{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T18:57:30Z","timestamp":1775069850704,"version":"3.50.1"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["autonomicneuroscience.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Autonomic Neuroscience"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.autneu.2019.102599","type":"journal-article","created":{"date-parts":[[2019,11,3]],"date-time":"2019-11-03T04:12:42Z","timestamp":1572754362000},"page":"102599","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Effects of high-fat diet on sympathetic neurotransmission in mesenteric arteries from Dahl salt-sensitive rat"],"prefix":"10.1016","volume":"222","author":[{"given":"Kibrom M.","family":"Alula","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Biltz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah","family":"Garver","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erinn L.","family":"Laimon-Thomson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory D.","family":"Fink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James J.","family":"Galligan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.autneu.2019.102599_bb0005","doi-asserted-by":"crossref","first-page":"H1904","DOI":"10.1152\/ajpheart.00308.2015","article-title":"Organic cation transporter 3 contributes to norepinephrine uptake into perivascular adipose tissue","volume":"309","author":"Ayala-Lopez","year":"2015","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.autneu.2019.102599_bb0010","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/S0031-9384(98)00194-2","article-title":"Possible mechanisms of salt-induced hypertension in Dahl salt-sensitive rats","volume":"65","author":"Bayorh","year":"1998","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.autneu.2019.102599_bb0015","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.lfs.2016.10.005","article-title":"Altered contractile responses of arteries from spontaneously hypertensive rat: the role of endogenous mediators and membrane depolarization","volume":"166","author":"Bencze","year":"2016","journal-title":"Life Sci."},{"key":"10.1016\/j.autneu.2019.102599_bb0020","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1476-5381.2010.01030.x","article-title":"Rosuvastatin restored adrenergic and nitrergic function in mesenteric arteries from obese rats","volume":"162","author":"Blanco-Rivero","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.autneu.2019.102599_bb0025","doi-asserted-by":"crossref","first-page":"4753","DOI":"10.1113\/JP272167","article-title":"Quantifying sympathetic neuro-haemodynamic transduction at rest in humans: insights into sex, ageing and blood pressure control","volume":"594","author":"Briant","year":"2016","journal-title":"J. Physiol."},{"key":"10.1016\/j.autneu.2019.102599_bb0030","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.arr.2016.01.007","article-title":"Hypertension and aging","volume":"26","author":"Buford","year":"2016","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.autneu.2019.102599_bb0035","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1124\/pr.113.008029","article-title":"Purinergic signaling and blood vessels in health and disease","volume":"66","author":"Burnstock","year":"2014","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.autneu.2019.102599_bb0040","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1161\/01.HYP.0000242642.42177.49","article-title":"Mechanisms of sympathetic activation in obesity-related hypertension","volume":"48","author":"Esler","year":"2006","journal-title":"Hypertension"},{"key":"10.1016\/j.autneu.2019.102599_bb0045","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1161\/HYPERTENSIONAHA.117.09980","article-title":"Sex differences in mechanisms of hypertension associated with obesity","volume":"71","author":"Faulkner","year":"2018","journal-title":"Hypertension"},{"key":"10.1016\/j.autneu.2019.102599_bb0050","doi-asserted-by":"crossref","first-page":"e43","DOI":"10.1161\/HYPERTENSIONAHA.118.11485","article-title":"Sex differences in renal inflammation and injury in high-fat diet-fed Dahl salt-sensitive rats","volume":"72","author":"Fernandes","year":"2018","journal-title":"Hypertension"},{"key":"10.1016\/j.autneu.2019.102599_bb0055","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1159\/000028346","article-title":"Renal vascular reactivity to P(2)-purinoceptor activation in spontaneously hypertensive rats","volume":"60","author":"Fernandez","year":"2000","journal-title":"Pharmacology"},{"key":"10.1016\/j.autneu.2019.102599_bb0060","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1161\/HYPERTENSIONAHA.117.10300","article-title":"Exaggerated sympathetic neurovascular transduction as a mechanism of neurogenic hypertension: