{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:32:23Z","timestamp":1791484343985,"version":"4.3.4"},"reference-count":94,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"CONACYT Frontera","award":["2017-1802"],"award-info":[{"award-number":["2017-1802"]}]},{"name":"DGAPA-PAPIIT","award":["IG200417"],"award-info":[{"award-number":["IG200417"]}]}],"content-domain":{"domain":["autonomicneuroscience.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Autonomic Neuroscience"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.autneu.2019.02.001","type":"journal-article","created":{"date-parts":[[2019,2,13]],"date-time":"2019-02-13T12:15:28Z","timestamp":1550060128000},"page":"43-50","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":56,"special_numbering":"C","title":["The suprachiasmatic nucleus; a responsive clock regulating homeostasis by daily changing the setpoints of physiological parameters"],"prefix":"10.1016","volume":"218","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3894-4632","authenticated-orcid":false,"given":"Ruud M.","family":"Buijs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara A.","family":"Guzm\u00e1n Ruiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebeca","family":"M\u00e9ndez Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betty","family":"Rodr\u00edguez Cort\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.autneu.2019.02.001_bb0005","doi-asserted-by":"crossref","first-page":"5813","DOI":"10.1073\/pnas.1015551108","article-title":"Interaction between hypothalamic dorsomedial nucleus and the suprachiasmatic nucleus determines intensity of food anticipatory behavior","volume":"108","author":"Acosta-Galvan","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.autneu.2019.02.001_bb0010","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1053\/gast.2001.22158","article-title":"Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin","volume":"120","author":"Asakawa","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1016\/j.autneu.2019.02.001_bb0015","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/nn1419","article-title":"Vasoactive Intestinal polypeptide mediates circadian rhythmicity and synchrony in mammalian clock neurons","volume":"8","author":"Aton","year":"2005","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.autneu.2019.02.001_bb0020","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1038\/nm.3249","article-title":"FGF21 regulates metabolism and circadian behavior by acting on the nervous system","volume":"19","author":"Bookout","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.autneu.2019.02.001_bb0025","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1046\/j.1460-9568.1999.00575.x","article-title":"Anatomical and functional demonstration of a multisynaptic suprachiasmatic nucleus adrenal (cortex) pathway","volume":"11","author":"Buijs","year":"1999","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.autneu.2019.02.001_bb0030","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/cne.10765","article-title":"The suprachiasmatic nucleus balances sympathetic and parasympathetic output to peripheral organs through separate preautonomic neurons","volume":"464","author":"Buijs","year":"2003","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.autneu.2019.02.001_bb0035","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.neuroscience.2014.02.018","article-title":"The suprachiasmatic nucleus is part of a neural feedback circuit adapting blood pressure response","volume":"266","author":"Buijs","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.autneu.2019.02.001_bb0040","series-title":"Suprachiasmatic Nucleus Interaction With the Arcuate Nucleus; Essential for Organizing Physiological Rhythms","author":"Buijs","year":"2017"},{"key":"10.1016\/j.autneu.2019.02.001_bb0045","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1111\/j.1460-9568.2005.04439.x","article-title":"The suprachiasmatic nucleus controls the daily variation of plasma glucose via the autonomic output to the liver: are the clock genes involved?","volume":"22","author":"Cailotto","year":"2005","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.autneu.2019.02.001_bb0050","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/nature.2017.22736","article-title":"Medicine nobel awarded for work on circadian clocks","volume":"550","author":"Callaway","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.autneu.2019.02.001_bb0055","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.cell.2015.03.022","article-title":"Vagal sensory neuron subtypes that differentially control breathing","volume":"161","author":"Chang","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.autneu.2019.02.001_bb0065","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/417405a","article-title":"Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus","volume":"417","author":"Cheng","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.autneu.2019.02.001_bb0070","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/(SICI)1096-9861(19981012)400:1<87::AID-CNE6>3.0.CO;2-P","article-title":"Postmortem tracing reveals the organization of