{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T06:20:54Z","timestamp":1790490054057,"version":"4.1.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["autonomicneuroscience.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Autonomic Neuroscience"],"published-print":{"date-parts":[[2012,1]]},"DOI":"10.1016\/j.autneu.2011.10.002","type":"journal-article","created":{"date-parts":[[2011,11,9]],"date-time":"2011-11-09T20:02:39Z","timestamp":1320868959000},"page":"96-99","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":66,"title":["The relationship between heart rate variability and time-course of carcinoembryonic antigen in colorectal cancer"],"prefix":"10.1016","volume":"166","author":[{"given":"Charlotte","family":"Mouton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Ronson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darius","family":"Razavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Delhaye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Kupper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Paesmans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Moreau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marie","family":"Nogaret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Hendlisz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yori","family":"Gidron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.autneu.2011.10.002_bb0005","first-page":"486","article-title":"A phase I study of CNI-1493, an inhibitor of cytokine release, in combination with high-dose interleukin-2 in patients with renal cancer and melanoma","volume":"7","author":"Atkins","year":"2001","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.autneu.2011.10.002_bb0010","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1084\/jem.20011714","article-title":"Pharmacological stimulation of the cholinergic antiinflammatory pathway","volume":"195","author":"Bernik","year":"2002","journal-title":"J. Exp. Med."},{"issue":"4","key":"10.1016\/j.autneu.2011.10.002_bb0015","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.jpainsymman.2009.09.014","article-title":"Association between cardiovascular autonomic functions and time to death in patients with terminal hepatocellular carcinoma","volume":"39","author":"Chiang","year":"2010","journal-title":"J. Pain Symptom Manage."},{"key":"10.1016\/j.autneu.2011.10.002_bb0025","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1089\/107999099313064","article-title":"Prevention of lethality and suppression of proinflammatory cytokines in experimental septic shock by microencapsulated CNI-1493","volume":"19","author":"D'Souza","year":"1999","journal-title":"J. Interferon Cytokine Res."},{"issue":"10","key":"10.1016\/j.autneu.2011.10.002_bb0020","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1093\/oxfordjournals.aje.a009049","article-title":"Heart rate variability from short electrocardiographic recordings predicts mortality from all causes in middle-aged and elderly men","volume":"145","author":"Dekker","year":"1997","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.autneu.2011.10.002_bb0030","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1136\/bmj.316.7130.518","article-title":"Relation of vagotomy to subsequent risk of lung cancer: population based cohort study","volume":"316","author":"Ekbom","year":"1998","journal-title":"BMJ"},{"issue":"4","key":"10.1016\/j.autneu.2011.10.002_bb0035","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/S1470-2045(04)01431-7","article-title":"Tumour-cell migration, invasion, and metastasis: navigation by neurotransmitters","volume":"5","author":"Entschladen","year":"2004","journal-title":"Lancet Oncol."},{"issue":"1\u20133","key":"10.1016\/j.autneu.2011.10.002_bb0040","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.regpep.2008.03.012","article-title":"Vagotomy enhances experimental metastases of 4THMpc breast cancer cells and alters substance P level","volume":"151","author":"Erin","year":"2008","journal-title":"Regul. Pept."},{"issue":"2","key":"10.1016\/j.autneu.2011.10.002_bb0050","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.jpainsymman.2009.06.014","article-title":"The association between autonomic dysfunction and survival in male patients with advanced cancer: a preliminary report","volume":"39","author":"Fadul","year":"2010","journal-title":"J. Pain Symptom Manage."},{"issue":"Suppl. 1","key":"10.1016\/j.autneu.2011.10.002_bb0045","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1080\/13547500902965047","article-title":"The role of oxidative stress in the biological responses of lung epithelial cells to cigarette smoke","volume":"14","author":"Faux","year":"2009","journal-title":"Biomarkers"},{"issue":"5","key":"10.1016\/j.autneu.2011.10.002_bb0055","first-page":"1013","article-title":"Prediction of postoperative survival by preoperative serum concentrations of anti-p53 compared to CEA, CA 50, CA 242 and conventional blood tests in patients with colorectal carcinoma","volume":"20","author":"Forslund","year":"2002","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.autneu.2011.10.002_bb0060","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S1470-2045(05)70096-6","article-title":"Does the vagus nerve inform the brain about preclinical tumours and modulate them?","volume":"6","author":"Gidron","year":"2005","journal-title":"Lancet Oncol."},{"issue":"1","key":"10.1016\/j.autneu.2011.10.002_bb0065","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.ijcard.2003.07.005","article-title":"Can cardiac vagal tone be estimated from the 10-second ECG?","volume":"95","author":"Hamilton","year":"2004","journal-title":"Int. J. Cardiol."},{"issue":"1","key":"10.1016\/j.autneu.2011.10.002_bb0070","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1159\/000051870","article-title":"Prognostic value of heart rate variability analysis in patients with carcinoid syndrome","volume":"63","author":"Hoffmann","year":"2001","journal-title":"Digestion"},{"issue":"22","key":"10.1016\/j.autneu.2011.10.002_bb0075","doi-asserted-by":"crossref","first-page":"3681","DOI":"10.1200\/JCO.2007.15.0904","article-title":"Usefulness of the serum carcinoembryonic antigen kinetic for chemotherapy monitoring in patients with unresectable metastasis of colorectal cancer","volume":"26","author":"Iwanicki-Caron","year":"2008","journal-title":"J. Clin. Oncol."