{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:14:16Z","timestamp":1761707656141,"version":"build-2065373602"},"reference-count":46,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2004,2,1]],"date-time":"2004-02-01T00:00:00Z","timestamp":1075593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,2,1]],"date-time":"2004-02-01T00:00:00Z","timestamp":1075593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["autonomicneuroscience.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Autonomic Neuroscience"],"published-print":{"date-parts":[[2004,2]]},"DOI":"10.1016\/j.autneu.2003.10.004","type":"journal-article","created":{"date-parts":[[2004,3,21]],"date-time":"2004-03-21T05:17:31Z","timestamp":1079846251000},"page":"65-80","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["The development of the medullary serotonergic system in the piglet"],"prefix":"10.1016","volume":"110","author":[{"given":"Mary M.","family":"Niblock","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah C.","family":"Kinney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine J.","family":"Luce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard A.","family":"Belliveau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James J.","family":"Filiano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.autneu.2003.10.004_BIB1","first-page":"407","article-title":"The primate 5-HT system: a review of human and animal studies and a report on Macaca fascicularis","volume":"43","author":"Azmitia","year":"1986","journal-title":"Adv. Neurol."},{"key":"10.1016\/j.autneu.2003.10.004_BIB2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0034-5687(98)00050-4","article-title":"Cardiorespiratory responses to glutamate microinjected into the medullary raph\u00e9","volume":"113","author":"Bernard","year":"1998","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.autneu.2003.10.004_BIB3","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1152\/jappl.1996.80.1.108","article-title":"Evidence for central chemoreception in the midline raph\u00e9","volume":"80","author":"Bernard","year":"1996","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.autneu.2003.10.004_BIB4","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1002\/(SICI)1096-9861(19970421)380:4<507::AID-CNE7>3.0.CO;2-5","article-title":"Distribution and morphology of serotonin-immunoreactive neurons in the brainstem of the New Zealand white rabbit","volume":"380","author":"Bjarkam","year":"1997","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.autneu.2003.10.004_BIB5","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/nn848","article-title":"Chemosensitive 5-HT neurons are closely associated with large medullary arteries","volume":"5","author":"Bradley","year":"2002","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.autneu.2003.10.004_BIB6","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1152\/jappl.1993.75.1.5","article-title":"Widespread sites of brain stem ventilatory chemoreceptors","volume":"75","author":"Coates","year":"1993","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.autneu.2003.10.004_BIB7","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1242\/jeb.100.1.223","article-title":"Respiratory and circulatory control during sleep","volume":"100","author":"Coote","year":"1982","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.autneu.2003.10.004_BIB8","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0034-5687(00)00143-2","article-title":"Lesion or muscimol in the rostral ventral medulla reduces ventilatory output and the CO2 response in decerebrate piglets","volume":"123","author":"Curran","year":"2000","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.autneu.2003.10.004_BIB9","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1152\/jappl.2001.90.3.971","article-title":"Muscimol dialysis in the rostral ventral medulla reduced the CO2 response in awake and sleeping piglets","volume":"90","author":"Curran","year":"2001","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.autneu.2003.10.004_BIB10","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1152\/japplphysiol.00895.2001","article-title":"Enhanced baroreflex-mediated inhibition of respiration after muscimol dialysis in the rostral ventral medulla","volume":"92","author":"Curran","year":"2002","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.autneu.2003.10.004_BIB11","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1093\/sleep\/24.5.514","article-title":"The effects of a GABAA agonist in the rostral ventral medulla on sleep and breathing in newborn piglets","volume":"24","author":"Darnall","year":"2001","journal-title":"Sleep"},{"key":"10.1016\/j.autneu.2003.10.004_BIB12","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0034-5687(97)00110-2","article-title":"Role of the medullary raph\u00e9 nuclei in the respiratory responses to CO2","volume":"111","author":"Dreshaj","year":"1998","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.autneu.2003.10.004_BIB13","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1002\/(SICI)1096-9861(19990906)411:4<535::AID-CNE1>3.0.CO;2-6","article-title":"5-HT neurons in the brainstem of the wallaby, Macropus eugenii","volume":"411","author":"Ferguson","year":"1999","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.autneu.2003.10.004_BIB14","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1093\/sleep\/16.7.610","article-title":"Sleep state organization in the developing piglet during exposure to different thermal stimuli","volume":"7","author":"Galland","year":"1993","journal-title":"Sleep"},{"key":"10.1016\/j.autneu.2003.10.004_BIB15","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/S0006-8993(01)02294-6","article-title":"The discharge of a subset of 5-HT raph\u00e9 magnus cells is influenced by baroreceptor input","volume":"900","author":"Gao","year":"2001","journal-title":"Brain Res."