{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:18:38Z","timestamp":1792001918207,"version":"4.4.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["annalsthoracicsurgery.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Annals of Thoracic Surgery"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.athoracsur.2020.12.010","type":"journal-article","created":{"date-parts":[[2021,8,7]],"date-time":"2021-08-07T01:20:43Z","timestamp":1628299243000},"page":"1782-1789","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Thymectomy in Myasthenic Patients With Thymoma: Killing Two Birds With One Stone"],"prefix":"10.1016","volume":"112","author":[{"given":"Vittorio","family":"Aprile","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stylianos","family":"Korasidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Bacchin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Petralli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iacopo","family":"Petrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Ricciardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcello Carlo","family":"Ambrogi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Lucchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.athoracsur.2020.12.010_bib1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.ejca.2007.11.004","article-title":"Thymic epithelial tumours: a population-based study of the incidence, diagnostic procedures and therapy","volume":"44","author":"De Jong","year":"2008","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.athoracsur.2020.12.010_bib2","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.lungcan.2015.03.007","article-title":"Does myasthenia gravis influence overall survival and cumulative incidence of recurrence in thymoma patients? A retrospective clinicopathological multicentre analysis on 797 patients","volume":"88","author":"Filosso","year":"2015","journal-title":"Lung Cancer"},{"key":"10.1016\/j.athoracsur.2020.12.010_bib3","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.lungcan.2018.01.025","article-title":"Optimal surgical approach to thymic malignancies: new trends challenging old dogmas","volume":"118","author":"Ruffini","year":"2018","journal-title":"Lung Cancer"},{"key":"10.1016\/j.athoracsur.2020.12.010_bib4","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.jtho.2016.08.131","article-title":"Determinants of complete resection of thymoma by minimally invasive and open thymectomy: analysis of an international registry","volume":"12","author":"Burt","year":"2017","journal-title":"J\u00a0Thorac Oncol"},{"key":"10.1016\/j.athoracsur.2020.12.010_bib5","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1212\/WNL.55.1.7","article-title":"Practice parameter: thymectomy\u00a0for autoimmune myasthenia gravis","volume":"55","author":"Gronseth","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.athoracsur.2020.12.010_bib6","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1056\/NEJMoa1602489","article-title":"Randomized trial of thymectomy in myasthenia gravis","volume":"375","author":"Wolfe","year":"2016","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.athoracsur.2020.12.010_bib7","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S0022-5223(19)40309-7","article-title":"Distribution of thymic tissue at the anterior mediastinum. Current procedures in thymectomy","volume":"70","author":"Masaoka","year":"1975","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.athoracsur.2020.12.010_bib8","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.ejcts.2009.01.014","article-title":"Association of thymoma and myasthenia gravis: oncological and neurological results of the surgical treatment","volume":"35","author":"Lucchi","year":"2009","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.athoracsur.2020.12.010_bib9","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1212\/WNL.0b013e3181dc1b1e","article-title":"for the MG Composite and MG-QOL15 Study Group. The MG Composite: a valid and reliable outcome measure for myasthenia gravis","volume":"74","author":"Burns","year":"2010","journal-title":"Neurology"},{"key":"10.1016\/j.athoracsur.2020.12.010_bib10","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.athoracsur.2018.08.071","article-title":"Nerve-sparing surgery in advanced stage thymomas","volume":"107","author":"Aprile","year":"2019","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.athoracsur.2020.12.010_bib11","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1093\/icvts\/ivaa019","article-title":"Surgical treatment of pleural recurrence of thymoma: is hyperthermic intrathoracic chemotherapy worthwhile?","volume":"30","author":"Aprile","year":"2020","journal-title":"Interactive Cardiovasc Thorac Surg"},{"key":"10.1016\/j.athoracsur.2020.12.010_bib12","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.thorsurg.2010.08.009","article-title":"Management of myasthenic patients with thymoma","volume":"21","author":"Zieli\u0144ski","year":"2011","journal-title":"Thorac Surg Clin"},{"key":"10.1016\/j.athoracsur.2020.12.010_bib13","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/1010-7940(89)90109-7","article-title":"Thymectomy in myasthenia gravis. Results of 662 cases operated upon in 15 years","volume":"3","author":"Maggi","year":"1989","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.athoracsur.2020.12.010_bib14","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/jso.23499","article-title":"Does