hypothalamic projections of the suprachiasmatic nucleus in the human brain","volume":"400","author":"Dai","year":"1998","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.autneu.2019.02.001_bb0075","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/0031-9384(87)90054-0","article-title":"Daily variations in plasma noradrenaline, adrenaline and corticosterone concentrations in rats","volume":"40","author":"De Boer","year":"1987","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.autneu.2019.02.001_bb0080","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1038\/nn1122","article-title":"Sleep states alter activity of suprachiasmatic nucleus neurons","volume":"6","author":"Deboer","year":"2003","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.autneu.2019.02.001_bb0085","doi-asserted-by":"crossref","first-page":"4222","DOI":"10.1210\/en.2016-1330","article-title":"Dissociation of molecular and endocrine circadian rhythms in male mice lacking Bmal1 in the adrenal cortex","volume":"15","author":"Dumbell","year":"2016","journal-title":"Endocrinology"},{"key":"10.1016\/j.autneu.2019.02.001_bb0090","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1159\/000125211","article-title":"Splanchnic nerve stimulation modulates steroid secretion in hypophysectomized dogs","volume":"50","author":"Engeland","year":"1989","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.autneu.2019.02.001_bb0095","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1113\/jphysiol.1970.sp009220","article-title":"Drinking induced by injection of angiotensin into the brain of the rat","volume":"210","author":"Epstein","year":"1970","journal-title":"J. Physiol. Lond."},{"key":"10.1016\/j.autneu.2019.02.001_bb0100","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/nature01314","article-title":"Rhythmic histone acetylation underlies transcription in the mammalian circadian clock","volume":"421","author":"Etchegaray","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.autneu.2019.02.001_bb0105","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/j.1365-2826.2008.01651.x","article-title":"Diurnal rhythmicity of the canonical clock genes Per1, Per2 and Bmal1 in the rat adrenal gland is unaltered after hypophysectomy","volume":"2","author":"Fahrenkrug","year":"2008","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.autneu.2019.02.001_bb0110","first-page":"R931","article-title":"Circadian rhythm in recognition threshold of salt taste in healthy subjects","volume":"259","author":"Fujimura","year":"1990","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.autneu.2019.02.001_bb0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/01.HYP.0000217362.34748.e0","article-title":"Short sleep duration as risk factor for hypertension: analysis of the NHANES I","volume":"47","author":"Gangwisch","year":"2006","journal-title":"Hypertension"},{"key":"10.1016\/j.autneu.2019.02.001_bb0120","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1093\/sleep\/30.12.1667","article-title":"Sleep duration as a risk factor for diabetes incidence in a large U.S. sample","volume":"30","author":"Gangwisch","year":"2007","journal-title":"Sleep"},{"key":"10.1016\/j.autneu.2019.02.001_bb0125","first-page":"1791","article-title":"Peripheral clocks and their role in circadian timing: insights from insects","volume":"356","author":"Giebultowicz","year":"2001","journal-title":"Philos. Trans. R. Soc. Lond. Ser. B Biol. Sci."},{"key":"10.1016\/j.autneu.2019.02.001_bb0130","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/nature19756","article-title":"Clock-driven vasopressin neurotransmission mediates anticipatory thirst prior to sleep","volume":"537","author":"Gizowski","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.autneu.2019.02.001_bb0135","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1002\/1096-9861(20010312)431:3<320::AID-CNE1073>3.0.CO;2-2","article-title":"Neuropeptide changes in the suprachiasmatic nucleus in primary hypertension indicate functional impairment of the biological clock","volume":"431","author":"Goncharuk","year":"2001","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.autneu.2019.02.001_bb0140","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/0006-8993(82)90361-4","article-title":"Circadian rhythm of firing rate recorded from single cells in the rat suprachiasmatic brain slice","volume":"245","author":"Green","year":"1982","journal-title":"Brain Res."},{"key":"10.1016\/j.autneu.2019.02.001_bb0145","first-page":"2790","article-title":"Electrical and pharmacological properties of the suprachiasmatic nuclei","volume":"42","author":"Groos","year":"1983","journal-title":"Fed. Proc."},{"key":"10.1016\/j.autneu.2019.02.001_bb0150","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1210\/en.2014-1570","article-title":"Leptin normalizes photic synchronization in male OB\/OB mice, via indirect effects on the suprachiasmatic nucleus","volume":"156","author":"Grosbellet","year":"2015","journal-title":"Endocrinology"},{"key":"10.1016\/j.autneu.2019.02.001_bb0155","doi-asserted-by":"crossref","first-page":"450","DOI":"10.4103\/0253-7176.211764","article-title":"Physical comorbidity and its impact on symptom profile of depression among elderly patients attending psychiatry services of A tertiary care hospital","volume":"39","author":"Grover","year":"2017","journal-title":"Indian J. Psychol. Med."