{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T06:12:47Z","timestamp":1771740767524,"version":"3.50.1"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T00:00:00Z","timestamp":1566259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"University Medical Center in Utrecht, the Netherlands"}],"content-domain":{"domain":["autonomicneuroscience.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Autonomic Neuroscience"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1016\/j.autneu.2019.102580","type":"journal-article","created":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T18:49:36Z","timestamp":1565981376000},"page":"102580","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Effect of vagus nerve stimulation on tissue damage and function loss in a mouse myocardial ischemia-reperfusion model"],"prefix":"10.1016","volume":"221","author":[{"given":"M.G.J.","family":"Nederhoff","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.E.","family":"Fransen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.A.M.W.","family":"Verlinde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.A.D.","family":"Brans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Pasterkamp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.L.A.W.","family":"Bleys","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.autneu.2019.102580_bb0005","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1161\/CIRCULATIONAHA.109.880187","article-title":"Myocardial ischemia\/reperfusion injury is mediated by leukocytic toll-like receptor-2 and reduced by systemic administration of a novel anti-toll-like receptor-2 antibody","volume":"121","author":"Arslan","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.autneu.2019.102580_bb0010","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/imr.12601","article-title":"High-mobility group box 1 protein orchestrates responses to tissue damage via inflammation, innate and adaptive immunity, and tissue repair","volume":"280","author":"Bianchi","year":"2017","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.autneu.2019.102580_bb0015","doi-asserted-by":"crossref","DOI":"10.1111\/joim.12611","article-title":"Vagus nerve stimulation: a new promising therapeutic tool in inflammatory bowel disease","author":"Bonaz","year":"2017","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.autneu.2019.102580_bb0020","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/35013070","article-title":"Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin","volume":"405","author":"Borovikova","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.autneu.2019.102580_bb0025","doi-asserted-by":"crossref","first-page":"H1289","DOI":"10.1152\/ajpheart.00286.2017","article-title":"Vagal stimulation mimics preconditioning and postconditioning of ischemic myocardium in mice by activating different protection mechanisms","volume":"314","author":"Buchholz","year":"2018","journal-title":"Am. J. Physiol. Circ. Physiol."},{"key":"10.1016\/j.autneu.2019.102580_bb0030","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/path.4942","article-title":"The peritoneum: healing, immunity, and diseases","author":"Capobianco","year":"2017","journal-title":"J. Pathol."},{"key":"10.1016\/j.autneu.2019.102580_bb0035","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.4049\/jimmunol.1601613","article-title":"Essential neuroscience in immunology","volume":"198","author":"Chavan","year":"2017","journal-title":"J. Immunol."},{"key":"10.1016\/j.autneu.2019.102580_bb0040","doi-asserted-by":"crossref","first-page":"4073","DOI":"10.1113\/jphysiol.2013.257758","article-title":"Myths and realities of the cardiac vagus","volume":"591","author":"Coote","year":"2013","journal-title":"J. Physiol."},{"key":"10.1016\/j.autneu.2019.102580_bb0045","series-title":"Statistical Power Analyses Using G* Power 3. 1: Tests for Correlation and Regression Analyses","first-page":"1149","volume":"vol. 41","author":"Erdfelder","year":"2009"},{"key":"10.1016\/j.autneu.2019.102580_bb0050","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.atherosclerosis.2006.10.009","article-title":"Vagus \u2013 brain communication in atherosclerosis-related inflammation: a neuroimmunomodulation perspective of CAD","volume":"195","author":"Gidron","year":"2007","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.autneu.2019.102580_bb0055","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jacc.2016.03.525","article-title":"Vagus nerve stimulation for the treatment of heart failure: the INOVATE-HF trial","volume":"68","author":"Gold","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.autneu.2019.102580_bb0060","unstructured":"GraphPad Prism Version 7 for Windows, GraphPad Software, La Jolla California USA, www.graphpad.com"},{"key":"10.1016\/j.autneu.2019.102580_bb0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/00401706.1969.10490657","article-title":"Procedures for detecting outlying observations in samples","volume":"11","author":"Grubbs","year":"1969","journal-title":"Technometrics"},{"key":"10.1016\/j.autneu.2019.102580_bb0070","first-page":"2762","article-title":"Transcutaneous vagus nerve stimulation reduces serum high mobility group box 1 levels and improves survival in murine sepsis","volume":"35","author":"Huston","year":"2007","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.autneu.2019.102580_bb0075","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.neuint.2016.02.009","article-title":"Auricular vagus nerve stimulation promotes functional recovery and enhances the post-ischemic angiogenic response in an ischemia\/reperfusion rat model","volume":"97","author":"Jiang","year":"2016","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.autneu.2019.102580_bb0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/JAHA.112.004887","article-title":"Heart-specific overexpression of choline acetyltransferase gene protects murine heart against ischemia through hypoxia-inducible factor-1?