{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:12:31Z","timestamp":1791400351287,"version":"4.3.3"},"reference-count":76,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["autonomicneuroscience.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Autonomic Neuroscience"],"published-print":{"date-parts":[[2011,4]]},"DOI":"10.1016\/j.autneu.2010.08.004","type":"journal-article","created":{"date-parts":[[2010,9,2]],"date-time":"2010-09-02T05:08:33Z","timestamp":1283404113000},"page":"20-27","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":82,"title":["Orexin links emotional stress to autonomic functions"],"prefix":"10.1016","volume":"161","author":[{"given":"Tomoyuki","family":"Kuwaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.autneu.2010.08.004_bb0005","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1097\/00001756-200102120-00048","article-title":"The suprachiasmatic nucleus projects to posterior hypothalamic arousal systems","volume":"12","author":"Abrahamson","year":"2001","journal-title":"NeuroReport"},{"key":"10.1016\/j.autneu.2010.08.004_bb0010","doi-asserted-by":"crossref","first-page":"R1801","DOI":"10.1152\/ajpregu.2001.281.6.R1801","article-title":"Orexins\/hypocretins excite rat sympathetic preganglionic neurons in vivo and in vitro","volume":"281","author":"Antunes","year":"2001","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.autneu.2010.08.004_bb0015","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1093\/sleep\/9.1.232","article-title":"Comparative polysomnographic study of narcolepsy and idiopathic central nervous system hypersomnia","volume":"9","author":"Baker","year":"1986","journal-title":"Sleep"},{"key":"10.1016\/j.autneu.2010.08.004_bb0020","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0361-9230(00)00313-0","article-title":"Central circuits mediating patterned autonomic activity during active vs. passive emotional coping","volume":"53","author":"Bandler","year":"2000","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.autneu.2010.08.004_bb0025","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s00418-005-0761-x","article-title":"Orexin inputs to caudal raphe neurons involved in thermal, cardiovascular, and gastrointestinal regulation","volume":"123","author":"Berthoud","year":"2005","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.autneu.2010.08.004_bb0030","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0092-8674(00)81973-X","article-title":"Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation","volume":"98","author":"Chemelli","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.autneu.2010.08.004_bb0035","doi-asserted-by":"crossref","first-page":"R692","DOI":"10.1152\/ajpregu.2000.278.3.R692","article-title":"Pressor effects of orexins injected intracisternally and to rostral ventrolateral medulla of anesthetized rats","volume":"278","author":"Chen","year":"2000","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.autneu.2010.08.004_bb0040","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0168-0102(03)00026-9","article-title":"Morphological study of orexin neurons in the hypothalamus of the Long\u2013Evans rat, with special reference to co-expression of orexin and NADPH-diaphorase or nitric oxide synthase activities","volume":"46","author":"Cheng","year":"2003","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.autneu.2010.08.004_bb0045","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1093\/sleep\/9.1.250","article-title":"Sleep apnea in narcolepsy","volume":"9","author":"Chokroverty","year":"1986","journal-title":"Sleep"},{"issue":"RC168","key":"10.1016\/j.autneu.2010.08.004_bb0050","first-page":"161","article-title":"Orexin (hypocretin) neurons contain dynorphin","volume":"21","author":"Chou","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.autneu.2010.08.004_bb0055","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1152\/japplphysiol.00075.2007","article-title":"Contribution of orexin in hypercapnic chemoreflex: evidence from genetic and pharmacological disruption and supplementation studies in mice","volume":"103","author":"Deng","year":"2007","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.autneu.2010.08.004_bb0060","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1073\/pnas.95.1.322","article-title":"The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity","volume":"95","author":"de Lecea","year":"1998","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.autneu.2010.08.004_bb0065","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1124\/jpet.105.086421","article-title":"Hypocretin-1 (orexin-a) facilitates inhibitory and diminishes excitatory synaptic pathways to cardiac vagal neurons in the nucleus ambiguus","volume":"314","author":"Dergacheva","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.autneu.2010.08.004_bb0070","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1113\/jphysiol.2008.168260","article-title":"Antagonism of orexin receptor-1 in the retrotrapezoid nucleus inhibits the ventilatory response to hypercapnia predominantly in wakefulness","volume":"587","author":"Dias","year":"2009","journal-title":"J. Physiol."