{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T08:29:20Z","timestamp":1793867360517,"version":"4.6.1"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association Inc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["annalsthoracicsurgery.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Annals of Thoracic Surgery"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.athoracsur.2026.09.049","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:56:30Z","timestamp":1791474990000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Shear-Induced Macrophage Secretome on Endothelial Permeability"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2067-8655","authenticated-orcid":false,"given":"Elysa","family":"Jui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Griffin","family":"Kingsley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E.","family":"Jimenez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong T. Kim","family":"Phan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George I.","family":"Ezeokeke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0799-8342","authenticated-orcid":false,"given":"Fariha N.","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi K.","family":"Birla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sundeep G.","family":"Keswani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1533-3767","authenticated-orcid":false,"given":"K. Jane","family":"Grande-Allen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.athoracsur.2026.09.049_bib1","doi-asserted-by":"crossref","first-page":"122","DOI":"10.3389\/fcvm.2018.00122","article-title":"Discrete subaortic stenosis: perspective roadmap to a complex disease","volume":"5","author":"Mass\u00e9","year":"2018","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.athoracsur.2026.09.049_bib2","doi-asserted-by":"crossref","first-page":"114","DOI":"10.3389\/fbioe.2020.00114","article-title":"Impact of aortoseptal angle abnormalities and discrete subaortic stenosis on left-ventricular outflow tract hemodynamics: preliminary computational assessment","volume":"8","author":"Shar","year":"2020","journal-title":"Front Bioeng Biotechnol"},{"key":"10.1016\/j.athoracsur.2026.09.049_bib3","doi-asserted-by":"crossref","first-page":"2932","DOI":"10.1007\/s10439-024-03546-5","article-title":"Shear stress induces a time-dependent inflammatory response in human monocyte-derived macrophages","volume":"52","author":"Jui","year":"2024","journal-title":"Ann Biomed Eng"},{"key":"10.1016\/j.athoracsur.2026.09.049_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.787541","article-title":"Dysfunctional vascular endothelium as a driver of atherosclerosis: emerging insights into pathogenesis and treatment","volume":"12","author":"Botts","year":"2021","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.athoracsur.2026.09.049_bib5","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.molmed.2020.11.006","article-title":"Permeability of the endothelial barrier: identifying and reconciling controversies","volume":"27","author":"Claesson-Welsh","year":"2021","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.athoracsur.2026.09.049_bib6","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1093\/cvr\/cvx226","article-title":"Endothelial permeability, LDL deposition, and cardiovascular risk factors\u2013a review","volume":"114","author":"Mundi","year":"2018","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.athoracsur.2026.09.049_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines11061728","article-title":"The role of sphingolipids in regulating vascular permeability in idiopathic pulmonary fibrosis","volume":"11","author":"Jayant","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.athoracsur.2026.09.049_bib8","doi-asserted-by":"crossref","DOI":"10.1172\/JCI172058","article-title":"Beyond epithelial damage: vascular and endothelial contributions to idiopathic pulmonary fibrosis","volume":"133","author":"May","year":"2023","journal-title":"J Clin Invest"},{"key":"10.1016\/j.athoracsur.2026.09.049_bib9","doi-asserted-by":"crossref","first-page":"1900100","DOI":"10.1183\/13993003.00100-2019","article-title":"Vascular permeability in the fibrotic lung","volume":"56","author":"Probst","year":"2020","journal-title":"Eur Respir J"},{"key":"10.1016\/j.athoracsur.2026.09.049_bib10","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1083\/jcb.201010051","article-title":"PKC\u03b6 mediates disturbed flow-induced endothelial apoptosis via p53 SUMOylation","volume":"193","author":"Heo","year":"2011","journal-title":"J Cell Biol"},{"key":"10.1016\/j.athoracsur.2026.09.049_bib11","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1089\/ars.2006.8.1609","article-title":"Role of NADPH