{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T05:06:18Z","timestamp":1789621578443,"version":"build-2803163510"},"reference-count":40,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Autoimmunity Reviews"],"published-print":{"date-parts":[[2006,8]]},"DOI":"10.1016\/j.autrev.2006.02.006","type":"journal-article","created":{"date-parts":[[2006,3,8]],"date-time":"2006-03-08T12:31:19Z","timestamp":1141821079000},"page":"449-457","source":"Crossref","is-referenced-by-count":44,"title":["B cells and autoimmune liver diseases"],"prefix":"10.1016","volume":"5","author":[{"given":"Yuki","family":"Moritoki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe-Xiong","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Ohsugi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Ueno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Eric","family":"Gershwin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.autrev.2006.02.006_bib1","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1002\/hep.510250510","article-title":"Anti-neutrophil cytoplasmic antibodies in type 1 and 2 autoimmune hepatitis","volume":"25","author":"Zauli","year":"1997","journal-title":"Hepatology"},{"key":"10.1016\/j.autrev.2006.02.006_bib2","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1053\/jhep.2001.24101","article-title":"Characterization of autoantibodies against uridine-diphosphate glucuronosyltransferase in patients with inflammatory liver diseases","volume":"33","author":"Bachrich","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.autrev.2006.02.006_bib3","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1053\/jhep.2001.27179","article-title":"Distinct epitopes on formiminotransferase cyclodeaminase induce autoimmune liver cytosol antibody type 1","volume":"34","author":"Muratori","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.autrev.2006.02.006_bib4","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1016\/S0140-6736(00)02166-8","article-title":"Identification of target antigen for SLA\/LP autoantibodies in autoimmune hepatitis","volume":"355","author":"Wies","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.autrev.2006.02.006_bib5","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/hep.20726","article-title":"A murine model of acute liver injury induced by human monoclonal autoantibody","volume":"42","author":"Yamauchi","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.autrev.2006.02.006_bib6","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1034\/j.1600-0528.2002.017401.x","article-title":"Genetic susceptibilities for immune expression and liver cell injury in autoimmune hepatitis","volume":"174","author":"Czaja","year":"2000","journal-title":"Immunol Rev"},{"key":"10.1016\/j.autrev.2006.02.006_bib7","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S1568-9972(03)00017-X","article-title":"Autoimmune hepatitis","volume":"2","author":"Vergani","year":"2003","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.autrev.2006.02.006_bib8","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1016\/S0198-8859(01)00344-5","article-title":"CTLA-4\/CD 28 region polymorphisms in children from families with autoimmune hepatitis","volume":"62","author":"Djilali-Saiah","year":"2001","journal-title":"Hum Immunol"},{"key":"10.1016\/j.autrev.2006.02.006_bib9","doi-asserted-by":"crossref","first-page":"3.1","DOI":"10.1146\/annurev.immunol.24.021605.090535","article-title":"A molecular perspective of CTLA-4 function","volume":"24","author":"Teft","year":"2006","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.autrev.2006.02.006_bib10","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jhep.2004.03.008","article-title":"Impairment of CD4(+)CD25(+) regulatory T-cells in autoimmune liver disease","volume":"41","author":"Longhi","year":"2004","journal-title":"J Hepatol"},{"key":"10.1016\/j.autrev.2006.02.006_bib11","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1056\/NEJMra043898","article-title":"Primary biliary cirrhosis","volume":"353","author":"Kaplan","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.autrev.2006.02.006_bib12","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1084\/jem.167.6.1791","article-title":"The autoepitope of the 74-kD mitochondrial autoantigen of primary biliary cirrhosis corresponds to the functional site of dihydrolipoamide acetyltransferase","volume":"167","author":"Van de Water","year":"1988","journal-title":"J Exp Med"},{"key":"10.1016\/j.autrev.2006.02.006_bib13","doi-asserted-by":"crossref","first-page":"3367","DOI":"10.4049\/jimmunol.144.9.3367","article-title":"Structural requirement for autoreactivity on human pyruvate