{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T23:06:42Z","timestamp":1794265602789,"version":"4.9.0"},"reference-count":123,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["autonomicneuroscience.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Autonomic Neuroscience"],"published-print":{"date-parts":[[2009,11]]},"DOI":"10.1016\/j.autneu.2009.09.001","type":"journal-article","created":{"date-parts":[[2009,9,24]],"date-time":"2009-09-24T08:58:25Z","timestamp":1253782705000},"page":"61-69","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":81,"title":["Enteric nervous system development: Recent progress and future challenges"],"prefix":"10.1016","volume":"151","author":[{"given":"C\u00e1tia","family":"Laranjeira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vassilis","family":"Pachnis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.autneu.2009.09.001_bib1","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/nrn812","article-title":"The GDNF family: signalling, biological functions and therapeutic value","volume":"3","author":"Airaksinen","year":"2002","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.autneu.2009.09.001_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/jmg.2007.053959","article-title":"Hirschsprung disease, associated syndromes and genetics: a review","volume":"45","author":"Amiel","year":"2008","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.autneu.2009.09.001_bib3","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.ydbio.2007.02.020","article-title":"Effects of different regions of the developing gut on the migration of enteric neural crest-derived cells: a role for Sema3A, but not Sema3F","volume":"305","author":"Anderson","year":"2007","journal-title":"Dev. Biol."},{"key":"10.1016\/j.autneu.2009.09.001_bib4","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0012-1606(89)90217-0","article-title":"Transient catecholaminergic (TC) cells in the vagus nerves and bowel of fetal mice: relationship to the development of enteric neurons","volume":"132","author":"Baetge","year":"1989","journal-title":"Dev. Biol."},{"key":"10.1016\/j.autneu.2009.09.001_bib5","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/0012-1606(90)90391-U","article-title":"Transiently catecholaminergic (TC) cells in the bowel of the fetal rat: precursors of noncatecholaminergic enteric neurons","volume":"141","author":"Baetge","year":"1990","journal-title":"Dev. Biol."},{"key":"10.1016\/j.autneu.2009.09.001_bib6","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/S0896-6273(03)00730-X","article-title":"Enteric nervous system progenitors are coordinately controlled by the G protein-coupled receptor EDNRB and the receptor tyrosine kinase RET","volume":"40","author":"Barlow","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.autneu.2009.09.001_bib7","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1242\/dev.017418","article-title":"Critical numbers of neural crest cells are required in the pathways from the neural tube to the foregut to ensure complete enteric nervous system formation","volume":"135","author":"Barlow","year":"2008","journal-title":"Development"},{"key":"10.1016\/j.autneu.2009.09.001_bib8","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.devcel.2004.12.004","article-title":"Sprouty1 is a critical regulator of GDNF\/RET-mediated kidney induction","volume":"8","author":"Basson","year":"2005","journal-title":"Dev. Cell"},{"key":"10.1016\/j.autneu.2009.09.001_bib9","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.ydbio.2006.08.051","article-title":"Branching morphogenesis of the ureteric epithelium during kidney development is coordinated by the opposing functions of GDNF and Sprouty1","volume":"299","author":"Basson","year":"2006","journal-title":"Dev. Biol."},{"key":"10.1016\/j.autneu.2009.09.001_bib10","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1002\/bies.20221","article-title":"STOP and GO with NO: nitric oxide as a regulator of cell motility in simple brains","volume":"27","author":"Bicker","year":"2005","journal-title":"Bioessays"},{"key":"10.1016\/j.autneu.2009.09.001_bib11","doi-asserted-by":"crossref","first-page":"031912","DOI":"10.1103\/PhysRevE.78.031912","article-title":"Modeling proliferative tissue growth: a general approach and an avian case study","volume":"78","author":"Binder","year":"2008","journal-title":"Phys. Rev. E Stat. Nonlin. Soft Matter Phys."