{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T17:44:06Z","timestamp":1774460646466,"version":"3.50.1"},"reference-count":52,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100008456","name":"A. Alfred Taubman Medical Research Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008456","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Program for Neurology Research and Discovery"},{"name":"JDRF postdoctoral fellowship"}],"content-domain":{"domain":["autonomicneuroscience.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Autonomic Neuroscience"],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1016\/j.autneu.2013.03.001","type":"journal-article","created":{"date-parts":[[2013,4,3]],"date-time":"2013-04-03T04:15:52Z","timestamp":1364962552000},"page":"74-80","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Diabetic cardiac autonomic neuropathy: Insights from animal models"],"prefix":"10.1016","volume":"177","author":[{"given":"Catherine L.","family":"Stables","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca L.","family":"Glasser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva L.","family":"Feldman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.autneu.2013.03.001_bb0195","first-page":"224","article-title":"Natural progression of cardiac autonomic neuropathy in patients with type 1 diabetes: a four-year follow-up study","volume":"11","author":"Abd El Dayem","year":"2011","journal-title":"Anadolu. Kardiyol. Derg."},{"key":"10.1016\/j.autneu.2013.03.001_bb0010","doi-asserted-by":"crossref","first-page":"334","DOI":"10.2337\/diacare.29.02.06.dc05-1242","article-title":"Cardiac autonomic neuropathy predicts cardiovascular morbidity and mortality in type 1 diabetic patients with diabetic nephropathy","volume":"29","author":"Astrup","year":"2006","journal-title":"Diabetes Care"},{"key":"10.1016\/j.autneu.2013.03.001_bb0015","doi-asserted-by":"crossref","first-page":"E1104","DOI":"10.1152\/ajpendo.2000.279.5.E1104","article-title":"Altered metabolism causes cardiac dysfunction in perfused hearts from diabetic (db\/db) mice","volume":"279","author":"Belke","year":"2000","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.autneu.2013.03.001_bb0020","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s11154-010-9131-7","article-title":"Diabetic cardiomyopathy, causes and effects","volume":"11","author":"Boudina","year":"2010","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"10.1016\/j.autneu.2013.03.001_bb0025","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1007\/s00125-002-0869-7","article-title":"Effects on heart rate variability of metoprolol supplementary to ongoing ACE-inhibitor treatment in type I diabetic patients with abnormal albuminuria","volume":"45","author":"Ebbehoj","year":"2002","journal-title":"Diabetologia"},{"key":"10.1016\/j.autneu.2013.03.001_bb0030","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1161\/HYPERTENSIONAHA.108.124776","article-title":"Diabetic hypertensive leptin receptor-deficient db\/db mice develop cardioregulatory autonomic dysfunction","volume":"53","author":"Goncalves","year":"2009","journal-title":"Hypertension"},{"key":"10.1016\/j.autneu.2013.03.001_bb0200","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.autneu.2007.11.006","article-title":"Cardiovascular autonomic regulation in Non-Obese Diabetic (NOD) mice","volume":"138","author":"Gross","year":"2008","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.autneu.2013.03.001_bb0040","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1113\/expphysiol.2005.031252","article-title":"Long-term effects of streptozotocin-induced diabetes on the electrocardiogram, physical activity and body temperature in rats","volume":"90","author":"Howarth","year":"2005","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.autneu.2013.03.001_bb0045","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1113\/expphysiol.2007.040055","article-title":"Long-term effects of type 2 diabetes mellitus on heart rhythm in the Goto\u2013Kakizaki rat","volume":"93","author":"Howarth","year":"2008","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.autneu.2013.03.001_bb0050","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.2337\/diab.43.12.1469","article-title":"Neural dysfunction and metabolic imbalances in diabetic rats. Prevention by acetyl-l-carnitine","volume":"43","author":"Ido","year":"1994","journal-title":"Diabetes"},{"key":"10.1016\/j.autneu.2013.03.001_bb0055","doi-asserted-by":"crossref","first-page":"R1545","DOI":"10.1152\/ajpregu.00714.2001","article-title":"Autonomic control of blood pressure in mice: basic physiology and effects of genetic modification","volume":"282","author":"Janssen","year":"2002","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.autneu.2013.03.001_bb0060","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1084\/jem.20120988","article-title":"Unstressing