},{"key":"10.1016\/j.autneu.2010.08.004_bb0075","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.resp.2009.12.002","article-title":"The orexin receptor-1 (OX1R) in the rostral medullary raphe contributes to the hypercapnic chemoreflex in wakefulness, during the active period of the diurnal cycle","volume":"170","author":"Dias","year":"2010","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.autneu.2010.08.004_bb0080","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0091-3057(01)00689-X","article-title":"The dorsomedial hypothalamus and the response to stress: part renaissance, part revolution","volume":"71","author":"DiMicco","year":"2002","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.autneu.2010.08.004_bb0085","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0167-0115(00)00202-0","article-title":"Orexins: a role in medullary sympathetic outflow","volume":"96","author":"Dun","year":"2000","journal-title":"Regul. Pept."},{"key":"10.1016\/j.autneu.2010.08.004_bb0090","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.resp.2007.06.004","article-title":"Activation of Orexin B receptors in the pontine K\u00f6lliker\u2013Fuse nucleus modulates pre-inspiratory hypoglossal motor activity in rat","volume":"159","author":"Dutschmann","year":"2007","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.autneu.2010.08.004_bb0095","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1002\/(SICI)1096-9861(19981228)402:4<442::AID-CNE2>3.0.CO;2-R","article-title":"Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area","volume":"402","author":"Elias","year":"1998","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.autneu.2010.08.004_bb0100","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0306-4522(03)00334-8","article-title":"Fos immunoreactivity in hypocretin-synthesizing and hypocretin-1 receptor-expressing neurons: effects of diurnal and nocturnal spontaneous waking, stress and hypocretin-1 administration","volume":"121","author":"Espana","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.autneu.2010.08.004_bb0105","doi-asserted-by":"crossref","first-page":"248","DOI":"10.5664\/jcsm.27188","article-title":"Increased heart rate variability but normal resting metabolic rate in hypocretin\/orexin-deficient human narcolepsy","volume":"4","author":"Fronczek","year":"2008","journal-title":"J. Clin. Sleep Med."},{"key":"10.1016\/j.autneu.2010.08.004_bb0110","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0006-8993(01)02318-6","article-title":"Hypocretin (orexin) input to trigeminal and hypoglossal motoneurons in the cat: a double-labeling immunohistochemical study","volume":"903","author":"Fung","year":"2001","journal-title":"Brain Res."},{"key":"10.1016\/j.autneu.2010.08.004_bb0115","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1111\/j.1460-9568.2009.06952.x","article-title":"Hypocretin\/orexin contributes to the expression of some but not all forms of stress and arousal","volume":"30","author":"Furlong","year":"2009","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.autneu.2010.08.004_bb0120","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.neuroscience.2003.07.008","article-title":"Orexin neurons project to diverse sympathetic outflow systems","volume":"122","author":"Geerling","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.autneu.2010.08.004_bb0125","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1093\/sleep\/16.3.199a","article-title":"Amphetamines and narcolepsy: use of the Stanford database","volume":"16","author":"Guilleminault","year":"1993","journal-title":"Sleep"},{"key":"10.1016\/j.autneu.2010.08.004_bb0130","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1046\/j.1365-2826.1999.00378.x","article-title":"Leptin receptor- and STAT3-immunoreactivities in hypocretin\/orexin neurones of the lateral hypothalamus","volume":"11","author":"Hakansson","year":"1999","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.autneu.2010.08.004_bb0135","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/ng.372","article-title":"Narcolepsy is strongly associated with the T-cell receptor alpha locus","volume":"41","author":"Hallmayer","year":"2009","journal-title":"Nature Genet."