},{"key":"10.1016\/j.autneu.2009.09.001_bib12","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1242\/dev.122.1.309","article-title":"Distinct subpopulations of enteric neuronal progenitors defined by time of development, sympathoadrenal lineage markers and Mash-1-dependence","volume":"122","author":"Blaugrund","year":"1996","journal-title":"Development"},{"key":"10.1016\/j.autneu.2009.09.001_bib13","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1242\/dev.025163","article-title":"Non-cell-autonomous effects of Ret deletion in early enteric neurogenesis","volume":"135","author":"Bogni","year":"2008","journal-title":"Development"},{"key":"10.1016\/j.autneu.2009.09.001_bib14","doi-asserted-by":"crossref","first-page":"6387","DOI":"10.1242\/dev.00857","article-title":"Neuron and glia generating progenitors of the mammalian enteric nervous system isolated from foetal and postnatal gut cultures","volume":"130","author":"Bondurand","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.autneu.2009.09.001_bib15","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1242\/dev.02375","article-title":"Maintenance of mammalian enteric nervous system progenitors by SOX10 and endothelin 3 signalling","volume":"133","author":"Bondurand","year":"2006","journal-title":"Development"},{"key":"10.1016\/j.autneu.2009.09.001_bib16","doi-asserted-by":"crossref","first-page":"4056","DOI":"10.1093\/emboj\/19.15.4056","article-title":"The RET proto-oncogene induces apoptosis: a novel mechanism for Hirschsprung disease","volume":"19","author":"Bordeaux","year":"2000","journal-title":"Embo J."},{"key":"10.1016\/j.autneu.2009.09.001_bib17","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/1097-0185(20010101)262:1<58::AID-AR1011>3.0.CO;2-V","article-title":"Classes of enteric nerve cells in the guinea-pig small intestine","volume":"262","author":"Brookes","year":"2001","journal-title":"Anat. Rec."},{"issue":"Pt 2","key":"10.1016\/j.autneu.2009.09.001_bib18","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/j.1469-7793.1997.473bb.x","article-title":"Orally projecting interneurones in the guinea-pig small intestine","volume":"505","author":"Brookes","year":"1997","journal-title":"J. Physiol."},{"key":"10.1016\/j.autneu.2009.09.001_bib19","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1387\/ijdb.041935ab","article-title":"Migration of neural crest-derived enteric nervous system precursor cells to and within the gastrointestinal tract","volume":"49","author":"Burns","year":"2005","journal-title":"Int. J. Dev. Biol."},{"key":"10.1016\/j.autneu.2009.09.001_bib20","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1242\/dev.129.12.2785","article-title":"In ovo transplantation of enteric nervous system precursors from vagal to sacral neural crest results in extensive hindgut colonisation","volume":"129","author":"Burns","year":"2002","journal-title":"Development"},{"key":"10.1016\/j.autneu.2009.09.001_bib21","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/j.1365-2982.2008.01256.x","article-title":"Genetic model system studies of the development of the enteric nervous system, gut motility and Hirschsprung's disease","volume":"21","author":"Burzynski","year":"2009","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.autneu.2009.09.001_bib22","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1038\/sj.emboj.7601636","article-title":"The dependence receptor Ret induces apoptosis in somatotrophs through a Pit-1\/p53 pathway, preventing tumor growth","volume":"26","author":"Canibano","year":"2007","journal-title":"EMBO J."},{"key":"10.1016\/j.autneu.2009.09.001_bib23","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1038\/nature07441","article-title":"Contact inhibition of locomotion in vivo controls neural crest directional migration","volume":"456","author":"Carmona-Fontaine","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.autneu.2009.09.001_bib24","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/ng998","article-title":"Genome-wide association study and mouse model identify interaction between RET and EDNRB pathways in Hirschsprung disease","volume":"32","author":"Carrasquillo","year":"2002","journal-title":"Nat. Genet."},{"key":"10.1016\/j.autneu.2009.09.001_bib25","doi-asserted-by":"crossref","first-page":"4266","DOI":"10.1523\/JNEUROSCI.3688-03.2004","article-title":"Bone morphogenetic protein-2 and -4 limit the number of enteric neurons but promote development of a TrkC-expressing neurotrophin-3-dependent subset","volume":"24","author":"Chalazonitis","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.autneu.2009.09.001_bib26","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1006\/dbio.1998.9090","article-title":"Age-dependent differences in the effects of GDNF and NT-3 on the development of neurons and glia from neural crest-derived precursors immunoselected from the fetal rat gut: expression of GFRalpha-1 in vitro and in vivo","volume":"204","author":"Chalazonitis","year":"1998","journal-title":"Dev. Biol."},{"key":"10.1016\/j.autneu.2009.09.001_bib27","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1002\/cne.21770","article-title":"Bone morphogenetic protein regulation of enteric neuronal phenotypic diversity: relationship to timing of cell cycle exit","volume":"509","author":"Chalazonitis","year":"2008","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.autneu.2009.09.001_bib28","first-page":"S129","article-title":"The enteric nervous system","volume":"89","author":"Costa","year":"1994","journal-title":"Am. J. Gastroenterol."