{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:14:16Z","timestamp":1791000856645,"version":"4.1.0"},"reference-count":93,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["autonomicneuroscience.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Autonomic Neuroscience"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.autneu.2015.04.005","type":"journal-article","created":{"date-parts":[[2015,4,26]],"date-time":"2015-04-26T01:42:27Z","timestamp":1430012547000},"page":"16-24","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["P2X3 receptors and sensitization of autonomic reflexes"],"prefix":"10.1016","volume":"191","author":[{"given":"Anthony P.","family":"Ford","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley J.","family":"Undem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori A.","family":"Birder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Grundy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wioletta","family":"Pijacka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian F.R.","family":"Paton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9974","key":"10.1016\/j.autneu.2015.04.005_bb0005","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/S0140-6736(14)61255-1","article-title":"P2X3 receptor antagonist (AF-219) in refractory chronic cough: a randomised, double-blind, placebo-controlled phase 2 study","volume":"385","author":"Abdulqawi","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.autneu.2015.04.005_bb0010","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1056\/NEJM200010123431501","article-title":"Long-term effects of budesonide or nedocromil in children with asthma. The Childhood Asthma Management Program Research Group","volume":"343","author":"Anonymous","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.autneu.2015.04.005_bb0015","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0034-5687(84)90150-6","article-title":"The relationship between bronchial hyperresponsiveness to methacholine and airway smooth muscle structure and reactivity","volume":"58","author":"Armour","year":"1984","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.autneu.2015.04.005_bb0020","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1091\/mbc.e06-09-0842","article-title":"Apical epidermal growth factor receptor signaling: regulation of stretch-dependent exocytosis in bladder umbrella cells","volume":"18","author":"Balestreire","year":"2007","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.autneu.2015.04.005_bb0025","first-page":"175","article-title":"Endoscopic scoring system in patients with allergic rhinitis","volume":"7","author":"Bavbek","year":"1997","journal-title":"J. Investig. Allergol. Clin. Immunol."},{"key":"10.1016\/j.autneu.2015.04.005_bb0030","doi-asserted-by":"crossref","first-page":"4767","DOI":"10.1523\/JNEUROSCI.22-12-04767.2002","article-title":"ATP as a putative sensory mediator: activation of intrinsic sensory neurons of the myenteric plexus via P2X receptors","volume":"22","author":"Bertrand","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.autneu.2015.04.005_bb0035","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1113\/jphysiol.2003.044172","article-title":"Peristalsis is impaired in the small intestine of mice lacking the P2X3 subunit","volume":"551","author":"Bian","year":"2003","journal-title":"J. Physiol."},{"key":"10.1016\/j.autneu.2015.04.005_bb0040","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1152\/physrev.00030.2012","article-title":"Urothelial signaling","volume":"93","author":"Birder","year":"2013","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.autneu.2015.04.005_bb0045","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/apha.12011","article-title":"From urothelial signalling to experiencing a sensation related to the urinary bladder","volume":"207","author":"Birder","year":"2013","journal-title":"Acta Physiol."},{"key":"10.1016\/j.autneu.2015.04.005_bb0050","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1113\/jphysiol.2007.129031","article-title":"Involvement of l-glutamate and ATP in the neurotransmission of the sympathoexcitatory component of the chemoreflex in the commissural nucleus tractus solitarii of awake rats and in the working heart\u2013brainstem preparation","volume":"581","author":"Braga","year":"2007","journal-title":"J. Physiol."