intemperate models: how cold stress undermines mouse modeling","volume":"209","author":"Karp","year":"2012","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.autneu.2013.03.001_bb0065","doi-asserted-by":"crossref","first-page":"H453","DOI":"10.1152\/ajpheart.00678.2008","article-title":"Effects of cyclooxygenase-2 gene inactivation on cardiac autonomic and left ventricular function in experimental diabetes","volume":"296","author":"Kellogg","year":"2009","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.autneu.2013.03.001_bb0070","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1476-5381.1988.tb11399.x","article-title":"A comparison between atria from control and streptozotocin-diabetic rats: the effects of dietary myoinositol","volume":"93","author":"Kofo-Abayomi","year":"1988","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.autneu.2013.03.001_bb0075","doi-asserted-by":"crossref","first-page":"355","DOI":"10.2337\/diacare.20.3.355","article-title":"Effect of chronic quinapril administration on heart rate variability in patients with diabetic autonomic neuropathy","volume":"20","author":"Kontopoulos","year":"1997","journal-title":"Diabetes Care"},{"key":"10.1016\/j.autneu.2013.03.001_bb0080","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.2967\/jnumed.108.054361","article-title":"Whole-body evaluation of MIBG tissue extraction in a mouse model of long-lasting type II diabetes and its relationship with norepinephrine transport protein concentration","volume":"49","author":"Kusmic","year":"2008","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.autneu.2013.03.001_bb0085","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.autneu.2010.01.004","article-title":"Impairment of baroreflex control of heart rate and structural changes of cardiac ganglia in conscious streptozotocin (STZ)-induced diabetic mice","volume":"155","author":"Lin","year":"2010","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.autneu.2013.03.001_bb0205","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0168-8227(01)00375-8","article-title":"Autonomic neuropathy in streptozotocin diabetic rats: effect of acetyl-l-carnitine","volume":"56","author":"Lo Giudice","year":"2002","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.autneu.2013.03.001_bb0095","doi-asserted-by":"crossref","first-page":"2942","DOI":"10.2337\/diacare.27.12.2942","article-title":"Autonomic symptoms and diabetic neuropathy: a population-based study","volume":"27","author":"Low","year":"2004","journal-title":"Diabetes Care"},{"key":"10.1016\/j.autneu.2013.03.001_bb0100","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1080\/00365510802018330","article-title":"A combined abnormality in heart rate variation and QT corrected interval is a strong predictor of cardiovascular death in type 1 diabetes","volume":"68","author":"Lykke","year":"2008","journal-title":"Scand. J. Clin. Lab. Invest."},{"key":"10.1016\/j.autneu.2013.03.001_bb0105","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.autneu.2011.01.008","article-title":"Remodeling of cardiac cholinergic innervation and control of heart rate in mice with streptozotocin-induced diabetes","volume":"162","author":"Mabe","year":"2011","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.autneu.2013.03.001_bb0110","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1016\/S0140-6736(98)02478-7","article-title":"Effect of angiotensin-converting-enzyme (ACE) inhibitor trandolapril on human diabetic neuropathy: randomised double-blind controlled trial","volume":"352","author":"Malik","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.autneu.2013.03.001_bb0115","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1093\/ajcn\/73.6.1052","article-title":"Chronic administration of pharmacologic doses of vitamin E improves the cardiac autonomic nervous system in patients with type 2 diabetes","volume":"73","author":"Manzella","year":"2001","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.autneu.2013.03.001_bb0120","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.2337\/diacare.26.6.1895","article-title":"The association between cardiovascular autonomic neuropathy and mortality in individuals with diabetes: a meta-analysis","volume":"26","author":"Maser","year":"2003","journal-title":"Diabetes Care"},{"key":"10.1016\/j.autneu.2013.03.001_bb0125","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1253\/circj.CJ-09-0402","article-title":"Fluvastatin attenuates diabetes-induced cardiac sympathetic neuropathy in association with a decrease in oxidative stress","volume":"74","author":"Matsuki","year":"2010","journal-title":"Circ. J."