{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:42:43Z","timestamp":1791916963052,"version":"4.3.4"},"reference-count":30,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Autoimmunity Reviews"],"published-print":{"date-parts":[[2005,11]]},"DOI":"10.1016\/j.autrev.2005.04.019","type":"journal-article","created":{"date-parts":[[2005,6,14]],"date-time":"2005-06-14T07:25:50Z","timestamp":1118733950000},"page":"497-502","source":"Crossref","is-referenced-by-count":98,"title":["Altered circadian rhythms in rheumatoid arthritis patients play a role in the disease's symptoms"],"prefix":"10.1016","volume":"4","author":[{"given":"M.","family":"Cutolo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Villaggio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Otsa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Aakre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Sulli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Seriolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.autrev.2005.04.019_bib1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.rdc.2004.09.005","article-title":"Circadian rhythms and arthritis","volume":"31","author":"Cutolo","year":"2005","journal-title":"Rheum Dis Clin North Am"},{"key":"10.1016\/j.autrev.2005.04.019_bib2","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/j.1749-6632.1999.tb07645.x","article-title":"Melatonin influences interleukin-12 and nitric oxide production by primary cultures of rheumatoid synovial macrophages and THP-1 cells","volume":"876","author":"Cutolo","year":"1999","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.autrev.2005.04.019_bib3","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jneuroim.2004.08.015","article-title":"Does melatonin play a disease-promoting role in rheumatoid arthritis?","volume":"158","author":"Maestroni","year":"2005","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.autrev.2005.04.019_bib4","unstructured":"Cutolo M, Otsa K, Aakre O, et al. Nocturnal hormones and clinical rhythms in rheumatoid arthritis. N.Y. Ann, Acad Sci in press."},{"key":"10.1016\/j.autrev.2005.04.019_bib5","first-page":"203","article-title":"Integrated hormonal\u2013immunological\u2013vascular (\u201cH\u2013I\u2013V\u201d triad) systems interactions in the rheumatic diseases","volume":"13","author":"Masi","year":"1995","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.autrev.2005.04.019_bib6","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1056\/NEJM199505183322008","article-title":"The hypothalamic\u2013pituitary\u2013adrenal axis and immune-mediated inflammation","volume":"332","author":"Chrousos","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1016\/j.autrev.2005.04.019_bib7","first-page":"596","article-title":"Intact adrenocorticotropic hormone secretion but impaired cortisol response in patients with active rheumatoid arthritis. Effect of glucocorticoids","volume":"23","author":"Gudbjornsson","year":"1996","journal-title":"J Rheumatol"},{"key":"10.1016\/j.autrev.2005.04.019_bib8","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1136\/ard.16.2.173","article-title":"Corticosteroid metabolism and rheumatoid arthritis","volume":"16","author":"West","year":"1996","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.autrev.2005.04.019_bib9","doi-asserted-by":"crossref","first-page":"635","DOI":"10.3109\/08830189809043012","article-title":"The chronobiology of human cytokine production","volume":"16","author":"Peytrovsky","year":"1998","journal-title":"Int Rev Immunol"},{"key":"10.1016\/j.autrev.2005.04.019_bib10","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1002\/1529-0131(200103)44:3<493::AID-ANR95>3.0.CO;2-U","article-title":"Involvement of the hypothalamic\u2013pituitary\u2013adrenal\/gonadal axis and the peripheral nervous system in rheumatoid arthritis: viewpoint based on a systemic pathogenetic role","volume":"44","author":"Straub","year":"2001","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.autrev.2005.04.019_bib11","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1210\/jc.82.4.1279","article-title":"Circadian relationships between interleukin IL-6 and hypothalamic\u2013pituitary\u2013adrenal axis hormones: failure of IL-6 to cause sustained hypercortisolism in patients with early untreated rheumatoid arthritis","volume":"82","author":"Crofford","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.autrev.2005.04.019_bib12","first-page":"282","article-title":"Hypothalamic\u2013pituitary\u2013adrenocortical axis function in premenopausal women with rheumatoid arthritis: not treated with glucocorticoids","volume":"26","author":"Cutolo","year":"1999","journal-title":"J Rheumatol"},{"key":"10.1016\/j.autrev.2005.04.019_bib13","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1136\/ard.53.8.521","article-title":"Circadian rhythm of serum interleukin-6 in rheumatoid arthritis","volume":"53","author":"Arvidson","year":"1994","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.autrev.2005.04.019_bib14","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1093\/rheumatology\/35.4.350","article-title":"Anterior pituitary function in patients with newly diagnosed rheumatoid arthritis","volume":"35","author":"Templ","year":"1996","journal-title":"Br J Rheumatol"},{"key":"10.1016\/j.autrev.2005.04.019_bib15","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1210\/jc.77.6.1690","article-title":"Recombinant interleukin-6 activates the hypothalamic pituitary\u2013adrenal axis in