},{"key":"10.1016\/j.autneu.2015.04.005_bb0055","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1046\/j.1365-2222.2003.01652.x","article-title":"Mucosal and systemic inflammatory changes in allergic rhinitis and asthma: a comparison between upper and lower airways","volume":"33","author":"Braunstahl","year":"2003","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.autneu.2015.04.005_bb0060","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1111\/j.1365-2222.2007.02695.x","article-title":"Lower airways inflammation in allergic rhinitics: a comparison with asthmatics and normal controls","volume":"37","author":"Brown","year":"2007","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.autneu.2015.04.005_bb0065","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.resp.2007.02.013","article-title":"TASK-like potassium channels and oxygen sensing in the carotid body","volume":"157","author":"Buckler","year":"2007","journal-title":"Respir. Physiol. Neurobiol."},{"issue":"2","key":"10.1016\/j.autneu.2015.04.005_bb0095","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/j.1476-5381.2012.02008.x","article-title":"Discovery of purinergic signalling, the initial resistance and current explosion of interest","volume":"167","author":"Burnstock","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.autneu.2015.04.005_bb0070","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s11302-013-9397-9","article-title":"Purinergic signalling in the gastrointestinal tract and related organs in health and disease","volume":"10","author":"Burnstock","year":"2014","journal-title":"Purinergic Signal"},{"key":"10.1016\/j.autneu.2015.04.005_bb0075","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s11302-013-9395-y","article-title":"Purinergic signalling in the urinary tract in health and disease","volume":"10","author":"Burnstock","year":"2014","journal-title":"Purinergic Signal"},{"key":"10.1016\/j.autneu.2015.04.005_bb0090","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/B978-0-12-385526-8.00011-4","article-title":"P2X receptors in health and disease","volume":"61","author":"Burnstock","year":"2011","journal-title":"Adv. Pharmacol."},{"issue":"1","key":"10.1016\/j.autneu.2015.04.005_bb0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11302-014-9436-1","article-title":"Cardiac purinergic signalling in health and disease","volume":"11","author":"Burnstock","year":"2015","journal-title":"Purinergic Signal"},{"issue":"4","key":"10.1016\/j.autneu.2015.04.005_bb0080","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1124\/pr.111.005389","article-title":"Purinergic signaling in the airways","volume":"64","author":"Burnstock","year":"2012","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.autneu.2015.04.005_bb0100","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0034-5687(00)00208-5","article-title":"Neural regulation of airway smooth muscle tone","volume":"125","author":"Canning","year":"2001","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.autneu.2015.04.005_bb0105","first-page":"57","article-title":"Comparison of human bronchial muscle responses to histamine in vivo with histamine and isoproterenol agonists in vitro","volume":"134","author":"Cerrina","year":"1986","journal-title":"Am. Rev. Respir. Dis."},{"key":"10.1016\/j.autneu.2015.04.005_bb0110","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/ncpuro1124","article-title":"Drug Insight: biological effects of botulinum toxin A in the lower urinary tract","volume":"5","author":"Chancellor","year":"2008","journal-title":"Nat. Clin. Pract. Urol."},{"key":"10.1016\/j.autneu.2015.04.005_bb0115","doi-asserted-by":"crossref","first-page":"e25769","DOI":"10.1371\/journal.pone.0025769","article-title":"ATP enhances spontaneous calcium activity in cultured suburothelial myofibroblasts of the human bladder","volume":"6","author":"Cheng","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.autneu.2015.04.005_bb0120","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1002\/cne.10123","article-title":"Localization of P2X3 receptors and coexpression with P2X2 receptors during rat embryonic neurogenesis","volume":"443","author":"Cheung","year":"2002","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.autneu.2015.04.005_bb0125","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1523\/JNEUROSCI.3295-09.2010","article-title":"P2X7-dependent release of interleukin-1beta and nociception in the spinal cord following