it is not all about activity","volume":"71","author":"Fink","year":"2018","journal-title":"Hypertension"},{"key":"10.1016\/j.autneu.2019.102599_bb0065","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1161\/01.HYP.35.1.464","article-title":"Mechanisms of increased venous smooth muscle tone in desoxycorticosterone acetate-salt hypertension","volume":"35","author":"Fink","year":"2000","journal-title":"Hypertension"},{"key":"10.1016\/j.autneu.2019.102599_bb0070","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/S0022-3565(24)38771-3","article-title":"Differential localization of P2 receptor subtypes in mesenteric arteries and veins of normotensive and hypertensive rats","volume":"296","author":"Galligan","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.autneu.2019.102599_bb0075","doi-asserted-by":"crossref","first-page":"R62","DOI":"10.1152\/ajpregu.00377.2014","article-title":"The Dahl salt-sensitive rat is a spontaneous model of superimposed preeclampsia","volume":"309","author":"Gillis","year":"2015","journal-title":"American journal of physiology. Regulatory, integrative and comparative physiology"},{"key":"10.1016\/j.autneu.2019.102599_bb0080","doi-asserted-by":"crossref","first-page":"3289","DOI":"10.1113\/jphysiol.2011.207944","article-title":"Sympathetic overdrive in obesity involves purinergic hyperactivity in the resistance vasculature","volume":"589","author":"Haddock","year":"2011","journal-title":"J. Physiol."},{"key":"10.1016\/j.autneu.2019.102599_bb0085","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1161\/CIRCRESAHA.116.305697","article-title":"Obesity-induced hypertension: interaction of neurohumoral and renal mechanisms","volume":"116","author":"Hall","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.autneu.2019.102599_bb0090","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/0026-2862(72)90043-X","article-title":"Vascular reactivity to ATP in vitro in experimental hypertension","volume":"4","author":"Harris","year":"1972","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.autneu.2019.102599_bb0095","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/BF01977661","article-title":"Some properties of the junctional and extrajunctional receptors in the vas deferens of the guinea-pig","volume":"1","author":"Hotta","year":"1969","journal-title":"Agents and actions"},{"key":"10.1016\/j.autneu.2019.102599_bb0100","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1113\/jphysiol.1983.sp014985","article-title":"Roles of extrajunctional receptors in the response of guinea-pig mesenteric and rat tail arteries to adrenergic nerves","volume":"345","author":"Itoh","year":"1983","journal-title":"J. Physiol."},{"key":"10.1016\/j.autneu.2019.102599_bb0105","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/FJC.0b013e318235156a","article-title":"Vascular hyporeactivity to angiotensin II and noradrenaline in a rabbit model of obesity","volume":"59","author":"Jerez","year":"2012","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.autneu.2019.102599_bb0110","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1161\/01.RES.38.6.21","article-title":"Sympathetic nerve activity: role in regulation of blood pressure in the spontaenously hypertensive rat","volume":"38","author":"Judy","year":"1976","journal-title":"Circ. Res."},{"key":"10.1016\/j.autneu.2019.102599_bb0115","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1161\/01.HYP.35.3.807","article-title":"Overweight and hypertension: a 2-way street?","volume":"35","author":"Julius","year":"2000","journal-title":"Hypertension"},{"key":"10.1016\/j.autneu.2019.102599_bb0120","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/hr.2011.173","article-title":"Sympathetic nervous system in obesity-related hypertension: mechanisms and clinical implications","volume":"35","author":"Kalil","year":"2012","journal-title":"Hypertens. Res."},{"key":"10.1016\/j.autneu.2019.102599_bb0125","doi-asserted-by":"crossref","first-page":"H1965","DOI":"10.1152\/ajpheart.00086.2011","article-title":"Splanchnic sympathetic nerves in the development of mild DOCA-salt hypertension","volume":"301","author":"Kandlikar","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.autneu.2019.102599_bb0130","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1161\/01.HYP.14.6.660","article-title":"Perivascular innervation of the mesenteric artery in spontaneously hypertensive rats","volume":"14","author":"Kawamura","year":"1989","journal-title":"Hypertension"},{"key":"10.1016\/j.autneu.2019.102599_bb0135","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1161\/HYPERTENSIONAHA.107.090696","article-title":"Splanchnic circulation is a critical neural target in angiotensin II salt hypertension in rats","volume":"50","author":"King","year":"2007","journal-title":"Hypertension"},{"key":"10.1016\/j.autneu.2019.102599_bb0140","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1038\/hr.2017.75","article-title":"The relationship between obesity and hypertension: an updated comprehensive overview on vicious twins","volume":"40","author":"Leggio","year":"2017","journal-title":"Hypertens. Res."