oxidases in disturbed flow- and BMP4- induced inflammation and atherosclerosis","volume":"8","author":"Jo","year":"2006","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.athoracsur.2026.09.049_bib12","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0076-6879(08)02002-8","article-title":"Physiologic stress-mediated signaling in the endothelium","volume":"443","author":"Reinhart-King","year":"2008","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.athoracsur.2026.09.049_bib13","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1086\/677356","article-title":"Mechanisms regulating endothelial permeability","volume":"4","author":"Sukriti","year":"2014","journal-title":"Pulm Circ"},{"key":"10.1016\/j.athoracsur.2026.09.049_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114566","article-title":"Shear stress induces monocyte\/macrophage-mediated inflammation by upregulating cell-surface expression of heat shock proteins","volume":"161","author":"Son","year":"2023","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.athoracsur.2026.09.049_bib15","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1615\/CritRevEukarGeneExpr.v20.i2.10","article-title":"Tumor necrosis factor-\u03b1 signaling in macrophages","volume":"20","author":"Parameswaran","year":"2010","journal-title":"Crit Rev Eukaryot Gene Expr"},{"key":"10.1016\/j.athoracsur.2026.09.049_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.734215","article-title":"The mechanobiology of endothelial-to-mesenchymal transition in cardiovascular disease","volume":"12","author":"Islam","year":"2021","journal-title":"Front Physiol"},{"key":"10.1016\/j.athoracsur.2026.09.049_bib17","doi-asserted-by":"crossref","first-page":"3375","DOI":"10.1038\/s41598-017-03532-z","article-title":"Shear stress induces endothelial-to-mesenchymal transition via the transcription factor Snail","volume":"7","author":"Mahmoud","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.athoracsur.2026.09.049_bib18","doi-asserted-by":"crossref","first-page":"C572","DOI":"10.1152\/ajpcell.1997.273.2.C572","article-title":"Differential activation of NF-kappa B in human aortic endothelial cells conditioned to specific flow environments","volume":"273","author":"Mohan","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1016\/j.athoracsur.2026.09.049_bib19","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1083\/jcb.200609008","article-title":"Matrix-specific p21-activated kinase activation regulates vascular permeability in atherogenesis","volume":"176","author":"Orr","year":"2007","journal-title":"J Cell Biol"},{"key":"10.1016\/j.athoracsur.2026.09.049_bib20","doi-asserted-by":"crossref","first-page":"C814","DOI":"10.1152\/ajpcell.00226.2009","article-title":"Focal adhesion kinase modulates activation of NF-kappaB by flow in endothelial cells","volume":"297","author":"Petzold","year":"2009","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.athoracsur.2026.09.049_bib21","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1006\/mvre.2000.2260","article-title":"Shear stress-induced cytoskeleton rearrangement mediates NF-kappaB-dependent endothelial expression of ICAM-1","volume":"60","author":"Imberti","year":"2000","journal-title":"Microvasc Res"},{"key":"10.1016\/j.athoracsur.2026.09.049_bib22","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.freeradbiomed.2013.05.034","article-title":"Mechanosensitive microRNAs-role in endothelial responses to shear stress and redox state","volume":"64","author":"Marin","year":"2013","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.athoracsur.2026.09.049_bib23","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1084\/jem.20031132","article-title":"KLF2 is a novel transcriptional regulator of endothelial proinflammatory activation","volume":"199","author":"SenBanerjee","year":"2004","journal-title":"J Exp Med"}],"container-title":["The Annals of Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003497526010143?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003497526010143?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T08:17:21Z","timestamp":1793866641000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003497526010143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":23,"alternative-id":["S0003497526010143"],"URL":"https:\/\/doi.org\/10.1016\/j.athoracsur.2026.09.049","relation":{},"ISSN":["0003-4975"],"issn-type":[{"value":"0003-4975","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of Shear-Induced Macrophage Secretome on Endothelial Permeability","name":"articletitle","label":"Article Title"},{"value":"The Annals of Thoracic Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.athoracsur.2026.09.049","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}