},{"issue":"Suppl 4","key":"10.1016\/j.autneu.2009.09.001_bib29","doi-asserted-by":"crossref","first-page":"iv15","DOI":"10.1136\/gut.47.suppl_4.iv15","article-title":"Anatomy and physiology of the enteric nervous system","volume":"47","author":"Costa","year":"2000","journal-title":"Gut"},{"key":"10.1016\/j.autneu.2009.09.001_bib30","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0304-3940(92)90819-S","article-title":"Projections and chemical coding of neurons with immunoreactivity for nitric oxide synthase in the guinea-pig small intestine","volume":"148","author":"Costa","year":"1992","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.autneu.2009.09.001_bib31","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/0306-4522(96)00275-8","article-title":"Neurochemical classification of myenteric neurons in the guinea-pig ileum","volume":"75","author":"Costa","year":"1996","journal-title":"Neuroscience"},{"key":"10.1016\/j.autneu.2009.09.001_bib32","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1111\/j.1749-6632.1998.tb09077.x","article-title":"Intestinal peristalsis: a mammalian motor pattern controlled by enteric neural circuits","volume":"860","author":"Costa","year":"1998","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.autneu.2009.09.001_bib33","doi-asserted-by":"crossref","first-page":"3707","DOI":"10.1242\/dev.026773","article-title":"The development of motor coordination in Drosophila embryos","volume":"135","author":"Crisp","year":"2008","journal-title":"Development"},{"key":"10.1016\/j.autneu.2009.09.001_bib34","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1242\/dev.003814","article-title":"Hand2 is necessary for terminal differentiation of enteric neurons from crest-derived precursors but not for their migration into the gut or for formation of glia","volume":"134","author":"D'Autreaux","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.autneu.2009.09.001_bib35","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1101\/gad.205001","article-title":"Differential activities of the RET tyrosine kinase receptor isoforms during mammalian embryogenesis","volume":"15","author":"de Graaff","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/j.autneu.2009.09.001_bib36","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1002\/dvdy.20554","article-title":"Bone morphogenetic protein signaling pathway plays multiple roles during gastrointestinal tract development","volume":"234","author":"De Santa Barbara","year":"2005","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.autneu.2009.09.001_bib37","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.ydbio.2007.10.028","article-title":"The receptor tyrosine kinase RET regulates hindgut colonization by sacral neural crest cells","volume":"313","author":"Delalande","year":"2008","journal-title":"Dev. Biol."},{"key":"10.1016\/j.autneu.2009.09.001_bib38","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1242\/dev.009324","article-title":"Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network","volume":"135","author":"Dessaud","year":"2008","journal-title":"Development"},{"key":"10.1016\/j.autneu.2009.09.001_bib39","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1365-2036.2008.03707.x","article-title":"Review article: molecular, pathological and therapeutic features of human enteric neuropathies","volume":"28","author":"Di Nardo","year":"2008","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.autneu.2009.09.001_bib40","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ydbio.2005.08.040","article-title":"The pattern of neural crest advance in the cecum and colon","volume":"287","author":"Druckenbrod","year":"2005","journal-title":"Dev. Biol."},{"key":"10.1016\/j.autneu.2009.09.001_bib41","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1002\/dvdy.20974","article-title":"Behavior of enteric neural crest-derived cells varies with respect to the migratory wavefront","volume":"236","author":"Druckenbrod","year":"2007","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.autneu.2009.09.001_bib42","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1242\/dev.122.1.349","article-title":"Common origin and developmental dependence on c-ret of subsets of enteric and sympathetic neuroblasts","volume":"122","author":"Durbec","year":"1996","journal-title":"Development"},{"key":"10.1016\/j.autneu.2009.09.001_bib43","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1111\/j.1365-2982.2009.01325.x","article-title":"Death comes early: apoptosis observed in ENS precursors","volume":"21","author":"Enomoto","year":"2009","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.autneu.2009.09.001_bib44","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0896-6273(00)80541-3","article-title":"GFR alpha1-deficient mice have deficits in the enteric nervous system and