lipopolysaccharide","volume":"30","author":"Clark","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.autneu.2015.04.005_bb0130","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1038\/35039519","article-title":"Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice","volume":"407","author":"Cockayne","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.autneu.2015.04.005_bb0135","first-page":"L709","article-title":"Antigen-induced hyperreactivity to histamine: role of the vagus nerves and eosinophils","volume":"276","author":"Costello","year":"1999","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.autneu.2015.04.005_bb0140","doi-asserted-by":"crossref","first-page":"8287","DOI":"10.1073\/pnas.1402436111","article-title":"Bitter triggers acetylcholine release from polymodal urethral chemosensory cells and bladder reflexes","volume":"111","author":"Deckmann","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.autneu.2015.04.005_bb0145","first-page":"131","article-title":"Mechanisms of bronchial hyperreactivity in normal subjects after upper respiratory tract infection","volume":"113","author":"Empey","year":"1976","journal-title":"Am. Rev. Respir. Dis."},{"key":"10.1016\/j.autneu.2015.04.005_bb0150","doi-asserted-by":"crossref","first-page":"3877","DOI":"10.4049\/jimmunol.176.7.3877","article-title":"The P2X7 receptor: a key player in IL-1 processing and release","volume":"176","author":"Ferrari","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.autneu.2015.04.005_bb0155","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s11302-011-9271-6","article-title":"In pursuit of P2X3 antagonists: novel therapeutics for chronic pain and afferent sensitization","volume":"8","author":"Ford","year":"2012","journal-title":"Purinergic Signal"},{"key":"10.1016\/j.autneu.2015.04.005_bb0160","doi-asserted-by":"crossref","first-page":"267","DOI":"10.3389\/fncel.2013.00267","article-title":"The therapeutic promise of ATP antagonism at P2X3 receptors in respiratory and urological disorders","volume":"7","author":"Ford","year":"2013","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.autneu.2015.04.005_bb0165","doi-asserted-by":"crossref","first-page":"F1447","DOI":"10.1152\/ajprenal.00436.2011","article-title":"Modulation of spontaneous activity in the overactive bladder: the role of P2Y agonists","volume":"302","author":"Fry","year":"2012","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.autneu.2015.04.005_bb0170","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1113\/jphysiol.2011.224345","article-title":"Purinergic neuromuscular transmission is absent in the colon of P2Y(1) knocked out mice","volume":"590","author":"Gallego","year":"2012","journal-title":"J. Physiol."},{"key":"10.1016\/j.autneu.2015.04.005_bb0175","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0165-1838(00)00130-2","article-title":"Multiple mechanisms of fast excitatory synaptic transmission in the enteric nervous system","volume":"81","author":"Galligan","year":"2000","journal-title":"J. Auton. Nerv. Syst."},{"key":"10.1016\/j.autneu.2015.04.005_bb0180","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1111\/j.1365-2125.1986.tb02956.x","article-title":"In vitro responsiveness of human asthmatic bronchus to carbachol, histamine, beta-adrenoceptor agonists and theophylline","volume":"22","author":"Goldie","year":"1986","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.autneu.2015.04.005_bb0185","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1113\/jphysiol.2005.095968","article-title":"On the peripheral and central chemoreception and control of breathing: an emerging role of ATP","volume":"568","author":"Gourine","year":"2005","journal-title":"J. Physiol."},{"key":"10.1016\/j.autneu.2015.04.005_bb0190","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/nm.2679","article-title":"Activation of neuronal P2X7 receptor\u2013pannexin-1 mediates death of enteric neurons during colitis","volume":"18","author":"Gulbransen","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.autneu.2015.04.005_bb0195","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1679\/aohc.62.181","article-title":"Scanning electron microscopic observation of apical sites of open-type paraneurons in the stomach, intestine and urethra","volume":"62","author":"Hashimoto","year":"1999","journal-title":"Arch. Histol. Cytol."