{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:16:38Z","timestamp":1791090998189,"version":"4.1.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100006726","name":"R\u00e5dman och Fru Ernst Collianders Stiftelse","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006726","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006685","name":"Kungliga och Hvitfeldtska stiftelsen","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006685","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Wilhelm och Martina Lundgrens Vetenskapsfond"},{"DOI":"10.13039\/100007397","name":"Charles University in Prague","doi-asserted-by":"crossref","award":["SVV 265 004"],"award-info":[{"award-number":["SVV 265 004"]}],"id":[{"id":"10.13039\/100007397","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["autonomicneuroscience.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Autonomic Neuroscience"],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.1016\/j.autneu.2012.10.006","type":"journal-article","created":{"date-parts":[[2012,11,8]],"date-time":"2012-11-08T07:16:10Z","timestamp":1352358970000},"page":"49-57","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Adenosine receptor antagonism suppresses functional and histological inflammatory changes in the rat urinary bladder"],"prefix":"10.1016","volume":"171","author":[{"given":"Patrik","family":"Aronsson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Johnsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Vesela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Winder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar","family":"Tobin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.autneu.2012.10.006_bb0005","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1038\/bjp.2008.6","article-title":"Cholinergic nitric oxide release from the urinary bladder mucosa in cyclophosphamide-induced cystitis of the anaesthetized rat","volume":"153","author":"Andersson","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.autneu.2012.10.006_bb0010","doi-asserted-by":"crossref","first-page":"3323","DOI":"10.1002\/art.30556","article-title":"Pharmacologic P2X purinergic receptor antagonism in the treatment of collagen-induced arthritis","volume":"63","author":"Ardissone","year":"2011","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.autneu.2012.10.006_bb0015","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1111\/j.1742-7843.2010.00554.x","article-title":"Assessment and characterization of purinergic contractions and relaxations in the rat urinary bladder","volume":"107","author":"Aronsson","year":"2010","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.autneu.2012.10.006_bb0020","series-title":"Oral presentation at the Joint meeting ISAN\/AAS 2011, Buzios, Rio de Janeiro, Brazil","article-title":"Pre-treatment with purinergic antagonists alter the functional response to methacholine in the inflamed rat urinary bladder","author":"Aronsson","year":"2011"},{"key":"10.1016\/j.autneu.2012.10.006_bb0025","doi-asserted-by":"crossref","first-page":"F423","DOI":"10.1152\/ajprenal.00056.2003","article-title":"Feline interstitial cystitis results in mechanical hypersensitivity and altered ATP release from bladder urothelium","volume":"285","author":"Birder","year":"2003","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.autneu.2012.10.006_bb0030","doi-asserted-by":"crossref","first-page":"F1084","DOI":"10.1152\/ajprenal.00118.2004","article-title":"Alterations in P2X and P2Y purinergic receptor expression in urinary bladder from normal cats and cats with interstitial cystitis","volume":"287","author":"Birder","year":"2004","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.autneu.2012.10.006_bb0035","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1111\/j.1476-5381.1995.tb14939.x","article-title":"The biphasic response of rat vesical smooth muscle to ATP","volume":"114","author":"Bolego","year":"1995","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.autneu.2012.10.006_bb0040","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0022-5347(05)67495-2","article-title":"Cyclophosphamide-induced cystitis in freely-moving conscious rats: behavioral approach to a new model of visceral pain","volume":"164","author":"Boucher","year":"2000","journal-title":"J. Urol."},{"key":"10.1016\/j.autneu.2012.10.006_bb0045","series-title":"Goodman & Gilman\u00b4s The Pharmaclogical Basis of Therapeutics","first-page":"219","article-title":"Muscarinic receptor agonists and antagonists","author":"Brown","year":"2011"},{"key":"10.1016\/j.autneu.2012.10.006_bb0050","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/BF00165037","article-title":"Binding of the A1-selective adenosine antagonist 8-cyclopentyl-1,3-dipropylxanthine to rat brain membranes","volume":"335","author":"Bruns","year":"1987","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/j.autneu.2012.10.006_bb0055","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/j.1476-5381.1972.tb07283.x","article-title":"Atropine resistant excitation of the urinary bladder: the possibility of transmission via nerves releasing a purine nucleotide","volume":"44","author":"Burnstock","year":"1972","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.autneu.2012.10.006_bb0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0022-5347(17)39848-8","article-title":"Hemorrhagic cystitis: a review","volume":"143","author":"deVries","year":"1990","journal-title":"J. Urol."},{"key":"10.1016\/j.autneu.2012.10.006_bb0065","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/j.1476-5381.1988.tb11427.x","article-title":"Suramin \u2014 a reversible P2-purinoceptor antagonist in the mouse vasdeferens","volume":"93","author":"Dunn","year":"1988","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.autneu.2012.10.006_bb0070","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/S0022-5347(17)42981-8","article-title":"Increased mast cells of the bladder in suspected cases of interstitial cystitis: a possible disease marker","volume":"138","author":"Feltis","year":"1987","journal-title":"J. Urol."