the mode of surgical resection affect the prognosis\/recurrence in patients with thymoma?","volume":"109","author":"Nakagawa","year":"2014","journal-title":"J\u00a0Surg Oncol"},{"key":"10.1016\/j.athoracsur.2020.12.010_bib15","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/S0003-4975(96)00376-1","article-title":"Extended thymectomy for myasthenia gravis patients: a 20-year review","volume":"62","author":"Masaoka","year":"1996","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.athoracsur.2020.12.010_bib16","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S0022-5223(19)35684-3","article-title":"\u201cMaximal\u201d thymectomy for myasthenia gravis: results","volume":"95","author":"Jaretzki","year":"1988","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.athoracsur.2020.12.010_bib17","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/S1474-4422(15)00145-3","article-title":"Myasthenia gravis: subgroup classification and therapeutic strategies","volume":"14","author":"Gilhus","year":"2015","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.athoracsur.2020.12.010_bib18","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/S0022-5223(95)70343-8","article-title":"Prevalence of ectopic thymic tissue in myasthenia gravis and its clinical significance","volume":"109","author":"Ashour","year":"1995","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.athoracsur.2020.12.010_bib19","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jneuroim.2008.07.012","article-title":"Thymoma-associated myasthenia gravis: outcome, clinical and pathological correlations in 197 patients on a 20-year experience","volume":"201","author":"Maggi","year":"2008","journal-title":"J\u00a0Neuroimmunol"},{"key":"10.1016\/j.athoracsur.2020.12.010_bib20","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/S0022-5223(96)70265-9","article-title":"Prognostic factors and long-term results after thymoma resection: a series of 307 patients","volume":"112","author":"Regnard","year":"1996","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.athoracsur.2020.12.010_bib21","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.athoracsur.2004.06.090","article-title":"Thymoma and myasthenia gravis: a clinical study of 1,089 patients from Japan","volume":"79","author":"Kondo","year":"2005","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.athoracsur.2020.12.010_bib22","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1212\/01.WNL.0000032502.89361.0C","article-title":"Thymoma in patients with MG: characteristics and long-term outcome","volume":"59","author":"Evoli","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.athoracsur.2020.12.010_bib23","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.athoracsur.2009.08.074","article-title":"Thirty-five\u2013year follow-up analysis of clinical and pathologic outcomes of thymoma surgery","volume":"89","author":"Margaritora","year":"2010","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.athoracsur.2020.12.010_bib24","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/S1010-7940(99)00052-4","article-title":"Thymectomy for myasthenia gravis: a 27-year experience","volume":"15","author":"Venuta","year":"1999","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.athoracsur.2020.12.010_bib25","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.ejcts.2006.06.009","article-title":"Complete stable remission after extended transsternal thymectomy in myasthenia gravis","volume":"30","author":"Park","year":"2006","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.athoracsur.2020.12.010_bib26","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1016\/S0003-4975(03)01139-1","article-title":"Clinical and pathologic predictors of outcome in thymoma-associated myasthenia gravis","volume":"76","author":"L\u00f3pez-Cano","year":"2003","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.athoracsur.2020.12.010_bib27","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1093\/ejcts\/ezz334","article-title":"Predictors of post-thymectomy long-term neurological remission in thymomatous myasthenia gravis: an analysis from a multi-institutional database","volume":"57","author":"Na","year":"2020","journal-title":"Eur J Cardiothorac Surg"}],"container-title":["The Annals of Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003497520321494?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003497520321494?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T04:09:11Z","timestamp":1757736551000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003497520321494"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":27,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["S0003497520321494"],"URL":"https:\/\/doi.org\/10.1016\/j.athoracsur.2020.12.010","relation":{},"ISSN":["0003-4975"],"issn-type":[{"value":"0003-4975","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Thymectomy in Myasthenic Patients With Thymoma: Killing Two Birds With One Stone","name":"articletitle","label":"Article Title"},{"value":"The Annals of Thoracic Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.athoracsur.2020.12.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 by The Society of Thoracic Surgeons Published by Elsevier","name":"copyright","label":"Copyright"}]}}