},{"key":"10.1016\/j.autneu.2019.102599_bb0145","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.autneu.2009.11.009","article-title":"The effects of celiac ganglionectomy on sympathetic innervation to the splanchnic organs in the rat","volume":"154","author":"Li","year":"2010","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.autneu.2019.102599_bb0150","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S1566-0702(02)00287-4","article-title":"Differential alterations in sympathetic neurotransmission in mesenteric arteries and veins in DOCA-salt hypertensive rats","volume":"104","author":"Luo","year":"2003","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.autneu.2019.102599_bb0155","doi-asserted-by":"crossref","first-page":"H1558","DOI":"10.1152\/ajpheart.00592.2003","article-title":"Impaired function of alpha2-adrenergic autoreceptors on sympathetic nerves associated with mesenteric arteries and veins in DOCA-salt hypertension","volume":"286","author":"Luo","year":"2004","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.autneu.2019.102599_bb0160","doi-asserted-by":"crossref","first-page":"I86","DOI":"10.1161\/01.HYP.17.1_Suppl.I86","article-title":"Sympathetic neural contribution to salt-induced hypertension in Dahl rats","volume":"17","author":"Mark","year":"1991","journal-title":"Hypertension"},{"key":"10.1016\/j.autneu.2019.102599_bb0165","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1097\/HJH.0000000000001434","article-title":"Role of the sympathetic nervous system in regulation of the sodium glucose cotransporter 2","volume":"35","author":"Matthews","year":"2017","journal-title":"J. Hypertens."},{"key":"10.1016\/j.autneu.2019.102599_bb0170","doi-asserted-by":"crossref","first-page":"H863","DOI":"10.1152\/ajpheart.00536.2017","article-title":"Macrophage-dependent impairment of alpha2-adrenergic autoreceptor inhibition of Ca(2+) channels in sympathetic neurons from DOCA-salt but not high-fat diet-induced hypertensive rats","volume":"314","author":"Mui","year":"2018","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.autneu.2019.102599_bb0175","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1080\/10641960902825487","article-title":"Effect of high fat loading in Dahl salt-sensitive rats","volume":"31","author":"Nagae","year":"2009","journal-title":"Clin. Exp. Hypertens."},{"key":"10.1016\/j.autneu.2019.102599_bb0180","doi-asserted-by":"crossref","first-page":"6756","DOI":"10.1021\/ac060440u","article-title":"In vitro continuous amperometry with a diamond microelectrode coupled with video microscopy for simultaneously monitoring endogenous norepinephrine and its effect on the contractile response of a rat mesenteric artery","volume":"78","author":"Park","year":"2006","journal-title":"Anal. Chem."},{"key":"10.1016\/j.autneu.2019.102599_bb0185","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.autneu.2009.08.008","article-title":"Alterations in sympathetic neuroeffector transmission to mesenteric arteries but not veins in DOCA-salt hypertension","volume":"152","author":"Park","year":"2010","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.autneu.2019.102599_bb0190","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1124\/jpet.103.056184","article-title":"Increased reactivity of murine mesenteric veins to adrenergic agonists: functional evidence supporting increased alpha1-adrenoceptor reserve in veins compared with arteries","volume":"308","author":"Perez-Rivera","year":"2004","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.autneu.2019.102599_bb0195","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1124\/jpet.302.2.525","article-title":"Gender differences in hypothalamic tyrosine hydroxylase and alpha(2)-adrenoceptor subtype gene expression in cafeteria diet-induced hypertension and consequences of neonatal androgenization","volume":"302","author":"Plut","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.autneu.2019.102599_bb0200","doi-asserted-by":"crossref","first-page":"R463","DOI":"10.1152\/ajpregu.00305.2018","article-title":"Relation between resting sympathetic outflow and vasoconstrictor responses to sympathetic nerve bursts: sex differences in healthy young adults","volume":"316","author":"Robinson","year":"2019","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.autneu.2019.102599_bb0205","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/2042-6410-3-7","article-title":"Sex differences in primary hypertension","volume":"3","author":"Sandberg","year":"2012","journal-title":"Biol. Sex Differ."