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Physiol."},{"key":"10.1016\/j.autneu.2020.102658_bb0355","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0304-3940(93)9003-3","article-title":"Compared effects of serotonin on the inspiratory activity of glossopharyngeal, vagal, hypoglossal and cervical motoneurons in neonatal rat brain stem-spinal cord preparations","volume":"160","author":"Morin","year":"1993","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.autneu.2020.102658_bb0360","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0006-8993(90)91611-J","article-title":"Serotonergic influences on central respiratory activity: an in vitro study of the new born rat","volume":"535","author":"Morin","year":"1990","journal-title":"Brain Res."},{"key":"10.1016\/j.autneu.2020.102658_bb0365","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.neures.2018.05.004","article-title":"Serotonergic projections to the ventral respiratory column from raphe nuclei in rats","volume":"143","author":"Morinaga","year":"2019","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.autneu.2020.102658_bb0370","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/0006-8993(84)90502-X","article-title":"Excitatory effects of iontophoretically applied substance P on neurons in the nucleus tractus solitarius of the cat: lack of interaction with opiates and opioids","volume":"307","author":"Morin-Surin","year":"1984","journal-title":"Brain Res."},{"key":"10.1016\/j.autneu.2020.102658_bb0375","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1152\/japplphysiol.00347.2006","article-title":"Neurokinin-1 receptor-expressing neurons in the ventral medulla are essential for normal central and peripheral chemoreception in the conscious rat","volume":"101","author":"Nattie","year":"2006","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.autneu.2020.102658_bb0380","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/j.2040-4603.2012.tb00403.x","article-title":"Central chemoreceptors: locations and functions","volume":"2","author":"Nattie","year":"2012","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.autneu.2020.102658_bb0385","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1113\/jphysiol.2003.059766","article-title":"Medullary serotonergic neurones and adjacent neurones that express neurokinin-1 receptors are both involved in chemoreception in vivo","volume":"556","author":"Nattie","year":"2004","journal-title":"J. Physiol."},{"key":"10.1016\/j.autneu.2020.102658_bb0390","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1111\/j.1476-5381.1991.tb12221.x","article-title":"Evidence that the 5-HT3 receptors of the rat, mouse and Guinea-pig superior cervical ganglion may be different","volume":"102","author":"Newberry","year":"1991","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.autneu.2020.102658_bb0395","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1476-5381.1975.tb07606.x","article-title":"The action of 5-hydroxytryptanine on chemoreceptor discharges of the cat\u2019s carotid body","volume":"55","author":"Nishi","year":"1975","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.autneu.2020.102658_bb0400","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/0304-3940(90)90422-6","article-title":"Serotonergic projections from the nodose ganglia to the nucleus tractus solitarius. An immunohistochemical and double labelling study in the rat","volume":"114","author":"Nosjean","year":"1990","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.autneu.2020.102658_bb0405","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1055\/s-2002-33678","article-title":"Alteration of serotonergic receptors in the brain stems of human patients with respiratory disorders","volume":"33","author":"Ozawa","year":"2002","journal-title":"Neuropediatrics"},{"key":"10.1016\/j.autneu.2020.102658_bb0410","doi-asserted-by":"crossref","first-page":"11055","DOI":"10.1523\/JNEUROSCI.22-24-11055.2002","article-title":"Endogenous activation of serotonin-2A receptors is required for respiratory rhythm generation in vitro","volume":"22","author":"Pe\u00f1a","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.autneu.2020.102658_bb0415","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0031-6997(25)06575-5","article-title":"Substance P","volume":"35","author":"Pernow","year":"1983","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.autneu.2020.102658_bb0420","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1523\/JNEUROSCI.10-04-01091.1990","article-title":"Serotonin immunoreactive boutons make synapses with feline phrenic motoneurons","volume":"10","author":"Pilowsky","year":"1990","journal-title":"J. Neurosci."},{"key":"10.1016\/j.autneu.2020.102658_bb0425","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.1748-1716.1984.tb07460.x","article-title":"Effect of substance P antagonist on the hypoxia-induced carotid chemoreceptor activity","volume":"121","author":"Prabhakar","year":"1984","journal-title":"Acta Physiol. Scand."},{"key":"10.1016\/j.autneu.2020.102658_bb0430","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/j.1748-1716.1987.tb08206.x","article-title":"Role of the vagal afferents in substance P-induced respiratory responses in anaesthetized rabbits","volume":"131","author":"Prabhakar","year":"1987","journal-title":"Acta Physiol. Scand."