{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T02:04:47Z","timestamp":1780970687663,"version":"3.54.1"},"reference-count":26,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["annalsthoracicsurgery.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Annals of Thoracic Surgery"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.athoracsur.2021.11.010","type":"journal-article","created":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T00:13:37Z","timestamp":1638922417000},"page":"394-400","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Persistent N2 After Induction Is Not a Contraindication to Surgery for Lung Cancer"],"prefix":"10.1016","volume":"114","author":[{"given":"Weston G.","family":"Andrews","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian E.","family":"Louie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Castiglioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankit","family":"Dhamija","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex S.","family":"Farivar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Chansky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter T.","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph W.","family":"Aye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Valli\u00e8res","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam J.","family":"Bograd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.athoracsur.2021.11.010_bib1","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/1759-7714.12959","article-title":"Survival comparison of right and left side non-small cell lung cancer in stage I-IIIA patients: a Surveillance Epidemiology and End Results (SEER) analysis","volume":"10","author":"Jia","year":"2019","journal-title":"Thorac Cancer"},{"key":"10.1016\/j.athoracsur.2021.11.010_bib2","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/0003-4975(92)90373-C","article-title":"Randomized trial of neoadjuvant therapy for lung cancer: interim analysis","volume":"53","author":"Pass","year":"1992","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.athoracsur.2021.11.010_bib3","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1056\/NEJM199401203300301","article-title":"A\u00a0randomized trial comparing preoperative chemotherapy plus surgery with surgery alone in patients with non-small-cell lung cancer","volume":"330","author":"Rosell","year":"1994","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.athoracsur.2021.11.010_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0169-5002(98)00046-4","article-title":"Long-term follow-up of patients enrolled in a randomized trial comparing perioperative chemotherapy and surgery with surgery alone in resectable stage IIIA non-small-cell lung cancer","volume":"21","author":"Roth","year":"1998","journal-title":"Lung Cancer"},{"key":"10.1016\/j.athoracsur.2021.11.010_bib5","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1200\/JCO.2003.11.040","article-title":"Mediastinal lymph node clearance after docetaxel-cisplatin neoadjuvant chemotherapy is prognostic of survival in patients with stage IIIA pN2 non-small-cell lung cancer: a multicenter phase II trial","volume":"21","author":"Betticher","year":"2003","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.athoracsur.2021.11.010_bib6","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0140-6736(09)60737-6","article-title":"Radiotherapy plus chemotherapy with or without surgical resection for stage III non-small-cell lung cancer : a phase III randomised controlled trial","volume":"374","author":"Albain","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.athoracsur.2021.11.010_bib7","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1093\/jnci\/djk093","article-title":"Randomized controlled trial of resection versus radiotherapy after induction chemotherapy in stage IIIA-N2 non-small-cell lung cancer","volume":"99","author":"van Meerbeeck","year":"2007","journal-title":"J\u00a0Natl Cancer Inst"},{"key":"10.1016\/j.athoracsur.2021.11.010_bib8","doi-asserted-by":"crossref","first-page":"4194","DOI":"10.1200\/JCO.2015.62.6812","article-title":"Phase III study of surgery versus definitive concurrent chemoradiotherapy boost in patients with resectable stage IIIA(N2) and selected IIIB non-small-cell lung cancer after induction chemotherapy and concurrent chemoradiotherapy (ESPATUE)","volume":"33","author":"Eberhardt","year":"2015","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.athoracsur.2021.11.010_bib9","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/S0140-6736(15)60294-X","article-title":"Induction chemoradiation in stage IIIA\/N2 non-small-cell lung cancer: a phase 3 randomised trial","volume":"386","author":"Pless","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.athoracsur.2021.11.010_bib10","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1016\/j.jtcvs.2015.06.062","article-title":"Adding radiation to induction chemotherapy does not improve survival of patients with operable clinical N2 non-small cell lung cancer","volume":"150","author":"Yang","year":"2015","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.athoracsur.2021.11.010_bib11","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.athoracsur.2018.07.033","article-title":"Multimodality therapy for N2 non-small cell lung cancer: an evolving paradigm","volume":"107","author":"Spicer","year":"2019","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.athoracsur.2021.11.010_bib12","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1056\/NEJMoa1809697","article-title":"Overall survival with durvalumab after chemoradiotherapy in stage III NSCLC","volume":"379","author":"Antonia","year":"2018","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.athoracsur.2021.11.010_bib13","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1038\/sj.bjc.6603075","article-title":"Prognostic