{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T08:29:12Z","timestamp":1793867352523,"version":"4.6.1"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":29,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["annalsthoracicsurgery.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Annals of Thoracic Surgery"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.athoracsur.2026.07.025","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T15:38:27Z","timestamp":1785512307000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Rare Germline Variants in Cancer Susceptibility Genes and Lung Cancer Risk"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8878-971X","authenticated-orcid":false,"given":"Sierra R.","family":"Broad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keri","family":"Denson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuqing","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wara","family":"Naeem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huy","family":"Tran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arsalan A.","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew S.","family":"Rifkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annabelle","family":"Ashworth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Lilly","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1520-7966","authenticated-orcid":false,"given":"Jeffrey A.","family":"Borgia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A.","family":"Hensing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Liptay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher W.","family":"Seder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfeng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7623-6720","authenticated-orcid":false,"given":"Seth B.","family":"Krantz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.athoracsur.2026.07.025_bib1","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S1470-2045(10)70126-1","article-title":"Genetics of lung-cancer susceptibility","volume":"12","author":"Brennan","year":"2011","journal-title":"Lancet Oncol"},{"issue":"suppl","key":"10.1016\/j.athoracsur.2026.07.025_bib2","doi-asserted-by":"crossref","first-page":"e1S","DOI":"10.1378\/chest.12-2345","article-title":"Epidemiology of lung cancer: diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines","volume":"143","author":"Alberg","year":"2013","journal-title":"Chest"},{"key":"10.1016\/j.athoracsur.2026.07.025_bib3","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1001\/jama.2015.17703","article-title":"Familial risk and heritability of cancer among twins in Nordic countries","volume":"315","author":"Mucci","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.athoracsur.2026.07.025_bib4","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1001\/jama.292.24.2977","article-title":"Familial risk of lung carcinoma in the Icelandic population","volume":"292","author":"Jonsson","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.athoracsur.2026.07.025_bib5","doi-asserted-by":"crossref","first-page":"8629","DOI":"10.1038\/s41467-024-52129-4","article-title":"Multi-ancestry GWAS meta-analyses of lung cancer reveal susceptibility loci and elucidate smoking-independent genetic risk","volume":"15","author":"Gorman","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.athoracsur.2026.07.025_bib6","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1038\/ng.3892","article-title":"Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes","volume":"49","author":"McKay","year":"2017","journal-title":"Nat Genet"},{"key":"10.1016\/j.athoracsur.2026.07.025_bib7","doi-asserted-by":"crossref","first-page":"4980","DOI":"10.1093\/hmg\/dds334","article-title":"Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls","volume":"21","author":"Timofeeva","year":"2012","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.athoracsur.2026.07.025_bib8","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1016\/j.ajhg.2025.07.009","article-title":"Genetic analysis in African ancestry populations reveals genetic contributors to lung cancer susceptibility","volume":"112","author":"Betti","year":"2025","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.athoracsur.2026.07.025_bib9","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/S2213-2600(24)00124-3","article-title":"Biological and therapeutic implications of the cancer-related germline mutation landscape in lung cancer","volume":"12","author":"Panagiotou","year":"2024","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.athoracsur.2026.07.025_bib10","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.cllc.2023.01.005","article-title":"Association of reported candidate monogenic genes with lung cancer risk","volume":"24","author":"Rifkin","year":"2023","journal-title":"Clin Lung Cancer"},{"key":"10.1016\/j.athoracsur.2026.07.025_bib11","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1038\/s41588-024-01966-6","article-title":"Gene-based burden tests of rare germline variants identify six cancer susceptibility genes","volume":"56","author":"Ivarsdottir","year":"2024","journal-title":"Nat Genet"},{"key":"10.1016\/j.athoracsur.2026.07.025_bib12","doi-asserted-by":"crossref","DOI":"10.1002\/cam4.70990","article-title":"Estimating cancer penetrance in carriers of BRCA2 pathogenic variants using cancer-specific polygenic scores","volume":"14","author":"Prassas","year":"2025","journal-title":"Cancer Med"},{"key":"10.1016\/j.athoracsur.2026.07.025_bib13","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1001\/jamaoncol.2025.2879","article-title":"Established cancer predisposition genes in single and multiple cancer diagnoses","volume":"11","author":"Shevach","year":"2025","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.athoracsur.2026.07.025_bib14","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1158\/1055-9965.EPI-21-1287","article-title":"Germline pathogenic variants impact clinicopathology of advanced lung cancer","volume":"31","author":"Mukherjee","year":"2022","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.athoracsur.2026.07.025_bib15","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/s41586-018-0579-z","article-title":"The UK Biobank