},{"key":"10.1016\/j.autneu.2010.08.004_bb0140","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0896-6273(01)00293-8","article-title":"Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity","volume":"30","author":"Hara","year":"2001","journal-title":"Neuron"},{"key":"10.1016\/j.autneu.2010.08.004_bb0145","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.tins.2006.08.002","article-title":"Arousal and reward: a dichotomy in orexin function","volume":"29","author":"Harris","year":"2006","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.autneu.2010.08.004_bb0150","series-title":"The Diencephalon: Autonomic and Extrapyramidal Functions","first-page":"79","author":"Hess","year":"1954"},{"key":"10.1016\/j.autneu.2010.08.004_bb0155","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1006\/bbrc.2000.2412","article-title":"Possible involvement of orexin in the stress reaction in rats","volume":"270","author":"Ida","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.autneu.2010.08.004_bb0160","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1046\/j.1365-2826.2000.00572.x","article-title":"Effects of orexins on the hypothalamic-pituitary-adrenal system","volume":"12","author":"J\u00e1szber\u00e9nyi","year":"2000","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.autneu.2010.08.004_bb0165","series-title":"Central Regulation of Autonomic Functions","first-page":"349","article-title":"Autonomic changes in affective behavior","author":"Jordan","year":"1990"},{"key":"10.1016\/j.autneu.2010.08.004_bb0170","doi-asserted-by":"crossref","first-page":"R581","DOI":"10.1152\/ajpregu.00671.2002","article-title":"Attenuated defense response and low basal blood pressure in orexin knockout mice","volume":"285","author":"Kayaba","year":"2003","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.autneu.2010.08.004_bb0175","first-page":"H1549","article-title":"Role of rostral ventrolateral medulla in centrally mediated pressor responses","volume":"267","author":"Kiely","year":"1994","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.autneu.2010.08.004_bb0180","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.neubiorev.2004.08.009","article-title":"The Darwinian concept of stress: benefits of allostasis and costs of allostatic load and the trade-offs in health and disease","volume":"29","author":"Korte","year":"2005","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.autneu.2010.08.004_bb0185","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.brainres.2005.04.090","article-title":"CNS neurons with links to both mood-related cortex and sympathetic nervous system","volume":"1050","author":"Krout","year":"2005","journal-title":"Brain Res."},{"key":"10.1016\/j.autneu.2010.08.004_bb0190","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/S0306-4522(02)00997-1","article-title":"Single CNS neurons link both central motor and cardiosympathetic systems: a double-virus tracing study","volume":"118","author":"Krout","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.autneu.2010.08.004_bb0195","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/0301-0082(90)90036-G","article-title":"Arterial baroreceptor reflex: its central and peripheral neural mechanisms","volume":"35","author":"Kumada","year":"1990","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.autneu.2010.08.004_bb0200","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.resp.2008.03.011","article-title":"Orexinergic modulation of breathing across vigilance states","volume":"164","author":"Kuwaki","year":"2008","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.autneu.2010.08.004_bb0205","series-title":"Central Mechanisms of Cardiovascular Regulation","first-page":"57","article-title":"State-dependent adjustment of the central autonomic regulation: role of orexin in emotional behavior and sleep\/wake cycle","author":"Kuwaki","year":"2007"},{"key":"10.1016\/j.autneu.2010.08.004_bb0210","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0092-8674(00)81965-0","article-title":"The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene","volume":"98","author":"Lin","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.autneu.2010.08.004_bb0215","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0167-0115(01)00351-2","article-title":"Pressor response to microinjection of orexin\/hypocretin into rostral ventrolateral medulla of awake rats","volume":"104","author":"Machado","year":"2002","journal-title":"Regul. Pept."},{"key":"10.1016\/j.autneu.2010.08.004_bb0220","doi-asserted-by":"crossref","first-page":"R1020","DOI":"10.1152\/ajpregu.00541.2005","article-title":"Modulation of the baroreceptor reflex by the dorsomedial hypothalamic nucleus and perifornical area","volume":"290","author":"McDowall","year":"2006","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.autneu.2010.08.004_bb0225","doi-asserted-by":"crossref","first-page":"R596","DOI":"10.1152\/ajpregu.00845.2004","article-title":"Activation of 5-HT1A receptors in the medullary raphe reduces cardiovascular changes elicited by acute psychological and inflammatory stresses in rabbits","volume":"289","author":"Nalivaiko","year":"2005","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.autneu.2010.08.004_bb0230","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0006-8993(99)01336-0","article-title":"Distribution of orexin neurons in the adult rat brain","volume":"827","author":"Nambu","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.autneu.2010.08.004_bb0235","doi-asserted-by":"crossref","first-page":"271","DOI":"10.2170\/jjphysiol.46.271","article-title":"Modifications of arterial baroreflexes: obligatory roles in cardiovascular regulation in stress and poststress recovery","volume":"46","author":"Nosaka","year":"1996","journal-title":"Jpn J. Physiol."