},{"key":"10.1016\/j.autneu.2015.04.005_bb0200","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1164\/rccm.201201-0088OC","article-title":"Bronchoconstriction triggered by breathing hot humid air in patients with asthma: role of cholinergic reflex","volume":"185","author":"Hayes","year":"2012","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.autneu.2015.04.005_bb0205","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1113\/jphysiol.2011.224634","article-title":"P2Y1 purinoreceptors are fundamental to inhibitory motor control of murine colonic excitability and transit","volume":"590","author":"Hwang","year":"2012","journal-title":"J. Physiol."},{"key":"10.1016\/j.autneu.2015.04.005_bb0210","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1113\/expphysiol.2014.078873","article-title":"The human carotid body releases acetylcholine, ATP and cytokines during hypoxia","volume":"99","author":"Kahlin","year":"2014","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.autneu.2015.04.005_bb0215","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1096\/fj.12-223404","article-title":"Loss of beta1-integrin from urothelium results in overactive bladder and incontinence in mice: a mechanosensory rather than structural phenotype","volume":"27","author":"Kanasaki","year":"2013","journal-title":"FASEB J."},{"key":"10.1016\/j.autneu.2015.04.005_bb0220","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1152\/jappl.1988.65.3.1007","article-title":"Afferent neural pathways in cough and reflex bronchoconstriction","volume":"65","author":"Karlsson","year":"1988","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.autneu.2015.04.005_bb0225","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.4049\/jimmunol.1100423","article-title":"P2X7 receptor-dependent intestinal afferent hypersensitivity in a mouse model of postinfectious irritable bowel syndrome","volume":"187","author":"Keating","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.autneu.2015.04.005_bb0230","doi-asserted-by":"crossref","first-page":"F1477","DOI":"10.1152\/ajprenal.00327.2009","article-title":"Cell biology and physiology of the uroepithelium","volume":"297","author":"Khandelwal","year":"2009","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.autneu.2015.04.005_bb0235","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1038\/emboj.2010.91","article-title":"Compensatory endocytosis in bladder umbrella cells occurs through an integrin-regulated and RhoA- and dynamin-dependent pathway","volume":"29","author":"Khandelwal","year":"2010","journal-title":"EMBO J."},{"issue":"Pt 2","key":"10.1016\/j.autneu.2015.04.005_bb0240","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1111\/j.1469-7793.1999.00551.x","article-title":"Excitatory effect of P2X receptor activation on mesenteric afferent nerves in the anaesthetised rat","volume":"520","author":"Kirkup","year":"1999","journal-title":"J. Physiol."},{"key":"10.1016\/j.autneu.2015.04.005_bb0245","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1113\/jphysiol.2002.035147","article-title":"Enhanced excitability of myenteric AH neurones in the inflamed guinea-pig distal colon","volume":"547","author":"Linden","year":"2003","journal-title":"J. Physiol."},{"key":"10.1016\/j.autneu.2015.04.005_bb0250","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1136\/thx.53.5.419","article-title":"Measurement of airway hyperresponsiveness: new considerations","volume":"53","author":"Lotvall","year":"1998","journal-title":"Thorax"},{"key":"10.1016\/j.autneu.2015.04.005_bb0255","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1124\/mol.104.000851","article-title":"Selective modulation of ligand\u2013gated P2X purinoceptor channels by acute hypoxia is mediated by reactive oxygen species","volume":"66","author":"Mason","year":"2004","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.autneu.2015.04.005_bb0260","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.resp.2015.03.007","article-title":"Vagotomy reverses established allergen-induced airway hyperreactivity to methacholine in the mouse","volume":"212\u2013214C","author":"McAlexander","year":"2015","journal-title":"Respir. Physiol. Neurobiol"},{"key":"10.1016\/j.autneu.2015.04.005_bb0265","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1038\/ncomms3395","article-title":"The carotid body as a putative therapeutic target for the treatment of neurogenic hypertension","volume":"4","author":"McBryde","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.autneu.2015.04.005_bb0270","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1002\/nau.20739","article-title":"Interstitial cells in the urinary bladder\u2014localization and function","volume":"29","author":"McCloskey","year":"2010","journal-title":"Neurourol. Urodyn."