{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T22:31:05Z","timestamp":1765233065203,"version":"3.44.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["annalsthoracicsurgery.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Annals of Thoracic Surgery"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.athoracsur.2021.03.069","type":"journal-article","created":{"date-parts":[[2021,4,5]],"date-time":"2021-04-05T12:12:54Z","timestamp":1617624774000},"page":"966-974","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Prognostic Significance of Pulmonary Multifocal Neuroendocrine Proliferation With Typical Carcinoid"],"prefix":"10.1016","volume":"113","author":[{"given":"Valentina","family":"Tassi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Scarnecchia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piero","family":"Ferolla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ozgur","family":"Mete","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maganti","family":"Manjula","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frances","family":"Allison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rossella","family":"Potenza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacopo","family":"Vannucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Ceccarelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Yasufuku","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"De Perrot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Pierre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gail","family":"Darling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato","family":"Colella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Ascani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandro","family":"Mattioli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaf","family":"Keshavjee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas Kenneth","family":"Waddell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Puma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niccol\u00f2","family":"Daddi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.athoracsur.2021.03.069_bib1","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1136\/jclinpath-2012-201310","article-title":"Neuroendocrine tumours\u2014challenges in the diagnosis and classification of pulmonary neuroendocrine tumours","volume":"66","author":"den Bakker","year":"2013","journal-title":"J\u00a0Clin Pathol"},{"key":"10.1016\/j.athoracsur.2021.03.069_bib2","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.prp.2015.12.006","article-title":"Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH)\u2014An uncommon precursor of a common cancer?","volume":"212","author":"Baniak","year":"2016","journal-title":"Pathol Res Pract"},{"key":"10.1016\/j.athoracsur.2021.03.069_bib3","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1093\/ejcts\/ezt470","article-title":"Prognostic factors in a multicentre study of 247 atypical pulmonary carcinoids","volume":"45","author":"Daddi","year":"2014","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.athoracsur.2021.03.069_bib4","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1097\/JTO.0b013e318197f2e7","article-title":"Tumorlets, multicentric carcinoids, lymph-nodal metastases, and long-term behavior in bronchial carcinoids","volume":"4","author":"Ferolla","year":"2009","journal-title":"J\u00a0Thorac Oncol"},{"key":"10.1016\/j.athoracsur.2021.03.069_bib5","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1097\/JTO.0000000000000630","article-title":"The 2015 World Health Organization classification of lung tumors: impact of genetic, clinical and radiologic advances since 2004 classification","volume":"10","author":"Travis","year":"2015","journal-title":"J\u00a0Thorac Oncol"},{"key":"10.1016\/j.athoracsur.2021.03.069_bib6","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1097\/PAS.0000000000001033","article-title":"Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) syndrome and carcinoid tumors with\/without NECH: a clinicopathologic, radiologic, and immunomolecular comparison study","volume":"42","author":"Mengoli","year":"2018","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.athoracsur.2021.03.069_bib7","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1097\/JTO.0000000000000663","article-title":"Introduction to the 2015 World Health Organization classification of tumors of the lung, pleura, thymus, and heart","volume":"10","author":"Travis","year":"2015","journal-title":"J\u00a0Thorac Oncol"},{"key":"10.1016\/j.athoracsur.2021.03.069_bib8","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1183\/13993003.01954-2015","article-title":"Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia syndrome","volume":"47","author":"Rossi","year":"2016","journal-title":"Eur Respir J"},{"key":"10.1016\/j.athoracsur.2021.03.069_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2265.2006.02739.x","article-title":"Epidemiology of non-gastroenteropancreatic (neuro)endocrine tumours","volume":"66","author":"Ferolla","year":"2007","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.athoracsur.2021.03.069_bib10","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1097\/00000478-199506000-00005","article-title":"Neuroendocrine cell hyperplasia and obliterative bronchiolitis in patients with peripheral carcinoid tumors","volume":"19","author":"Miller","year":"1995","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.athoracsur.2021.03.069_bib11","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1093\/annonc\/mds267","article-title":"Neuroendocrine bronchial and thymic tumors: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up","volume":"23","author":"\u00d6berg","year":"2012","journal-title":"Ann Oncol"},{"key":"10.1016\/j.athoracsur.2021.03.069_bib12","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/path.1711570207","article-title":"Pulmonary endocrine cells in chronic bronchitis and emphysema","volume":"157","author":"Gosney","year":"1989","journal-title":"J\u00a0Pathol"},{"key":"10.1016\/j.athoracsur.2021.03.069_bib13","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/s12931-018-0915-8","article-title":"Selective activation and proliferation of a quiescent stem cell population in the neuroepithelial body microenvironment","volume":"19","author":"Verckist","year":"2018","journal-title":"Respir Res"},{"key":"10.1016\/j.athoracsur.2021.03.069_bib14","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1093\/annonc\/mdv041","article-title":"Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids","volume":"26","author":"Caplin","year":"2015","journal-title":"Ann