{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T04:37:31Z","timestamp":1785818251164,"version":"3.56.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["autonomicneuroscience.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Autonomic Neuroscience"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1016\/j.autneu.2011.07.004","type":"journal-article","created":{"date-parts":[[2011,8,6]],"date-time":"2011-08-06T12:36:06Z","timestamp":1312634166000},"page":"89-95","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Beta-1 and beta-2 adrenergic receptor polymorphism and association with cardiovascular response to orthostatic screening"],"prefix":"10.1016","volume":"164","author":[{"given":"E.D.","family":"Wittwer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.D.","family":"Warner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.R.","family":"Schroeder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.M.","family":"Nadeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.R.","family":"Allen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.J.","family":"Murillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.L.","family":"Elvebak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.M.","family":"Aakre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.H.","family":"Eisenach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.autneu.2011.07.004_bb0005","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1053\/eupc.2002.0271","article-title":"Catecholamine response during haemodynamically stable upright posture in individuals with and without tilt-table induced vasovagal syncope","volume":"5","author":"Benditt","year":"2003","journal-title":"Europace"},{"key":"10.1016\/j.autneu.2011.07.004_bb0010","doi-asserted-by":"crossref","first-page":"2877","DOI":"10.1161\/01.CIR.101.25.2877","article-title":"Positional genomic analysis identifies the beta(2)-adrenergic receptor gene as a susceptibility locus for human hypertension","volume":"101","author":"Bray","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.autneu.2011.07.004_bb0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pharmthera.2007.07.002","article-title":"Beta-1 and beta-2 adrenoceptor polymorphisms: functional importance, impact on cardiovascular diseases and drug responses","volume":"117","author":"Brodde","year":"2008","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.autneu.2011.07.004_bb0020","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1161\/01.HYP.0000052831.85600.79","article-title":"Beta(2)-adrenergic receptor gene polymorphism, age, and cardiovascular phenotypes","volume":"41","author":"Castellano","year":"2003","journal-title":"Hypertension"},{"key":"10.1016\/j.autneu.2011.07.004_bb0025","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/BF02332974","article-title":"Influences of female reproductive hormones on sympathetic control of the circulation in humans","volume":"11","author":"Charkoudian","year":"2001","journal-title":"Clin. Auton. Res."},{"key":"10.1016\/j.autneu.2011.07.004_bb0030","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1113\/expphysiol.2009.048330","article-title":"Beta-adrenoceptor gene variation and intermediate physiological traits: prediction of distant phenotype","volume":"95","author":"Eisenach","year":"2010","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.autneu.2011.07.004_bb0035","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1152\/physiolgenomics.00152.2003","article-title":"The Arg16\/Gly beta2-adrenergic receptor polymorphism is associated with altered cardiovascular responses to isometric exercise","volume":"16","author":"Eisenach","year":"2004","journal-title":"Physiol. Genomics"},{"key":"10.1016\/j.autneu.2011.07.004_bb0040","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1152\/japplphysiol.00469.2005","article-title":"The Arg16\/Gly {beta}2-adrenergic receptor polymorphism alters the cardiac output response to isometric exercise","volume":"99","author":"Eisenach","year":"2005","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.autneu.2011.07.004_bb0045","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/S0002-9149(02)03422-7","article-title":"Adrenal\/renal contribution to circulating norepinephrine in posturally induced neurally mediated reflex syncope","volume":"91","author":"Ermis","year":"2003","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.autneu.2011.07.004_bb0050","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1056\/NEJMra0907175","article-title":"Genomic medicine\u2014an updated primer","volume":"362","author":"Feero","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.autneu.2011.07.004_bb0055","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1113\/jphysiol.2002.031138","article-title":"Beta(2)-adrenergic receptor polymorphism and nitric oxide-dependent forearm blood flow responses to isoproterenol in humans","volume":"546","author":"Garovic","year":"2003","journal-title":"J. Physiol."},{"key":"10.1016\/j.autneu.2011.07.004_bb0060","first-page":"111","article-title":"Adrenomedullary, adrenocortical, and sympathoneural responses to stressors: a meta-analysis","volume":"42","author":"Goldstein","year":"2008","journal-title":"Endocr. Regul."},{"key":"10.1016\/j.autneu.2011.07.004_bb0065","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1161\/01.HYP.5.4.552","article-title":"Relationship between plasma norepinephrine and sympathetic neural activity","volume":"5","author":"Goldstein","year":"1983","journal-title":"Hypertension"},{"key":"10.1016\/j.autneu.2011.07.004_bb0070","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0002-9149(02)02997-1","article-title":"Sympathoadrenal imbalance before neurocardiogenic syncope","volume":"91","author":"Goldstein","year":"2003","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.autneu.2011.07.004_bb0075","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1113\/jphysiol.2010.190058","article-title":"Beta2-adrenoceptor gene variation and systemic vasodilatation during ganglionic blockade","volume":"588","author":"Hesse","year":"2010","journal-title":"J. Physiol."