kidneys","volume":"21","author":"Enomoto","year":"1998","journal-title":"Neuron"},{"key":"10.1016\/j.autneu.2009.09.001_bib45","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/dvdy.20943","article-title":"Gangliogenesis in the enteric nervous system: roles of the polysialylation of the neural cell adhesion molecule and its regulation by bone morphogenetic protein-4","volume":"236","author":"Faure","year":"2007","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.autneu.2009.09.001_bib46","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.ydbio.2006.07.016","article-title":"BMP signaling regulates murine enteric nervous system precursor migration, neurite fasciculation, and patterning via altered Ncam1 polysialic acid addition","volume":"299","author":"Fu","year":"2006","journal-title":"Dev. Biol."},{"key":"10.1016\/j.autneu.2009.09.001_bib47","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.stem.2009.01.017","article-title":"Stage-specific control of neural crest stem cell proliferation by the small rho GTPases Cdc42 and Rac1","volume":"4","author":"Fuchs","year":"2009","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.autneu.2009.09.001_bib48","doi-asserted-by":"crossref","first-page":"19114","DOI":"10.1074\/jbc.M200643200","article-title":"Novel mechanism of regulation of Rac activity and lamellipodia formation by RET tyrosine kinase","volume":"277","author":"Fukuda","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.autneu.2009.09.001_bib49","series-title":"The Enteric Nervous System","author":"Furness","year":"2006"},{"key":"10.1016\/j.autneu.2009.09.001_bib50","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0165-1838(00)00127-2","article-title":"Types of neurons in the enteric nervous system","volume":"81","author":"Furness","year":"2000","journal-title":"J. Auton. Nerv. Syst."},{"issue":"Suppl 1","key":"10.1016\/j.autneu.2009.09.001_bib51","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/j.1365-2982.2008.01094.x","article-title":"The enteric nervous system: normal functions and enteric neuropathies","volume":"20","author":"Furness","year":"2008","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.autneu.2009.09.001_bib52","series-title":"The Second Brain","author":"Gershon","year":"1998"},{"key":"10.1016\/j.autneu.2009.09.001_bib53","series-title":"Physiology of the Gastrointestinal Tract","first-page":"381","article-title":"Functional anatomy of the enteric nervous system","author":"Gershon","year":"1994"},{"key":"10.1016\/j.autneu.2009.09.001_bib54","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1242\/dev.00433","article-title":"GDNF availability determines enteric neuron number by controlling precursor proliferation","volume":"130","author":"Gianino","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.autneu.2009.09.001_bib55","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.mod.2005.03.003","article-title":"BMP signaling is necessary for neural crest cell migration and ganglion formation in the enteric nervous system","volume":"122","author":"Goldstein","year":"2005","journal-title":"Mech. Dev."},{"key":"10.1016\/j.autneu.2009.09.001_bib56","doi-asserted-by":"crossref","DOI":"10.1111\/j.1582-4934.2009.00813.x","article-title":"Development of enteric neuron diversity","author":"Hao","year":"2009","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.autneu.2009.09.001_bib57","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/dneu.20683","article-title":"The migratory behavior of immature enteric neurons","volume":"69","author":"Hao","year":"2009","journal-title":"Dev. Neurobiol."},{"key":"10.1016\/j.autneu.2009.09.001_bib58","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1053\/j.sempedsurg.2008.07.005","article-title":"Hirschsprung disease","volume":"17","author":"Haricharan","year":"2008","journal-title":"Semin. Pediatr. Surg."},{"key":"10.1016\/j.autneu.2009.09.001_bib59","doi-asserted-by":"crossref","first-page":"6919","DOI":"10.1073\/pnas.0602152103","article-title":"Expression profiling the developing mammalian enteric nervous system identifies marker and candidate Hirschsprung disease genes","volume":"103","author":"Heanue","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.autneu.2009.09.001_bib60","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/nrn2137","article-title":"Enteric nervous system development and Hirschsprung's disease: advances in genetic and stem cell studies","volume":"8","author":"Heanue","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.autneu.2009.09.001_bib61","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/dvdy.20989","article-title":"Expression of Hand2 is sufficient for neurogenesis and cell type-specific gene expression in the enteric nervous system","volume":"236","author":"Hendershot","year":"2007","journal-title":"Dev. Dyn."},{"issue":"Pt 2","key":"10.1016\/j.autneu.2009.09.001_bib62","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/j.1469-7793.1999.0575t.x","article-title":"Quantitative analysis of peristalsis in the guinea-pig small intestine using spatio-temporal maps","volume":"517","author":"Hennig","year":"1999","journal-title":"J. Physiol."