{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T06:33:50Z","timestamp":1792046030759,"version":"4.4.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2006,4,1]],"date-time":"2006-04-01T00:00:00Z","timestamp":1143849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,4,1]],"date-time":"2006-04-01T00:00:00Z","timestamp":1143849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["autonomicneuroscience.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Autonomic Neuroscience"],"published-print":{"date-parts":[[2006,4]]},"DOI":"10.1016\/j.autneu.2006.01.004","type":"journal-article","created":{"date-parts":[[2006,3,21]],"date-time":"2006-03-21T07:49:17Z","timestamp":1142927357000},"page":"70-75","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":89,"title":["Efferent-like roles of afferent neurons in the gut: Blood flow regulation and tissue protection"],"prefix":"10.1016","volume":"125","author":[{"given":"Peter","family":"Holzer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.autneu.2006.01.004_bib1","first-page":"G268","article-title":"Acid-sensing pathways of rat duodenum","volume":"277","author":"Akiba","year":"1999","journal-title":"Am. J. Physiol."},{"issue":"Suppl. 14","key":"10.1016\/j.autneu.2006.01.004_bib2","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/BF03326432","article-title":"Acid-sensing pathways in rat gastrointestinal mucosa","volume":"37","author":"Akiba","year":"2002","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.autneu.2006.01.004_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1566-0702(00)00215-0","article-title":"Functional and chemical anatomy of the afferent vagal system","volume":"85","author":"Berthoud","year":"2000","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.autneu.2006.01.004_bib4","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1053\/gast.2002.31026","article-title":"Experimental ulcers alter voltage-sensitive sodium currents in rat gastric sensory neurons","volume":"122","author":"Bielefeldt","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.autneu.2006.01.004_bib5","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/39807","article-title":"The capsaicin receptor: a heat-activated ion channel in the pain pathway","volume":"389","author":"Caterina","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.autneu.2006.01.004_bib6","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1152\/physrev.1994.74.1.95","article-title":"Sensory innervation of the viscera: peripheral basis of visceral pain","volume":"74","author":"Cervero","year":"1994","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.autneu.2006.01.004_bib7","first-page":"H1350","article-title":"Role of calcitonin gene-related peptide in capsaicin-induced gastric submucosal arteriolar dilation","volume":"262","author":"Chen","year":"1992","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.autneu.2006.01.004_bib8","first-page":"G403","article-title":"Stomach\u2013brain communication by vagal afferents in response to luminal acid backdiffusion, gastrin, and gastric acid secretion","volume":"286","author":"Danzer","year":"2004","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.autneu.2006.01.004_bib9","series-title":"Rome II. The Functional Gastrointestinal Disorders","year":"2000"},{"key":"10.1016\/j.autneu.2006.01.004_bib10","first-page":"G834","article-title":"Pathobiology of visceral pain: molecular mechanisms and therapeutic implications: IV. Visceral afferent contributions to the pathobiology of visceral pain","volume":"278","author":"Gebhart","year":"2000","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.autneu.2006.01.004_bib11","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S1566-0702(00)00219-8","article-title":"Vagal immune-to-brain communication: a visceral chemosensory pathway","volume":"85","author":"Goehler","year":"2000","journal-title":"Auton. Neurosci."},{"issue":"Suppl. 1","key":"10.1016\/j.autneu.2006.01.004_bib12","doi-asserted-by":"crossref","first-page":"i2","DOI":"10.1136\/gut.51.suppl_1.i2","article-title":"Neuroanatomy of visceral nociception: vagal and splanchnic afferent","volume":"51","author":"Grundy","year":"2002","journal-title":"Gut"},{"key":"10.1016\/j.autneu.2006.01.004_bib13","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1111\/j.1476-5381.1996.tb16068.x","article-title":"Tachykinin inhibition of acid-induced gastric hyperaemia in the rat","volume":"119","author":"Heinemann","year":"1996","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.autneu.2006.01.004_bib14","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/0306-4522(88)90064-4","article-title":"Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides","volume":"24","author":"Holzer","year":"1988","journal-title":"Neuroscience"},{"key":"10.1016\/j.autneu.2006.01.004_bib15","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0031-6997(25)06664-5","article-title":"Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons","volume":"43","author":"Holzer","year":"1991","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.autneu.2006.01.004_bib16","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/S0016-5085(98)70597-9","article-title":"Neural emergency system in the stomach","volume":"114","author":"Holzer","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1016\/j.autneu.2006.01.004_bib17","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0306-3623(97)00078-5","article-title":"Neurogenic vasodilatation and plasma leakage in the skin","volume":"30","author":"Holzer","year":"1998","journal-title":"Gen. Pharmacol."