},{"key":"10.1016\/j.autneu.2011.07.004_bb0080","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1161\/01.HYP.0000205120.46149.34","article-title":"Beta2-adrenoceptor genotype and function affect hemodynamic profile heterogeneity in postural tachycardia syndrome","volume":"47","author":"Jacob","year":"2006","journal-title":"Hypertension"},{"key":"10.1016\/j.autneu.2011.07.004_bb0085","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1016\/0002-8703(87)90666-1","article-title":"Heart rate and cardiovascular mortality: the Framingham Study","volume":"113","author":"Kannel","year":"1987","journal-title":"Am. Heart J."},{"key":"10.1016\/j.autneu.2011.07.004_bb0090","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1053\/euhj.1999.1741","article-title":"The association of resting heart rate with cardiovascular, cancer and all-cause mortality. Eight year follow-up of 3527 male Israeli employees (the CORDIS Study)","volume":"21","author":"Kristal-Boneh","year":"2000","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.autneu.2011.07.004_bb0095","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1161\/01.CIR.101.8.862","article-title":"Influence of the menstrual cycle on sympathetic activity, baroreflex sensitivity, and vascular transduction in young women","volume":"101","author":"Minson","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.autneu.2011.07.004_bb0100","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.autneu.2005.05.001","article-title":"A screen of candidate genes and influence of beta2-adrenergic receptor genotypes in postural tachycardia syndrome","volume":"120","author":"Nickander","year":"2005","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.autneu.2011.07.004_bb0105","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1152\/japplphysiol.90796.2008","article-title":"Cardiovascular dynamics in healthy subjects with differing heart rate responses to tilt","volume":"105","author":"Ramirez-Marrero","year":"2008","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.autneu.2011.07.004_bb0110","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1086\/339621","article-title":"A polymorphism in the beta1 adrenergic receptor is associated with resting heart rate","volume":"70","author":"Ranade","year":"2002","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.autneu.2011.07.004_bb0115","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1113\/jphysiol.2005.098558","article-title":"Arg16Gly polymorphism of the beta2-adrenergic receptor is associated with differences in cardiovascular function at rest and during exercise in humans","volume":"571","author":"Snyder","year":"2006","journal-title":"J. Physiol."},{"key":"10.1016\/j.autneu.2011.07.004_bb0120","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1249\/01.mss.0000218144.02831.f6","article-title":"Genotype related differences in beta2 adrenergic receptor density and cardiac function","volume":"38","author":"Snyder","year":"2006","journal-title":"Med. Sci. Sports Exerc."},{"key":"10.1016\/j.autneu.2011.07.004_bb0125","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.autneu.2010.01.002","article-title":"Lack of association between genetic polymorphisms affecting sympathetic activity and tilt-induced vasovagal syncope","volume":"155","author":"Sorrentino","year":"2010","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.autneu.2011.07.004_bb0130","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1536\/jhj.44.493","article-title":"Endogenous opioids and epinephrine in nitroglycerin provocation tilt test in patients with neurally mediated syncope","volume":"44","author":"Takase","year":"2003","journal-title":"Jpn. Heart J."},{"key":"10.1016\/j.autneu.2011.07.004_bb0135","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s00439-002-0780-9","article-title":"Evidence for a gene influencing heart rate on chromosome 4 among hypertensives","volume":"111","author":"Wilk","year":"2002","journal-title":"Hum. Genet."},{"key":"10.1016\/j.autneu.2011.07.004_bb0140","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1111\/j.1469-1809.2005.00258.x","article-title":"Adrenergic receptor polymorphisms associated with resting heart rate: the HyperGEN Study","volume":"70","author":"Wilk","year":"2006","journal-title":"Ann. Hum. Genet."},{"key":"10.1016\/j.autneu.2011.07.004_bb0145","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.hrthm.2008.01.039","article-title":"Polymorphisms in multiple genes are associated with resting heart rate in a stepwise allele-dependent manner","volume":"5","author":"Wilton","year":"2008","journal-title":"Heart Rhythm"}],"container-title":["Autonomic Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1566070211003663?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1566070211003663?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T12:01:10Z","timestamp":1761566470000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1566070211003663"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":29,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["S1566070211003663"],"URL":"https:\/\/doi.org\/10.1016\/j.autneu.2011.07.004","relation":{},"ISSN":["1566-0702"],"issn-type":[{"value":"1566-0702","type":"print"}],"subject":[],"published":{"date-parts":[[2011,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Beta-1 and beta-2 adrenergic receptor polymorphism and association with cardiovascular response to orthostatic screening","name":"articletitle","label":"Article Title"},{"value":"Autonomic Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.autneu.2011.07.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}