},{"key":"10.1016\/j.autneu.2012.10.006_bb0075","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1038\/sj.cdd.4402132","article-title":"Adenosine, an endogenous distress signal, modulates tissue damage and repair","volume":"14","author":"Fredholm","year":"2007","journal-title":"Cell Death Differ."},{"issue":"Suppl. 3","key":"10.1016\/j.autneu.2012.10.006_bb0080","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1464-410X.2008.07493.x","article-title":"The concept of neurogenic inflammation","volume":"101","author":"Geppetti","year":"2008","journal-title":"BJU Int."},{"key":"10.1016\/j.autneu.2012.10.006_bb0090","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.autneu.2005.07.005","article-title":"Altered muscarinic receptor subtype expression and functional responses in cyclophosphamide induced cystitis in rats","volume":"122","author":"Giglio","year":"2005","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.autneu.2012.10.006_bb0085","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/j.1742-7843.2007.00014.x","article-title":"In vitro characterization of parasympathetic and sympathetic responses in cyclophosphamide-induced cystitis in the rat","volume":"100","author":"Giglio","year":"2007","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.autneu.2012.10.006_bb0095","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/0024-3205(87)90369-9","article-title":"PD 116,948, a highly selective A1 adenosine receptor antagonist","volume":"40","author":"Haleen","year":"1987","journal-title":"Life Sci."},{"key":"10.1016\/j.autneu.2012.10.006_bb0100","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0014-2999(84)90135-3","article-title":"A novel non-adrenergic, non-cholinergic nerve-mediated relaxation of the pig bladder neck: an examination of possible neurotransmitter candidates","volume":"99","author":"Hills","year":"1984","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.autneu.2012.10.006_bb0105","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0090-4295(99)80330-6","article-title":"Mast cells and nerve fibers in interstitial cystitis (IC): an algorithm for histologic diagnosis via quantitative image analysis and morphometry (QIAM)","volume":"49","author":"Hofmeister","year":"1997","journal-title":"Urology"},{"key":"10.1016\/j.autneu.2012.10.006_bb0110","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1007\/s11605-008-0507-x","article-title":"Intravital microscopic characterization of suramin effects in an orthotopic immunocompetent rat model of pancreatic cancer","volume":"12","author":"Hotz","year":"2008","journal-title":"J. Gastrointest. Surg."},{"key":"10.1016\/j.autneu.2012.10.006_bb0115","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1111\/j.1476-5381.1990.tb15856.x","article-title":"The properties of the ATP-induced depolarization and current in single cells isolated from the guinea-pig urinary bladder","volume":"100","author":"Inoue","year":"1990","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.autneu.2012.10.006_bb0120","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/nrd1983","article-title":"Adenosine receptors as therapeutic targets","volume":"5","author":"Jacobson","year":"2006","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.autneu.2012.10.006_bb0125","first-page":"477","article-title":"Functional, histological structure and mastocytes alterations in rat urinary bladders following acute and chronic cyclophosphamide treatment","volume":"61","author":"Juszczak","year":"2010","journal-title":"J. Physiol. Pharmacol."},{"key":"10.1016\/j.autneu.2012.10.006_bb0130","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0014-2999(02)02766-8","article-title":"Adenosine A1 receptor blockade reverses experimental postoperative ileus in rat colon","volume":"458","author":"Kadowaki","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.autneu.2012.10.006_bb0135","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1523\/JNEUROSCI.4694-07.2008","article-title":"Activation of muscarinic receptors in rat bladder sensory pathways alters reflex bladder activity","volume":"28","author":"Kullmann","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.autneu.2012.10.006_bb0140","doi-asserted-by":"crossref","first-page":"6436","DOI":"10.4049\/jimmunol.168.12.6436","article-title":"Absence of the P2X7 receptor alters leukocyte function and attenuates an inflammatory response","volume":"168","author":"Labasi","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.autneu.2012.10.006_bb0145","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/j.1464-410X.1982.tb06976.x","article-title":"Mast cells in interstitial cystitis","volume":"54","author":"Larsen","year":"1982","journal-title":"Br. J. Urol."},{"key":"10.1016\/j.autneu.2012.10.006_bb0150","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1097\/01.ju.0000110501.96416.40","article-title":"Intravesical nitric oxide production discriminates between classic and nonulcer interstitial cystitis","volume":"171","author":"Logadottir","year":"2004","journal-title":"J. Urol."},{"key":"10.1016\/j.autneu.2012.10.006_bb0155","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1476-5381.2011.01535.x","article-title":"The role of P2X7 purinergic receptors in inflammatory and nociceptive changes accompanying cyclophosphamide-induced haemorrhagic cystitis in mice","volume":"165","author":"Martins","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.autneu.2012.10.006_bb0160","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/0090-4295(78)90286-8","article-title":"Interstitial cystitis: early diagnosis, pathology, and treatment","volume":"12","author":"Messing","year":"1978","journal-title":"Urology"},{"key":"10.1016\/j.autneu.2012.10.006_bb0165","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/S0968-0896(98)00025-X","article-title":"8-(Sulfostyryl)xanthines: water-soluble A2A-selective adenosine receptor antagonists","volume":"6","author":"Muller","year":"1998","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.autneu.2012.10.006_bb0170","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1016\/S0022-5347(17)35955-4","article-title":"Evidence for purinergic neurotransmission in human urinary bladder affected by interstitial cystitis","volume":"150","author":"Palea","year":"1993","journal-title":"J. Urol."