-related defense mechanisms","volume":"2","author":"Kakinuma","year":"2013","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.autneu.2019.102580_bb0085","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jtcvs.2008.08.020","article-title":"Vagal nerve stimulation prevents reperfusion injury through inhibition of opening of mitochondrial permeability transition pore independent of the bradycardiac effect","volume":"137","author":"Katare","year":"2009","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"10.1016\/j.autneu.2019.102580_bb0090","first-page":"6","article-title":"Myocardial protection by vagal stimulation in ischemia-reperfusion injury in mice Protecci\u00f3n mioc\u00e1rdica por estimulaci\u00f3n vagal en la injuria por isquemia y reperfusi\u00f3n en ratones","volume":"85","author":"Kelly","year":"2017","journal-title":"Rev. Argent. Cardiol."},{"key":"10.1016\/j.autneu.2019.102580_bb0095","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.berh.2014.10.015","article-title":"Vagus nerve stimulation: a new bioelectronics approach to treat rheumatoid arthritis?","volume":"28","author":"Koopman","year":"2014","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"10.1016\/j.autneu.2019.102580_bb0100","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1159\/000435843","article-title":"Modulation of the innate immune response through the vagus nerve","volume":"131","author":"Kox","year":"2015","journal-title":"Nephron"},{"key":"10.1016\/j.autneu.2019.102580_bb0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15424\/bioelectronmed.2016.00005","article-title":"Vagus nerve stimulation for treatment of inflammation: systematic review of animal models and clinical studies","volume":"3","author":"Kwan","year":"2016","journal-title":"Bioelectron. Med."},{"key":"10.1016\/j.autneu.2019.102580_bb0110","doi-asserted-by":"crossref","first-page":"R908","DOI":"10.1152\/ajpregu.00102.2013","article-title":"Increase in parasympathetic tone by pyridostigmine prevents ventricular dysfunction during the onset of heart failure","volume":"305","author":"Lataro","year":"2013","journal-title":"AJP Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.autneu.2019.102580_bb0115","doi-asserted-by":"crossref","unstructured":"Meesmann W, Schulz FW, Schley G, Adolphsen, P. Survival rate after acute experimental coronary occlusion as related to the spontaneous collateral vessels in hearts. Z Gesamte Exp Med. 153, 246\u2013264 (1970).","DOI":"10.1007\/BF02048758"},{"key":"10.1016\/j.autneu.2019.102580_bb0120","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1007\/s00011-014-0741-5","article-title":"Effects of anti-inflammatory vagus nerve stimulation in endotoxemic rats on blood and spleen lymphocyte subsets","volume":"63","author":"Mihaylova","year":"2014","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.autneu.2019.102580_bb0125","series-title":"Guide for the Care and Use of Laboratory Animals","author":"National Research Council","year":"2011"},{"key":"10.1016\/j.autneu.2019.102580_bb0130","series-title":"Minor Vascular Injury has a Major Influence on the Innate Immune Response in a Rodent Animal Model","first-page":"5","volume":"vol. 4","author":"Nederhoff","year":"2017"},{"key":"10.1016\/j.autneu.2019.102580_bb0135","first-page":"2110","article-title":"Nitric oxide as a mediator of parasympathetic vasodilation in ocular and extraocular tissues in the rabbit","volume":"37","author":"Nilsson","year":"1996","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.autneu.2019.102580_bb0140","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.bbi.2005.03.015","article-title":"The cholinergic anti-inflammatory pathway","volume":"19","author":"Pavlov","year":"2005","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.autneu.2019.102580_bb0145","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/BF03402177","article-title":"The cholinergic anti-inflammatory pathway: a missing link in neuroimmunomodulation","volume":"9","author":"Pavlov","year":"2003","journal-title":"Mol. Med."},{"key":"10.1016\/j.autneu.2019.102580_bb0150","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1002\/jcp.25307","article-title":"The involvement of parasympathetic and sympathetic nerve in the inflammatory reflex","volume":"231","author":"Pereira","year":"2016","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.autneu.2019.102580_bb0155","first-page":"198","article-title":"Selective vagal innervation of the heart","volume":"16","author":"Randall","year":"1986","journal-title":"Ann. Clin. Lab. Sci."},{"key":"10.1016\/j.autneu.2019.102580_bb0160","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH image to ImageJ: 25\u202fyears of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.autneu.2019.102580_bb0165","first-page":"17","article-title":"The crosstalk between autonomic nervous system and blood vessels","volume":"10","author":"Sheng","year":"2018","journal-title":"Int J Physiol Pathophysiol Pharmacol"},{"key":"10.1016\/j.autneu.2019.102580_bb0170","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1016\/j.hrthm.2014.08.001","article-title":"Vagus nerve stimulation initiated late during ischemia, but not reperfusion, exerts cardioprotection via amelioration of cardiac mitochondrial dysfunction","volume":"11","author":"Shinlapawittayatorn","year":"2014","journal-title":"Heart Rhythm."