{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T07:40:47Z","timestamp":1762674047926,"version":"build-2065373602"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"National Heart Foundation"},{"DOI":"10.13039\/100008247","name":"University of Otago","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008247","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["autonomicneuroscience.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Autonomic Neuroscience"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.autneu.2015.10.002","type":"journal-article","created":{"date-parts":[[2015,10,26]],"date-time":"2015-10-26T17:19:02Z","timestamp":1445879942000},"page":"117-126","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Effects of tertiapin-Q and ZD7288 on changes in sinoatrial pacemaker rhythm during vagal stimulation"],"prefix":"10.1016","volume":"193","author":[{"given":"Su Young","family":"Han","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris P.","family":"Bolter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.autneu.2015.10.002_bb0005","series-title":"Ganong's Review of Medical Physiology","first-page":"491","author":"Barrett","year":"2010"},{"key":"10.1016\/j.autneu.2015.10.002_bb0015","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1113\/expphysiol.2007.038901","article-title":"The effects of tertiapin-Q on responses of the sinoatrial pacemaker of the guinea-pig heart to vagal nerve stimulation and muscarinic agonists","volume":"93","author":"Bolter","year":"2007","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.autneu.2015.10.002_bb0020","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.autneu.2009.05.244","article-title":"Tertiapin-Q removes a large and rapidly acting component of vagal slowing of the guinea-pig cardiac pacemaker","volume":"150","author":"Bolter","year":"2009","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.autneu.2015.10.002_bb0025","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S1566-0702(01)00355-1","article-title":"Failure of Ba2+ and Cs+ to block the effects of vagal nerve stimulation in sinoatrial node cells of the guinea-pig heart","volume":"94","author":"Bolter","year":"2001","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.autneu.2015.10.002_bb0030","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1113\/jphysiol.1934.sp003176","article-title":"The action of a single vagal volley on the rhythm of the heart beat","volume":"82","author":"Brown","year":"1934","journal-title":"J. Physiol."},{"key":"10.1016\/j.autneu.2015.10.002_bb0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0165-1838(93)90374-4","article-title":"Sympathetic and parasympathetic neuromuscular junctions in the guinea-pig sino-atrial node","volume":"441","author":"Choate","year":"1993","journal-title":"J. Auton. Nerv. Syst."},{"key":"10.1016\/j.autneu.2015.10.002_bb0040","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1185\/030079905X50543","article-title":"Cardiac pacemaker If current and its inhibition by heart rate-reducing agents","volume":"21","author":"DiFrancesco","year":"2005","journal-title":"Curr. Med. Res. Opin."},{"key":"10.1016\/j.autneu.2015.10.002_bb0045","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/BF00581906","article-title":"Acetylcholine inhibits activation of the cardiac hyperpolarizing-activated current, If","volume":"410","author":"DiFrancesco","year":"1987","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.autneu.2015.10.002_bb0050","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1113\/jphysiol.1988.sp017344","article-title":"Muscarinic control of the hyperpolarization-activated current (If) in rabbit sino-atrial node myocytes","volume":"405","author":"DiFrancesco","year":"1988","journal-title":"J. Physiol. Lond."},{"key":"10.1016\/j.autneu.2015.10.002_bb0060","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1161\/01.RES.27.5.635","article-title":"Effect of timing of vagal stimulation on heart rate in the dog","volume":"27","author":"Dong","year":"1970","journal-title":"Circ. Res."},{"key":"10.1016\/j.autneu.2015.10.002_bb0065","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1113\/jphysiol.1976.sp011445","article-title":"Temporal response patterns of the human sinus node to brief carotid baroreceptor stimuli","volume":"258","author":"Eckberg","year":"1976","journal-title":"J. Physiol."},{"key":"10.1016\/j.autneu.2015.10.002_bb0070","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1152\/jappl.1983.54.4.961","article-title":"Human sinus arrhythmia as an index of vagal cardiac outflow","volume":"54","author":"Eckberg","year":"1983","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.autneu.2015.10.002_bb9000","first-page":"339","article-title":"The human respiratory gate","volume":"548","author":"Eckberg","year":"2003","journal-title":"J. Physiol."},{"key":"10.1016\/j.autneu.2015.10.002_bb0075","first-page":"149","article-title":"Analysis of the effects of vagal stimulation on the sinus venous of the toad","volume":"341","author":"Edwards","year":"1993","journal-title":"Philos. Trans. R. Soc. Lond. Ser. B Biol. Sci."},{"key":"10.1016\/j.autneu.2015.10.002_bb0080","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/S0026-895X(25)08774-7","article-title":"Cholinergic inhibition of slow delayed-rectifier K+ current in guinea pig sino-atrial node is not mediated by muscarinic receptors","volume":"47","author":"Freeman","year":"1995","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.autneu.2015.10.002_bb0085","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1113\/jphysiol.1976.sp011550","article-title":"Changes in membrane currents in bullfrog atrium produced by acetylcholine","volume":"261","author":"Giles","year":"1976","journal-title":"J. Physiol."