},{"key":"10.1016\/j.autneu.2012.10.006_bb0175","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0031-6997(24)01373-5","article-title":"Receptors for purines and pyrimidines","volume":"50","author":"Ralevic","year":"1998","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.autneu.2012.10.006_bb0180","doi-asserted-by":"crossref","first-page":"433","DOI":"10.3109\/00365599.2010.515613","article-title":"Does mast cell density predict the outcome after transurethral resection of Hunner's lesions in patients with type 3C bladder pain syndrome\/interstitial cystitis?","volume":"44","author":"Rossberger","year":"2010","journal-title":"Scand. J. Urol. Nephrol."},{"key":"10.1016\/j.autneu.2012.10.006_bb0185","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1111\/j.1464-410X.2009.08638.x","article-title":"Adenosine receptor expression in Escherichia coli-infected and cytokine-stimulated human urinary tract epithelial cells","volume":"104","author":"Save","year":"2009","journal-title":"BJU Int."},{"key":"10.1016\/j.autneu.2012.10.006_bb0190","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.neulet.2008.03.003","article-title":"Caffeine and a selective adenosine A(2B) receptor antagonist but not imidazoline receptor antagonists modulate antinociception induced by diphenyl diselenide in mice","volume":"436","author":"Savegnago","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.autneu.2012.10.006_bb0195","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1442-2042.2008.02207.x","article-title":"Purinergic receptor-mediated effects of adenosine 5\u2032-triphosphate in urological malignant diseases","volume":"16","author":"Shabbir","year":"2009","journal-title":"Int. J. Urol."},{"key":"10.1016\/j.autneu.2012.10.006_bb0200","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s002329900298","article-title":"Cloned ligand-gated channels activated by extracellular ATP (P2X receptors)","volume":"160","author":"Soto","year":"1997","journal-title":"J. Membr. Biol."},{"key":"10.1016\/j.autneu.2012.10.006_bb0205","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/BF02463644","article-title":"Globule leukocytes and mast cells in the rat trachea: their number, distribution, and response to compound 48\/80 and dexamethasone","volume":"178","author":"Tam","year":"1988","journal-title":"Anat. Embryol."},{"key":"10.1016\/j.autneu.2012.10.006_bb0220","doi-asserted-by":"crossref","first-page":"620","DOI":"10.3181\/0709-RM-240","article-title":"Upregulation of macrophage migration inhibitory factor (MIF) and CD74, receptor for MIF, in rat bladder during persistent cyclophosphamide-induced inflammation","volume":"233","author":"Vera","year":"2008","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1016\/j.autneu.2012.10.006_bb0225","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.autneu.2010.07.008","article-title":"Functional and morphological examinations of P1A1 purinoceptors in the normal and inflamed urinary bladder of the rat","volume":"159","author":"Vesela","year":"2011","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.autneu.2012.10.006_bb0210","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.neulet.2005.02.019","article-title":"Rapid tolerance to focal cerebral ischemia in rats is induced by preconditioning with electroacupuncture: window of protection and the role of adenosine","volume":"381","author":"Wang","year":"2005","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.autneu.2012.10.006_bb0215","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1007\/BF01966688","article-title":"Analysis of dimethyl sulfoxide immunosuppression in the rat model of collagen II autoimmune arthritis: an effect dependent upon intraperitoneal administration and associated with toxicity","volume":"17","author":"Watson","year":"1985","journal-title":"Agents Actions"},{"key":"10.1016\/j.autneu.2012.10.006_bb0230","doi-asserted-by":"crossref","first-page":"4644","DOI":"10.1523\/JNEUROSCI.19-11-04644.1999","article-title":"Increased excitability of afferent neurons innervating rat urinary bladder after chronic bladder inflammation","volume":"19","author":"Yoshimura","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.autneu.2012.10.006_bb0235","doi-asserted-by":"crossref","first-page":"C254","DOI":"10.1152\/ajpcell.00025.2006","article-title":"Adenosine receptor expression and function in bladder uroepithelium","volume":"291","author":"Yu","year":"2006","journal-title":"Am. J. Physiol. Cell Physiol."}],"container-title":["Autonomic Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1566070212001749?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1566070212001749?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T12:03:05Z","timestamp":1761566585000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1566070212001749"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":47,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["S1566070212001749"],"URL":"https:\/\/doi.org\/10.1016\/j.autneu.2012.10.006","relation":{},"ISSN":["1566-0702"],"issn-type":[{"value":"1566-0702","type":"print"}],"subject":[],"published":{"date-parts":[[2012,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adenosine receptor antagonism suppresses functional and histological inflammatory changes in the rat urinary bladder","name":"articletitle","label":"Article Title"},{"value":"Autonomic Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.autneu.2012.10.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}