},{"key":"10.1016\/j.autneu.2009.09.001_bib63","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/S0896-6273(03)00763-3","article-title":"Finding your way to the end. A tale of GDNF and endothelin-3","volume":"40","author":"Heuckeroth","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.autneu.2009.09.001_bib64","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1006\/dbio.1998.8955","article-title":"Neurturin and GDNF promote proliferation and survival of enteric neuron and glial progenitors in vitro [in process citation]","volume":"200","author":"Heuckeroth","year":"1998","journal-title":"Dev. Biol."},{"key":"10.1016\/j.autneu.2009.09.001_bib65","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.semcdb.2005.06.005","article-title":"Sox proteins and neural crest development","volume":"16","author":"Hong","year":"2005","journal-title":"Semin. Cell. Dev. Biol."},{"key":"10.1016\/j.autneu.2009.09.001_bib66","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1111\/j.1349-7006.2007.00457.x","article-title":"Sprouty2 regulates growth and differentiation of human neuroblastoma cells through RET tyrosine kinase","volume":"98","author":"Ishida","year":"2007","journal-title":"Cancer Sci."},{"key":"10.1016\/j.autneu.2009.09.001_bib67","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1242\/dev.116.1.167","article-title":"A transgenic model for studying development of the enteric nervous system in normal and aganglionic mice","volume":"116","author":"Kapur","year":"1992","journal-title":"Development"},{"key":"10.1016\/j.autneu.2009.09.001_bib68","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.1242\/dev.02477","article-title":"Replacement of the Sox10 transcription factor by Sox8 reveals incomplete functional equivalence","volume":"133","author":"Kellerer","year":"2006","journal-title":"Development"},{"key":"10.1016\/j.autneu.2009.09.001_bib69","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1242\/dev.026716","article-title":"Regulation of enteric neuron migration by the gaseous messenger molecules CO and NO","volume":"136","author":"Knipp","year":"2009","journal-title":"Development"},{"key":"10.1016\/j.autneu.2009.09.001_bib70","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.cell.2009.03.045","article-title":"The canonical Notch signaling pathway: unfolding the activation mechanism","volume":"137","author":"Kopan","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.autneu.2009.09.001_bib71","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1146\/annurev.neuro.051508.135600","article-title":"The glial nature of embryonic and adult neural stem cells","volume":"32","author":"Kriegstein","year":"2009","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.autneu.2009.09.001_bib72","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0896-6273(02)00827-9","article-title":"Neural crest stem cells persist in the adult gut but undergo changes in self-renewal, neuronal subtype potential, and factor responsiveness","volume":"35","author":"Kruger","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.autneu.2009.09.001_bib73","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/S0896-6273(03)00727-X","article-title":"Temporally distinct requirements for endothelin receptor B in the generation and migration of gut neural crest stem cells","volume":"40","author":"Kruger","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.autneu.2009.09.001_bib74","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/j.1440-169X.2007.00929.x","article-title":"Mathematical and experimental insights into the development of the enteric nervous system and Hirschsprung's disease","volume":"49","author":"Landman","year":"2007","journal-title":"Dev. Growth Differ."},{"key":"10.1016\/j.autneu.2009.09.001_bib75","author":"Le Douarin","year":"1999"},{"key":"10.1016\/j.autneu.2009.09.001_bib76","first-page":"31","article-title":"The migration of neural crest cells to the wall of the digestive tract in avian embryo","volume":"30","author":"Le Douarin","year":"1973","journal-title":"J. Embryol. Exp. Morphol."