{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T06:45:41Z","timestamp":1791096341628,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["autonomicneuroscience.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Autonomic Neuroscience"],"published-print":{"date-parts":[[2010,8]]},"DOI":"10.1016\/j.autneu.2010.02.005","type":"journal-article","created":{"date-parts":[[2010,3,25]],"date-time":"2010-03-25T02:22:46Z","timestamp":1269483766000},"page":"27-35","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":68,"title":["Norepinephrine-induced nerve growth factor depletion causes cardiac sympathetic denervation in severe heart failure"],"prefix":"10.1016","volume":"156","author":[{"given":"Kensuke","family":"Kimura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Kanazawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Ieda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruko","family":"Kawaguchi-Manabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiko","family":"Miyake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Yagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahide","family":"Arai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoaki","family":"Sano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiichi","family":"Fukuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.autneu.2010.02.005_bib1","first-page":"H324","article-title":"Renin-angiotensin system involvement in pressure-overload cardiac hypertrophy in rats","volume":"259","author":"Baker","year":"1990","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.autneu.2010.02.005_bib2","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/0735-1097(94)00353-R","article-title":"Evidence for reduction of norepinephrine uptake sites in the failing human heart","volume":"25","author":"Bohm","year":"1995","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.autneu.2010.02.005_bib3","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1161\/01.CIR.101.16.1960","article-title":"Relationship between regional cardiac hyperinnervation and ventricular arrhythmia","volume":"101","author":"Cao","year":"2000","journal-title":"Circ."},{"key":"10.1016\/j.autneu.2010.02.005_bib4","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1161\/01.HYP.18.1.56","article-title":"Does regional norepinephrine spillover represent local sympathetic activity?","volume":"18","author":"Chang","year":"1991","journal-title":"Hypertens."},{"key":"10.1016\/j.autneu.2010.02.005_bib5","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1056\/NEJM198409273111303","article-title":"Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure","volume":"311","author":"Cohn","year":"1984","journal-title":"N Engl J. Med."},{"key":"10.1016\/j.autneu.2010.02.005_bib6","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1161\/01.CIR.93.9.1667","article-title":"Cardiac sympathetic nerve function in congestive heart failure","volume":"93","author":"Eisenhofer","year":"1996","journal-title":"Circ."},{"key":"10.1016\/j.autneu.2010.02.005_bib7","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1161\/01.CIR.73.4.615","article-title":"Norepinephrine spillover to plasma in patients with congestive heart failure: evidence of increased overall and cardiorenal sympathetic nervous activity","volume":"73","author":"Hasking","year":"1986","journal-title":"Circ."},{"key":"10.1016\/j.autneu.2010.02.005_bib8","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1161\/01.CIR.78.5.1192","article-title":"Abnormal I-123 metaiodo-benzylguanidine myocardial washout and distribution may reflect myocardial adrenergic derangement in patients with congestive cardiomyopathy","volume":"78","author":"Henderson","year":"1988","journal-title":"Circ."},{"key":"10.1016\/j.autneu.2010.02.005_bib9","doi-asserted-by":"crossref","first-page":"3183","DOI":"10.1002\/j.1460-2075.1984.tb02277.x","article-title":"Relationship between levels of nerve growth factor (NGF) and its messenger RNA in sympathetic ganglia and peripheral target tissues","volume":"3","author":"Heumann","year":"1984","journal-title":"EMBO J."},{"key":"10.1016\/j.autneu.2010.02.005_bib10","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1161\/01.CIR.88.3.1299","article-title":"Cardiac noradrenergic nerve terminal abnormalities in dogs with experimental congestive heart failure","volume":"88","author":"Himura","year":"1993","journal-title":"Circ."},{"key":"10.1016\/j.autneu.2010.02.005_bib11","first-page":"E13","article-title":"Catecholamine measurements by highperformance liquid chromatography","volume":"247","author":"Hjemdahl","year":"1984","journal-title":"Am. J. Physisl."},{"key":"10.1016\/j.autneu.2010.02.005_bib31","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1172\/JCI200419480","article-title":"Endothelin-1 regulates cardiac sympathetic innervations in the rodent heart by controlling nerve growth factor expression","volume":"113","author":"Ieda","year":"2004","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.autneu.2010.02.005_bib32","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1161\/01.CIR.93.11.2068","article-title":"Endothelin-1 is involved in norepinephrine-induced ventricular hypertrophy in vivo","volume":"93","author":"Kaddoura","year":"1996","journal-title":"Circ."},{"key":"10.1016\/j.autneu.2010.02.005_bib12","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1172\/JCI39778","article-title":"Heart failure causes cholinergic transdifferentiation of cardiac sympathetic nerves via gp130-mediated cytokines","volume":"120","author":"Kanazawa","year":"2010","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.autneu.2010.02.005_bib13","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0014-5793(00)01338-7","article-title":"A novel reporter mouse strain that expresses enhanced green fluorescent protein upon Cre-mediated recombination","volume":"470","author":"Kawamoto","year":"2000","journal-title":"FEBS Lett."},{"key":"10.1016\/j.autneu.2010.02.005_bib14","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1161\/01.RES.86.7.e80","article-title":"Reduced myocardial nerve growth factor expression in human and experimental heart failure","volume":"86","author":"Kaye","year":"2000","journal-title":"Circ. Res."