N\u00a0Eng J Med"}],"container-title":["The Annals of Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003497520316271?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003497520316271?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T12:36:45Z","timestamp":1762087005000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003497520316271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":38,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["S0003497520316271"],"URL":"https:\/\/doi.org\/10.1016\/j.athoracsur.2020.07.052","relation":{},"ISSN":["0003-4975"],"issn-type":[{"value":"0003-4975","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Influenza Vaccination Blunts the Inflammatory Response in Patients Undergoing Cardiopulmonary Bypass","name":"articletitle","label":"Article Title"},{"value":"The Annals of Thoracic Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.athoracsur.2020.07.052","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 by The Society of Thoracic Surgeons Published by Elsevier","name":"copyright","label":"Copyright"}]}}