},{"key":"10.1016\/j.autneu.2019.02.001_bb0160","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jneuroim.2014.05.012","article-title":"Reciprocal interaction between the suprachiasmatic nucleus and the immune system tunes down the inflammatory response to lipopolysaccharide","volume":"273","author":"Guerrero-Vargas","year":"2014","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.autneu.2019.02.001_bb0165","doi-asserted-by":"crossref","first-page":"15419","DOI":"10.1523\/JNEUROSCI.1449-15.2015","article-title":"Role of the suprachiasmatic and arcuate nuclei in diurnal temperature regulation in the rat","volume":"35","author":"Guzman-Ruiz","year":"2015","journal-title":"J. Neurosci."},{"issue":"10","key":"10.1016\/j.autneu.2019.02.001_bb0170","article-title":"A neural circuit for gut-induced reward","volume":"18","author":"Han","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.autneu.2019.02.001_bb0175","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1177\/0748730415619745","article-title":"Distinct firing properties of vasoactive intestinal peptide-expressing neurons in the suprachiasmatic nucleus","volume":"31","author":"Hermanstyne","year":"2016","journal-title":"J. Biol. Rhythm."},{"key":"10.1016\/j.autneu.2019.02.001_bb0180","doi-asserted-by":"crossref","first-page":"3439","DOI":"10.1210\/en.2015-1751","article-title":"The suprachiasmatic nucleus modulates the sensitivity of arcuate nucleus to hypoglycemia in the male rat","volume":"157","author":"Herrera-Moro","year":"2016","journal-title":"Endocrinology"},{"key":"10.1016\/j.autneu.2019.02.001_bb0185","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s00394-003-0386-6","article-title":"Endocrine responses to nocturnal eating\u2014possible implications for night work","volume":"42","author":"Holmback","year":"2003","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.autneu.2019.02.001_bb0190","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.surg.2005.09.002","article-title":"The diurnal periodicity of hexose transporter mRNA and protein levels in the rat jejunum: role of vagal innervation","volume":"139","author":"Houghton","year":"2006","journal-title":"Surgery"},{"key":"10.1016\/j.autneu.2019.02.001_bb0195","doi-asserted-by":"crossref","first-page":"115","DOI":"10.2114\/jpa.21.115","article-title":"An epidemiological study on relationship between the hours of sleep and life style factors in Japanese factory workers","volume":"21","author":"Imaki","year":"2002","journal-title":"J. Physiol. Anthropol. Appl. Hum. Sci."},{"key":"10.1016\/j.autneu.2019.02.001_bb0200","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.cmet.2005.09.009","article-title":"Light activates the adrenal gland: timing of gene expression and glucocorticoid release","volume":"2","author":"Ishida","year":"2005","journal-title":"Cell Metab."},{"key":"10.1016\/j.autneu.2019.02.001_bb0205","doi-asserted-by":"crossref","first-page":"7986","DOI":"10.1523\/JNEUROSCI.1322-18.2018","article-title":"SCN VIP neurons are essential for normal light-mediated resetting of the circadian system","volume":"38","author":"Jones","year":"2018","journal-title":"J. Neurosci."},{"key":"10.1016\/j.autneu.2019.02.001_bb0210","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s11626-005-0001-7","article-title":"Clock genes of mammalian cells: practical implications in tissue culture","volume":"41","author":"Kaeffer","year":"2005","journal-title":"In Vitro Cell. Dev. Biol. Anim."},{"key":"10.1016\/j.autneu.2019.02.001_bb0215","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1126\/science.aat5236","article-title":"A gut-brain neural circuit for nutrient sensory transduction","volume":"361","author":"Kaelberer","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.autneu.2019.02.001_bb0220","doi-asserted-by":"crossref","first-page":"5555","DOI":"10.1523\/JNEUROSCI.16-17-05555.1996","article-title":"A diurnal rhythm of stimulatory input to the hypothalamo- pituitary-adrenal system as revealed by timed intrahypothalamic administration of the vasopressin V-1 antagonist","volume":"16","author":"Kalsbeek","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1016\/j.autneu.2019.02.001_bb0225","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1210\/endo.142.6.8197","article-title":"The suprachiasmatic nucleus generates the diurnal changes in plasma leptin levels","volume":"142","author":"Kalsbeek","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.autneu.2019.02.001_bb0230","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0079-6123(06)53017-1","article-title":"Chapter 17: the hypothalamic clock and its control of glucose homeostasis","volume":"153","author":"Kalsbeek","year":"2006","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.autneu.2019.02.001_bb0235","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1006\/appe.1996.0005","article-title":"Effect of exercise and dietary restraint on energy intake of reduced-obese women","volume":"26","author":"Keim","year":"1996","journal-title":"Appetite"},{"key":"10.1016\/j.autneu.2019.02.001_bb0240","doi-asserted-by":"crossref","first-page":"3199","DOI":"10.1523\/JNEUROSCI.2710-15.2016","article-title":"High-fat diet-induced obesity ablates gastric vagal afferent circadian rhythms","volume":"36","author":"Kentish","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.autneu.2019.02.001_bb0245","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1016\/j.cub.2017.05.089","article-title":"A peptidergic circuit links the circadian clock to locomotor activity","volume":"27","author":"King","year":"2017","journal-title":"Curr. Biol."