{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T13:12:37Z","timestamp":1777468357979,"version":"3.51.4"},"reference-count":41,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["autonomicneuroscience.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Autonomic Neuroscience"],"published-print":{"date-parts":[[2007,1]]},"DOI":"10.1016\/j.autneu.2006.06.005","type":"journal-article","created":{"date-parts":[[2006,7,27]],"date-time":"2006-07-27T07:16:19Z","timestamp":1153984579000},"page":"28-35","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Parasympathetic dysfunction is associated with baroreflex and chemoreflex impairment in streptozotocin-induced diabetes in rats"],"prefix":"10.1016","volume":"131","author":[{"given":"Pedro","family":"Dall'Ago","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz","family":"D'Agord Schaan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viviane Oliveira Kenne","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana","family":"Werner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro Paulo","family":"da Silva Soares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K\u00e1tia","family":"de Angelis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Cl\u00e1udia","family":"Irigoyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.autneu.2006.06.005_bib1","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.2337\/diab.38.12.1611","article-title":"Insulin prevention of altered muscarinic receptor-G protein coupling in diabetic rat atria","volume":"38","author":"Aronstam","year":"1989","journal-title":"Diabetes"},{"issue":"4","key":"10.1016\/j.autneu.2006.06.005_bib2","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1161\/01.HYP.4.4.556","article-title":"Streptozotocin diabetic rats are hypertensive despite reduced hypothalamic responsiveness","volume":"4","author":"Bunag","year":"1982","journal-title":"Hypertension"},{"issue":"10","key":"10.1016\/j.autneu.2006.06.005_bib3","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/S0022-2828(84)80032-2","article-title":"Cholinergic supersensitivity and decreased number of muscarinic receptors in atria from short-term diabetic rats","volume":"16","author":"Carrier","year":"1984","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"6","key":"10.1016\/j.autneu.2006.06.005_bib4","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/S0022-2828(86)80969-5","article-title":"Alterations in the baroreceptor reflex control of heart rate in streptozotocin diabetic rats","volume":"18","author":"Chang","year":"1986","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"2","key":"10.1016\/j.autneu.2006.06.005_bib5","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1124\/jpet.103.057570","article-title":"Insulin regulates neuronal M2 muscarinic receptor function in the ileum of diabetic rats","volume":"308","author":"Coulson","year":"2004","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"1","key":"10.1016\/j.autneu.2006.06.005_bib6","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1590\/S0100-879X1997000100018","article-title":"Baroreflex and chemoreflex dysfunction in streptozotocin-diabetic rats","volume":"30","author":"Dall'Ago","year":"1997","journal-title":"Braz. J. Med. Biol. Res."},{"issue":"7","key":"10.1016\/j.autneu.2006.06.005_bib7","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1590\/S0100-879X2002000700013","article-title":"Reflex control of arterial pressure and heart rate in short-term streptozotocin diabetic rats","volume":"35","author":"Dall'Ago","year":"2002","journal-title":"Braz. J. Med. Biol. Res."},{"issue":"11","key":"10.1016\/j.autneu.2006.06.005_bib8","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1590\/S0100-879X2000001100016","article-title":"Oxidative stress in the latissimus dorsi muscle of diabetic rats","volume":"33","author":"De Angelis","year":"2000","journal-title":"Braz. J. Med. Biol. Res."},{"issue":"6","key":"10.1016\/j.autneu.2006.06.005_bib9","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1590\/S0100-879X2000000600004","article-title":"Effects of exercise training on autonomic and myocardial dysfunction in streptozotocin-diabetic rats","volume":"33","author":"De Angelis","year":"2000","journal-title":"Braz. J. Med. Biol. Res."},{"issue":"9","key":"10.1016\/j.autneu.2006.06.005_bib10","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1590\/S0100-879X2002000900010","article-title":"Cardiovascular control in experimental diabetes","volume":"35","author":"De Angelis","year":"2002","journal-title":"Braz. J. Med. Biol. Res."},{"issue":"193","key":"10.1016\/j.autneu.2006.06.005_bib11","first-page":"95","article-title":"The natural history of diabetic autonomic neuropathy","volume":"49","author":"Ewing","year":"1980","journal-title":"Q. J. Med."},{"issue":"1","key":"10.1016\/j.autneu.2006.06.005_bib12","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0165-1838(93)90342-R","article-title":"Cardiovascular responses of conscious rats to carotid body chemoreceptor stimulation by intravenous KCN","volume":"42","author":"Franchini","year":"1993","journal-title":"J. Auton. Nerv. Syst."