Oncol"},{"key":"10.1016\/j.athoracsur.2021.03.069_bib15","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1164\/rccm.201010-1685PP","article-title":"Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: a systematic overview","volume":"184","author":"Nassar","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.athoracsur.2021.03.069_bib16","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1136\/thx.2006.063065","article-title":"Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: an under-recognised spectrum of disease","volume":"62","author":"Davies","year":"2007","journal-title":"Thorax"},{"key":"10.1016\/j.athoracsur.2021.03.069_bib17","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s00408-016-9854-7","article-title":"DIPNECH: association between histopathology and clinical presentation","volume":"194","author":"Trisolini","year":"2016","journal-title":"Lung"},{"key":"10.1016\/j.athoracsur.2021.03.069_bib18","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1002\/cncr.26200","article-title":"Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia and the associated lung neuroendocrine tumors: clinical experience with a rare entity","volume":"118","author":"Gorshtein","year":"2012","journal-title":"Cancer"},{"key":"10.1016\/j.athoracsur.2021.03.069_bib19","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1056\/NEJM199210293271806","article-title":"Brief report: idiopathic diffuse hyperplasia of pulmonary neuroendocrine cells and airways disease","volume":"327","author":"Aguayo","year":"1992","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.athoracsur.2021.03.069_bib20","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s12022-018-9530-y","article-title":"Clinical and pathological characteristics of pulmonary carcinoid tumors in central and peripheral locations","volume":"29","author":"Papaxoinis","year":"2018","journal-title":"Endocr Pathol"},{"key":"10.1016\/j.athoracsur.2021.03.069_bib21","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1213\/ANE.0000000000002920","article-title":"Propensity score methods: theory and practice for anesthesia research","volume":"127","author":"Schulte","year":"2018","journal-title":"Anesth Analg"},{"key":"10.1016\/j.athoracsur.2021.03.069_bib22","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/labinvest.3700412","article-title":"Functional facets of the pulmonary neuroendocrine system","volume":"86","author":"Linnoila","year":"2006","journal-title":"Lab Invest"},{"key":"10.1016\/j.athoracsur.2021.03.069_bib23","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1378\/chest.06-2788","article-title":"Significance of multiple carcinoid tumors and tumorlets in surgical lung specimens: analysis of 28 patients","volume":"131","author":"Aubry","year":"2007","journal-title":"Chest"},{"key":"10.1016\/j.athoracsur.2021.03.069_bib24","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1111\/j.1365-2559.2009.03371.x","article-title":"The frequency of neuroendocrine cell hyperplasia in patients with pulmonary neuroendocrine tumours and non-neuroendocrine cell carcinomas","volume":"55","author":"Rizvi","year":"2009","journal-title":"Histopathology"},{"key":"10.1016\/j.athoracsur.2021.03.069_bib25","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/s00408-018-0149-z","article-title":"Management of diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: review and a single center experience","volume":"196","author":"Myint","year":"2018","journal-title":"Lung"},{"key":"10.1016\/j.athoracsur.2021.03.069_bib26","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.jtho.2016.11.2222","article-title":"Neuroendocrine tumors of the lung: current challenges and advances in the diagnosis and management of well-differentiated disease","volume":"12","author":"Hendifar","year":"2017","journal-title":"J\u00a0Thorac Oncol"},{"key":"10.1016\/j.athoracsur.2021.03.069_bib27","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.crad.2014.10.012","article-title":"DIPNECH: when to suggest this diagnosis on CT","volume":"70","author":"Chessagnon","year":"2015","journal-title":"Clin Radiol"},{"key":"10.1016\/j.athoracsur.2021.03.069_bib28","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.clinimag.2014.10.017","article-title":"Imaging appearances of diffuse idiopathic pulmonary neuroendocrine cell hyperplasia","volume":"39","author":"Foran","year":"2015","journal-title":"Clin Imaging"},{"key":"10.1016\/j.athoracsur.2021.03.069_bib29","doi-asserted-by":"crossref","first-page":"510","DOI":"10.3390\/cancers10120510","article-title":"Management of typical and atypical pulmonary carcinoids based on different established guidelines","volume":"10","author":"Gosain","year":"2018","journal-title":"Cancers"},{"key":"10.1016\/j.athoracsur.2021.03.069_bib30","doi-asserted-by":"crossref","first-page":"872","DOI":"10.2967\/jnumed.115.165803","article-title":"68Ga-DOTATATE compared with 111In-DTPA-octreotide and conventional imaging for pulmonary and gastroenteropancreatic neuroendocrine tumors: a systematic review and meta-analysis","volume":"57","author":"Deppen","year":"2016","journal-title":"J\u00a0Nucl Med"},{"key":"10.1016\/j.athoracsur.2021.03.069_bib31","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.humpath.2014.10.019","article-title":"The spectrum of changes in adults with multifocal pulmonary neuroendocrine proliferations: what is the minimum set of pathologic criteria to diagnose DIPNECH?","volume":"46","author":"Marchevsky","year":"2015","journal-title":"Hum Pathol"},{"key":"10.1016\/j.athoracsur.2021.03.069_bib32","first-page":"123","article-title":"Multifocal pulmonary neuroendocrine tumours: genesis, diagnostics and treatment","volume":"70","author":"Kirschbaum","year":"2016","journal-title":"Pneumologie"}],"container-title":["The Annals of Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003497521006482?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003497521006482?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T04:13:57Z","timestamp":1757736837000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003497521006482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["S0003497521006482"],"URL":"https:\/\/doi.org\/10.1016\/j.athoracsur.2021.03.069","relation":{},"ISSN":["0003-4975"],"issn-type":[{"type":"print","value":"0003-4975"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prognostic Significance of Pulmonary Multifocal Neuroendocrine Proliferation With Typical Carcinoid","name":"articletitle","label":"Article Title"},{"value":"The Annals of Thoracic Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.athoracsur.2021.03.069","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 by The Society of Thoracic Surgeons","name":"copyright","label":"Copyright"}]}}