{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T12:46:42Z","timestamp":1785242802398,"version":"3.55.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100015679","name":"Heart and Stroke Foundation of Quebec","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100015679","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Quebec Heart Institute Research Foundation"}],"content-domain":{"domain":["autonomicneuroscience.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Autonomic Neuroscience"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1016\/j.autneu.2014.11.003","type":"journal-article","created":{"date-parts":[[2014,11,16]],"date-time":"2014-11-16T22:35:52Z","timestamp":1416177352000},"page":"70-75","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Nitric oxide bioavailability affects cardiovascular regulation dependent on cardiac nerve status"],"prefix":"10.1016","volume":"187","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2999-5748","authenticated-orcid":false,"suffix":"Jr.","given":"J.G.","family":"Kingma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Simard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.R.","family":"Rouleau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.autneu.2014.11.003_bb0005","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1139\/y88-114","article-title":"Cardiac effects of electrically induced intrathoracic autonomic reflexes","volume":"66","author":"Armour","year":"1988","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.autneu.2014.11.003_bb0010","series-title":"Reflex Control of the Circulation","first-page":"1","article-title":"Anatomy and function of the intrathoracic neurons regulating the mammalian heart","author":"Armour","year":"1991"},{"key":"10.1016\/j.autneu.2014.11.003_bb0015","first-page":"R403","article-title":"Modulation of intrinsic cardiac neuronal activity by nitric oxide donors induces cardiodynamic changes","volume":"268","author":"Armour","year":"1995","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.autneu.2014.11.003_bb0025","doi-asserted-by":"crossref","first-page":"R1314","DOI":"10.1152\/ajpregu.00333.2002","article-title":"Adenosine A1 receptor activation reduces myocardial reperfusion effects on intrinsic cardiac nervous system","volume":"284","author":"Arora","year":"2003","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.autneu.2014.11.003_bb0020","first-page":"188","article-title":"Cardiac denervation and cardiac function","volume":"2","author":"Arora","year":"2000","journal-title":"Curr. Interv. Cardiol. Rep."},{"key":"10.1016\/j.autneu.2014.11.003_bb0030","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1093\/eurheartj\/13.suppl_E.2","article-title":"Ventricular pressure-volume relations in vivo","volume":"13","author":"Baan","year":"1992","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.autneu.2014.11.003_bb0035","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1097\/00005768-199601000-00015","article-title":"Coronary alpha 1-adrenergic constrictor tone varies with intensity of exercise","volume":"28","author":"Dodd-o","year":"1996","journal-title":"Med. Sci. Sports Exerc."},{"key":"10.1016\/j.autneu.2014.11.003_bb0040","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0304-3940(93)90610-W","article-title":"Nitric oxide synthase immunoreactivity in rat superior cervical ganglia and adrenal glands","volume":"158","author":"Dun","year":"1993","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.autneu.2014.11.003_bb0045","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1161\/01.RES.87.2.146","article-title":"Endogenous nitric oxide and myocardial adaptation to ischemia","volume":"87","author":"Heusch","year":"2000","journal-title":"Circ. Res."},{"key":"10.1016\/j.autneu.2014.11.003_bb0050","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/0008-6363(95)00105-0","article-title":"Role of peripheral autonomic neurones in maintaining adequate cardiac function","volume":"30","author":"Horackova","year":"1995","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.autneu.2014.11.003_bb0055","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1161\/01.RES.62.2.286","article-title":"Adrenergic coronary vasoconstriction helps maintain uniform transmural blood flow distribution during exercise","volume":"62","author":"Huang","year":"1988","journal-title":"Circ. Res."},{"key":"10.1016\/j.autneu.2014.11.003_bb0060","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1161\/01.CIR.0000141294.25130.54","article-title":"Systemic inhibition of nitric oxide synthase unmasks neural constraint of maximal myocardial blood flow in humans","volume":"110","author":"Kaufmann","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.autneu.2014.11.003_bb0065","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1093\/cvr\/28.9.1403","article-title":"Chemical modulation of in situ intrinsic cardiac neurones influences myocardial blood flow in the anaesthetised dog","volume":"28","author":"Kingma","year":"1994","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.autneu.2014.11.003_bb0070","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1139\/y96-068","article-title":"Left ventricular intramyocardial pressure determination using two different solid-state micromanometric pressure sensors","volume":"74","author":"Kingma","year":"1996","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.autneu.2014.11.003_bb0075","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s11239-005-1201-4","article-title":"Comparison of neutron activated and radiolabeled microsphere methods for measurement of transmural myocardial blood flow in dogs","volume":"19","author":"Kingma","year":"2005","journal-title":"J. Thromb. Thrombolysis"},{"key":"10.1016\/j.autneu.2014.11.003_bb0080","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1093\/cvr\/cvq306","article-title":"Role of the autonomic nervous system in cardioprotection by remote preconditioning in isoflurane-anaesthetized dogs","volume":"89","author":"Kingma","year":"2011","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.autneu.2014.11.003_bb0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cardiores.2007.02.005","article-title":"NO with no NOS in ischemic heart","volume":"74","author":"Kudej","year":"2007","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.autneu.2014.11.003_bb0090","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1161\/01.RES.57.3.383","article-title":"Adverse effects of chronic cardiac denervation in conscious dogs with myocardial ischemia","volume":"57","author":"Lavallee","year":"1985","journal-title":"Circ. Res."