factors affecting long-term outcomes in patients with resected stage IIIA pN2 non-small-cell lung cancer: 5-year follow-up of a phase II study","volume":"94","author":"Betticher","year":"2006","journal-title":"Br J Cancer"},{"key":"10.1016\/j.athoracsur.2021.11.010_bib14","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jtcvs.2010.07.092","article-title":"Survival of patients with clinical stage IIIA non-small cell lung cancer after induction therapy: age, mediastinal downstaging, and extent of pulmonary resection as independent predictors","volume":"141","author":"Paul","year":"2011","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.athoracsur.2021.11.010_bib15","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.jtcvs.2015.09.127","article-title":"Postinduction positron emission tomography assessment of N2 nodes is not associated with ypN2 disease or overall survival in stage IIIA non-small cell lung cancer","volume":"151","author":"Ripley","year":"2016","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.athoracsur.2021.11.010_bib16","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.jtho.2019.10.019","article-title":"The IASLC Lung Cancer Staging Project: analysis of resection margin status and proposals for residual tumor descriptors for non-small cell lung cancer","volume":"15","author":"Edwards","year":"2020","journal-title":"J\u00a0Thorac Oncol"},{"key":"10.1016\/j.athoracsur.2021.11.010_bib17","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1093\/ejcts\/ezu028","article-title":"Revised ESTS guidelines for preoperative mediastinal lymph node staging for non-small-cell lung cancer","volume":"45","author":"De Leyn","year":"2014","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.athoracsur.2021.11.010_bib18","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/j.athoracsur.2010.05.014","article-title":"Systematic classification of morbidity and mortality after thoracic surgery","volume":"90","author":"Seely","year":"2010","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.athoracsur.2021.11.010_bib19","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1016\/j.athoracsur.2004.10.057","article-title":"Surgical resection for residual N2 disease after induction chemotherapy","volume":"79","author":"Port","year":"2005","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.athoracsur.2021.11.010_bib20","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.ejcts.2009.04.013","article-title":"Surgical multimodality treatment for baseline resectable stage IIIA-N2 non-small cell lung cancer. Degree of mediastinal lymph node involvement and impact on survival","volume":"36","author":"Decaluw\u00e9","year":"2009","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.athoracsur.2021.11.010_bib21","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.athoracsur.2008.01.019","article-title":"Persistent N2 disease after induction therapy does not jeopardize early and medium term outcomes of pneumonectomy","volume":"86","author":"Mansour","year":"2008","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.athoracsur.2021.11.010_bib22","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1097\/SLA.0000000000004065","article-title":"Propensity-matched analysis demonstrates long-term risk of respiratory and cardiac mortality after pneumonectomy compared with lobectomy for lung cancer","volume":"275","author":"Jones","year":"2022","journal-title":"Ann Surg"},{"key":"10.1016\/j.athoracsur.2021.11.010_bib23","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.athoracsur.2011.02.013","article-title":"Safety and utility of mediastinoscopy in non-small cell lung cancer in a complex mediastinum","volume":"92","author":"Louie","year":"2011","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.athoracsur.2021.11.010_bib24","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1093\/ejcts\/ezu226","article-title":"Is the lymphatic drainage of lung cancer lobe-specific? A surgical appraisal","volume":"47","author":"Riquet","year":"2015","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.athoracsur.2021.11.010_bib25","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/S1470-2045(08)70156-6","article-title":"Effect of preoperative chemoradiation in addition to preoperative chemotherapy: a randomised trial in stage III non-small-cell lung cancer","volume":"9","author":"Thomas","year":"2008","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.athoracsur.2021.11.010_bib26","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.jtho.2019.10.002","article-title":"Three-year overall survival with durvalumab after chemoradiotherapy in stage III NSCLC\u2014update from PACIFIC","volume":"15","author":"Gray","year":"2020","journal-title":"J\u00a0Thorac Oncol"}],"container-title":["The Annals of Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003497521020269?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003497521020269?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T04:13:57Z","timestamp":1757736837000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003497521020269"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["S0003497521020269"],"URL":"https:\/\/doi.org\/10.1016\/j.athoracsur.2021.11.010","relation":{},"ISSN":["0003-4975"],"issn-type":[{"value":"0003-4975","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Persistent N2 After Induction Is Not a Contraindication to Surgery for Lung Cancer","name":"articletitle","label":"Article Title"},{"value":"The Annals of Thoracic Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.athoracsur.2021.11.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 by The Society of Thoracic Surgeons","name":"copyright","label":"Copyright"}]}}