{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T14:22:39Z","timestamp":1790432559935,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["autonomicneuroscience.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Autonomic Neuroscience"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1016\/j.autneu.2011.05.006","type":"journal-article","created":{"date-parts":[[2011,6,25]],"date-time":"2011-06-25T12:18:34Z","timestamp":1309004314000},"page":"27-33","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Function and expression pattern of TRPM8 in bladder afferent neurons associated with bladder outlet obstruction in rats"],"prefix":"10.1016","volume":"164","author":[{"given":"Tokumasa","family":"Hayashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teruyoshi","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaru","family":"Ishimatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsue","family":"Takeya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachiyo","family":"Igata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei-ichiro","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Matsuoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.autneu.2011.05.006_bb0005","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.molbrainres.2005.01.013","article-title":"TRPM8 protein localization in trigeminal ganglion and taste papillae","volume":"136","author":"Abe","year":"2005","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.autneu.2011.05.006_bb0010","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1744-8069-1-36","article-title":"Detection of cold pain, cold allodynia and cold hyperalgesia in freely behaving rats","volume":"1","author":"Allchorne","year":"2005","journal-title":"Mol. Pain"},{"key":"10.1016\/j.autneu.2011.05.006_bb0020","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1111\/j.1460-9568.2004.03695.x","article-title":"Two populations of cold-sensitive neurons in rat dorsal root ganglia and their modulation by nerve growth factor","volume":"20","author":"Babes","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.autneu.2011.05.006_bb0275","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/ncpuro0672","article-title":"Mechanisms of disease: involvement of the urothelium in bladder dysfunction","volume":"4","author":"Birder","year":"2007","journal-title":"Nature Clin. Pract. Urol."},{"key":"10.1016\/j.autneu.2011.05.006_bb0025","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1124\/jpet.107.125435","article-title":"Activation of urothelial transient receptor potential vanilloid 4 by 4\u03b1-phorbol 12,13-didecanoate contributes to altered bladder reflexes in the rat","volume":"323","author":"Birder","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.autneu.2011.05.006_bb0035","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1001\/archneurpsyc.1957.02330400013002","article-title":"Spinal reflex activity from the vesical mucosa in paraplegic patients","volume":"160","author":"Bors","year":"1957","journal-title":"AMA Arch. Neurol. Psychiatry"},{"key":"10.1016\/j.autneu.2011.05.006_bb0265","doi-asserted-by":"crossref","first-page":"e7383","DOI":"10.1371\/journal.pone.0007383","article-title":"The contribution of TRPM8 and TRPA1 channels to cold allodynia and neuropathic pain","volume":"4","author":"Caspani","year":"2009","journal-title":"PloS One"},{"key":"10.1016\/j.autneu.2011.05.006_bb0040","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/S0022-5347(01)63020-9","article-title":"The incidence of a positive ice water test in bladder outlet obstructed patients: evidence for bladder neural plasticity","volume":"160","author":"Chai","year":"1998","journal-title":"J. Urol."},{"key":"10.1016\/j.autneu.2011.05.006_bb0045","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.eururo.2006.02.018","article-title":"A shifted paradigm for the further understanding, evaluation, and treatment of lower urinary tract symptoms in men: focus on the bladder","volume":"49","author":"Chapple","year":"2006","journal-title":"Eur. Urol."},{"key":"10.1016\/j.autneu.2011.05.006_bb0050","first-page":"R1271","article-title":"Detrusor-sphincter dyssynergia induced by cold stimulation of the urinary bladder of rats","volume":"272","author":"Cheng","year":"1997","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.autneu.2011.05.006_bb0055","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.neuron.2007.04.025","article-title":"TRP channel knockout mice lose their cool","volume":"54","author":"Chung","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.autneu.2011.05.006_bb0060","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.neuron.2007.04.017","article-title":"Attenuated cold sensitivity in TRPM8 null mice","volume":"54","author":"Colburn","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.autneu.2011.05.006_bb0065","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1080\/10790268.1996.11719431","article-title":"Intravesical capsaicin in neurologic impaired patients with detrusor hyperreflexia","volume":"19","author":"Das","year":"1996","journal-title":"J. Spinal Cord Med."},{"key":"10.1016\/j.autneu.2011.05.006_bb0260","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.urology.2007.06.1110","article-title":"Transient receptor potential channel A1 involved in sensory transduction of rat urinary bladder through C-fiber pathway","volume":"70","author":"Du","year":"2007","journal-title":"Urology"},{"key":"10.1016\/j.autneu.2011.05.006_bb0070","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.urology.2007.11.127","article-title":"Differential expression profile of cold (TRPA1) and cool (TRPM8) receptors in human urogenital organs","volume":"72","author":"Du","year":"2008","journal-title":"Urology"},{"key":"10.1016\/j.autneu.2011.05.006_bb0080","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1113\/jphysiol.1990.sp018172","article-title":"A bladder-to-bladder cooling reflex in the cat","volume":"427","author":"Fall","year":"1990","journal-title":"J. Physiol."