},{"key":"10.1016\/j.autneu.2015.10.002_bb0090","series-title":"Guyton and Hall Textbook of Medical Physiology","first-page":"128","author":"Hall","year":"2016"},{"key":"10.1016\/j.autneu.2015.10.002_bb0095","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.autneu.2011.05.009","article-title":"The muscarinic-activated potassium channel always participates in vagal slowing of the guinea-pig sinoatrial pacemaker","volume":"164","author":"Han","year":"2011","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.autneu.2015.10.002_bb0100","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1152\/jn.1995.74.6.2366","article-title":"Mechanism of block by ZD7288 of the hyperpolarization-activated inward rectifying current in guinea pig substantia nigra neurons in vitro","volume":"74","author":"Harris","year":"1995","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.autneu.2015.10.002_bb0105","first-page":"58P","article-title":"The action of acetylcholine on the movement of potassium ions in the sinus venosus of the heart","volume":"133","author":"Harris","year":"1956","journal-title":"J. Physiol."},{"key":"10.1016\/j.autneu.2015.10.002_bb0110","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0079-6107(88)90014-4","article-title":"Regulation of cardiac ion channels by catecholamines, acetylcholine and second messenger systems","volume":"52","author":"Hartzell","year":"1988","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"10.1016\/j.autneu.2015.10.002_bb0115","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S1566-0702(02)00149-2","article-title":"Respiratory sinus arrhythmia and the heart rate response to carotid baroreceptor activation after hard dynamic exercise in humans","volume":"100","author":"Herbert","year":"2002","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.autneu.2015.10.002_bb0120","first-page":"H620","article-title":"Respiratory sinus arrhythmia in humans: how breathing pattern modulates heart rate","volume":"241","author":"Hirsch","year":"1981","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.autneu.2015.10.002_bb0125","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0306-4522(96)00031-0","article-title":"Transmission by post-ganglionic axons of the autonomic nervous system: the importance of the specialized neuroeffector junction","volume":"73","author":"Hirst","year":"1996","journal-title":"Neurosci."},{"key":"10.1016\/j.autneu.2015.10.002_bb0135","series-title":"Nervous Inhibition","first-page":"114","article-title":"Ion movements during vagus inhibition of the heart","volume":"1961","author":"Hutter","year":"1961"},{"key":"10.1016\/j.autneu.2015.10.002_bb0140","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1113\/jphysiol.2012.227801","article-title":"The vagus and the heart: revisiting an early contribution to a still on-going dispute","volume":"590","author":"Hutter","year":"2012","journal-title":"J. Physiol."},{"key":"10.1016\/j.autneu.2015.10.002_bb0145","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1113\/jphysiol.2012.230854","article-title":"Reply to the letter of Otto Hutter \u201cThe vagus and the heart: revisiting an early contribution to a still on-going dispute\u201d","volume":"590","author":"Janig","year":"2012","journal-title":"J. Physiol."},{"key":"10.1016\/j.autneu.2015.10.002_bb0150","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1113\/jphysiol.1964.sp007520","article-title":"Activity of single efferent fibres in the cervical vagus nerve of the dog, with special referencing to possible cardio-inhibitory fibres","volume":"175","author":"Jewett","year":"1964","journal-title":"J. Physiol."},{"key":"10.1016\/j.autneu.2015.10.002_bb0160","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1152\/ajplegacy.1970.218.4.1030","article-title":"Cardiac vagal efferent activity and heart period in the carotid sinus reflex","volume":"218","author":"Katona","year":"1970","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.autneu.2015.10.002_bb0165","series-title":"Medical Physiology","first-page":"493","article-title":"Cardiac electrophysiology and the electrocardiogram","author":"Lederer","year":"2005"},{"key":"10.1016\/j.autneu.2015.10.002_bb0170","first-page":"631","article-title":"Non-muscarinic and non-nicotinic inhibition by the acetylcholine analogue carbachol of the delayed rectifier potassium current, iK, in rabbit isolated sino-atrial node cells","volume":"84","author":"Lei","year":"1999","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.autneu.2015.10.002_bb0175","series-title":"Principles of Physiology","first-page":"262","article-title":"Regulation of the heartbeat","author":"Levy","year":"2006"},{"key":"10.1016\/j.autneu.2015.10.002_bb0180","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1161\/01.RES.25.3.303","article-title":"Paradoxical effect of vagus nerve stimulation on heart rate in dogs","volume":"25","author":"Levy","year":"1969","journal-title":"Circ. Res."