},{"key":"10.1016\/j.autneu.2015.04.005_bb0275","doi-asserted-by":"crossref","first-page":"3807","DOI":"10.1113\/jphysiol.2012.231084","article-title":"The human carotid body transcriptome with focus on oxygen sensing and inflammation\u2014a comparative analysis","volume":"590","author":"Mkrtchian","year":"2012","journal-title":"J. Physiol."},{"key":"10.1016\/j.autneu.2015.04.005_bb0280","doi-asserted-by":"crossref","first-page":"16359","DOI":"10.1073\/pnas.0705510104","article-title":"Beta-nicotinamide adenine dinucleotide is an inhibitory neurotransmitter in visceral smooth muscle","volume":"104","author":"Mutafova-Yambolieva","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.autneu.2015.04.005_bb0285","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1152\/japplphysiol.00871.2010","article-title":"Ventilatory and carotid body chemoreceptor responses to purinergic P2X receptor antagonists in newborn rats","volume":"110","author":"Niane","year":"2011","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.autneu.2015.04.005_bb0290","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.1016\/j.ijcard.2013.03.011","article-title":"Carotid body removal for treatment of chronic systolic heart failure","volume":"168","author":"Niewinski","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.autneu.2015.04.005_bb0295","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.semcdb.2012.09.006","article-title":"Signal processing at mammalian carotid body chemoreceptors","volume":"24","author":"Nurse","year":"2013","journal-title":"Semin. Cell Dev. Biol."},{"issue":"Pt 2","key":"10.1016\/j.autneu.2015.04.005_bb0305","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/j.1469-7793.2000.00403.x","article-title":"P2X purinoceptor-induced sensitization of ferret vagal mechanoreceptors in oesophageal inflammation","volume":"523","author":"Page","year":"2000","journal-title":"J. Physiol."},{"key":"10.1016\/j.autneu.2015.04.005_bb0300","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1152\/jn.00785.2001","article-title":"Vagal mechanoreceptors and chemoreceptors in mouse stomach and esophagus","volume":"87","author":"Page","year":"2002","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.autneu.2015.04.005_bb0310","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.resp.2010.08.010","article-title":"Mechanisms for acute oxygen sensing in the carotid body","volume":"174","author":"Peers","year":"2010","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.autneu.2015.04.005_bb0315","doi-asserted-by":"crossref","first-page":"7147","DOI":"10.4049\/jimmunol.180.11.7147","article-title":"P2X7 receptor differentially couples to distinct release pathways for IL-1beta in mouse macrophage","volume":"180","author":"Pelegrin","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.autneu.2015.04.005_bb0320","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1002\/cne.22553","article-title":"Confocal immunofluorescence study of rat aortic body chemoreceptors and associated neurons in situ and in vitro","volume":"519","author":"Piskuric","year":"2011","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.autneu.2015.04.005_bb0325","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S1566-0702(02)00179-0","article-title":"The distribution of P2X3 purine receptor subunits in the guinea pig enteric nervous system","volume":"101","author":"Poole","year":"2002","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.autneu.2015.04.005_bb0330","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1113\/jphysiol.2012.247759","article-title":"Sensing hypoxia: physiology, genetics and epigenetics","volume":"591","author":"Prabhakar","year":"2013","journal-title":"J. Physiol."},{"key":"10.1016\/j.autneu.2015.04.005_bb0335","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1113\/jphysiol.2001.012836","article-title":"Expression of P2X2 and P2X3 receptor subunits in rat carotid body afferent neurones: role in chemosensory signalling","volume":"537","author":"Prasad","year":"2001","journal-title":"J. Physiol."},{"key":"10.1016\/j.autneu.2015.04.005_bb0340","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1113\/jphysiol.2003.047944","article-title":"P2X2 subunits contribute to fast synaptic excitation in myenteric neurons of the mouse small intestine","volume":"552","author":"Ren","year":"2003","journal-title":"J. Physiol."