dehydrogenase-E2, the major autoantigen of primary biliary cirrhosis. Implication for a conformational autoepitope","volume":"144","author":"Surh","year":"1990","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2006.02.006_bib14","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1055\/s-2005-916325","article-title":"The immune response to mitochondrial autoantigens","volume":"25","author":"Ishibashi","year":"2005","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.autrev.2006.02.006_bib15","doi-asserted-by":"crossref","first-page":"89","DOI":"10.4049\/jimmunol.146.1.89","article-title":"Evidence for the targeting by 2-oxo-dehydrogenase enzymes in the T cell response of primary biliary cirrhosis","volume":"146","author":"Van de Water","year":"1991","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2006.02.006_bib16","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1084\/jem.181.5.1835","article-title":"HLA DRB4 0101-restricted immunodominant T cell autoepitope of pyruvate dehydrogenase complex in primary biliary cirrhosis: evidence of molecular mimicry in human autoimmune diseases","volume":"181","author":"Shimoda","year":"1995","journal-title":"J Exp Med"},{"key":"10.1016\/j.autrev.2006.02.006_bib17","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1172\/JCI200110716","article-title":"Bcl-2-dependent oxidation of pyruvate dehydrogenase-E2, a primary biliary cirrhosis autoantigen, during apoptosis","volume":"108","author":"Odin","year":"2001","journal-title":"J Clin Invest"},{"key":"10.1016\/j.autrev.2006.02.006_bib18","first-page":"1383","article-title":"Characterization of recombinant monoclonal IgA anti-PDC-E2 autoantibodies derived from patients with PBC","volume":"36","author":"Fukushima","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.autrev.2006.02.006_bib19","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1002\/hep.20175","article-title":"Caspase induction by IgA antimitochondrial antibody: IgA-mediated biliary injury in primary biliary cirrhosis","volume":"39","author":"Matsumura","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.autrev.2006.02.006_bib20","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1038\/nature04267","article-title":"Control of B-cell responses by toll-like receptors","volume":"438","author":"Pasare","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.autrev.2006.02.006_bib21","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1053\/j.gastro.2004.11.005","article-title":"Bacterial CpG induces hyper-IgM production in CD27(+) memory B cells in primary biliary cirrhosis","volume":"128","author":"Kikuchi","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.autrev.2006.02.006_bib22","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1055\/s-2005-916319","article-title":"Genetics and geoepidemiology of primary biliary cirrhosis: following the footprints to disease etiology","volume":"25","author":"Selmi","year":"2005","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.autrev.2006.02.006_bib23","first-page":"113","article-title":"Cytokine patterns and cytotoxic mediators in primary biliary cirrhosis","volume":"21","author":"Martinez","year":"1995","journal-title":"Hepatology"},{"key":"10.1016\/j.autrev.2006.02.006_bib24","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.autrev.2004.09.003","article-title":"The immunobiology of primary sclerosing cholangitis","volume":"4","author":"Aoki","year":"2005","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.autrev.2006.02.006_bib25","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1053\/bega.2001.0209","article-title":"Anti-neutrophil antibodies in primary sclerosing cholangitis","volume":"15","author":"Terjung","year":"2001","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"10.1016\/j.autrev.2006.02.006_bib26","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.4049\/jimmunol.170.5.2323","article-title":"Heterogeneity of dendritic cells in the mouse liver: identification and characterization of four distinct populations","volume":"170","author":"Lian","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2006.02.006_bib27","doi-asserted-by":"crossref","first-page":"7031","DOI":"10.4049\/jimmunol.172.11.7031","article-title":"Distinct transcriptional programs activated by interleukin-10 with or without lipopolysaccharide in dendritic cells: induction of the B cell-activating chemokine, CXC chemokine ligand 13","volume":"172","author":"Perrier","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2006.02.006_bib28","doi-asserted-by":"crossref","first-page":"6918","DOI":"10.4049\/jimmunol.174.11.6918","article-title":"Association of B-1 B cells with