},{"key":"10.1016\/j.autneu.2019.102599_bb0210","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1007\/s11906-009-0036-3","article-title":"The role of the sympathetic nervous system in obesity-related hypertension","volume":"11","author":"da Silva","year":"2009","journal-title":"Curr. Hypertens. Rep."},{"key":"10.1016\/j.autneu.2019.102599_bb0215","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jdiacomp.2005.12.003","article-title":"Obesity impairs vascular relaxation in human subjects: hyperglycemia exaggerates adrenergic vasoconstriction arterial dysfunction in obesity and diabetes","volume":"21","author":"Sivitz","year":"2007","journal-title":"J. Diabetes Complicat."},{"key":"10.1016\/j.autneu.2019.102599_bb0220","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1161\/01.STR.21.5.785","article-title":"Analysis of cerebrovascular sympathetic nerve density in relation to stroke development in spontaneously hypertensive rats","volume":"21","author":"Smeda","year":"1990","journal-title":"Stroke"},{"key":"10.1016\/j.autneu.2019.102599_bb0225","doi-asserted-by":"crossref","first-page":"H2327","DOI":"10.1152\/ajpheart.01298.2005","article-title":"ATP and norepinephrine contributions to sympathetic vasoconstriction of tail artery are altered in streptozotocin-diabetic rats","volume":"291","author":"Speirs","year":"2006","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.autneu.2019.102599_bb0230","doi-asserted-by":"crossref","first-page":"H816","DOI":"10.1152\/ajpheart.00695.2001","article-title":"Augmented adrenergic vasoconstriction in hypertensive diabetic obese Zucker rats","volume":"282","author":"Stepp","year":"2002","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.autneu.2019.102599_bb0235","doi-asserted-by":"crossref","first-page":"516","DOI":"10.3389\/fphys.2016.00516","article-title":"Comparable attenuation of sympathetic nervous system activity in obese subjects with Normal glucose tolerance, impaired glucose tolerance, and treatment naive type 2 diabetes following equivalent weight loss","volume":"7","author":"Straznicky","year":"2016","journal-title":"Front. Physiol."},{"key":"10.1016\/j.autneu.2019.102599_bb0240","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/S0022-3565(24)38817-2","article-title":"Gender differences in the effect of age on electrical field stimulation (EFS)-induced adrenergic vasoconstriction in rat mesenteric resistance arteries","volume":"296","author":"Sullivan","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.autneu.2019.102599_bb0245","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1038\/hr.2017.31","article-title":"A high-salt diet enhances leukocyte adhesion in association with kidney injury in young Dahl salt-sensitive rats","volume":"40","author":"Takahashi","year":"2017","journal-title":"Hypertension research: official journal of the Japanese Society of Hypertension"},{"key":"10.1016\/j.autneu.2019.102599_bb0250","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jneumeth.2016.03.015","article-title":"Simultaneous analysis of vascular norepinephrine and ATP release using an integrated microfluidic system","volume":"266","author":"Townsend","year":"2016","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.autneu.2019.102599_bb0255","first-page":"89","article-title":"Neuropeptide Y and sympathetic control of vascular tone in hypertension","author":"Westfall","year":"2006","journal-title":"EXS"},{"key":"10.1016\/j.autneu.2019.102599_bb0260","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0895-7061(98)00238-6","article-title":"A high sucrose, high linoleic acid diet potentiates hypertension in the Dahl salt sensitive rat","volume":"12","author":"Zhang","year":"1999","journal-title":"Am. J. Hypertens."}],"container-title":["Autonomic Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1566070219301985?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1566070219301985?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T12:12:08Z","timestamp":1761567128000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1566070219301985"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":52,"alternative-id":["S1566070219301985"],"URL":"https:\/\/doi.org\/10.1016\/j.autneu.2019.102599","relation":{},"ISSN":["1566-0702"],"issn-type":[{"value":"1566-0702","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of high-fat diet on sympathetic neurotransmission in mesenteric arteries from Dahl salt-sensitive rat","name":"articletitle","label":"Article Title"},{"value":"Autonomic Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.autneu.2019.102599","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102599"}}