{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T04:22:38Z","timestamp":1775535758422,"version":"3.50.1"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T00:00:00Z","timestamp":1582848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013327","name":"Lundbeck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013327","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["autonomicneuroscience.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Autonomic Neuroscience"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.autneu.2020.102659","type":"journal-article","created":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T03:07:58Z","timestamp":1582859278000},"page":"102659","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Real-world droxidopa or midodrine treatment persistence in patients with neurogenic orthostatic hypotension or orthostatic hypotension"],"prefix":"10.1016","volume":"225","author":[{"given":"Steven M.","family":"Kymes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Sullivan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satish R.","family":"Raj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.autneu.2020.102659_bb0005","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s12883-017-0867-5","article-title":"Integrated analysis of droxidopa trials for neurogenic orthostatic hypotension","volume":"17","author":"Biaggioni","year":"2017","journal-title":"BMC Neurol."},{"issue":"1","key":"10.1016\/j.autneu.2020.102659_bb0010","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/s12883-018-1129-x","article-title":"Characterization of the symptoms of neurogenic orthostatic hypotension and their impact from a survey of patients and caregivers","volume":"18","author":"Claassen","year":"2018","journal-title":"BMC Neurol."},{"issue":"827","key":"10.1016\/j.autneu.2020.102659_bb0015","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1136\/pgmj.70.827.638","article-title":"Clinical presentation of orthostatic hypotension in the elderly","volume":"70","author":"Craig","year":"1994","journal-title":"Postgrad. Med. J."},{"issue":"3","key":"10.1016\/j.autneu.2020.102659_bb0020","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/mdc3.12726","article-title":"Six-month use of droxidopa for neurogenic orthostatic hypotension","volume":"6","author":"Fran\u00e7ois","year":"2019","journal-title":"Mov Disord Clin Pract"},{"issue":"6","key":"10.1016\/j.autneu.2020.102659_bb0025","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1056\/NEJMcp074189","article-title":"Clinical practice. Neurogenic orthostatic hypotension","volume":"358","author":"Freeman","year":"2008","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.autneu.2020.102659_bb0030","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s10286-011-0119-5","article-title":"Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome","volume":"21","author":"Freeman","year":"2011","journal-title":"Clin. Auton. Res."},{"issue":"11","key":"10.1016\/j.autneu.2020.102659_bb0035","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1016\/j.jacc.2018.05.079","article-title":"Orthostatic hypotension: JACC state-of-the-art review","volume":"72","author":"Freeman","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"issue":"8","key":"10.1016\/j.autneu.2020.102659_bb0040","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1007\/s00415-016-8375-x","article-title":"The recommendations of a consensus panel for the screening, diagnosis, and treatment of neurogenic orthostatic hypotension and associated supine hypertension","volume":"264","author":"Gibbons","year":"2017","journal-title":"J. Neurol."},{"issue":"5","key":"10.1016\/j.autneu.2020.102659_bb0045","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/mds.26086","article-title":"Droxidopa for the short-term treatment of symptomatic neurogenic orthostatic hypotension in Parkinson's disease (nOH306B)","volume":"30","author":"Hauser","year":"2015","journal-title":"Mov. Disord."},{"issue":"4","key":"10.1016\/j.autneu.2020.102659_bb0050","doi-asserted-by":"crossref","first-page":"751","DOI":"10.3233\/JPD-160860","article-title":"Safety and durability of effect with long-term, open-label droxidopa treatment in patients with symptomatic neurogenic orthostatic hypotension (NOH303)","volume":"6","author":"Isaacson","year":"2016","journal-title":"J. Parkinsons Dis."},{"issue":"10","key":"10.1016\/j.autneu.2020.102659_bb0055","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.jash.2016.07.010","article-title":"Long-term safety of droxidopa in patients with symptomatic neurogenic orthostatic hypotension","volume":"10","author":"Isaacson","year":"2016","journal-title":"J. Am. Soc. Hypertens."},{"issue":"6","key":"10.1016\/j.autneu.2020.102659_bb0060","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1080\/10410236.2013.873363","article-title":"The Health Belief Model as an explanatory framework in communication research: exploring parallel, serial, and moderated mediation","volume":"30","author":"Jones","year":"2015","journal-title":"Health Commun."},{"issue":"2","key":"10.1016\/j.autneu.2020.102659_bb0065","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s10286-011-0146-2","article-title":"The Orthostatic Hypotension Questionnaire (OHQ): validation of a novel symptom assessment scale","volume":"22","author":"Kaufmann","year":"2012","journal-title":"Clin. Auton. Res."