},{"key":"10.1016\/j.autneu.2003.10.004_BIB16","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/cne.901000107","article-title":"Cell migration from the rhombic lip to the inferior olive, the nucleus raph\u00e9 and the pons. A morphological and experimental investigation on chick embryos","volume":"100","author":"Harkmark","year":"1954","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.autneu.2003.10.004_BIB17","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S0165-1838(98)00009-5","article-title":"The role of the medullary raph\u00e9 nuclei in regulation of cholinergic outflow to the airways","volume":"69","author":"Haxhiu","year":"1998","journal-title":"J. Auton. Nerv. Syst."},{"issue":"2","key":"10.1016\/j.autneu.2003.10.004_BIB18","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0034-5687(00)00191-2","article-title":"Effect of 8-OH 8-OH-DPAT and ketanserin on the ventilatory acclimatization to hypoxia in awake goats","volume":"124","author":"Herman","year":"2001","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.autneu.2003.10.004_BIB19","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1002\/cne.902700402","article-title":"5-HT system in the brainstem of the marmoset: a combined immunocytochemical and three-dimensional reconstruction study","volume":"270","author":"Hornung","year":"1988","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.autneu.2003.10.004_BIB20","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0304-3940(83)90028-9","article-title":"Distribution of serotonin nerve cells in the rabbit brainstem","volume":"38","author":"Howe","year":"1983","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.autneu.2003.10.004_BIB21","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0304-3940(88)90691-X","article-title":"Quantitative analysis of the distribution of serotonin-immunoreactive cell bodies in the mouse brain","volume":"91","author":"Ishimura","year":"1988","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.autneu.2003.10.004_BIB22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0361-9230(84)90003-0","article-title":"Atlas of 5-HT cell bodies in the cat brainstem: an immunocytochemical analysis","volume":"13","author":"Jacobs","year":"1984","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.autneu.2003.10.004_BIB46","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1093\/jnen\/60.3.228","article-title":"Medullary serotonergic network deficiency in the sudden infant death syndrome: review of a 15-year study of a single dataset","volume":"60","author":"Kinney","year":"2001","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.autneu.2003.10.004_BIB23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0006-8993(97)01127-X","article-title":"Brain 5-HT1A receptor autoradiography and hypothermic responses in rats bred for differences in 8-OH-DPAT sensitivity","volume":"782","author":"Knapp","year":"1998","journal-title":"Brain Res."},{"key":"10.1016\/j.autneu.2003.10.004_BIB24","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/0361-9230(82)90164-2","article-title":"Immunohistochemical study of the development of 5-HT neurons in the rat CNS","volume":"9","author":"Lidov","year":"1982","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.autneu.2003.10.004_BIB25","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1111\/j.1469-7793.1998.863bd.x","article-title":"Medullary raph\u00e9 neurones and baroreceptor modulation of the respiratory motor pattern in the cat","volume":"512","author":"Lindsey","year":"1988","journal-title":"J. Physiol. (Lond.)"},{"key":"10.1016\/j.autneu.2003.10.004_BIB26","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1007\/BF02272148","article-title":"5-HT receptors in mammalian brain: receptor autoradiography and in situ hybridization studies of new ligands and newly identified receptors","volume":"28","author":"Mengod","year":"1996","journal-title":"Histochem. J."},{"key":"10.1016\/j.autneu.2003.10.004_BIB27","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0924-977X(01)00133-X","article-title":"Increased REM sleep after intra-dorsal raphe nucleus injection of flesinoxan or 8-OHDPAT: prevention with WAY 100635","volume":"12","author":"Monti","year":"2002","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.autneu.2003.10.004_BIB28","first-page":"R273","article-title":"RVLM and raph\u00e9 differentially regulate sympathetic outflows to splanchnic and brown adipose tissue","volume":"276","author":"Morrison","year":"1999","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.autneu.2003.10.004_BIB29","first-page":"R290","article-title":"GABA-mediated inhibition of raph\u00e9 pallidus neurons regulates sympathetic outflow to brown adipose tissue","volume":"276","author":"Morrison","year":"1999","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.autneu.2003.10.004_BIB30","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1152\/jappl.2001.90.4.1247","article-title":"CO2 dialysis in the medullary raph\u00e9 of the rat increases ventilation in sleep","volume":"90","author":"Nattie","year":"2001","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.autneu.2003.10.004_BIB31","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1093\/jnen\/59.5.377","article-title":"Decreased 5-HT receptor binding in rhombic lip derived regions of the medulla oblongata in the sudden infant death syndrome","volume":"59","author":"Panigrahy","year":"2000","journal-title":"J. Neuropathol. Exp. Neurol."