},{"key":"10.1016\/j.autneu.2010.08.004_bb0240","doi-asserted-by":"crossref","first-page":"9996","DOI":"10.1523\/JNEUROSCI.18-23-09996.1998","article-title":"Neurons containing hypocretin (orexin) project to multiple neuronal systems","volume":"18","author":"Peyron","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.autneu.2010.08.004_bb0245","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S0166-2236(97)01125-9","article-title":"Organization of intra-amygdaloid circuitries in the rat: an emerging framework for understanding functions of the amygdala","volume":"20","author":"Pitkanen","year":"1997","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.autneu.2010.08.004_bb0250","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1002\/cne.21105","article-title":"Afferent and efferent connections of the rat retrotrapezoid nucleus","volume":"499","author":"Rosin","year":"2006","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.autneu.2010.08.004_bb0255","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/cne.10860","article-title":"Hypothalamic orexin (hypocretin) neurons express vesicular glutamate transporters VGLUT1 or VGLUT2","volume":"465","author":"Rosin","year":"2003","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.autneu.2010.08.004_bb0260","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1093\/sleep\/5.3.227","article-title":"Autonomic regulation of cardiopulmonary functions in sleep apnea syndrome and narcolepsy","volume":"5","author":"Sachs","year":"1982","journal-title":"Sleep"},{"key":"10.1016\/j.autneu.2010.08.004_bb0265","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/nrn2092","article-title":"The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness","volume":"8","author":"Sakurai","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.autneu.2010.08.004_bb0270","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0092-8674(00)80949-6","article-title":"Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior","volume":"92","author":"Sakurai","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.autneu.2010.08.004_bb0275","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.neuron.2005.03.010","article-title":"Input of orexin\/hypocretin neurons revealed by a genetically encoded tracer in mice","volume":"46","author":"Sakurai","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.autneu.2010.08.004_bb0280","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/S0006-8993(99)01457-2","article-title":"Cardiovascular regulatory actions of the hypocretins in brain","volume":"831","author":"Samson","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.autneu.2010.08.004_bb0285","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1038\/nature04284","article-title":"Hypothalamic regulation of sleep and circadian rhythms","volume":"437","author":"Saper","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.autneu.2010.08.004_bb0290","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1152\/jn.00275.2003","article-title":"Role of nucleus tractus solitarius 5-HT3 receptors in the defense reaction-induced inhibition of the aortic baroreflex in rats","volume":"90","author":"S\u00e9voz-Couche","year":"2003","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.autneu.2010.08.004_bb0295","first-page":"R1780","article-title":"Sympathetic and cardiovascular actions of orexins in conscious rats","volume":"277","author":"Shirasaka","year":"1999","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.autneu.2010.08.004_bb0300","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/S0306-4522(02)00488-8","article-title":"Selective enhancement of excitatory synaptic activity in the rat nucleus tractus solitarius by hypocretin 2","volume":"115","author":"Smith","year":"2002","journal-title":"Neuroscience"},{"key":"10.1016\/j.autneu.2010.08.004_bb0305","first-page":"R798","article-title":"Hypothalamic glutamatergic input to medullary sympathoexcitatory neurons in rats","volume":"251","author":"Sun","year":"1986","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.autneu.2010.08.004_bb0310","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.resp.2009.03.006","article-title":"CO2 activates orexin-containing neurons in mice","volume":"166","author":"Sunanaga","year":"2009","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.autneu.2010.08.004_bb0315","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0896-6273(00)00058-1","article-title":"Reduced number of hypocretin neurons in human narcolepsy","volume":"27","author":"Thannickal","year":"2000","journal-title":"Neuron"},{"key":"10.1016\/j.autneu.2010.08.004_bb0320","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1113\/expphysiol.1996.sp003919","article-title":"The role of