},{"key":"10.1016\/j.autneu.2006.01.004_bib18","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1046\/j.1365-2982.2002.00353.x","article-title":"Sensory neurone responses to mucosal noxae in the upper gut: relevance to mucosal integrity and gastrointestinal pain","volume":"14","author":"Holzer","year":"2002","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.autneu.2006.01.004_bib19","series-title":"Experimental and Clinical Pharmacology of Gastroesophageal Reflux-Induced Asthma","first-page":"25","article-title":"Role of sensory neurons in mucosal protection from acid-induced lesions in the foregut","author":"Holzer","year":"2002"},{"key":"10.1016\/j.autneu.2006.01.004_bib20","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1517\/14728222.8.2.107","article-title":"Gastrointestinal pain in functional bowel disorders: sensory neurons as novel drug targets","volume":"8","author":"Holzer","year":"2004","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.autneu.2006.01.004_bib21","series-title":"Neurogenic Inflammation","first-page":"153","article-title":"Sensory neurons in the intestine","author":"Holzer","year":"1996"},{"key":"10.1016\/j.autneu.2006.01.004_bib22","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/0306-4522(88)90201-1","article-title":"Stimulation of afferent nerve endings by intragastric capsaicin protects against ethanol-induced damage of gastric mucosa","volume":"27","author":"Holzer","year":"1988","journal-title":"Neuroscience"},{"key":"10.1016\/j.autneu.2006.01.004_bib23","first-page":"389","article-title":"Dissociation of dorsal root ganglion neurons into afferent and efferent-like neurons","volume":"86","author":"Holzer","year":"1998","journal-title":"Neuroscience"},{"key":"10.1016\/j.autneu.2006.01.004_bib24","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/0016-5085(86)90702-X","article-title":"Gastric mucosal protection against ulcerogenic factors in the rat mediated by capsaicin-sensitive afferent neurons","volume":"91","author":"Holzer","year":"1986","journal-title":"Gastroenterology"},{"key":"10.1016\/j.autneu.2006.01.004_bib25","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/0016-5085(90)90005-L","article-title":"Afferent nerve-mediated protection against deep mucosal damage in the rat stomach","volume":"98","author":"Holzer","year":"1990","journal-title":"Gastroenterology"},{"key":"10.1016\/j.autneu.2006.01.004_bib26","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/0016-5085(91)90020-L","article-title":"Sensory neurons signal for an increase in rat gastric mucosal blood flow in the face of pending acid injury","volume":"101","author":"Holzer","year":"1991","journal-title":"Gastroenterology"},{"key":"10.1016\/j.autneu.2006.01.004_bib27","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1113\/jphysiol.1994.sp020385","article-title":"Vascular bed-dependent roles of the peptide CGRP and nitric oxide in acid-evoked hyperaemia of the rat stomach","volume":"480","author":"Holzer","year":"1994","journal-title":"J. Physiol. (Lond.)"},{"key":"10.1016\/j.autneu.2006.01.004_bib28","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.neuroscience.2004.07.040","article-title":"Vagal afferent input from the acid-challenged rat stomach to the brainstem: enhancement by interleukin-1beta","volume":"129","author":"Holzer","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.autneu.2006.01.004_bib29","first-page":"53","article-title":"Role of the nerve terminals in the mechanism of inflammatory reactions","volume":"7","author":"Jancs\u00f3","year":"1960","journal-title":"Bull. Millard Fillmore Hosp."},{"key":"10.1016\/j.autneu.2006.01.004_bib30","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/S0166-2236(00)02088-9","article-title":"Cytokine-induced sickness behaviour: mechanisms and implications","volume":"25","author":"Konsman","year":"2002","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.autneu.2006.01.004_bib31","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1016\/j.gastro.2003.07.010","article-title":"Gastric inflammation triggers hypersensitivity to acid in awake rats","volume":"125","author":"Lamb","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.autneu.2006.01.004_bib32","series-title":"Otto Loewi","author":"Lembeck","year":"1968"},{"key":"10.1016\/j.autneu.2006.01.004_bib33","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/0016-5085(92)90747-M","article-title":"Calcitonin gene-related peptide mediates the gastric hyperemic response to acid