{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T11:41:19Z","timestamp":1792669279576,"version":"4.5.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["autonomicneuroscience.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Autonomic Neuroscience"],"published-print":{"date-parts":[[2008,12]]},"DOI":"10.1016\/j.autneu.2008.08.004","type":"journal-article","created":{"date-parts":[[2008,9,26]],"date-time":"2008-09-26T05:02:32Z","timestamp":1222405352000},"page":"22-29","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Nerve sprouting suppresses myocardial Ito and IK1 channels and increases severity to ventricular fibrillation in rat"],"prefix":"10.1016","volume":"144","author":[{"given":"Chongyu","family":"Ren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuzhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dejie","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Min","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.autneu.2008.08.004_bib1","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1161\/01.RES.77.2.361","article-title":"Differential expression of voltage-gated K+ channel subunits in adult rat heart. Relation to functional K+ channels?","volume":"77","author":"Barry","year":"1995","journal-title":"Circ. Res."},{"key":"10.1016\/j.autneu.2008.08.004_bib2","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/(SICI)1521-2254(200001\/02)2:1<2::AID-JGM83>3.0.CO;2-O","article-title":"Myocardial injury-induced fibroblast proliferation facilitates retroviral-mediated gene transfer to the rat heart in vivo","volume":"2","author":"Byun","year":"2000","journal-title":"J. Gene Med."},{"key":"10.1016\/j.autneu.2008.08.004_bib3","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1161\/01.RES.84.11.1318","article-title":"Spatiotemporal heterogeneity in the induction of ventricular fibrillation by rapid pacing: importance of cardiac restitution properties","volume":"84","author":"Cao","year":"1999","journal-title":"Circ. Res."},{"key":"10.1016\/j.autneu.2008.08.004_bib4","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1161\/01.RES.86.7.816","article-title":"Nerve sprouting and sudden cardiac death","volume":"86","author":"Cao","year":"2000","journal-title":"Circ. Res."},{"key":"10.1016\/j.autneu.2008.08.004_bib5","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1161\/01.CIR.101.16.1960","article-title":"Regional cardiac hyperinnervation in patients with ventricular tachyarrhythmia","volume":"101","author":"Cao","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.autneu.2008.08.004_bib6","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1472-8206.1993.tb00214.x","article-title":"K+ channels and control of ventricular repolarization in the heart","volume":"7","author":"Carmeliet","year":"1993","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.autneu.2008.08.004_bib7","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1146\/annurev.neuro.24.1.551","article-title":"The path to the discovery of nerve growth factor","volume":"24","author":"Cowan","year":"2001","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.autneu.2008.08.004_bib8","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1161\/01.CIR.96.4.1337","article-title":"Heterogeneous sympathetic innervation in German shepherd dogs with inherited ventricular arrhythmia and sudden cardiac death","volume":"96","author":"Dae","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.autneu.2008.08.004_bib9","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1111\/j.1540-8167.1997.tb00848.x","article-title":"Decreased density of Ito in left ventricular myocytes from German shepherd dogs with inherited arrhythmias","volume":"8","author":"Freeman","year":"1997","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"10.1016\/j.autneu.2008.08.004_bib10","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1016\/0735-1097(95)00618-4","article-title":"Triggered activity as a mechanism for inherited ventricular arrhythmias in German shepherd Dogs","volume":"27","author":"Gilmour","year":"1996","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.autneu.2008.08.004_bib11","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/0014-4886(92)90064-W","article-title":"Effect of 4-methylcatechol on sciatic nerve growth factor level and motor nerve conduction velocity in experimental diabetic neuropathic process in rats","volume":"115","author":"Hanaoka","year":"1992","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.autneu.2008.08.004_bib12","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1006\/dbio.1995.1146","article-title":"Overexpression of NGF within the heart of transgenic mice causes hyperinnervation, cardiac enlargement, and hyperplasia of ectopic cells","volume":"169","author":"Hassankhani","year":"1995","journal-title":"Dev. Biol."},{"key":"10.1016\/j.autneu.2008.08.004_bib13","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1111\/j.1469-7793.1998.779bd.x","article-title":"Overexpression of nerve growth factor in the heart alters ion channel activity and beta-adrenergic signalling in an adult transgenic mouse","volume":"512","author":"Heath","year":"1998","journal-title":"J. Physiol."},{"key":"10.1016\/j.autneu.2008.08.004_bib14","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1469-7793.1999.0229z.x","article-title":"Relationship between K+ channel down-regulation and [Ca2+]i in rat ventricular myocytes following myocardial infarction","volume":"517","author":"Kaprielian","year":"1999","journal-title":"J. Physiol."},{"key":"10.1016\/j.autneu.2008.08.004_bib15","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/S0092-8674(01)00588-8","article-title":"A defect in the Kv channel-interacting protein 2 (KChIP2) gene leads to a complete loss of I(to) and confers susceptibility to ventricular tachycardia","volume":"107","author":"Kuo","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.autneu.2008.08.004_bib16","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/j.1469-7580.2006.00528.x","article-title":"Effects of increased nerve growth factor plasma levels on the expression of TrkA and p75 in rat testicles","volume":"208","author":"Levanti","year":"2006","journal-title":"J. Anat."