adenosine receptors in the rostral ventrolateral medulla in the cardiovascular response to defence area stimulation in the rat","volume":"81","author":"Thomas","year":"1996","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.autneu.2010.08.004_bb0325","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1097\/00001756-200203250-00014","article-title":"Developmental changes in the orexin 2 receptor mRNA in hypoglossal motoneurons","volume":"13","author":"Volgin","year":"2002","journal-title":"NeuroReport"},{"key":"10.1016\/j.autneu.2010.08.004_bb0330","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1097\/00001756-200501190-00002","article-title":"Persistent pain and stress activate pain-inhibitory orexin pathways","volume":"16","author":"Watanabe","year":"2005","journal-title":"NeuroReport"},{"key":"10.1016\/j.autneu.2010.08.004_bb0335","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1146\/annurev.neuro.24.1.429","article-title":"To eat or to sleep? Orexin in the regulation of feeding and wakefulness","volume":"24","author":"Willie","year":"2001","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.autneu.2010.08.004_bb0340","doi-asserted-by":"crossref","first-page":"11439","DOI":"10.1523\/JNEUROSCI.3459-04.2004","article-title":"Interaction between the corticotropin-releasing factor system and hypocretins (orexins): a novel circuit mediating stress response","volume":"24","author":"Winsky-Sommerer","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.autneu.2010.08.004_bb0345","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/sj.bjp.0704851","article-title":"Analgesic effect of intrathecally administered orexin-A in the rat formalin test and in the rat hot plate test","volume":"137","author":"Yamamoto","year":"2002","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.autneu.2010.08.004_bb0350","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1002\/cne.20859","article-title":"Afferents to the orexin neurons of the rat brain","volume":"494","author":"Yoshida","year":"2006","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.autneu.2010.08.004_bb0355","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1152\/japplphysiol.00914.2004","article-title":"Orexin stimulates breathing via medullary and spinal pathways","volume":"98","author":"Young","year":"2005","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.autneu.2010.08.004_bb0360","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.neulet.2005.05.032","article-title":"Respiratory and cardiovascular actions of orexin-A in mice","volume":"385","author":"Zhang","year":"2005","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.autneu.2010.08.004_bb0365","doi-asserted-by":"crossref","first-page":"R1654","DOI":"10.1152\/ajpregu.00704.2005","article-title":"Orexin neuron-mediated skeletal muscle vasodilation and shift of baroreflex during defense response in mice","volume":"290","author":"Zhang","year":"2006","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.autneu.2010.08.004_bb0370","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.autneu.2006.02.021","article-title":"Multiple components of the defense response depend on orexin: evidence from orexin knockout mice and orexin neuron-ablated mice","volume":"126\u2013127","author":"Zhang","year":"2006","journal-title":"Autom. Neurosci.: Basic Clin."},{"key":"10.1016\/j.autneu.2010.08.004_bb0375","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.brainres.2009.01.022","article-title":"Orexin neurons in the hypothalamus mediate cardiorespiratory responses induced by disinhibition of the amygdala and bed nucleus of the stria terminalis","volume":"1262","author":"Zhang","year":"2009","journal-title":"Brain Res."},{"key":"10.1016\/j.autneu.2010.08.004_bb0380","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1097\/00001756-200207190-00027","article-title":"Activation of orexin neurones after noxious but not conditioned fear stimuli in rats","volume":"13","author":"Zhu","year":"2002","journal-title":"NeuroReport"}],"container-title":["Autonomic Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1566070210001864?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1566070210001864?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T12:00:25Z","timestamp":1761566425000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1566070210001864"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4]]},"references-count":76,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["S1566070210001864"],"URL":"https:\/\/doi.org\/10.1016\/j.autneu.2010.08.004","relation":{},"ISSN":["1566-0702"],"issn-type":[{"value":"1566-0702","type":"print"}],"subject":[],"published":{"date-parts":[[2011,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Orexin links emotional stress to autonomic functions","name":"articletitle","label":"Article Title"},{"value":"Autonomic Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.autneu.2010.08.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}