},{"key":"10.1016\/j.autneu.2009.09.001_bib77","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1136\/gut.44.2.246","article-title":"Expression of endothelin 3 by mesenchymal cells of embryonic mouse caecum","volume":"44","author":"Leibl","year":"1999","journal-title":"Gut"},{"issue":"205\u2013216","key":"10.1016\/j.autneu.2009.09.001_bib78","first-page":"e206","article-title":"Human and mouse enteric nervous system neurosphere transplants regulate the function of aganglionic embryonic distal colon","volume":"135","author":"Lindley","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.autneu.2009.09.001_bib79","doi-asserted-by":"crossref","first-page":"9683","DOI":"10.1523\/JNEUROSCI.1145-09.2009","article-title":"5-HT4 receptor-mediated neuroprotection and neurogenesis in the enteric nervous system of adult mice","volume":"29","author":"Liu","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.autneu.2009.09.001_bib80","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/0896-6273(95)90142-6","article-title":"Postmigratory neural crest cells expressing c-RET display restricted developmental and proliferative capacities","volume":"15","author":"Lo","year":"1995","journal-title":"Neuron"},{"key":"10.1016\/j.autneu.2009.09.001_bib81","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1146\/annurev.physiol.69.031905.161516","article-title":"Understanding circuit dynamics using the stomatogastric nervous system of lobsters and crabs","volume":"69","author":"Marder","year":"2007","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.autneu.2009.09.001_bib82","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.tcb.2005.11.004","article-title":"Sprouty proteins: multifaceted negative-feedback regulators of receptor tyrosine kinase signaling","volume":"16","author":"Mason","year":"2006","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.autneu.2009.09.001_bib83","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1034\/j.1600-0749.2001.140305.x","article-title":"EDNRB\/EDN3 and Hirschsprung disease type II","volume":"14","author":"McCallion","year":"2001","journal-title":"Pigment Cell Res."},{"issue":"2214\u20132225","key":"10.1016\/j.autneu.2009.09.001_bib84","first-page":"e2211","article-title":"Enteric nervous system stem cells derived from human gut mucosa for the treatment of aganglionic gut disorders","volume":"136","author":"Metzger","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.autneu.2009.09.001_bib85","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.neuron.2007.04.019","article-title":"Timing is everything: making neurons versus glia in the developing cortex","volume":"54","author":"Miller","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.autneu.2009.09.001_bib86","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/nrn2151","article-title":"Neuronal subtype specification in the cerebral cortex","volume":"8","author":"Molyneaux","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.autneu.2009.09.001_bib87","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/382076a0","article-title":"Renal and neuronal abnormalities in mice lacking GDNF","volume":"382","author":"Moore","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.autneu.2009.09.001_bib88","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1242\/dev.126.1.157","article-title":"Multipotential progenitors of the mammalian enteric nervous system capable of colonising aganglionic bowel in organ culture [in process citation]","volume":"126","author":"Natarajan","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.autneu.2009.09.001_bib89","doi-asserted-by":"crossref","first-page":"5151","DOI":"10.1242\/dev.129.22.5151","article-title":"Requirement of signalling by receptor tyrosine kinase RET for the directed migration of enteric nervous system progenitor cells during mammalian embryogenesis","volume":"129","author":"Natarajan","year":"2002","journal-title":"Development"},{"key":"10.1016\/j.autneu.2009.09.001_bib90","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1242\/dev.00463","article-title":"The regional pattern of retinoic acid synthesis by RALDH2 is essential for the development of posterior pharyngeal arches and the enteric nervous system","volume":"130","author":"Niederreither","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.autneu.2009.09.001_bib91","doi-asserted-by":"crossref","first-page":"3555","DOI":"10.1242\/dev.022319","article-title":"Notch signaling is required for the maintenance of enteric neural crest progenitors","volume":"135","author":"Okamura","year":"2008","journal-title":"Development"},{"key":"10.1016\/j.autneu.2009.09.001_bib92","doi-asserted-by":"crossref","first-page":"3075","DOI":"10.1093\/hmg\/11.24.3075","article-title":"Sox10 haploinsufficiency affects maintenance of progenitor cells in a mouse model of Hirschsprung disease","volume":"11","author":"Paratore","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.autneu.2009.09.001_bib93","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/20700","article-title":"The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives [in process citation]","volume":"399","author":"Pattyn","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.autneu.2009.09.001_bib94","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/aja.1001960305","article-title":"Ablation of various regions within the avian vagal neural crest has differential effects on ganglion formation in the fore-, mid- and hindgut","volume":"196","author":"Peters-van der Sanden","year":"1993","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.autneu.2009.09.001_bib95","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1002\/cne.903140411","article-title":"Time