},{"key":"10.1016\/j.autneu.2013.03.001_bb0130","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S0008-6363(99)00406-X","article-title":"Early detection of cardiovascular autonomic neuropathy in diabetic pigs using blood pressure and heart rate variability","volume":"45","author":"Mesangeau","year":"2000","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.autneu.2013.03.001_bb0135","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/mus.880050205","article-title":"Ganglioside treatment of neuropathy in diabetic mice","volume":"5","author":"Norido","year":"1982","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.autneu.2013.03.001_bb0140","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0014-4886(84)90094-3","article-title":"Development of diabetic neuropathy in the C57BL\/Ks (db\/db) mouse and its treatment with gangliosides","volume":"83","author":"Norido","year":"1984","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.autneu.2013.03.001_bb0145","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1161\/01.RES.0000207406.94146.c2","article-title":"Diabetic cardiomyopathy: the search for a unifying hypothesis","volume":"98","author":"Poornima","year":"2006","journal-title":"Circ. Res."},{"key":"10.1016\/j.autneu.2013.03.001_bb0150","doi-asserted-by":"crossref","first-page":"434","DOI":"10.2337\/dc09-1294","article-title":"Cardiac autonomic neuropathy in diabetes: a clinical perspective","volume":"33","author":"Pop-Busui","year":"2010","journal-title":"Diabetes Care"},{"key":"10.1016\/j.autneu.2013.03.001_bb0155","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s12265-012-9367-6","article-title":"What do we know and we do not know about cardiovascular autonomic neuropathy in diabetes","volume":"5","author":"Pop-Busui","year":"2012","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"10.1016\/j.autneu.2013.03.001_bb0160","doi-asserted-by":"crossref","first-page":"603","DOI":"10.2337\/diabetes.48.3.603","article-title":"Heterogeneous cardiac sympathetic denervation and decreased myocardial nerve growth factor in streptozotocin-induced diabetic rats: implications for cardiac sympathetic dysinnervation complicating diabetes","volume":"48","author":"Schmid","year":"1999","journal-title":"Diabetes"},{"key":"10.1016\/j.autneu.2013.03.001_bb0165","first-page":"1581","article-title":"Cardiovascular autonomic neuropathy in spontaneously diabetic rats with and without application of EGb 761","volume":"25","author":"Schneider","year":"2010","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.autneu.2013.03.001_bb0170","doi-asserted-by":"crossref","first-page":"H976","DOI":"10.1152\/ajpheart.00088.2002","article-title":"Echocardiographic assessment of cardiac function in diabetic db\/db and transgenic db\/db-hGLUT4 mice","volume":"283","author":"Semeniuk","year":"2002","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.autneu.2013.03.001_bb0175","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1113\/expphysiol.2008.046474","article-title":"Cardiovascular and autonomic phenotype of db\/db diabetic mice","volume":"94","author":"Senador","year":"2009","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.autneu.2013.03.001_bb0180","doi-asserted-by":"crossref","first-page":"157","DOI":"10.2337\/diabetes.52.1.157","article-title":"The effectiveness of treatments of diabetic autonomic neuropathy is not the same in autonomic nerves supplying different organs","volume":"52","author":"Shotton","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.autneu.2013.03.001_bb0210","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1002\/dmrr.1239","article-title":"Cardiovascular autonomic neuropathy in diabetes: clinical impact, assessment, diagnosis, and management","volume":"27","author":"Spallone","year":"2011","journal-title":"Diabetes Metab. Res. Rev."},{"key":"10.1016\/j.autneu.2013.03.001_bb0190","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1056-8727(00)00054-4","article-title":"Cardiovascular autonomic neuropathy (expiration and inspiration ratio) in type 1 diabetes. Incidence and predictors","volume":"14","author":"Stella","year":"2000","journal-title":"J. Diabetes Complications"},{"key":"10.1016\/j.autneu.2013.03.001_bb0215","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/S0026-0495(96)90161-4","article-title":"Acetyl-l-carnitine deficiency as a cause of altered nerve myo-inositol content, Na, K-ATPase activity, and motor conduction velocity in the streptozotocin-diabetic rat","volume":"45","author":"Stevens","year":"1996","journal-title":"Metabolism"},{"key":"10.1016\/j.autneu.2013.03.001_bb0220","doi-asserted-by":"crossref","first-page":"835932","DOI":"10.1155\/2011\/835932","article-title":"Alteration of the cardiac sympathetic innervation is modulated by duration of diabetes in female rats","volume":"2011","author":"Sviglerova","year":"2011","journal-title":"Exp. Diabetes Res."