},{"key":"10.1016\/j.autneu.2011.05.006_bb0085","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/j.bbrc.2007.05.029","article-title":"Increased TRPA1, TRPM8, and TRPV2 expression in dorsal root ganglia by nerve injury","volume":"358","author":"Frederick","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.autneu.2011.05.006_bb0090","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0022-5347(17)35501-5","article-title":"Evidence of cold receptors in the human bladder: effect of menthol on the bladder cooling reflex","volume":"150","author":"Geirsson","year":"1993","journal-title":"J. Urol."},{"key":"10.1016\/j.autneu.2011.05.006_bb0095","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1016\/S0022-5347(05)68062-7","article-title":"The bladder cooling reflex and the use of cooling as stimulus to the lower urinary tract","volume":"162","author":"Geirsson","year":"1999","journal-title":"J. Urol."},{"key":"10.1016\/j.autneu.2011.05.006_bb0100","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/s003450050118","article-title":"Positive bladder cooling reflex in patients with bladder outlet obstruction due to benign prostatic hyperplasia","volume":"17","author":"Gotoh","year":"1999","journal-title":"World J. Urol."},{"key":"10.1016\/j.autneu.2011.05.006_bb0105","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.neures.2009.07.005","article-title":"Expression of the TRPM8-immunoreactivity in dorsal root ganglion neurons innervating the rat urinary bladder","volume":"65","author":"Hayashi","year":"2009","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.autneu.2011.05.006_bb0110","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1097\/00001756-199705060-00012","article-title":"NGF involvement in pain induced by chronic constriction injury of the rat sciatic nerve","volume":"8","author":"Herzberg","year":"1997","journal-title":"NeuroReport"},{"key":"10.1016\/j.autneu.2011.05.006_bb0115","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/S0090-4295(03)00588-0","article-title":"Positive response to ice water test associated with high-grade bladder outlet obstruction in patients with benign prostatic hyperplasia","volume":"62","author":"Hirayama","year":"2003","journal-title":"Urology"},{"key":"10.1016\/j.autneu.2011.05.006_bb0120","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1113\/jphysiol.2002.019042","article-title":"Cold- and menthol-sensitive C afferents of cat urinary bladder","volume":"543","author":"Jiang","year":"2002","journal-title":"J. Physiol."},{"key":"10.1016\/j.autneu.2011.05.006_bb0125","doi-asserted-by":"crossref","first-page":"9874","DOI":"10.1523\/JNEUROSCI.2221-07.2007","article-title":"Bimodal action of menthol on the transient receptor potential channel TRPA1","volume":"27","author":"Karashima","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.autneu.2011.05.006_bb0130","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1002\/cne.20794","article-title":"Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with A \u03b4\/C-fibers and colocalization with Trk receptors","volume":"493","author":"Kobayashi","year":"2005","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.autneu.2011.05.006_bb0135","doi-asserted-by":"crossref","first-page":"F892","DOI":"10.1152\/ajprenal.90718.2008","article-title":"Functional TRP and ASIC-like channels in cultured urothelial cells from the rat","volume":"296","author":"Kullmann","year":"2009","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.autneu.2011.05.006_bb0140","doi-asserted-by":"crossref","first-page":"F803","DOI":"10.1152\/ajprenal.90269.2008","article-title":"AMTB, a TRPM8 channel blocker: evidence in rats for activity in overactive bladder and painful bladder syndrome","volume":"295","author":"Lashinger","year":"2008","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.autneu.2011.05.006_bb0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1748-1716.1991.tb09037.x","article-title":"Effect of menthol on the bladder cooling reflex in the cat","volume":"141","author":"Lindstr\u00f6m","year":"1991","journal-title":"Acta Physiol. Scand."},{"key":"10.1016\/j.autneu.2011.05.006_bb0150","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1097\/01.ju.0000134381.95274.a4","article-title":"Inhibition of the bladder cooling reflex in the awake state: an experimental study in the cat","volume":"172","author":"Lindstr\u00f6m","year":"2004","journal-title":"J. Urol."},{"key":"10.1016\/j.autneu.2011.05.006_bb0155","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.mcn.2006.05.005","article-title":"More than cool: promiscuous relationships of menthol and other sensory compounds","volume":"32","author":"Macpherson","year":"2006","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.autneu.2011.05.006_bb0160","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1016\/S0022-5347(17)53503-X","article-title":"Changes in contractile properties in hypertrophic rat urinary bladder","volume":"128","author":"Mattiasson","year":"1982","journal-title":"J. Urol."},{"key":"10.1016\/j.autneu.2011.05.006_bb0165","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/j.1469-7793.1998.531bb.x","article-title":"The C fibre reflex of the cat urinary bladder","volume":"513","author":"Mazi\u00e8res","year":"1998","journal-title":"J. Physiol."},{"key":"10.1016\/j.autneu.2011.05.006_bb0170","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/nature719","article-title":"Identification of a cold receptor reveals a general role for TRP channels in thermosensation","volume":"416","author":"McKemy","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.autneu.2011.05.006_bb0175","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1471-2490-6-6","article-title":"Cool and menthol receptor TRPM8 in human urinary bladder disorders and clinical correlations","volume":"6","author":"Mukerji","year":"2006","journal-title":"BMC Urol."