follicular dendritic cells in spleen","volume":"174","author":"Wen","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2006.02.006_bib29","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1002\/(SICI)1096-9896(1998100)186:2<126::AID-PATH167>3.0.CO;2-1","article-title":"Expression of co-stimulatory factor B7-2 on the intrahepatic bile ducts in primary biliary cirrhosis and primary sclerosing cholangitis: an immunohistochemical study","volume":"186","author":"Tsuneyama","year":"1998","journal-title":"J Pathol"},{"key":"10.1016\/j.autrev.2006.02.006_bib30","first-page":"925","article-title":"Peptide antibiotic human beta-defensin-1 and -2 contribute to antimicrobial defense of the intrahepatic biliary tree","volume":"40","author":"Harada","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.autrev.2006.02.006_bib31","doi-asserted-by":"crossref","first-page":"3072","DOI":"10.1172\/JCI24798","article-title":"Attenuated liver fibrosis in the absence of B cells","volume":"115","author":"Novobrantseva","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.autrev.2006.02.006_bib32","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1182\/blood-2002-11-3355","article-title":"The toll-like receptor repertoire of human B lymphocytes: inducible and selective expression of TLR9 and TLR10 in normal and transformed cells","volume":"102","author":"Bourke","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.autrev.2006.02.006_bib33","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1093\/intimm\/dxf069","article-title":"Variable expression of Toll-like receptor in murine innate and adaptive immune cell lines","volume":"14","author":"Applequist","year":"2002","journal-title":"Int Immunol"},{"key":"10.1016\/j.autrev.2006.02.006_bib34","doi-asserted-by":"crossref","first-page":"3433","DOI":"10.1128\/IAI.70.7.3433-3442.2002","article-title":"Role of toll-like receptors in changes in gene expression and NF-kappa B activation in mouse hepatocytes stimulated with lipopolysaccharide","volume":"70","author":"Liu","year":"2002","journal-title":"Infect Immun"},{"key":"10.1016\/j.autrev.2006.02.006_bib35","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jaut.2005.05.003","article-title":"Hepatic expression of toll-like receptor 4 in primary biliary cirrhosis","volume":"25","author":"Wang","year":"2005","journal-title":"J Autoimmun"},{"key":"10.1016\/j.autrev.2006.02.006_bib36","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1089\/10799900050163299","article-title":"Endotoxin and cytokine regulation of toll-like receptor (TLR) 2 and TLR4 gene expression in murine liver and hepatocytes","volume":"20","author":"Matsumura","year":"2000","journal-title":"J Interferon Cytokine Res"},{"key":"10.1016\/j.autrev.2006.02.006_bib37","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.micinf.2004.04.010","article-title":"Implication of CpG-ODN and reactive oxygen species in the inhibition of intracellular growth of Salmonella typhimurium in hepatocytes","volume":"6","author":"Sanchez-Campillo","year":"2004","journal-title":"Microbes Infect"},{"key":"10.1016\/j.autrev.2006.02.006_bib38","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1097\/01.LAB.0000097190.56734.FE","article-title":"Lipopolysaccharide activates nuclear factor-kappaB through toll-like receptors and related molecules in cultured biliary epithelial cells","volume":"83","author":"Harada","year":"2003","journal-title":"Lab Invest"},{"key":"10.1016\/j.autrev.2006.02.006_bib39","first-page":"202A","article-title":"TH1 cytokines promote toll-like receptor signaling in human biliary epithelial cells","volume":"42","author":"Mueller","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.autrev.2006.02.006_bib40","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1053\/gast.2001.22441","article-title":"The lymphoid liver: considerations on pathways to autoimmune injury","volume":"120","author":"Kita","year":"2001","journal-title":"Gastroenterology"}],"container-title":["Autoimmunity Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568997206000255?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568997206000255?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,6]],"date-time":"2023-05-06T18:06:06Z","timestamp":1683396366000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568997206000255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8]]},"references-count":40,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["S1568997206000255"],"URL":"https:\/\/doi.org\/10.1016\/j.autrev.2006.02.006","relation":{},"ISSN":["1568-9972"],"issn-type":[{"value":"1568-9972","type":"print"}],"subject":[],"published":{"date-parts":[[2006,8]]}}}