},{"key":"10.1016\/j.autneu.2019.02.001_bb0250","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1096\/fj.13-229559","article-title":"TSH restores a summer phenotype in photoinhibited mammals via the RF-amides RFRP3 and kisspeptin","volume":"27","author":"Klosen","year":"2013","journal-title":"FASEB J."},{"key":"10.1016\/j.autneu.2019.02.001_bb0255","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1172\/JCI0215736","article-title":"Selective parasympathetic innervation of subcutaneous and intra-abdominal fat - functional implications","volume":"110","author":"Kreier","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.autneu.2019.02.001_bb0260","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.2337\/diabetes.52.11.2652","article-title":"Hypothesis: shifting the equilibrium from activity to food leads to autonomic unbalance and the metabolic syndrome","volume":"52","author":"Kreier","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.autneu.2019.02.001_bb0265","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1210\/en.2005-0667","article-title":"Tracing from fat tissue, liver and pancreas: a neuroanatomical framework for the role of the brain in type 2 diabetes","volume":"147","author":"Kreier","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.autneu.2019.02.001_bb0270","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1046\/j.1365-2826.1999.00373.x","article-title":"A suprachiasmatic nucleus generated rhythm in basal glucose concentrations","volume":"11","author":"La Fleur","year":"1999","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.autneu.2019.02.001_bb0275","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/S0006-8993(00)02423-9","article-title":"Polysynaptic neural pathways between the hypothalamus, including the suprachiasmatic nucleus, and the liver","volume":"871","author":"La Fleur","year":"2000","journal-title":"Brain Res."},{"key":"10.1016\/j.autneu.2019.02.001_bb0280","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.2337\/diabetes.50.6.1237","article-title":"A daily rhythm in glucose tolerance: a role for the suprachiasmatic nucleus","volume":"50","author":"La Fleur","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.autneu.2019.02.001_bb5005","doi-asserted-by":"crossref","first-page":"15172","DOI":"10.1073\/pnas.0806717105","article-title":"Physiological significance of a peripheral tissue circadian clock","volume":"105","author":"Lamia","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.autneu.2019.02.001_bb0285","series-title":"The Arcuate Nucleus: A Site of Fast Negative Feedback for Corticosterone Secretion in Male Rats","author":"Leon-Mercado","year":"2017"},{"key":"10.1016\/j.autneu.2019.02.001_bb0290","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/cne.902100306","article-title":"An HRP study of the connections of the subfornical organ of the rat","volume":"210","author":"Lind","year":"1982","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.autneu.2019.02.001_bb0295","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S0006-8993(01)03374-1","article-title":"Involvement of the suprachiasmatic nucleus in body temperature modulation by food deprivation in rats","volume":"929","author":"Liu","year":"2002","journal-title":"Brain Res."},{"key":"10.1016\/j.autneu.2019.02.001_bb0300","doi-asserted-by":"crossref","first-page":"R751","DOI":"10.1152\/ajpregu.00746.2009","article-title":"Lateralization of the central circadian pacemaker output: a test of neural control of peripheral oscillator phase","volume":"299","author":"Mahoney","year":"2010","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.autneu.2019.02.001_bb0305","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1507\/endocrj.K11E-131","article-title":"Fasting reduces the kiss1 mRNA levels in the caudal hypothalamus of gonadally intact adult female rats","volume":"58","author":"Matsuzaki","year":"2011","journal-title":"Endocr. J."