},{"key":"10.1016\/j.autneu.2011.05.006_bb0270","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.pain.2008.03.007","article-title":"Role of TRPM8 and TRPA1 for cold allodynia in patients with cold injury","volume":"139","author":"Namer","year":"2008","journal-title":"Pain"},{"key":"10.1016\/j.autneu.2011.05.006_bb0180","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.urology.2007.11.137","article-title":"Effect of menthol on detrusor smooth-muscle contraction and the micturition reflex in rats","volume":"72","author":"Nomoto","year":"2008","journal-title":"Urology"},{"key":"10.1016\/j.autneu.2011.05.006_bb0190","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S0092-8674(02)00652-9","article-title":"A TRP channel that senses cold stimuli and menthol","volume":"108","author":"Peier","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.autneu.2011.05.006_bb0195","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/j.cub.2006.07.061","article-title":"Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain","volume":"16","author":"Proudfoot","year":"2006","journal-title":"Curr. Biol."},{"key":"10.1016\/j.autneu.2011.05.006_bb0200","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1113\/jphysiol.2002.024331","article-title":"A cold- and menthol-activated current in rat dorsal root ganglion neurones: properties and role in cold transduction","volume":"545","author":"Reid","year":"2002","journal-title":"J. Physiol."},{"key":"10.1016\/j.autneu.2011.05.006_bb0205","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1016\/S0022-5347(17)37092-1","article-title":"The effect of experimental urethral obstruction and its reversal on changes in passive electrical properties of detrusor muscle","volume":"148","author":"Seki","year":"1992","journal-title":"J. Urol."},{"key":"10.1016\/j.autneu.2011.05.006_bb0210","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1016\/S0022-5347(17)43675-5","article-title":"Bladder outflow obstruction\u2014a cause of denervation supersensitivity","volume":"138","author":"Speakman","year":"1987","journal-title":"J. Urol."},{"key":"10.1016\/j.autneu.2011.05.006_bb0220","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/S0022-5347(17)41846-5","article-title":"Effect of bladder outlet obstruction on micturition reflex pathways in the rat","volume":"140","author":"Steers","year":"1988","journal-title":"J. Urol."},{"key":"10.1016\/j.autneu.2011.05.006_bb0225","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1172\/JCI115488","article-title":"Nerve growth factor in the urinary bladder of the adult regulates neuronal form and function","volume":"88","author":"Steers","year":"1991","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.autneu.2011.05.006_bb0255","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0022-5347(01)66664-3","article-title":"Immunity to nerve growth factor prevents afferent plasticity following urinary bladder hypertrophy","volume":"155","author":"Steers","year":"1996","journal-title":"J. Urol."},{"key":"10.1016\/j.autneu.2011.05.006_bb0230","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1097\/01.ju.0000134880.55119.cf","article-title":"Cool (TRPM8) and hot (TRPV1) receptors in the bladder and male genital tract","volume":"172","author":"Stein","year":"2004","journal-title":"J. Urol."},{"key":"10.1016\/j.autneu.2011.05.006_bb0235","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S0092-8674(03)00158-2","article-title":"ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures","volume":"112","author":"Story","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.autneu.2011.05.006_bb0240","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1097\/01.ju.0000071479.02427.7d","article-title":"Effect of preemptive treatment of capsaicin or resiniferatoxin on the development of pre-micturition contractions after partial urethral obstruction in the rat","volume":"170","author":"Tanaka","year":"2003","journal-title":"J. Urol."},{"key":"10.1016\/j.autneu.2011.05.006_bb0245","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.urology.2004.10.006","article-title":"Cold response of the bladder in guinea pig: involvement of transient receptor potential channel, TRPM8","volume":"65","author":"Tsukimi","year":"2005","journal-title":"Urology"},{"key":"10.1016\/j.autneu.2011.05.006_bb0250","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1152\/jn.01035.2005","article-title":"Chemical and cold sensitivity of two distinct populations of TRPM8-expressing somatosensory neurons","volume":"95","author":"Xing","year":"2006","journal-title":"J. Neurophysiol."}],"container-title":["Autonomic Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1566070211001019?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1566070211001019?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T12:00:34Z","timestamp":1761566434000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1566070211001019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":50,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["S1566070211001019"],"URL":"https:\/\/doi.org\/10.1016\/j.autneu.2011.05.006","relation":{},"ISSN":["1566-0702"],"issn-type":[{"value":"1566-0702","type":"print"}],"subject":[],"published":{"date-parts":[[2011,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Function and expression pattern of TRPM8 in bladder afferent neurons associated with bladder outlet obstruction in rats","name":"articletitle","label":"Article Title"},{"value":"Autonomic Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.autneu.2011.05.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}