},{"issue":"1","key":"10.1016\/j.autneu.2011.10.002_bb0080","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s10484-006-9029-z","article-title":"Preliminary results of an open label study of heart rate variability biofeedback for the treatment of major depression","volume":"32","author":"Karavidas","year":"2007","journal-title":"Appl. Psychophysiol. Biofeedback"},{"issue":"8","key":"10.1016\/j.autneu.2011.10.002_bb0085","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.3346\/jkms.2010.25.8.1140","article-title":"Heart rate variability and length of survival in hospice cancer patients","volume":"25","author":"Kim do","year":"2010","journal-title":"J. Korean Med. Sci."},{"issue":"8","key":"10.1016\/j.autneu.2011.10.002_bb0090","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1111\/j.1540-8167.2005.40656.x","article-title":"Regression analysis between heart rate variability and baroreflex-related vagus nerve activity in rats","volume":"16","author":"Kuo","year":"2005","journal-title":"J. Cardiovasc. Electrophysiol."},{"issue":"Suppl. 5","key":"10.1016\/j.autneu.2011.10.002_bb0095","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1093\/annonc\/mdq168","article-title":"Primary colon cancer: ESMO Clinical Practice Guidelines for diagnosis, adjuvant treatment and follow-up","volume":"21","author":"Labianca","year":"2010","journal-title":"Ann. Oncol."},{"issue":"2","key":"10.1016\/j.autneu.2011.10.002_bb0100","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1378\/chest.126.2.352","article-title":"Biofeedback treatment for asthma","volume":"126","author":"Lehrer","year":"2004","journal-title":"Chest"},{"key":"10.1016\/j.autneu.2011.10.002_bb0105","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/nature07205","article-title":"Cancer-related inflammation","volume":"454","author":"Mantovani","year":"2008","journal-title":"Nature"},{"issue":"1\u20132","key":"10.1016\/j.autneu.2011.10.002_bb0110","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jneuroim.2006.07.003","article-title":"Neural-endocrine-immune complex in the central modulation of tumorigenesis: facts, assumptions, and hypotheses","volume":"180","author":"Mravec","year":"2006","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.autneu.2011.10.002_bb0115","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2165\/00023210-200317020-00003","article-title":"Stimulation of the nervous system for the management of seizures: current and future developments","volume":"17","author":"Murphy","year":"2003","journal-title":"CNS Drugs"},{"key":"10.1016\/j.autneu.2011.10.002_bb0120","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/S1470-2045(09)70337-7","article-title":"Role of nervous system in cancer aetiopathogenesis","volume":"11","author":"Ondicova","year":"2010","journal-title":"Lancet Oncol."},{"issue":"7","key":"10.1016\/j.autneu.2011.10.002_bb0125","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1007\/PL00012376","article-title":"Prognostic factors in 2230 Korean colorectal cancer patients: analysis of consecutively operated cases","volume":"23","author":"Park","year":"1999","journal-title":"World J. Surg."},{"issue":"7","key":"10.1016\/j.autneu.2011.10.002_bb0130","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1080\/10641960802251875","article-title":"Short-term heart variability and oxidative stress in newly diagnosed essential hypertension","volume":"30","author":"Pavithran","year":"2008","journal-title":"Clin. Exp. Hypertens."},{"key":"10.1016\/j.autneu.2011.10.002_bb0135","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/nature02924","article-title":"NF-kappaB functions as a tumour promoter in inflammation-associated cancer","volume":"431","author":"Pikarsky","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.autneu.2011.10.002_bb0145","first-page":"5664","article-title":"Predicting imminent episodes of ventricular tachyarrhythmia\u2013retrospective analysis of short R-R records from ICD","volume":"2008","author":"Thong","year":"2008","journal-title":"Conf. Proc. IEEE Eng. Med. Biol. Soc."},{"key":"10.1016\/j.autneu.2011.10.002_bb0140","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/nature01321","article-title":"The inflammatory reflex","volume":"420","author":"Tracey","year":"2002","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.autneu.2011.10.002_bb0150","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1093\/cvr\/cvm092","article-title":"Modulation of the myocardial redox state by vagal nerve stimulation after experimental myocardial infarction","volume":"77","author":"Tsutsumi","year":"2008","journal-title":"Cardiovasc. Res."},{"issue":"26","key":"10.1016\/j.autneu.2011.10.002_bb0155","first-page":"709","article-title":"The medical treatment of colorectal cancer: actual status and new developments","volume":"46","author":"Van Cutsem","year":"1999","journal-title":"Hepatogastroenterology"},{"issue":"1\u20132","key":"10.1016\/j.autneu.2011.10.002_bb0160","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.autneu.2008.08.001","article-title":"Heart rate variability and catecholamines during hypoglycemia and orthostasis","volume":"143","author":"Vlcek","year":"2008","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.autneu.2011.10.002_bb0165","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1073\/pnas.0437939100","article-title":"IL-1 is required for tumour invasiveness and angiogenesis","volume":"100","author":"Voronov","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Autonomic Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1566070211004772?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1566070211004772?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T12:01:57Z","timestamp":1761566517000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1566070211004772"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":33,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["S1566070211004772"],"URL":"https:\/\/doi.org\/10.1016\/j.autneu.2011.10.002","relation":{},"ISSN":["1566-0702"],"issn-type":[{"value":"1566-0702","type":"print"}],"subject":[],"published":{"date-parts":[[2012,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The relationship between heart rate variability and time-course of carcinoembryonic antigen in colorectal cancer","name":"articletitle","label":"Article Title"},{"value":"Autonomic Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.autneu.2011.10.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}