},{"year":"1986","author":"Paxinos","series-title":"The Rat Brain In Stereotaxic Coordinates","key":"10.1016\/j.autneu.2003.10.004_BIB32"},{"key":"10.1016\/j.autneu.2003.10.004_BIB33","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.1523\/JNEUROSCI.16-08-02820.1996","article-title":"Microdialysis perfusion of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) in the dorsal raphe nucleus decreases serotonin release and increases rapid eye movement sleep in the freely moving cat","volume":"16","author":"Portas","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1016\/j.autneu.2003.10.004_BIB34","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0301-0082(98)00097-5","article-title":"Serotonin and the sleep\/wake cycle: special emphasis on microdialysis studies","volume":"60","author":"Portas","year":"2000","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.autneu.2003.10.004_BIB35","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0034-5687(01)00289-4","article-title":"Chemosensitivity of 5-HT neurons in the rostral ventral medulla","volume":"129","author":"Richerson","year":"2001","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.autneu.2003.10.004_BIB36","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1073\/pnas.98.4.1912","article-title":"Genetic and pharmacological disruption of neurokinin 1 receptor function decreases anxiety-related behaviors and increases 5-HT function","volume":"98","author":"Santarelli","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"year":"1961","author":"Snider","series-title":"A Stereotaxic Atlas of the Cat Brain","key":"10.1016\/j.autneu.2003.10.004_BIB37"},{"key":"10.1016\/j.autneu.2003.10.004_BIB38","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/BF00216872","article-title":"Immunohistochemical demonstration of the distribution of serotonin neurons in the brainstem of the rat and cat","volume":"224","author":"Takeuchi","year":"1982","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.autneu.2003.10.004_BIB39","doi-asserted-by":"crossref","first-page":"4473","DOI":"10.1523\/JNEUROSCI.17-11-04473.1997","article-title":"Postnatal development of 5-HT innervation, 5-HT1A receptor expression, and 5-HT responses in rat motoneurons","volume":"17","author":"Talley","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/j.autneu.2003.10.004_BIB40","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/0306-4522(87)90073-X","article-title":"Immunocytochemical localization of serotonin-containing neurons in the myelencephalon, brainstem, and diencephalon of the sheep","volume":"23","author":"Tillet","year":"1987","journal-title":"Neuroscience"},{"key":"10.1016\/j.autneu.2003.10.004_BIB41","series-title":"The Human Nervous System","first-page":"1001","article-title":"Raphe nuclei and the 5-HT system","author":"Tork","year":"1990"},{"key":"10.1016\/j.autneu.2003.10.004_BIB42","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/j.1469-7793.1998.433bh.x","article-title":"Chemosensitivity of rat medullary raph\u00e9 neurons in primary tissue culture","volume":"511","author":"Wang","year":"1998","journal-title":"J. Physiol."},{"key":"10.1016\/j.autneu.2003.10.004_BIB43","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1152\/jn.2001.85.5.2224","article-title":"Acidosis-stimulated neurons of the medullary raph\u00e9 are sertonergic","volume":"85","author":"Wang","year":"2001","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.autneu.2003.10.004_BIB44","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0166-4328(98)00112-0","article-title":"Forebrain serotonin depletion facilitates the acquisition and performace of a conditional visual discrimination task in rats","volume":"100","author":"Ward","year":"1999","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.autneu.2003.10.004_BIB45","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1097\/00005072-199601000-00012","article-title":"Developmental changes in [3H]-lysergic acid diethylamide (LSD) binding to serotonin receptors in the human brainstem","volume":"55","author":"Zec","year":"1996","journal-title":"J. Neuropathol. Exp. Neurol."}],"container-title":["Autonomic Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1566070203002546?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1566070203002546?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T11:50:34Z","timestamp":1761565834000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1566070203002546"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,2]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,2]]}},"alternative-id":["S1566070203002546"],"URL":"https:\/\/doi.org\/10.1016\/j.autneu.2003.10.004","relation":{},"ISSN":["1566-0702"],"issn-type":[{"type":"print","value":"1566-0702"}],"subject":[],"published":{"date-parts":[[2004,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The development of the medullary serotonergic system in the piglet","name":"articletitle","label":"Article Title"},{"value":"Autonomic Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.autneu.2003.10.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}