},{"key":"10.1016\/j.autneu.2019.102580_bb0175","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0735-1097(86)80329-1","article-title":"Early thrombolysis in acute myocardial infarction: limitation of infarct size and improved survival","volume":"7","author":"Simoons","year":"1986","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.autneu.2019.102580_bb0180","unstructured":"SPSS 22; IBM Corp. Released 2013. IBM SPSS Statistics for Windows, Version 22.0. Armonk, NY: IBM Corp."},{"key":"10.1016\/j.autneu.2019.102580_bb0185","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1152\/advan.00094.2013","article-title":"Neural control of the immune system","volume":"38","author":"Sundman","year":"2014","journal-title":"AJP Adv. Physiol. Educ."},{"key":"10.1016\/j.autneu.2019.102580_bb0190","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1172\/JCI30555","article-title":"Physiology and immunology of the cholinergic antiinflammatory pathway","volume":"117","author":"Tracey","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.autneu.2019.102580_bb0195","doi-asserted-by":"crossref","DOI":"10.1007\/s00395-015-0508-3","article-title":"Vagal nerve stimulation started just prior to reperfusion limits infarct size and no-reflow","volume":"110","author":"Uitterdijk","year":"2015","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.autneu.2019.102580_bb0200","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.molimm.2017.02.012","article-title":"The molecular mechanisms of signaling by cooperative assembly formation in innate immunity pathways","volume":"86","author":"Vajjhala","year":"2017","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.autneu.2019.102580_bb0205","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/SHK.0b013e31817d43bf","article-title":"Toll-like receptor 2 and 4 response and expression on monocytes decrease rapidly in patients undergoing arterial surgery and are related to preoperative smoking","volume":"31","author":"Versteeg","year":"2009","journal-title":"Shock"},{"key":"10.1016\/j.autneu.2019.102580_bb0210","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.4049\/jimmunol.175.4.2570","article-title":"Identification of high and low responders to lipopolysaccharide in normal subjects: an unbiased approach to identify modulators of innate immunity","volume":"175","author":"Wurfel","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.autneu.2019.102580_bb0215","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1097\/01.shk.0000065704.84144.a4","article-title":"Relative cytokine and cytokine inhibitor production by mononuclear cells and neutrophils","volume":"20","author":"Xing","year":"2003","journal-title":"Shock"},{"key":"10.1016\/j.autneu.2019.102580_bb0220","doi-asserted-by":"crossref","first-page":"H722","DOI":"10.1152\/ajpheart.00279.2014","article-title":"Electrophysiological effects of right and left vagal nerve stimulation on the ventricular myocardium","volume":"307","author":"Yamakawa","year":"2014","journal-title":"Am. J. Physiol. Circ. Physiol."},{"key":"10.1016\/j.autneu.2019.102580_bb0225","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.yjmcc.2013.04.023","article-title":"Temporal dynamics of cardiac immune cell accumulation following acute myocardial infarction","volume":"62","author":"Yan","year":"2013","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.autneu.2019.102580_bb0230","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1056\/NEJMra071667","article-title":"Myocardial reperfusion injury","volume":"357","author":"Yellon","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.autneu.2019.102580_bb0235","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3892\/etm.2015.2880","article-title":"Vagus nerve stimulation attenuates myocardial ischemia\/reperfusion injury by inhibiting the expression of interleukin-17A","volume":"11","author":"Yi","year":"2016","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.autneu.2019.102580_bb0240","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1111\/j.1440-1681.2011.05644.x","article-title":"Vagal nerve modulation: a promising new therapeutic approach for cardiovascular diseases","volume":"39","author":"Zhao","year":"2012","journal-title":"Clin. Exp. Pharmacol. Physiol."}],"container-title":["Autonomic Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1566070219301031?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1566070219301031?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T12:13:34Z","timestamp":1761567214000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1566070219301031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":48,"alternative-id":["S1566070219301031"],"URL":"https:\/\/doi.org\/10.1016\/j.autneu.2019.102580","relation":{},"ISSN":["1566-0702"],"issn-type":[{"value":"1566-0702","type":"print"}],"subject":[],"published":{"date-parts":[[2019,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of vagus nerve stimulation on tissue damage and function loss in a mouse myocardial ischemia-reperfusion model","name":"articletitle","label":"Article Title"},{"value":"Autonomic Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.autneu.2019.102580","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102580"}}