},{"key":"10.1016\/j.autneu.2015.04.005_bb0345","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1136\/thx.39.11.837","article-title":"Comparison of in vivo airway responsiveness and in vitro smooth muscle sensitivity to methacholine in man","volume":"39","author":"Roberts","year":"1984","journal-title":"Thorax"},{"key":"10.1016\/j.autneu.2015.04.005_bb0350","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1046\/j.1365-2982.2003.00456.x","article-title":"Characterization of the primary spinal afferent innervation of the mouse colon using retrograde labelling","volume":"16","author":"Robinson","year":"2004","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.autneu.2015.04.005_bb0355","doi-asserted-by":"crossref","first-page":"11315","DOI":"10.1523\/JNEUROSCI.23-36-11315.2003","article-title":"Pivotal role of nucleotide P2X2 receptor subunit of the ATP-gated ion channel mediating ventilatory responses to hypoxia","volume":"23","author":"Rong","year":"2003","journal-title":"J. Neurosci."},{"issue":"665\u2013671","key":"10.1016\/j.autneu.2015.04.005_bb0360","first-page":"e632","article-title":"Purinergic contribution to small intestinal afferent hypersensitivity in a murine model of postinfectious bowel disease","volume":"21","author":"Rong","year":"2009","journal-title":"Neurogastroenterol. Motil."},{"issue":"Suppl. 1","key":"10.1016\/j.autneu.2015.04.005_bb0365","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1365-2982.2008.01108.x","article-title":"Regulation of smooth muscle excitation and contraction","volume":"20","author":"Sanders","year":"2008","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.autneu.2015.04.005_bb0370","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1007\/s11906-013-0368-x","article-title":"Role of the carotid body in the pathophysiology of heart failure","volume":"15","author":"Schultz","year":"2013","journal-title":"Curr. Hypertens. Rep."},{"key":"10.1016\/j.autneu.2015.04.005_bb0375","doi-asserted-by":"crossref","first-page":"11890","DOI":"10.1523\/JNEUROSCI.0698-12.2012","article-title":"Differential expression and pharmacology of native P2X receptors in rat and primate sensory neurons","volume":"32","author":"Serrano","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.autneu.2015.04.005_bb0380","first-page":"130","article-title":"Effect of route of atropine delivery on bronchospasm from cold air and methacholine","volume":"54","author":"Sheppard","year":"1983","journal-title":"J. Appl. Physiol. Respir. Environ. Exerc. Physiol."},{"key":"10.1016\/j.autneu.2015.04.005_bb0385","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.1172\/JCI118296","article-title":"Airway hyperresponsiveness in asthma: a problem of limited smooth muscle relaxation with inspiration","volume":"96","author":"Skloot","year":"1995","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.autneu.2015.04.005_bb0390","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s11302-011-9249-4","article-title":"Expression of P2X(2) and P2X (3) receptors in the rat carotid sinus, aortic arch, vena cava, and heart, as well as petrosal and nodose ganglia","volume":"8","author":"Song","year":"2012","journal-title":"Purinergic Signal"},{"key":"10.1016\/j.autneu.2015.04.005_bb0395","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1152\/jn.00587.2011","article-title":"Long-term IL-1beta exposure causes subpopulation-dependent alterations in rat dorsal root ganglion neuron excitability","volume":"107","author":"Stemkowski","year":"2012","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.autneu.2015.04.005_bb0400","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1113\/jphysiol.2009.185082","article-title":"Purinergic neuromuscular transmission is selectively attenuated in ulcerated regions of inflamed guinea pig distal colon","volume":"588","author":"Strong","year":"2010","journal-title":"J. Physiol."},{"key":"10.1016\/j.autneu.2015.04.005_bb0405","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1111\/j.1471-4159.2012.07810.x","article-title":"Functional differences between ATP-gated human and rat P2X3 receptors are caused by critical residues of the intracellular C-terminal domain","volume":"122","author":"Sundukova","year":"2012","journal-title":"J. Neurochem."