},{"key":"10.1016\/j.autneu.2010.02.005_bib15","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1161\/01.RES.0000269828.62250.ab","article-title":"Cardiac sympathetic rejuvenation: a link between nerve function and cardiac hypertrophy","volume":"100","author":"Kimura","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.autneu.2010.02.005_bib16","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1161\/01.HYP.0000200157.25792.26","article-title":"Injection of nerve growth factor into stellate ganglia improves norepinephrine reuptake into failing hearts","volume":"47","author":"Kreusser","year":"2006","journal-title":"Hypertens."},{"key":"10.1016\/j.autneu.2010.02.005_bib17","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s00441-006-0215-3","article-title":"Localization of cholinergic innervation and neurturin receptors in adult mouse heart and expression of the neurturin gene","volume":"326","author":"Mabe","year":"2006","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.autneu.2010.02.005_bib18","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/jnr.20229","article-title":"Fate of transient catecholaminergic cell types revealed by site-specific recombination in transgenic mice","volume":"78","author":"Matsushita","year":"2004","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.autneu.2010.02.005_bib19","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1161\/01.CIR.88.1.136","article-title":"Cardiac sympathetic nervous activity in congestive heart failure: evidence for increased neuronal norepinephrine release and preserved neuronal uptake","volume":"88","author":"Meredith","year":"1993","journal-title":"Circ."},{"key":"10.1016\/j.autneu.2010.02.005_bib20","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1161\/HYPERTENSIONAHA.108.127290","article-title":"Exercise training alters left ventricular geometry and attenuates heart failure in dahl salt-sensitive hypertensive rats","volume":"53","author":"Miyachi","year":"2009","journal-title":"Hypertens."},{"key":"10.1016\/j.autneu.2010.02.005_bib21","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1161\/01.CIR.92.1.114","article-title":"Role of endothelin-1 in beagles with dehydromonocrotaline-induced pulmonary hypertension","volume":"92","author":"Okada","year":"1995","journal-title":"Circ."},{"key":"10.1016\/j.autneu.2010.02.005_bib22","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1056\/NEJM199605233342101","article-title":"The effect of carvedilol on morbidity and mortality in patients with chronic heart failure","volume":"334","author":"Packer","year":"1996","journal-title":"N Engl J. Med."},{"key":"10.1016\/j.autneu.2010.02.005_bib23","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1161\/01.RES.20.3.349","article-title":"Reduction of cardiac tyrosine hydroxylase activity in experimental congestive heart failure: its role in the depletion of cardiac norepinephrine stores","volume":"20","author":"Pool","year":"1967","journal-title":"Circ. Res."},{"key":"10.1016\/j.autneu.2010.02.005_bib24","first-page":"H363","article-title":"Loss of cardiac sympathetic neurotransmitters in heart failure and NE infusion is associated with reduced NGF","volume":"282","author":"Qin","year":"2002","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.autneu.2010.02.005_bib25","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.yjmcc.2008.12.006","article-title":"Regulation of nerve growth factor in the heart: The role of the calcineurin-NFAT pathway","volume":"46","author":"Rana","year":"2009","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.autneu.2010.02.005_bib26","doi-asserted-by":"crossref","first-page":"29717","DOI":"10.1074\/jbc.M003128200","article-title":"Interleukin-6 family of cytokines mediate angiotensin II-induced cardiac hypertrophy in rodent cardiomyocytes","volume":"275","author":"Sano","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.autneu.2010.02.005_bib27","doi-asserted-by":"crossref","first-page":"3870","DOI":"10.1172\/JCI34472","article-title":"An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice","volume":"118","author":"Sheikh","year":"2008","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.autneu.2010.02.005_bib28","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/0092-8674(94)90048-5","article-title":"Functions of the neurotrophins during nervous system development: what the knockouts are teaching us","volume":"77","author":"Snider","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.autneu.2010.02.005_bib29","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0002-9149(78)90162-5","article-title":"Plasma norepinephrine in congestive heart failure","volume":"41","author":"Thomas","year":"1978","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.autneu.2010.02.005_bib30","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1161\/01.CIR.103.9.1296","article-title":"Functional significance of hemodynamic overload-induced expression of leukemia-inhibitory factor in the adult mammalian heart","volume":"103","author":"Wang","year":"2001","journal-title":"Circ."}],"container-title":["Autonomic Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1566070210000470?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1566070210000470?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T11:59:24Z","timestamp":1761566364000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1566070210000470"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8]]},"references-count":32,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["S1566070210000470"],"URL":"https:\/\/doi.org\/10.1016\/j.autneu.2010.02.005","relation":{},"ISSN":["1566-0702"],"issn-type":[{"value":"1566-0702","type":"print"}],"subject":[],"published":{"date-parts":[[2010,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Norepinephrine-induced nerve growth factor depletion causes cardiac sympathetic denervation in severe heart failure","name":"articletitle","label":"Article Title"},{"value":"Autonomic Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.autneu.2010.02.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}