},{"key":"10.1016\/j.autneu.2014.11.003_bb0095","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/mnfr.201300033","article-title":"Arginine and nitric oxide synthase: regulatory mechanisms and cardiovascular aspects","volume":"58","author":"Lorin","year":"2014","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.autneu.2014.11.003_bb0100","doi-asserted-by":"crossref","first-page":"181","DOI":"10.12659\/MSMBR.883964","article-title":"Differential effects of selective and non-selective nitric oxide synthase inhibitors on the blood perfusion of ischemia-reperfused myocardium in dogs","volume":"19","author":"Luo","year":"2013","journal-title":"Med. Sci. Monit. Basic Res."},{"key":"10.1016\/j.autneu.2014.11.003_bb0105","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.tcm.2010.02.007","article-title":"Neuronal nitric oxide synthase and human vascular regulation","volume":"19","author":"Melikian","year":"2009","journal-title":"Trends Cardiovasc. Med."},{"key":"10.1016\/j.autneu.2014.11.003_bb0110","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1056\/NEJM199312303292706","article-title":"The L-arginine-nitric oxide pathway","volume":"329","author":"Moncada","year":"1993","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.autneu.2014.11.003_bb0115","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0031-6997(25)06663-3","article-title":"Nitric oxide: physiology, pathophysiology, and pharmacology","volume":"43","author":"Moncada","year":"1991","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.autneu.2014.11.003_bb0120","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1016\/S0003-4975(00)01240-6","article-title":"The heart reinnervates after transplantation","volume":"69","author":"Murphy","year":"2000","journal-title":"Ann. Thorac. Surg."},{"key":"10.1016\/j.autneu.2014.11.003_bb0125","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1080\/00365520600548966","article-title":"Intestinal nitric oxide synthase activity changes during experimental colon obstruction","volume":"41","author":"Palasthy","year":"2006","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.autneu.2014.11.003_bb0130","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1113\/jphysiol.2003.048769","article-title":"Reduced left ventricular compliance and mechanical efficiency after prolonged inhibition of NO synthesis in conscious dogs","volume":"552","author":"Post","year":"2003","journal-title":"J. Physiol."},{"key":"10.1016\/j.autneu.2014.11.003_bb0140","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1139\/y85-131","article-title":"Effects of coronary sinus pressure elevation on coronary blood flow distribution in dogs with normal preload","volume":"63","author":"Rouleau","year":"1985","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.autneu.2014.11.003_bb0135","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S1566-0702(02)00002-4","article-title":"Myocardial blood flow after chronic cardiac decentralization in anesthetized dogs: effects of ACE-inhibition","volume":"97","author":"Rouleau","year":"2002","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.autneu.2014.11.003_bb0145","doi-asserted-by":"crossref","first-page":"H491","DOI":"10.1152\/ajpheart.1995.269.2.H491","article-title":"Splenic contraction-induced increases in arterial O2 reduce requirement for CBF in conscious dogs","volume":"269","author":"Sato","year":"1995","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.autneu.2014.11.003_bb0150","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1161\/CIRCULATIONAHA.107.744540","article-title":"Neuronal nitric oxide synthase regulates basal microvascular tone in humans in vivo","volume":"117","author":"Seddon","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.autneu.2014.11.003_bb0155","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0006-8993(92)91492-W","article-title":"Evidence that nitric oxide mediates the cyclic GMP response to synaptic activity in the rat superior cervical ganglion","volume":"597","author":"Sheng","year":"1992","journal-title":"Brain Res."},{"key":"10.1016\/j.autneu.2014.11.003_bb0160","doi-asserted-by":"crossref","first-page":"H625","DOI":"10.1152\/ajpheart.1980.238.5.H625","article-title":"Systolic and diastolic pressure gradients within the left ventricular wall","volume":"238","author":"Stein","year":"1980","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.autneu.2014.11.003_bb0165","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0304-3940(93)90614-Q","article-title":"Direct synaptic contacts of nitric oxide synthase-immunoreactive nerve terminals on the neurons of the intracardiac ganglia of the guinea pig","volume":"158","author":"Tanaka","year":"1993","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.autneu.2014.11.003_bb0170","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1124\/pr.55.2.3","article-title":"The pharmacology of nitric oxide in the peripheral nervous system of blood vessels","volume":"55","author":"Toda","year":"2003","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.autneu.2014.11.003_bb0175","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1161\/01.CIR.83.1.315","article-title":"Nonlinearity and load sensitivity of end-systolic pressure- volume relation of canine left ventricle in vivo","volume":"83","author":"Van der Velde","year":"1991","journal-title":"Circulation"},{"key":"10.1016\/j.autneu.2014.11.003_bb0180","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.resuscitation.2006.07.026","article-title":"Different roles of nitric oxide synthase isoforms in cardiopulmonary resuscitation in pigs","volume":"73","author":"Wu","year":"2007","journal-title":"Resuscitation"},{"key":"10.1016\/j.autneu.2014.11.003_bb0185","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1073\/pnas.96.2.657","article-title":"Nitric oxide synthase in cardiac sarcoplasmic reticulum","volume":"96","author":"Xu","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Autonomic Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1566070214001829?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1566070214001829?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T12:05:44Z","timestamp":1761566744000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1566070214001829"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":37,"alternative-id":["S1566070214001829"],"URL":"https:\/\/doi.org\/10.1016\/j.autneu.2014.11.003","relation":{},"ISSN":["1566-0702"],"issn-type":[{"value":"1566-0702","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nitric oxide bioavailability affects cardiovascular regulation dependent on cardiac nerve status","name":"articletitle","label":"Article Title"},{"value":"Autonomic Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.autneu.2014.11.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}