},{"issue":"2","key":"10.1016\/j.autneu.2006.06.005_bib13","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0006-8993(79)90861-8","article-title":"Administration of an organophosphate causes a decrease in muscarinic receptor levels in rat brain","volume":"174","author":"Gazit","year":"1979","journal-title":"Brain Res."},{"issue":"8 Pt 1","key":"10.1016\/j.autneu.2006.06.005_bib14","doi-asserted-by":"crossref","first-page":"730","DOI":"10.2337\/diab.31.8.730","article-title":"Pathophysiology in diabetic autonomic neuropathy: cardiovascular, hormonal, and metabolic studies","volume":"31","author":"Hilsted","year":"1982","journal-title":"Diabetes"},{"issue":"2","key":"10.1016\/j.autneu.2006.06.005_bib15","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1097\/00005344-198303000-00016","article-title":"Influence of short-term experimental diabetes on blood pressure and heart rate in response to norepinephrine and angiotensin II in the conscious rat","volume":"5","author":"Jackson","year":"1983","journal-title":"J. Cardiovasc. Pharmacol."},{"issue":"12","key":"10.1016\/j.autneu.2006.06.005_bib16","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1111\/j.2042-7158.1987.tb03151.x","article-title":"Muscarinic receptor density is reduced in diabetic rat atria, an effect prevented by the aldose reductase inhibitor, Statil","volume":"39","author":"Kofo-Abayomi","year":"1987","journal-title":"J. Pharm. Pharmacol."},{"issue":"6","key":"10.1016\/j.autneu.2006.06.005_bib17","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/S0026-895X(24)12084-6","article-title":"Quantitation of mRNAs for M(1) to M(5) subtypes of muscarinic receptors in rat heart and brain cortex","volume":"61","author":"Krejci","year":"2002","journal-title":"Mol. Pharmacol."},{"issue":"5","key":"10.1016\/j.autneu.2006.06.005_bib18","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1161\/01.HYP.10.5.517","article-title":"Does so-called streptozocin hypertension exist in rats?","volume":"10","author":"Kusaka","year":"1987","journal-title":"Hypertension"},{"issue":"1\u20132","key":"10.1016\/j.autneu.2006.06.005_bib19","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.neulet.2005.03.063","article-title":"The role of sorbitol pathway and treatment effect of aldose reductase inhibitor ONO2235 in the up-regulation of cardiac M2-muscarinic receptors in streptozotocin-induced diabetic rats","volume":"383","author":"Liu","year":"2005","journal-title":"Neurosci. Lett."},{"issue":"6 Pt 2","key":"10.1016\/j.autneu.2006.06.005_bib20","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1161\/01.HYP.26.6.1100","article-title":"Autonomic dysfunction in short-term experimental diabetes","volume":"26","author":"Maeda","year":"1995","journal-title":"Hypertension"},{"issue":"2 Pt 1","key":"10.1016\/j.autneu.2006.06.005_bib21","first-page":"E202","article-title":"Sarcolemmal Ca2+ transport in streptozotocin-induced diabetic cardiomyopathy in rats","volume":"253","author":"Makino","year":"1987","journal-title":"Am. J. Physiol."},{"issue":"7","key":"10.1016\/j.autneu.2006.06.005_bib22","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1590\/S0100-879X1998000700002","article-title":"Chemoreceptors and cardiovascular control in acute and chronic systemic hypoxia","volume":"31","author":"Marshall","year":"1998","journal-title":"Braz. J. Med. Biol. Res."},{"issue":"1 Pt 2","key":"10.1016\/j.autneu.2006.06.005_bib23","first-page":"H235","article-title":"Baroreflex dysfunction in diabetes mellitus: I. Selective impairment of parasympathetic control of heart rate","volume":"266","author":"McDowell","year":"1994","journal-title":"Am. J. Physiol."},{"issue":"2","key":"10.1016\/j.autneu.2006.06.005_bib24","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1017\/S0317167100023519","article-title":"Autonomic neuropathy in the streptozotocin diabetic rat","volume":"7","author":"Monckton","year":"1980","journal-title":"Can. J. Neurol. Sci."},{"issue":"9","key":"10.1016\/j.autneu.2006.06.005_bib25","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.2337\/diabetes.53.9.2392","article-title":"Increased expression of Gi-coupled muscarinic acetylcholine receptor and Gi in atrium of elderly diabetic subjects","volume":"53","author":"Richardson","year":"2004","journal-title":"Diabetes"},{"issue":"10","key":"10.1016\/j.autneu.2006.06.005_bib26","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1093\/cvr\/26.10.913","article-title":"The diabetic heart: metabolic causes for the development of a cardiomyopathy","volume":"26","author":"Rodrigues","year":"1992","journal-title":"Cardiovasc. Res."},{"issue":"278","key":"10.1016\/j.autneu.2006.06.005_bib27","first-page":"635","article-title":"Progression of diabetic autonomic neuropathy over a decade in insulin-dependent diabetics","volume":"75","author":"Sampson","year":"1990","journal-title":"Q. J. Med."},{"issue":"9","key":"10.1016\/j.autneu.2006.06.005_bib28","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1590\/S0100-879X1997000900006","article-title":"Time course of changes in heart rate and blood pressure variability in streptozotocin-induced diabetic rats treated with insulin","volume":"30","author":"Schaan","year":"1997","journal-title":"Braz. J. Med. Biol. Res."