},{"key":"10.1016\/j.autneu.2020.102658_bb0435","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0006-8993(89)90795-6","article-title":"Substance P an neurokinin A in the cat carotid body: localization, exogenous effects and changes in content in response to arterial PO2","volume":"481","author":"Prabhakar","year":"1989","journal-title":"Brain Res."},{"key":"10.1016\/j.autneu.2020.102658_bb0440","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0165-1838(94)00143-8","article-title":"Analysis of carotid chemoreceptor responses to substance P analogue in anaesthetized cats","volume":"52","author":"Prabhakar","year":"1995","journal-title":"J. Auton. Nerv. Syst."},{"key":"10.1016\/j.autneu.2020.102658_bb0445","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/0028-3908(89)90012-9","article-title":"The 5-HT3 receptor ligand, [3 H]BRL 43694, binds to presynaptic sites in the nucleus tractus solitarius of the rat","volume":"28","author":"Pratt","year":"1989","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.autneu.2020.102658_bb0450","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0165-3806(99)00044-9","article-title":"Substance P and central respiratory activity: a comparative in vitro study on foetal and newborn rat","volume":"114","author":"Ptak","year":"1999","journal-title":"Dev. Brain Res."},{"key":"10.1016\/j.autneu.2020.102658_bb0455","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1046\/j.1460-9568.2000.00886.x","article-title":"Cellular and synaptic effect of substance P on neonatal phrenic motoneurons","volume":"12","author":"Ptak","year":"2000","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.autneu.2020.102658_bb0460","doi-asserted-by":"crossref","first-page":"3720","DOI":"10.1523\/JNEUROSCI.5271-08.2009","article-title":"Raphe neurons stimulate respiratory circuit activity by multiple mechanisms via endogenously released serotonin and substance P","volume":"29","author":"Ptak","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.autneu.2020.102658_bb0465","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.resp.2015.03.005","article-title":"Activation of 5-HT1A receptors in the pre-B\u00f6tzinger region has little impact on the respiratory pattern","volume":"214","author":"Radocaj","year":"2015","journal-title":"Respir. Physiol. 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Med."},{"key":"10.1016\/j.autneu.2020.102658_bb0485","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0034-5687(95)00008-2","article-title":"Central effects of 5-HT on respiratory and hypoglossal activities in the adult cat","volume":"101","author":"Rose","year":"1995","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.autneu.2020.102658_bb0490","first-page":"245","article-title":"Effect of 5-hydroxytryptamine on the peripheral chemoreceptors in the rat","volume":"16","author":"Sapru","year":"1977","journal-title":"Res. Commun. Chem. Pathol. Pharmacol."},{"key":"10.1016\/j.autneu.2020.102658_bb0495","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/0891-0618(91)90025-8","article-title":"Up-regulation of substance P binding sites in the vagus nerve projection area of the cat brainstem after nodosectomy. A quantitative autoradiographic study","volume":"4","author":"Segu","year":"1991","journal-title":"J. Chem. Neuroanat."},{"key":"10.1016\/j.autneu.2020.102658_bb0500","doi-asserted-by":"crossref","first-page":"3967","DOI":"10.1097\/00001756-199912160-00044","article-title":"Serotonin and substance P co-exist in dorsal raphe neurons of the human brain","volume":"10","author":"Sergeev","year":"1999","journal-title":"Neuroreport"},{"key":"10.1016\/j.autneu.2020.102658_bb0505","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0006-8993(85)91515-X","article-title":"Effects of enkephalin and 5-hydroxytryptamine on solitary tract neurons involved in respiration and respiratory reflexes","volume":"327","author":"Sessle","year":"1985","journal-title":"Brain Res."},{"key":"10.1016\/j.autneu.2020.102658_bb0510","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/0306-4522(81)90146-9","article-title":"Distribution of serotonin immunoreactivity in the central nervous system of the rat \u2013 cell bodies and terminals","volume":"6","author":"Steinbusch","year":"1981","journal-title":"Neuroscience"},{"key":"10.1016\/j.autneu.2020.102658_bb0515","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/cne.10329","article-title":"Serotonin inputs to inspiratory laryngeal motoneurons in the rat","volume":"451","author":"Sun","year":"2002","journal-title":"J. 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Physiol."},{"key":"10.1016\/j.autneu.2020.102658_bb0530","doi-asserted-by":"crossref","first-page":"209","DOI":"10.55782\/ane-1997-1228","article-title":"Action of serotonin on the laryngeal airway in anaesthetized cats","volume":"57","author":"Szereda-Przestaszewska","year":"1997","journal-title":"Acta Neurobiol. Exp."},{"key":"10.1016\/j.autneu.2020.102658_bb0535","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0034-5687(95)00031-8","article-title":"Effect of vagal and laryngeal afferents on apnoeic response to serotonin in cats","volume":"101","author":"Szereda-Przestaszewska","year":"1995","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.autneu.2020.102658_bb0540","first-page":"71","article-title":"Diverging respiratory effects of serotonin and nicotine in vagotomised cats prior to and after section of carotid sinus nerves","volume":"52","author":"Szereda-Przestaszewska","year":"2001","journal-title":"J. Physiol. 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