back-diffusion","volume":"102","author":"Li","year":"1992","journal-title":"Gastroenterology"},{"key":"10.1016\/j.autneu.2006.01.004_bib34","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1111\/j.1476-5381.1992.tb09043.x","article-title":"Participation of endothelium-derived nitric oxide but not prostacyclin in the gastric mucosal hyperaemia due to acid back-diffusion","volume":"105","author":"Lippe","year":"1992","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.autneu.2006.01.004_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0301-0082(94)E0017-B","article-title":"Tachykinins and calcitonin gene-related peptide (CGRP) as co-transmitters released from peripheral endings of sensory nerves","volume":"45","author":"Maggi","year":"1995","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.autneu.2006.01.004_bib36","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0304-3959(00)00467-X","article-title":"Vagal afferent signaling of a gastric mucosal acid insult to medullary, pontine, thalamic, hypothalamic and limbic, but not cortical, nuclei of the rat brain","volume":"92","author":"Michl","year":"2001","journal-title":"Pain"},{"key":"10.1016\/j.autneu.2006.01.004_bib37","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0196-9781(92)90104-B","article-title":"Selective ablation of spinal afferent neurons containing CGRP attenuates gastric hyperemic response to acid","volume":"13","author":"Raybould","year":"1992","journal-title":"Peptides"},{"key":"10.1016\/j.autneu.2006.01.004_bib38","first-page":"G1316","article-title":"Mucosal acid challenge activates nitrergic neurons in the myenteric plexus of the rat stomach","volume":"281","author":"Schicho","year":"2001","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.autneu.2006.01.004_bib39","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1046\/j.1365-2982.2003.00384.x","article-title":"Capsaicin-sensitive extrinsic afferents are involved in acid-induced activation of distinct myenteric neurons in the rat stomach","volume":"15","author":"Schicho","year":"2003","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.autneu.2006.01.004_bib40","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1111\/j.1460-9568.2004.03290.x","article-title":"Increased expression of TRPV1 receptor in dorsal root ganglia by acid insult of the rat gastric mucosa","volume":"19","author":"Schicho","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.autneu.2006.01.004_bib41","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S0016-5085(98)70144-1","article-title":"Gastric acid-evoked c-fos messenger RNA expression in rat brainstem is signaled by capsaicin-resistant vagal afferents","volume":"115","author":"Schuligoi","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1016\/j.autneu.2006.01.004_bib42","first-page":"G1017","article-title":"Tachykinin-induced increase in gastric mucosal resistance: role of primary afferent neurons, CGRP, and NO","volume":"271","author":"Stroff","year":"1996","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.autneu.2006.01.004_bib43","series-title":"Gastrointestinal Defense Mechanisms","first-page":"39","article-title":"Impaired defense mechanism to peptic ulcer in the capsaicin-desensitized rat","author":"Szolcs\u00e1nyi","year":"1981"},{"key":"10.1016\/j.autneu.2006.01.004_bib44","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/0306-4522(96)00173-X","article-title":"Differential c-fos expression in the nucleus of the solitary tract and spinal cord following noxious gastric distention in the rat","volume":"74","author":"Traub","year":"1996","journal-title":"Neuroscience"},{"key":"10.1016\/j.autneu.2006.01.004_bib45","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1007\/BF02064374","article-title":"Chili protects against aspirin-induced gastroduodenal mucosal injury in humans","volume":"40","author":"Yeoh","year":"1995","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.autneu.2006.01.004_fr1","series-title":"Proceedings of the Pavlov Centenary Symposium Held in St. Petersburg, Russia, 19\u201322 June","year":"2004"}],"container-title":["Autonomic Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1566070206000075?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1566070206000075?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T11:53:47Z","timestamp":1761566027000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1566070206000075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4]]},"references-count":46,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2006,4]]}},"alternative-id":["S1566070206000075"],"URL":"https:\/\/doi.org\/10.1016\/j.autneu.2006.01.004","relation":{},"ISSN":["1566-0702"],"issn-type":[{"value":"1566-0702","type":"print"}],"subject":[],"published":{"date-parts":[[2006,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efferent-like roles of afferent neurons in the gut: Blood flow regulation and tissue protection","name":"articletitle","label":"Article Title"},{"value":"Autonomic Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.autneu.2006.01.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}