resource with deep phenotyping and genomic data","volume":"562","author":"Bycroft","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.athoracsur.2026.07.025_bib16","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.18632\/oncotarget.26797","article-title":"Clinical validation of the tempus xT next-generation targeted oncology sequencing assay","volume":"10","author":"Beaubier","year":"2019","journal-title":"Oncotarget"},{"key":"10.1016\/j.athoracsur.2026.07.025_bib17","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1002\/humu.24309","article-title":"Variant interpretation using population databases: lessons from gnomAD","volume":"43","author":"Gudmundsson","year":"2022","journal-title":"Hum Mutat"},{"key":"10.1016\/j.athoracsur.2026.07.025_bib27","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.ajhg.2012.06.007","article-title":"Optimal unified approach for rare-variant association testing with application to small-sample case-control whole-exome sequencing studies","volume":"91","author":"Lee","year":"2012","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.athoracsur.2026.07.025_bib28","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ajhg.2019.11.012","article-title":"UK Biobank whole-exome sequence binary phenome analysis with robust region-based rare-variant test","volume":"106","author":"Zhao","year":"2020","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.athoracsur.2026.07.025_bib29","doi-asserted-by":"crossref","first-page":"3941","DOI":"10.1534\/g3.116.035485","article-title":"On robust association testing for quantitative traits and rare variants","volume":"6","author":"Wei","year":"2016","journal-title":"G3 (Bethesda)"},{"key":"10.1016\/j.athoracsur.2026.07.025_bib30","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1016\/j.jtho.2025.06.005","article-title":"Genomic profiles of pathogenic and moderate-penetrance germline variants associated with risk of early-onset lung adenocarcinoma","volume":"20","author":"Cho","year":"2025","journal-title":"J Thorac Oncol"},{"key":"10.1016\/j.athoracsur.2026.07.025_bib31","doi-asserted-by":"crossref","first-page":"21219","DOI":"10.1002\/cam4.6692","article-title":"Pathogenic germline variants in BRCA1 and TP53 increase lung cancer risk in Chinese","volume":"12","author":"Wei","year":"2023","journal-title":"Cancer Med"},{"key":"10.1016\/j.athoracsur.2026.07.025_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.lungcan.2024.107864","article-title":"Prevalence of pathogenic or likely pathogenic germline variants in cancer predisposition genes among selected patients with lung adenocarcinoma: the GERMLUNG study","volume":"194","author":"Arrieta","year":"2024","journal-title":"Lung Cancer"},{"key":"10.1016\/j.athoracsur.2026.07.025_bib33","article-title":"Rate of pathogenic germline variants in patients with lung cancer","volume":"7","author":"Sorscher","year":"2023","journal-title":"JCO Precis Oncol"},{"key":"10.1016\/j.athoracsur.2026.07.025_bib34","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1056\/NEJMoa2002787","article-title":"Capmatinib in MET exon 14\u2013mutated or MET-amplified non-small-cell lung cancer","volume":"383","author":"Wolf","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.athoracsur.2026.07.025_bib35","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/1542786","article-title":"CYLD promotes TNF-\u03b1\u2013induced cell necrosis mediated by RIP-1 in human lung cancer cells","volume":"2016","author":"Lin","year":"2016","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.athoracsur.2026.07.025_bib36","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.humpath.2018.02.014","article-title":"Familial PDGFRA-mutation syndrome: somatic and gastrointestinal phenotype","volume":"76","author":"Manley","year":"2018","journal-title":"Hum Pathol"},{"key":"10.1016\/j.athoracsur.2026.07.025_bib37","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1136\/gutjnl-2024-334601","article-title":"Hereditary diffuse gastric cancer spectrum associated with germline CTNNA1 loss of function revealed by clinical and molecular data from 351 carrier families and over 37 000 non-carrier controls","volume":"75","author":"Lobo","year":"2026","journal-title":"Gut"},{"key":"10.1016\/j.athoracsur.2026.07.025_bib38","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1164\/rccm.202406-1168ST","article-title":"Premalignant progression in the lung: knowledge gaps and novel opportunities for interception of non-small cell lung cancer. An official American Thoracic Society research statement","volume":"210","author":"Moghaddam","year":"2024","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.athoracsur.2026.07.025_bib39","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1016\/j.jtho.2017.08.011","article-title":"Germline mutations in DNA repair genes in lung adenocarcinoma","volume":"12","author":"Parry","year":"2017","journal-title":"J Thorac Oncol"},{"key":"10.1016\/j.athoracsur.2026.07.025_bib40","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1038\/s41467-020-16293-7","article-title":"Germline variant burden in cancer genes correlates with age at diagnosis and somatic mutation burden","volume":"11","author":"Qing","year":"2020","journal-title":"Nat Commun"}],"container-title":["The Annals of Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003497526007526?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003497526007526?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T08:16:46Z","timestamp":1793866606000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003497526007526"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":31,"alternative-id":["S0003497526007526"],"URL":"https:\/\/doi.org\/10.1016\/j.athoracsur.2026.07.025","relation":{},"ISSN":["0003-4975"],"issn-type":[{"value":"0003-4975","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association Between Rare Germline Variants in Cancer Susceptibility Genes and Lung Cancer Risk","name":"articletitle","label":"Article Title"},{"value":"The Annals of Thoracic Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.athoracsur.2026.07.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc. on behalf of The Society of Thoracic Surgeons.","name":"copyright","label":"Copyright"}]}}