human","volume":"77","author":"Mastorakos","year":"1993","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.autrev.2005.04.019_bib16","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1210\/er.19.2.101","article-title":"Intraadrenal interactions in the regulation of adrenocortical steroidogenesis","volume":"19","author":"Ehrhart-Bornstein","year":"1998","journal-title":"Endocr Rev"},{"key":"10.1016\/j.autrev.2005.04.019_bib17","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1002\/1529-0131(200002)43:2<465::AID-ANR31>3.0.CO;2-Q","article-title":"Diurnal rhythm of salivary cortisol levels in patients with recent onset rheumatoid arthritis","volume":"43","author":"Dekkers","year":"2000","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.autrev.2005.04.019_bib18","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1002\/art.10177","article-title":"Inadequately low serum levels of steroid hormones in relation to IL-6 and TNF in untreated patients with early rheumatoid arthritis and reactive arthritis","volume":"46","author":"Straub","year":"2002","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.autrev.2005.04.019_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7326\/0003-4819-136-1-200201010-00006","article-title":"Low-dose prednisone therapy for patients with early active rheumatoid arthritis: clinical efficacy, disease-modifying properties, and side effects: a randomized, double-blind, placebo-controlled clinical trial","volume":"136","author":"Van Everdingen","year":"2002","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.autrev.2005.04.019_bib20","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1111\/j.1749-6632.2002.tb04227.x","article-title":"Melatonin serum levels in rheumatoid arthritis","volume":"966","author":"Sulli","year":"2002","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.autrev.2005.04.019_bib21","doi-asserted-by":"crossref","first-page":"5029","DOI":"10.4049\/jimmunol.155.10.5029","article-title":"Elevated Th1 or Th2-like cytokine mRNA in peripheral circulation of patients with rheumatoid arthritis","volume":"155","author":"Schulze-Koops","year":"1995","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2005.04.019_bib22","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1749-6632.2002.tb04226.x","article-title":"Melatonin in rheumatoid arthritis: synovial macrophages show melatonin receptors","volume":"966","author":"Maestroni","year":"2002","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.autrev.2005.04.019_bib23","first-page":"872","article-title":"Melatonin in rheumatoid arthritis: a disease promoting and modulating hormone?","volume":"20","author":"Maestroni","year":"2002","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.autrev.2005.04.019_bib24","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1046\/j.1525-1373.2000.22333.x","article-title":"Vitamin D and autoimmunity: is vitamin D status an environmental factor affecting autoimmune disease prevalence?","volume":"223","author":"Cantorna","year":"2000","journal-title":"Proc Soc Exp Biol Med"},{"key":"10.1016\/j.autrev.2005.04.019_bib25","first-page":"161","article-title":"Seasonal distribution of relapse onset in rheumatoid arthritis and spondyloarthropathy: the possible effect of solar factor","volume":"21","author":"Rozin","year":"2003","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.autrev.2005.04.019_bib26","first-page":"148","article-title":"Solar light effects on onset\/releases and circannual\/circadian symptomatology in rheumatoid arthritis","volume":"21","author":"Cutolo","year":"2003","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.autrev.2005.04.019_bib27","first-page":"S139","article-title":"Circadian rhythms of melatonin in Estonian rheumatoid arthritis patients","volume":"63","author":"Otsa","year":"2004","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.autrev.2005.04.019_bib28","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1136\/ard.2004.023416","article-title":"Circadian melatonin and cortisol levels in rheumatoid arthritis patients in winter time: a north and south Europe comparison","volume":"64","author":"Cutolo","year":"2005","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.autrev.2005.04.019_bib29","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0049-0172(97)80012-1","article-title":"Epidemiological and clinical aspects relating to the variability of rheumatoid arthritis","volume":"27","author":"Abdel-Nasser","year":"1997","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.autrev.2005.04.019_bib30","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/S0889-857X(21)00886-3","article-title":"Rheumatoid arthritis","volume":"16","author":"Spector","year":"1990","journal-title":"Rheum Dis Clin North Am"}],"container-title":["Autoimmunity Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568997205000650?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568997205000650?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,1,26]],"date-time":"2024-01-26T15:15:28Z","timestamp":1706282128000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568997205000650"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11]]},"references-count":30,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2005,11]]}},"alternative-id":["S1568997205000650"],"URL":"https:\/\/doi.org\/10.1016\/j.autrev.2005.04.019","relation":{},"ISSN":["1568-9972"],"issn-type":[{"value":"1568-9972","type":"print"}],"subject":[],"published":{"date-parts":[[2005,11]]}}}