{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T02:18:13Z","timestamp":1791166693327,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Autoimmunity Reviews"],"published-print":{"date-parts":[[2008,7]]},"DOI":"10.1016\/j.autrev.2008.04.013","type":"journal-article","created":{"date-parts":[[2008,5,6]],"date-time":"2008-05-06T14:44:01Z","timestamp":1210085041000},"page":"544-549","source":"Crossref","is-referenced-by-count":117,"title":["Is the generation of neo-antigenic determinants by free radicals central to the development of autoimmune rheumatoid disease?"],"prefix":"10.1016","volume":"7","author":[{"given":"Helen R.","family":"Griffiths","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.autrev.2008.04.013_bib1","doi-asserted-by":"crossref","first-page":"6301","DOI":"10.4049\/jimmunol.165.11.6301","article-title":"Clonality and longevity of CD4+CD28null T cells are associated with defects in apoptotic pathways","volume":"165","author":"Vallejo","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2008.04.013_bib2","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1186\/ar1447","article-title":"Oxidation in rheumatoid arthritis","volume":"6","author":"Hitchon","year":"2004","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.autrev.2008.04.013_bib3","doi-asserted-by":"crossref","first-page":"101","DOI":"10.4049\/jimmunol.178.Supp.101.13","article-title":"Increased nitric oxide production by peripheral blood monocytes and selective elevation of serum IgE in patients with systemic lupus erythematosus (SLE)","volume":"178","author":"Khalifa","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2008.04.013_bib4","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1172\/JCI113310","article-title":"Oxidative cross-linking of immune complexes by human polymorphonuclear leukocytes","volume":"81","author":"Jasin","year":"1988","journal-title":"J Clin Invest"},{"key":"10.1016\/j.autrev.2008.04.013_bib5","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0014-5793(93)80636-9","article-title":"A comparative evaluation of the metabolic profiles of normal and inflammatory knee-joint synovial fluids by high resolution proton NMR spectroscopy","volume":"332","author":"Naughton","year":"1993","journal-title":"FEBS Lett"},{"key":"10.1016\/j.autrev.2008.04.013_bib6","doi-asserted-by":"crossref","first-page":"3551","DOI":"10.2174\/138161206778343082","article-title":"Role of nitric oxide and reactive oxygen species in arthritis","volume":"12","author":"Cuzzocrea","year":"2006","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.autrev.2008.04.013_bib7","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/BF02686087","article-title":"Molecular mimicry and auto-immunity","volume":"32","author":"Blank","year":"2007","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1016\/j.autrev.2008.04.013_bib8","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1002\/1529-0131(199905)42:5<1017::AID-ANR22>3.0.CO;2-7","article-title":"Immunization of mice with human 60-kd Ro peptides results in epitope spreading if the peptides are highly homologous between human and mouse","volume":"42","author":"Scofield","year":"1999","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.autrev.2008.04.013_bib9","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S1471-4906(01)01976-7","article-title":"Post-translational protein modifications in antigen recognition and autoimmunity","volume":"22","author":"Doyle","year":"2001","journal-title":"Trends Immunol"},{"key":"10.1016\/j.autrev.2008.04.013_bib10","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1146\/annurev.bi.50.070181.004031","article-title":"In vivo chemical modification of proteins (post-translational modification)","volume":"50","author":"Wold","year":"1981","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.autrev.2008.04.013_bib11","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.coi.2004.09.001","article-title":"Post-translational modifications of self antigens: implications for autoimmunity","volume":"16","author":"Anderton","year":"2004","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.autrev.2008.04.013_bib12","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S0891-5849(96)00389-9","article-title":"A modified form of low-density lipoprotein with increased electronegative charge is present in rheumatoid arthritis synovial fluid","volume":"22","author":"Dai","year":"1997","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.autrev.2008.04.013_bib13","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/0161-5890(87)90160-X","article-title":"Immunogenic and antigenic