},{"key":"10.1016\/j.autneu.2008.08.004_bib17","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/j.1469-7793.2000.t01-1-00285.x","article-title":"Molecular basis of functional voltage-gated K+ channel diversity in the mammalian myocardium","volume":"525","author":"Nerbonne","year":"2000","journal-title":"J. Physiol."},{"key":"10.1016\/j.autneu.2008.08.004_bib18","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1152\/physrev.00002.2005","article-title":"Molecular physiology of cardiac repolarization","volume":"85","author":"Nerbonne","year":"2005","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.autneu.2008.08.004_bib19","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.cardiores.2005.05.028","article-title":"The cAMP response element binding protein modulates expression of the transient outward current: implications for cardiac memory","volume":"68","author":"Patberg","year":"2005","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.autneu.2008.08.004_bib20","doi-asserted-by":"crossref","first-page":"H255","DOI":"10.1152\/ajpheart.00668.2005","article-title":"Critical mass hypothesis revisited: role of dynamical wave stability in spontaneous termination of cardiac fibrillation","volume":"290","author":"Qu","year":"2006","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.autneu.2008.08.004_bib21","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/0896-6273(94)90438-3","article-title":"Membrane depolarization and calcium influx stimulate MEK and MAP kinase via activation of Ras","volume":"12","author":"Rosen","year":"1994","journal-title":"Neuron"},{"key":"10.1016\/j.autneu.2008.08.004_bib22","first-page":"403","article-title":"Effects of 4-methylcatechol, a stimulator of endogenous nerve growth factor synthesis, on experimental acrylamide-induced neuropathy in rats","volume":"16","author":"Saita","year":"1995","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.autneu.2008.08.004_bib23","doi-asserted-by":"crossref","first-page":"C852","DOI":"10.1152\/ajpcell.00358.2005","article-title":"ERK\/MAPK regulates the Kv4.2 potassium channel by direct phosphorylation of the pore-forming subunit","volume":"290","author":"Schrader","year":"2006","journal-title":"Am. J. Physiol. Cell. Physiol."},{"key":"10.1016\/j.autneu.2008.08.004_bib24","doi-asserted-by":"crossref","first-page":"10240","DOI":"10.1523\/JNEUROSCI.2764-04.2004","article-title":"Extracellular signal-regulated kinase 1\/2 signaling pathway in solitary nucleus mediates cholecystokinin-induced suppression of food intake in rats","volume":"24","author":"Sutton","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.autneu.2008.08.004_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1471-4159.2001.00054.x","article-title":"The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory","volume":"76","author":"Sweatt","year":"2001","journal-title":"J. Neurochem."},{"key":"10.1016\/j.autneu.2008.08.004_bib26","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1152\/physrev.1999.79.1.215","article-title":"Molecular mechanisms of myocardial remodeling","volume":"79","author":"Swynghedauw","year":"1999","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.autneu.2008.08.004_bib27","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1046\/j.1540-8167.2002.00051.x","article-title":"T-wave alternans as a predictor of spontaneous ventricular tachycardia in a canine model of sudden cardiac death","volume":"13","author":"Tsai","year":"2002","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"10.1016\/j.autneu.2008.08.004_bib28","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1161\/01.RES.80.6.772","article-title":"Outward K+ current densities and Kv1.5 expression are reduced in chronic human atrial fibrillation","volume":"80","author":"Van Wagoner","year":"1997","journal-title":"Circ. Res."},{"key":"10.1016\/j.autneu.2008.08.004_bib29","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1093\/cvr\/19.2.76","article-title":"Freeze-thaw injury of rat heart across an intact diaphragm: a new model for the study of the response of myocardium to injury","volume":"19","author":"Vracko","year":"1985","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.autneu.2008.08.004_bib30","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1152\/japplphysiol.00267.2005","article-title":"Role of parasympathetic overactivity in water immersion stress-induced gastric mucosal lesion in rat","volume":"99","author":"Xie","year":"2005","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.autneu.2008.08.004_bib31","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0006-8993(93)91012-H","article-title":"Elevated concentrations of nerve growth factor in heart and mesenteric arteries of spontaneously hypertensive rats","volume":"614","author":"Zettler","year":"1993","journal-title":"Brain Res."},{"key":"10.1016\/j.autneu.2008.08.004_bib32","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1046\/j.1540-8167.2001.01068.x","article-title":"Modulation of QT interval by cardiac sympathetic nerve sprouting and the mechanisms of ventricular arrhythmia in a canine model of sudden cardiac death","volume":"12","author":"Zhou","year":"2001","journal-title":"J. Cardiovasc. Electrophysiol."}],"container-title":["Autonomic Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1566070208001409?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1566070208001409?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T11:55:58Z","timestamp":1761566158000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1566070208001409"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12]]},"references-count":32,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["S1566070208001409"],"URL":"https:\/\/doi.org\/10.1016\/j.autneu.2008.08.004","relation":{},"ISSN":["1566-0702"],"issn-type":[{"value":"1566-0702","type":"print"}],"subject":[],"published":{"date-parts":[[2008,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nerve sprouting suppresses myocardial Ito and IK1 channels and increases severity to ventricular fibrillation in rat","name":"articletitle","label":"Article Title"},{"value":"Autonomic Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.autneu.2008.08.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}