of origin of neurons in the murine enteric nervous system: sequence in relation to phenotype","volume":"314","author":"Pham","year":"1991","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.autneu.2009.09.001_bib96","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1016\/S0016-5085(97)70011-8","article-title":"The neurochemical coding and projections of circular muscle motor neurons in the human colon","volume":"113","author":"Porter","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1016\/j.autneu.2009.09.001_bib97","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1046\/j.1440-1746.1999.02026.x","article-title":"Projections of nitric oxide synthase and vasoactive intestinal polypeptide-reactive submucosal neurons in the human colon","volume":"14","author":"Porter","year":"1999","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.autneu.2009.09.001_bib98","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s00441-008-0684-7","article-title":"Immunohistochemical analysis of neuron types in the mouse small intestine","volume":"334","author":"Qu","year":"2008","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.autneu.2009.09.001_bib99","first-page":"G930","article-title":"Development of colonic motility in the neonatal mouse-studies using spatiotemporal maps","volume":"292","author":"Roberts","year":"2007","journal-title":"Am. J. Physiol: gastrointest. Liver Physiol."},{"key":"10.1016\/j.autneu.2009.09.001_bib100","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1681\/ASN.2008030267","article-title":"Loss of Sprouty1 rescues renal agenesis caused by Ret mutation","volume":"20","author":"Rozen","year":"2009","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.autneu.2009.09.001_bib101","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1023\/A:1015085923245","article-title":"Widespread changes in neurotransmitter expression and number of enteric neurons and interstitial cells of Cajal in lethal spotted mice: an explanation for persisting dysmotility after operation for Hirschsprung's disease?","volume":"47","author":"Sandgren","year":"2002","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.autneu.2009.09.001_bib102","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.ydbio.2008.05.524","article-title":"Retinoic acid regulates murine enteric nervous system precursor proliferation, enhances neuronal precursor differentiation, and reduces neurite growth in vitro","volume":"320","author":"Sato","year":"2008","journal-title":"Dev. Biol."},{"key":"10.1016\/j.autneu.2009.09.001_bib103","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/367380a0","article-title":"Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret [see comments]","volume":"367","author":"Schuchardt","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.autneu.2009.09.001_bib104","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1006\/dbio.2000.0145","article-title":"Functional analysis of zebrafish GDNF","volume":"231","author":"Shepherd","year":"2001","journal-title":"Dev. Biol."},{"key":"10.1016\/j.autneu.2009.09.001_bib105","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1242\/dev.00912","article-title":"Roles for GFRalpha1 receptors in zebrafish enteric nervous system development","volume":"131","author":"Shepherd","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.autneu.2009.09.001_bib106","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.ydbio.2006.03.031","article-title":"Interactions between Sox10, Edn3 and Ednrb during enteric nervous system and melanocyte development","volume":"295","author":"Stanchina","year":"2006","journal-title":"Dev. Biol."},{"key":"10.1016\/j.autneu.2009.09.001_bib107","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/nn1485","article-title":"Loss of mammalian Sprouty2 leads to enteric neuronal hyperplasia and esophageal achalasia","volume":"8","author":"Taketomi","year":"2005","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.autneu.2009.09.001_bib108","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1242\/dev.126.12.2785","article-title":"Signalling by the RET receptor tyrosine kinase and its role in the development of the mammalian enteric nervous system","volume":"126","author":"Taraviras","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.autneu.2009.09.001_bib109","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1242\/dev.005520","article-title":"Physiological Notch signaling promotes gliogenesis in the developing peripheral and central nervous systems","volume":"134","author":"Taylor","year":"2007","journal-title":"Development"},{"issue":"Suppl 2","key":"10.1016\/j.autneu.2009.09.001_bib110","first-page":"S92","article-title":"New frontiers in the treatment of Hirschsprung disease","volume":"48","author":"Thapar","year":"2009","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"10.1016\/j.autneu.2009.09.001_bib111","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1242\/dev.001388","article-title":"Conditional