},{"key":"10.1016\/j.autneu.2015.10.002_bb0185","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1152\/ajplegacy.1970.218.5.1256","article-title":"Effects of single vagal stimuli on heart rate and atrioventricular conduction","volume":"218","author":"Levy","year":"1970","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.autneu.2015.10.002_bb0190","series-title":"Human Anatomy and Physiology","first-page":"702","author":"Marieb","year":"2007"},{"key":"10.1016\/j.autneu.2015.10.002_bb0195","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1097\/00005344-199306000-00008","article-title":"ICI D7288, a novel sinoatrial node modulator","volume":"21","author":"Marshall","year":"1993","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.autneu.2015.10.002_bb0200","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1113\/jphysiol.1978.sp012469","article-title":"The baroreceptor input to cardiac vagal motoneurones","volume":"282","author":"McAllen","year":"1978","journal-title":"J. Physiol."},{"key":"10.1016\/j.autneu.2015.10.002_bb0205","first-page":"814","article-title":"Trigeminal and chemoreceptor contributions to bradycardia during voluntary dives in rats","volume":"273","author":"McCulloch","year":"1997","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.autneu.2015.10.002_bb0215","series-title":"Lecture Notes: Human Physiology","first-page":"347","author":"Petersen","year":"2007"},{"key":"10.1016\/j.autneu.2015.10.002_bb0220","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/BF00374956","article-title":"Mechanism of muscarinic control of the high-threshold calcium current in rabbit sino-atrial node myocytes","volume":"423","author":"Petit-Jacques","year":"1993","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.autneu.2015.10.002_bb0225","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/317536a0","article-title":"GTP-binding proteins couple cardiac muscarinic receptors to a K channel","volume":"317","author":"Pfaffinger","year":"1985","journal-title":"Nature (London)"},{"key":"10.1016\/j.autneu.2015.10.002_bb0230","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1006\/jmcc.1996.0340","article-title":"Acetylcholine modulates I(f) and IK(ACh) via different pathways in rabbit sino-atrial node cells","volume":"29","author":"Renaudon","year":"1997","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.autneu.2015.10.002_bb0240","series-title":"Anatomy and Physiology","first-page":"707","author":"Seeley","year":"2006"},{"key":"10.1016\/j.autneu.2015.10.002_bb0245","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1242\/jeb.198.11.2307","article-title":"Effect of pharmacological blockade on cardiovascular responses to voluntary and forced diving in muskrats","volume":"198","author":"Signore","year":"1995","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.autneu.2015.10.002_bb0250","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/sj.bjp.0706101","article-title":"Responses of the sustained inward current to autonomic agonists in guinea-pig sino-atrial node pacemaker cells","volume":"144","author":"Toyoda","year":"2005","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.autneu.2015.10.002_bb0255","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1007\/BF00416781","article-title":"Mechanism of membrane effect of acetylcholine on myocardial fibers","volume":"266","author":"Trautwein","year":"1958","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.autneu.2015.10.002_bb0260","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/BF00587492","article-title":"Quantitative effect of vagal stimulation on heart interval in newborn and older rabbits","volume":"325","author":"Versprille","year":"1971","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.autneu.2015.10.002_bb0265","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1161\/01.RES.24.4.567","article-title":"Effect of combined sympathetic and vagal stimulation on heart rate in the dog","volume":"24","author":"Warner","year":"1969","journal-title":"Circ. Res."},{"key":"10.1016\/j.autneu.2015.10.002_bb0270","series-title":"Vander's Human Physiology","first-page":"379","author":"Widmaier","year":"2006"},{"key":"10.1016\/j.autneu.2015.10.002_bb0275","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1161\/01.RES.54.6.703","article-title":"The phase-dependency of the cardiac chronotropic responses to vagal stimulation as a factor in sympathetic-vagal interactions","volume":"54","author":"Yang","year":"1984","journal-title":"Circ. Res."},{"key":"10.1016\/j.autneu.2015.10.002_bb0280","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1113\/jphysiol.1996.sp021220","article-title":"Basal responses of the L-type Ca2+ and hyperpolarization-activated currents to autonomic agonists in the rabbit sino-atrial node","volume":"491","author":"Zaza","year":"1996","journal-title":"J. Physiol."}],"container-title":["Autonomic Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1566070215300278?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1566070215300278?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T12:06:55Z","timestamp":1761566815000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1566070215300278"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":51,"alternative-id":["S1566070215300278"],"URL":"https:\/\/doi.org\/10.1016\/j.autneu.2015.10.002","relation":{},"ISSN":["1566-0702"],"issn-type":[{"type":"print","value":"1566-0702"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of tertiapin-Q and ZD7288 on changes in sinoatrial pacemaker rhythm during vagal stimulation","name":"articletitle","label":"Article Title"},{"value":"Autonomic Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.autneu.2015.10.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}