},{"issue":"4","key":"10.1016\/j.autneu.2020.102659_bb0070","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1212\/WNL.0000000000000615","article-title":"Droxidopa for neurogenic orthostatic hypotension: a randomized, placebo-controlled, phase 3 trial","volume":"83","author":"Kaufmann","year":"2014","journal-title":"Neurology"},{"issue":"35","key":"10.1016\/j.autneu.2020.102659_bb0075","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000004481","article-title":"Comparative persistence of antiepileptic drugs in patients with epilepsy: a STROBE-compliant retrospective cohort study","volume":"95","author":"Lai","year":"2016","journal-title":"Medicine (Baltimore)."},{"issue":"8","key":"10.1016\/j.autneu.2020.102659_bb0080","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s12325-010-0050-5","article-title":"Greater refill adherence to adalimumab therapy for patients using specialty versus retail pharmacies","volume":"27","author":"Liu","year":"2010","journal-title":"Adv. Ther."},{"issue":"9","key":"10.1016\/j.autneu.2020.102659_bb0085","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1111\/jch.13619","article-title":"Initiation of droxidopa during hospital admission for management of refractory neurogenic orthostatic hypotension in severely ill patients","volume":"21","author":"McDonell","year":"2019","journal-title":"J. Clin. Hypertens. (Greenwich)."},{"issue":"3","key":"10.1016\/j.autneu.2020.102659_bb0090","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/j.1369-7625.2010.00619.x","article-title":"Frequency of and reasons for medication non-fulfillment and non-persistence among American adults with chronic disease in 2008","volume":"14","author":"McHorney","year":"2011","journal-title":"Health Expect."},{"key":"10.1016\/j.autneu.2020.102659_bb0095","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.parkreldis.2017.11.344","article-title":"Orthostatic hypotension in Parkinson disease: impact on health care utilization","volume":"47","author":"Merola","year":"2017","journal-title":"Parkinsonism Relat. Disord."},{"issue":"3","key":"10.1016\/j.autneu.2020.102659_bb0100","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1002\/mds.27268","article-title":"Autonomic dysfunction in Parkinson's disease: a prospective cohort study","volume":"33","author":"Merola","year":"2018","journal-title":"Mov. Disord."},{"key":"10.1016\/j.autneu.2020.102659_bb0105","series-title":"Full Prescribing Information","author":"Northera\u00ae (droxidopa)","year":"2017"},{"key":"10.1016\/j.autneu.2020.102659_bb0110","series-title":"Full Prescribing Information","author":"ProAmatine\u00ae (midodrine hydrochloride tablets)","year":"2017"},{"issue":"8","key":"10.1016\/j.autneu.2020.102659_bb0115","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1056\/NEJMp1307084","article-title":"Taking our medicine--improving adherence in the accountability era","volume":"369","author":"Rosenbaum","year":"2013","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.autneu.2020.102659_bb0120","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1177\/109019818801500203","article-title":"Social learning theory and the Health Belief Model","volume":"15","author":"Rosenstock","year":"1988","journal-title":"Health Educ. Q."},{"issue":"1","key":"10.1016\/j.autneu.2020.102659_bb0125","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s10286-013-0219-5","article-title":"The relationship between orthostatic hypotension and falling in older adults","volume":"24","author":"Shaw","year":"2014","journal-title":"Clin. Auton. Res."},{"issue":"2","key":"10.1016\/j.autneu.2020.102659_bb0130","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.autneu.2013.08.064","article-title":"Early discontinuation of treatment in patients with orthostatic hypotension","volume":"177","author":"Shibao","year":"2013","journal-title":"Auton. Neurosci."},{"issue":"1","key":"10.1016\/j.autneu.2020.102659_bb0135","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1186\/s12913-017-2373-2","article-title":"Impact of pharmacy channel on adherence to oral oncolytics","volume":"17","author":"Stokes","year":"2017","journal-title":"BMC Health Serv. Res."},{"issue":"4","key":"10.1016\/j.autneu.2020.102659_bb0140","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.amjopharm.2010.08.001","article-title":"Drug therapies for Parkinson's disease: a database analysis of patient compliance and persistence","volume":"8","author":"Tarrants","year":"2010","journal-title":"Am. J. Geriatr. Pharmacother."},{"key":"10.1016\/j.autneu.2020.102659_bb0145","author":"World Health Organization"}],"container-title":["Autonomic Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1566070219301444?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1566070219301444?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T12:13:57Z","timestamp":1761567237000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1566070219301444"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":29,"alternative-id":["S1566070219301444"],"URL":"https:\/\/doi.org\/10.1016\/j.autneu.2020.102659","relation":{},"ISSN":["1566-0702"],"issn-type":[{"value":"1566-0702","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Real-world droxidopa or midodrine treatment persistence in patients with neurogenic orthostatic hypotension or orthostatic hypotension","name":"articletitle","label":"Article Title"},{"value":"Autonomic Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.autneu.2020.102659","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102659"}}