},{"issue":"8","key":"10.1016\/j.autneu.2006.06.005_bib29","first-page":"889","article-title":"Relationship between cardiovascular dysfunction and hyperglycemia in streptozotocin-induced diabetes","volume":"37","author":"Schaan BDDA","year":"2004","journal-title":"Braz. J. Med. Biol. Res."},{"issue":"9","key":"10.1016\/j.autneu.2006.06.005_bib30","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1016\/S0026-0495(96)90018-9","article-title":"Cardioprotective effects of troglitazone in streptozotocin-induced diabetic rats","volume":"45","author":"Shimabukuro","year":"1996","journal-title":"Metabolism"},{"issue":"2","key":"10.1016\/j.autneu.2006.06.005_bib31","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1097\/00005344-199208000-00002","article-title":"Effects of probucol on impaired cardiac performance and lipid metabolism in streptozotocin-induced diabetic rats","volume":"20","author":"Tada","year":"1992","journal-title":"J. Cardiovasc. Pharmacol."},{"issue":"11","key":"10.1016\/j.autneu.2006.06.005_bib32","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/0024-3205(86)90229-8","article-title":"Diabetes-induced abnormalities in the myocardium","volume":"38","author":"Tahiliani","year":"1986","journal-title":"Life Sci."},{"issue":"5","key":"10.1016\/j.autneu.2006.06.005_bib33","first-page":"250","article-title":"Changes in vascular reactivity in experimental diabetic rats: comparison with hypothyroid rats","volume":"25","author":"Takiguchi","year":"1988","journal-title":"Blood Vessels"},{"issue":"2","key":"10.1016\/j.autneu.2006.06.005_bib34","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0304-3940(82)90115-X","article-title":"Reversal, by treatment with an aldose reductase inhibitor, of impaired axonal transport and motor nerve conduction velocity in experimental diabetes mellitus","volume":"31","author":"Tomlinson","year":"1982","journal-title":"Neurosci. Lett."},{"issue":"1","key":"10.1016\/j.autneu.2006.06.005_bib35","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0304-3940(02)00713-9","article-title":"Effects of Ba-Wei-Die-Huang-Wan on the cholinergic function and protein expression of M2 muscarinic receptor of the urinary bladder in diabetic rats","volume":"330","author":"Tong","year":"2002","journal-title":"Neurosci. Lett."},{"issue":"3","key":"10.1016\/j.autneu.2006.06.005_bib36","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/S0008-6363(98)00038-8","article-title":"In vivo cardiovascular reactivity and baroreflex activity in diabetic rats","volume":"38","author":"Van Buren","year":"1998","journal-title":"Cardiovasc. Res."},{"issue":"5","key":"10.1016\/j.autneu.2006.06.005_bib37","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1124\/mol.59.5.1029","article-title":"Expression of multiple subtypes of muscarinic receptors and cellular distribution in the human heart","volume":"59","author":"Wang","year":"2001","journal-title":"Mol. Pharmacol."},{"issue":"3","key":"10.1016\/j.autneu.2006.06.005_bib38","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/sj.bjp.0705787","article-title":"Functional M3 muscarinic acetylcholine receptors in mammalian hearts","volume":"142","author":"Wang","year":"2004","journal-title":"Br. J. Pharmacol."},{"issue":"5","key":"10.1016\/j.autneu.2006.06.005_bib39","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1249\/00005768-198710000-00013","article-title":"Select cardiovascular and metabolic responses of diabetic rats to moderate exercise training","volume":"19","author":"Wegner","year":"1987","journal-title":"Med. Sci. Sports Exerc."},{"issue":"4","key":"10.1016\/j.autneu.2006.06.005_bib40","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/0006-291X(80)90405-2","article-title":"Decrease or increase in cardiac muscarinic cholinergic receptor number in rats treated with methacholine or atropine","volume":"92","author":"Wise","year":"1980","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"3","key":"10.1016\/j.autneu.2006.06.005_bib41","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/dmr.5610110304","article-title":"Pathology and pathogenetic mechanisms of diabetic neuropathy","volume":"11","author":"Yagihashi","year":"1995","journal-title":"Diabetes Metab. Rev."}],"container-title":["Autonomic Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1566070206001962?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1566070206001962?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T11:53:45Z","timestamp":1761566025000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1566070206001962"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1]]},"references-count":41,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["S1566070206001962"],"URL":"https:\/\/doi.org\/10.1016\/j.autneu.2006.06.005","relation":{},"ISSN":["1566-0702"],"issn-type":[{"value":"1566-0702","type":"print"}],"subject":[],"published":{"date-parts":[[2007,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Parasympathetic dysfunction is associated with baroreflex and chemoreflex impairment in streptozotocin-induced diabetes in rats","name":"articletitle","label":"Article Title"},{"value":"Autonomic Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.autneu.2006.06.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}