epitopes of immunoglobulin-XX. Denaturation of human IgG3 by free radicals","volume":"24","author":"Jose","year":"1987","journal-title":"Mol Immunol"},{"key":"10.1016\/j.autrev.2008.04.013_bib14","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/0192-0561(93)90006-K","article-title":"Study of procainamide hapten-specific antibodies in rabbits and humans","volume":"15","author":"Adams","year":"1993","journal-title":"Int J Immunopharmacol"},{"issue":"2","key":"10.1016\/j.autrev.2008.04.013_bib15","first-page":"231","article-title":"The predictive value of antibodies to cyclic citrullinated peptide in patients with very early inflammatory arthritis","volume":"32","author":"Raza","year":"2005","journal-title":"J Rheumatol"},{"key":"10.1016\/j.autrev.2008.04.013_bib16","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/S0731-7085(99)00230-7","article-title":"Isoaspartate in peptides and proteins: formation, significance, and analysis","volume":"21","author":"Aswad","year":"2000","journal-title":"J Pharm Biomed Anal"},{"key":"10.1016\/j.autrev.2008.04.013_bib17","doi-asserted-by":"crossref","first-page":"4397","DOI":"10.1046\/j.1432-1327.2000.01485.x","article-title":"Increased methyl esterification of altered aspartyl residues in erythrocyte membrane proteins in response to oxidative stress","volume":"267","author":"Ingrosso","year":"2000","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.autrev.2008.04.013_bib18","doi-asserted-by":"crossref","first-page":"22321","DOI":"10.1074\/jbc.274.32.22321","article-title":"Isoaspartyl post-translational modification triggers autoimmune responses to self-proteins","volume":"274","author":"Mamula","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.autrev.2008.04.013_bib19","doi-asserted-by":"crossref","first-page":"4541","DOI":"10.4049\/jimmunol.177.7.4541","article-title":"Intracellular protein modification associated with altered T cell functions in autoimmunity","volume":"177","author":"Yang","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2008.04.013_bib20","doi-asserted-by":"crossref","first-page":"37161","DOI":"10.1074\/jbc.M106682200","article-title":"Structural integrity of histone H2B in vivo requires the activity of protein l-isoaspartate O-methyltransferase, a putative protein repair enzyme","volume":"276","author":"Young","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.autrev.2008.04.013_bib21","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0098-2997(02)00017-1","volume":"23","author":"Griffiths","year":"2002","journal-title":"Mol Aspects Med"},{"key":"10.1016\/j.autrev.2008.04.013_bib22","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0098-2997(91)90006-8","article-title":"Effects of reactive oxygen species on immunoglobulin G function","volume":"12","author":"Griffiths","year":"1991","journal-title":"Mol Aspects Med"},{"key":"10.1016\/j.autrev.2008.04.013_bib23","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1080\/10715760000300481","article-title":"Evidence for oxidised low density lipoprotein in synovial fluid from rheumatoid arthritis patients","volume":"32","author":"Dai","year":"2000","journal-title":"Free Radic Res"},{"issue":"5","key":"10.1016\/j.autrev.2008.04.013_bib24","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1093\/rheumatology\/keg175","article-title":"Tackling ischaemic heart disease in rheumatoid arthritis","volume":"42","author":"Kitas","year":"2003","journal-title":"Rheumatology"},{"key":"10.1016\/j.autrev.2008.04.013_bib25","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0014-5793(94)00722-5","article-title":"Evidence for nitric oxide-mediated oxidative damage in chronic inflammation. Nitrotyrosine in serum and synovial fluid from rheumatoid patients","volume":"350","author":"Kaur","year":"1994","journal-title":"FEBS Lett"},{"key":"10.1016\/j.autrev.2008.04.013_bib26","doi-asserted-by":"crossref","first-page":"62","DOI":"10.2310\/6650.2004.12395","article-title":"Nitric oxide induces apoptosis in spleen lymphocytes from MRL\/lpr mice","volume":"52","author":"Oates","year":"2004","journal-title":"J Investig Med"},{"key":"10.1016\/j.autrev.2008.04.013_bib27","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1002\/art.21130","article-title":"Increased levels of serum protein oxidation and correlation with disease activity in systemic lupus erythematosus","volume":"52","author":"Morgan","year":"2005","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.autrev.2008.04.013_bib28","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0014-5793(94)00583-4","article-title":"8-Hydroxydeoxyguanosine. A marker of oxidative DNA