},{"key":"10.1016\/j.autneu.2019.02.001_bb0310","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1126\/science.1132430","article-title":"Dissecting the functions of the mammalian clock protein BMAL1 by tissue-specific rescue in mice","volume":"314","author":"Mcdearmon","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.autneu.2019.02.001_bb0315","doi-asserted-by":"crossref","first-page":"E1338","DOI":"10.1152\/ajpendo.00021.2013","article-title":"Leptin sensitive sensory nerves innervate white fat","volume":"304","author":"Murphy","year":"2013","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.autneu.2019.02.001_bb0320","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.2337\/db07-1103","article-title":"Diurnal variation of human sweet taste recognition thresholds is correlated with plasma leptin levels","volume":"57","author":"Nakamura","year":"2008","journal-title":"Diabetes"},{"key":"10.1016\/j.autneu.2019.02.001_bb5000","series-title":"Circadian Regulation of Endocrine Systems","author":"Neumann","year":"2019"},{"key":"10.1016\/j.autneu.2019.02.001_bb0325","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0304-3940(99)00054-3","article-title":"Reflex effects from leptin sensors in the white adipose tissue of the epididymis to the efferent activity of the sympathetic and vagus nerve in the rat","volume":"262","author":"Niijima","year":"1999","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.autneu.2019.02.001_bb0330","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1101\/sqb.2007.72.033","article-title":"Suprachiasmatic nucleus clock time in the mammalian circadian system","volume":"72","author":"Okamura","year":"2007","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"key":"10.1016\/j.autneu.2019.02.001_bb0335","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1126\/science.aah4967","article-title":"Circadian physiology of metabolism","volume":"354","author":"Panda","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.autneu.2019.02.001_bb0340","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1046\/j.1460-9568.2003.02442.x","article-title":"Suprachiasmatic control of melatonin synthesis in rats: inhibitory and stimulatory mechanisms","volume":"17","author":"Perreau-Lenz","year":"2003","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.autneu.2019.02.001_bb0345","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1111\/j.0953-816X.2003.03132.x","article-title":"Glutamatergic clock output stimulates melatonin synthesis at night","volume":"19","author":"Perreau-Lenz","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.autneu.2019.02.001_bb0350","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1056\/NEJM198804283181701","article-title":"Body fat and the activity of the autonomic nervous system","volume":"318","author":"Peterson","year":"1988","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.autneu.2019.02.001_bb0355","doi-asserted-by":"crossref","first-page":"3102","DOI":"10.1016\/j.celrep.2017.11.066","article-title":"Functional and molecular characterization of mechanoinsensitive \u201csilent\u201d nociceptors","volume":"21","author":"Prato","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.autneu.2019.02.001_bb0360","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1038\/nature00965","article-title":"Coordination of circadian timing in mammals","volume":"418","author":"Reppert","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.autneu.2019.02.001_bb0365","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0040070","article-title":"NPY and VGF immunoreactivity increased in the arcuate nucleus, but decreased in the nucleus of the tractus solitarius, of type-ii diabetic patients","volume":"7","author":"Saderi","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.autneu.2019.02.001_bb0370","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.neuroscience.2013.05.004","article-title":"The NPY intergeniculate leaflet projections to the suprachiasmatic nucleus transmit metabolic conditions","volume":"246","author":"Saderi","year":"2013","journal-title":"Neuroscience"},{"issue":"7","key":"10.1016\/j.autneu.2019.02.001_bb0375","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1046\/j.1365-2826.2000.00503.x","article-title":"Neural connections of hypothalamic neuroendocrine nuclei in the rat","volume":"12","author":"Saeb-Parsy","year":"2000","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.autneu.2019.02.001_bb0380","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0060052","article-title":"Shift work or food intake during the rest phase promotes metabolic disruption and desynchrony of liver genes in male rats","volume":"8","author":"Salgado-Delgado","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.autneu.2019.02.001_bb0385","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1515\/BC.2003.078","article-title":"Cardiovascular control by the suprachiasmatic nucleus: neural and neuroendocrine mechanisms in human and rat","volume":"384","author":"Scheer","year":"2003","journal-title":"Biol. Chem."},{"key":"10.1016\/j.autneu.2019.02.001_bb0390","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1210\/jcem.87.1.8129","article-title":"Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion","volume":"87","author":"Shiiya","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.autneu.2019.02.001_bb0395","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1210\/js.2016-1104","article-title":"Systemic glucoregulation by glucose-sensing neurons in the ventromedial hypothalamic nucleus (VMH)","volume":"1","author":"Shimazu","year":"2017","journal-title":"J. Endocr. Soc."