ablation of GFRalpha1 in postmigratory enteric neurons triggers unconventional neuronal death in the colon and causes a Hirschsprung's disease phenotype","volume":"134","author":"Uesaka","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.autneu.2009.09.001_bib112","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1172\/JCI34425","article-title":"Diminished Ret expression compromises neuronal survival in the colon and causes intestinal aganglionosis in mice","volume":"118","author":"Uesaka","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.autneu.2009.09.001_bib113","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/nature05597","article-title":"Tyrosine kinase receptor RET is a key regulator of Peyer's patch organogenesis","volume":"446","author":"Veiga-Fernandes","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.autneu.2009.09.001_bib114","doi-asserted-by":"crossref","first-page":"768-e749","DOI":"10.1111\/j.1365-2982.2009.01309.x","article-title":"Inhibition of cell death results in hyperganglionosis: implications for enteric nervous system development","volume":"21","author":"Wallace","year":"2009","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.autneu.2009.09.001_bib115","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1053\/gast.1997.v113.pm9247469","article-title":"The polarity of neurochemically defined myenteric neurons in the human colon","volume":"113","author":"Wattchow","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1016\/j.autneu.2009.09.001_bib116","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1097\/MOG.0b013e3282f56125","article-title":"Enteric nervous system: reflexes, pattern generators and motility","volume":"24","author":"Wood","year":"2008","journal-title":"Curr. Opin. Gastroenterol."},{"key":"10.1016\/j.autneu.2009.09.001_bib117","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/cne.901010212","article-title":"The origin of intrinsic ganglia of trunk viscera from vagal neural crest in the chick embryo","volume":"101","author":"Yntema","year":"1954","journal-title":"J. Comp. Neurol."},{"issue":"Suppl 1","key":"10.1016\/j.autneu.2009.09.001_bib118","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1365-2982.2008.01098.x","article-title":"Functional development of the enteric nervous system\u2014from migration to motility","volume":"20","author":"Young","year":"2008","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.autneu.2009.09.001_bib119","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/1097-0185(20010101)262:1<1::AID-AR1006>3.0.CO;2-2","article-title":"Enteric neural crest-derived cells: origin, identification, migration, and differentiation","volume":"262","author":"Young","year":"2001","journal-title":"Anat. Rec."},{"key":"10.1016\/j.autneu.2009.09.001_bib120","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1006\/dbio.2000.0100","article-title":"GDNF is a chemoattractant for enteric neural cells","volume":"229","author":"Young","year":"2001","journal-title":"Dev. Biol."},{"key":"10.1016\/j.autneu.2009.09.001_bib121","doi-asserted-by":"crossref","first-page":"6005","DOI":"10.1523\/JNEUROSCI.22-14-06005.2002","article-title":"The projections of early enteric neurons are influenced by the direction of neural crest cell migration","volume":"22","author":"Young","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.autneu.2009.09.001_bib122","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cne.10448","article-title":"Acquisition of neuronal and glial markers by neural crest-derived cells in the mouse intestine","volume":"456","author":"Young","year":"2003","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.autneu.2009.09.001_bib123","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.ydbio.2004.03.015","article-title":"Dynamics of neural crest-derived cell migration in the embryonic mouse gut","volume":"270","author":"Young","year":"2004","journal-title":"Dev. Biol."}],"container-title":["Autonomic Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1566070209004718?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1566070209004718?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T11:58:48Z","timestamp":1761566328000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1566070209004718"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11]]},"references-count":123,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["S1566070209004718"],"URL":"https:\/\/doi.org\/10.1016\/j.autneu.2009.09.001","relation":{},"ISSN":["1566-0702"],"issn-type":[{"value":"1566-0702","type":"print"}],"subject":[],"published":{"date-parts":[[2009,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Enteric nervous system development: Recent progress and future challenges","name":"articletitle","label":"Article Title"},{"value":"Autonomic Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.autneu.2009.09.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}