damage in systemic lupus erythematosus","volume":"348","author":"Lunec","year":"1994","journal-title":"FEBS Lett"},{"key":"10.1016\/j.autrev.2008.04.013_bib29","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0014-5793(88)80661-6","article-title":"Oxygen radical induced alterations in polyclonal IgG","volume":"230","author":"Griffiths","year":"1988","journal-title":"FEBS Lett"},{"key":"10.1016\/j.autrev.2008.04.013_bib30","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/BF00806783","article-title":"Oxygen radical induced fluorescence in proteins; identification of the fluorescent tryptophan metabolite, N-formyl kynurenine, as a biological index of radical damage","volume":"3","author":"Griffiths","year":"1992","journal-title":"Amino Acids"},{"key":"10.1016\/j.autrev.2008.04.013_bib31","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.4049\/jimmunol.130.4.1918","article-title":"Generation of IgG aggregates by the myeloperoxidase-hydrogen peroxide system","volume":"130","author":"Jasin","year":"1983","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2008.04.013_bib32","doi-asserted-by":"crossref","first-page":"6532","DOI":"10.4049\/jimmunol.165.11.6532","article-title":"Inflammatory properties of IgG modified by oxygen radicals and peroxynitrite","volume":"165","author":"Uesugi","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2008.04.013_bib33","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.freeradbiomed.2006.05.020","article-title":"Oxidatively modified autoantigens in autoimmune diseases","volume":"41","author":"Kurien","year":"2006","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.autrev.2008.04.013_bib34","doi-asserted-by":"crossref","first-page":"R19","DOI":"10.1186\/ar2129","article-title":"Patients with early rheumatoid arthritis exhibit elevated autoantibody titers against mildly oxidized low-density lipoprotein and exhibit decreased activity of the lipoprotein-associated phospholipase A2","volume":"9","author":"Lourida","year":"2007","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.autrev.2008.04.013_bib35","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.freeradbiomed.2005.08.039","article-title":"Homocysteine from endothelial cells promotes LDL nitration and scavenger receptor uptake","volume":"40","author":"Griffiths","year":"2006","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.autrev.2008.04.013_bib36","first-page":"319","article-title":"Association between IgM response to IgG damaged by glyoxidation and disease activity in rheumatoid arthritis","volume":"27","author":"Lucey","year":"2000","journal-title":"J Rheumatol"},{"key":"10.1016\/j.autrev.2008.04.013_bib37","doi-asserted-by":"crossref","first-page":"15405","DOI":"10.1016\/S0021-9258(18)82272-4","article-title":"Hydrophobicity as the signal for selective degradation of hydroxyl radical-modified hemoglobin by the multicatalytic proteinase complex, proteasome","volume":"268","author":"Pacifici","year":"1993","journal-title":"J Biol Chem"},{"key":"10.1016\/j.autrev.2008.04.013_bib38","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/j.1365-2249.1990.tb05343.x","article-title":"Reactive oxygen species modify human DNA, eliciting a more discriminating antigen for the diagnosis of systemic lupus erythematosus","volume":"81","author":"Blount","year":"1990","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.autrev.2008.04.013_bib39","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1042\/BA20050156","article-title":"Peroxynitrite-modified DNA: a better antigen for systemic lupus erythematosus anti-DNA autoantibodies","volume":"43","author":"Habib","year":"2006","journal-title":"Biotechnol Appl Biochem"},{"key":"10.1016\/j.autrev.2008.04.013_bib40","first-page":"289","article-title":"Enhanced recognition of hydroxyl radical modified plasmid DNA by circulating cancer antibodies","volume":"24","author":"Khan","year":"2005","journal-title":"J Exp Clin Cancer Res"}],"container-title":["Autoimmunity Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568997208000529?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568997208000529?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T01:29:07Z","timestamp":1684373347000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568997208000529"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7]]},"references-count":40,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["S1568997208000529"],"URL":"https:\/\/doi.org\/10.1016\/j.autrev.2008.04.013","relation":{},"ISSN":["1568-9972"],"issn-type":[{"value":"1568-9972","type":"print"}],"subject":[],"published":{"date-parts":[[2008,7]]}}}