},{"key":"10.1016\/j.autneu.2019.02.001_bb0405","doi-asserted-by":"crossref","first-page":"G1056","DOI":"10.1152\/ajpgi.00319.2016","article-title":"Spinal afferent nerve endings in visceral organs: recent advances","volume":"311","author":"Spencer","year":"2016","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.autneu.2019.02.001_bb0410","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.mce.2015.12.011","article-title":"The role of feeding rhythm, adrenal hormones and neuronal inputs in synchronizing daily clock gene rhythms in the liver","volume":"422","author":"Su","year":"2016","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.autneu.2019.02.001_bb0415","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1126\/science.1158822","article-title":"Searching for genes underlying behavior: lessons from circadian rhythms","volume":"322","author":"Takahashi","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.autneu.2019.02.001_bb0420","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1126\/science.1126010","article-title":"Neuronal pathway from the liver modulates energy expenditure and systemic insulin sensitivity","volume":"312","author":"Uno","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.autneu.2019.02.001_bb0425","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1365-2826.1993.tb00373.x","article-title":"Lesions of the suprachiasmatic nucleus indicate the presence of a direct vasoactive intestinal polypeptide- containing projection to gonadotrophin-releasing hormone neurons in the female rat","volume":"5","author":"Van der Beek","year":"1993","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.autneu.2019.02.001_bb0430","doi-asserted-by":"crossref","first-page":"16493","DOI":"10.1073\/pnas.0902768106","article-title":"Intrinsic, nondeterministic circadian rhythm generation in identified mammalian neurons","volume":"106","author":"Webb","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.autneu.2019.02.001_bb0435","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1176\/ajp.148.12.1688","article-title":"How the medical comorbidity of depressed patients differs across health care settings: results from the medical outcomes study","volume":"148","author":"Wells","year":"1991","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.autneu.2019.02.001_bb0440","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1210\/en.2010-0943","article-title":"Circadian control of kisspeptin and a gated GnRH response mediate the preovulatory luteinizing hormone surge","volume":"152","author":"Williams","year":"2011","journal-title":"Endocrinology"},{"key":"10.1016\/j.autneu.2019.02.001_bb0445","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.cell.2016.05.011","article-title":"Sensory neurons that detect stretch and nutrients in the digestive system","volume":"166","author":"Williams","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.autneu.2019.02.001_bb0450","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1161\/HYPERTENSIONAHA.112.198002","article-title":"Enhanced adipose afferent reflex contributes to sympathetic activation in diet-induced obesity hypertension","volume":"60","author":"Xiong","year":"2012","journal-title":"Hypertension"},{"key":"10.1016\/j.autneu.2019.02.001_bb0455","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1126\/science.1238599","article-title":"Mice genetically deficient in vasopressin V1A and V1B receptors are resistant to jet lag","volume":"342","author":"Yamaguchi","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.autneu.2019.02.001_bb0460","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aad3305","article-title":"Timing of expression of the core clock gene BMAL1 influences its effects on aging and survival","volume":"8","author":"Yang","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.autneu.2019.02.001_bb0465","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1210\/en.2005-1051","article-title":"Ventromedial arcuate nucleus communicates peripheral metabolic information to the suprachiasmatic nucleus","volume":"147","author":"Yi","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.autneu.2019.02.001_bb0470","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1126\/science.aak9748","article-title":"Molecular and neural basis of contagious itch behavior in mice","volume":"355","author":"Yu","year":"2017","journal-title":"Science"}],"container-title":["Autonomic Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1566070218302832?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1566070218302832?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T12:13:59Z","timestamp":1761567239000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1566070218302832"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":94,"alternative-id":["S1566070218302832"],"URL":"https:\/\/doi.org\/10.1016\/j.autneu.2019.02.001","relation":{},"ISSN":["1566-0702"],"issn-type":[{"value":"1566-0702","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The suprachiasmatic nucleus; a responsive clock regulating homeostasis by daily changing the setpoints of physiological parameters","name":"articletitle","label":"Article Title"},{"value":"Autonomic Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.autneu.2019.02.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}