},{"key":"10.1016\/j.autneu.2013.03.001_bb0225","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/0891-6632(88)90026-8","article-title":"Effects of long-term diabetes and treatment with gangliosides on cardiac sympathetic innervation: a biochemical and functional study in mice","volume":"2","author":"Tessari","year":"1988","journal-title":"J. Diabet. Complications"},{"key":"10.1016\/j.autneu.2013.03.001_bb0230","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/j.1474-8673.1983.tb00543.x","article-title":"Autonomic neuropathy in the alloxan-diabetic rat","volume":"3","author":"Tomlinson","year":"1983","journal-title":"J. Auton. Pharmacol."},{"key":"10.1016\/j.autneu.2013.03.001_bb0235","doi-asserted-by":"crossref","first-page":"339","DOI":"10.2337\/diacare.24.2.339","article-title":"Predictive value of cardiac autonomic neuropathy in diabetic patients with or without silent myocardial ischemia","volume":"24","author":"Valensi","year":"2001","journal-title":"Diabetes Care"},{"key":"10.1016\/j.autneu.2013.03.001_bb0240","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/1475-2840-9-56","article-title":"Electrocardiographic changes with the onset of diabetes and the impact of aerobic exercise training in the Zucker diabetic fatty (ZDF) rat","volume":"9","author":"Vanhoose","year":"2010","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.autneu.2013.03.001_bb0245","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1210\/er.2003-0019","article-title":"Oxidative stress in the pathogenesis of diabetic neuropathy","volume":"25","author":"Vincent","year":"2004","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.autneu.2013.03.001_bb0250","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.2337\/diacare.26.5.1553","article-title":"Diabetic autonomic neuropathy","volume":"26","author":"Vinik","year":"2003","journal-title":"Diabetes Care"},{"key":"10.1016\/j.autneu.2013.03.001_bb0255","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000336148","article-title":"Risk of ventricular arrhythmias after myocardial infarction with diabetes associated with sympathetic neural remodeling in rabbits","volume":"121","author":"Wang","year":"2012","journal-title":"Cardiology"},{"key":"10.1016\/j.autneu.2013.03.001_bb0260","first-page":"247","article-title":"The roles of glucose-induced metabolic hypoxia and imbalances in carnitine metabolism in mediating diabetes-induced vascular dysfunction","volume":"12","author":"Williamson","year":"1992","journal-title":"Int. J. Clin. Pharmacol. Res."},{"key":"10.1016\/j.autneu.2013.03.001_bb0265","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/s00125-004-1617-y","article-title":"Risk factors for cardiac autonomic neuropathy in type 1 diabetes mellitus","volume":"48","author":"Witte","year":"2005","journal-title":"Diabetologia"},{"key":"10.1016\/j.autneu.2013.03.001_bb0270","first-page":"6560","article-title":"Assessment of diabetic cardiac autonomic neuropathy in type I diabetic mice","volume":"2011","author":"Yang","year":"2011","journal-title":"Conf. Proc. IEEE Eng. Med. Biol. Soc."},{"key":"10.1016\/j.autneu.2013.03.001_bb0275","doi-asserted-by":"crossref","first-page":"369","DOI":"10.2337\/diacare.20.3.369","article-title":"Effects of treatment with the antioxidant alpha-lipoic acid on cardiac autonomic neuropathy in NIDDM patients. A 4-month randomized controlled multicenter trial (DEKAN Study). Deutsche Kardiale Autonome Neuropathie","volume":"20","author":"Ziegler","year":"1997","journal-title":"Diabetes Care"},{"key":"10.1016\/j.autneu.2013.03.001_bb0280","doi-asserted-by":"crossref","first-page":"556","DOI":"10.2337\/dc07-1615","article-title":"Prediction of mortality using measures of cardiac autonomic dysfunction in the diabetic and nondiabetic population: the MONICA\/KORA Augsburg cohort study","volume":"31","author":"Ziegler","year":"2008","journal-title":"Diabetes care"}],"container-title":["Autonomic Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1566070213000593?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1566070213000593?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T12:05:31Z","timestamp":1761566731000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1566070213000593"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":52,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["S1566070213000593"],"URL":"https:\/\/doi.org\/10.1016\/j.autneu.2013.03.001","relation":{},"ISSN":["1566-0702"],"issn-type":[{"value":"1566-0702","type":"print"}],"subject":[],"published":{"date-parts":[[2013,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diabetic cardiac autonomic neuropathy: Insights from animal models","name":"articletitle","label":"Article Title"},{"value":"Autonomic Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.autneu.2013.03.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}