},{"key":"10.1016\/j.autneu.2015.04.005_bb0410","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.bcp.2013.11.007","article-title":"ATP released via pannexin-1 hemichannels mediates bladder overactivity triggered by urothelial P2Y6 receptors","volume":"87","author":"Timoteo","year":"2014","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.autneu.2015.04.005_bb0415","doi-asserted-by":"crossref","first-page":"11515","DOI":"10.1073\/pnas.1411032111","article-title":"Population of sensory neurons essential for asthmatic hyperreactivity of inflamed airways","volume":"111","author":"Trankner","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.autneu.2015.04.005_bb0420","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1002\/j.2040-4603.2012.tb00428.x","article-title":"Autonomic neural control of intrathoracic airways","volume":"2","author":"Undem","year":"2012","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.autneu.2015.04.005_bb0425","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.eururo.2013.05.031","article-title":"Chronic administration of anticholinergics in rats induces a shift from muscarinic to purinergic transmission in the bladder wall","volume":"64","author":"Uvin","year":"2013","journal-title":"Eur. Urol."},{"key":"10.1016\/j.autneu.2015.04.005_bb0430","doi-asserted-by":"crossref","first-page":"5670","DOI":"10.1523\/JNEUROSCI.21-15-05670.2001","article-title":"P2X3 knock-out mice reveal a major sensory role for urothelially released ATP","volume":"21","author":"Vlaskovska","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.autneu.2015.04.005_bb0435","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1152\/jappl.1999.86.1.294","article-title":"Methacholine causes reflex bronchoconstriction","volume":"86","author":"Wagner","year":"1999","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.autneu.2015.04.005_bb0440","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1172\/JCI24086","article-title":"ATP and purinergic receptor-dependent membrane traffic in bladder umbrella cells","volume":"115","author":"Wang","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.autneu.2015.04.005_bb0445","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.autneu.2008.01.002","article-title":"Role of P2X3 receptor in myocardial ischemia injury and nociceptive sensory transmission","volume":"139","author":"Wang","year":"2008","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.autneu.2015.04.005_bb0450","doi-asserted-by":"crossref","first-page":"4109","DOI":"10.1113\/jphysiol.2012.233460","article-title":"A role for ATP in bronchoconstriction-induced activation of guinea pig vagal intrapulmonary C-fibres","volume":"590","author":"Weigand","year":"2012","journal-title":"J. Physiol."},{"key":"10.1016\/j.autneu.2015.04.005_bb0455","doi-asserted-by":"crossref","first-page":"G647","DOI":"10.1152\/ajpgi.00020.2004","article-title":"Purinergic component of mechanosensory transduction is increased in a rat model of colitis","volume":"287","author":"Wynn","year":"2004","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.autneu.2015.04.005_bb0460","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1113\/jphysiol.2003.051862","article-title":"Mechanotransduction by intraganglionic laminar endings of vagal tension receptors in the guinea-pig oesophagus","volume":"553","author":"Zagorodnyuk","year":"2003","journal-title":"J. Physiol."},{"issue":"Pt 1","key":"10.1016\/j.autneu.2015.04.005_bb0465","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1469-7793.2000.t01-1-00143.x","article-title":"Co-release of ATP and ACh mediates hypoxic signalling at rat carotid body chemoreceptors","volume":"525","author":"Zhang","year":"2000","journal-title":"J. Physiol."}],"container-title":["Autonomic Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1566070215000417?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1566070215000417?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T12:09:44Z","timestamp":1761566984000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1566070215000417"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":93,"alternative-id":["S1566070215000417"],"URL":"https:\/\/doi.org\/10.1016\/j.autneu.2015.04.005","relation":{},"ISSN":["1566-0702"],"issn-type":[{"value":"1566-0702","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"P2X3 receptors and sensitization of autonomic reflexes","name":"articletitle","label":"Article Title"},{"value":"Autonomic Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.autneu.2015.04.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}