{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T21:12:32Z","timestamp":1793394752520,"version":"4.5.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Autoimmunity Reviews"],"published-print":{"date-parts":[[2009,1]]},"DOI":"10.1016\/j.autrev.2008.07.041","type":"journal-article","created":{"date-parts":[[2008,9,7]],"date-time":"2008-09-07T19:12:45Z","timestamp":1220814765000},"page":"184-189","source":"Crossref","is-referenced-by-count":90,"title":["Metabolic control of T cell activation and death in SLE"],"prefix":"10.1016","volume":"8","author":[{"given":"David","family":"Fernandez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andras","family":"Perl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.autrev.2008.07.041_bib1","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1097\/01.bor.0000170479.01451.ab","article-title":"Immune cells and cytokines in systemic lupus erythematosus: an update","volume":"17","author":"Kyttaris","year":"2005","journal-title":"Curr Opin Rheumatol"},{"key":"10.1016\/j.autrev.2008.07.041_bib2","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.it.2004.05.001","article-title":"Mitochondrial hyperpolarization: a checkpoint of T cell life, death, and autoimmunity","volume":"25","author":"Perl","year":"2004","journal-title":"Trends Immunol"},{"key":"10.1016\/j.autrev.2008.07.041_bib3","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1084\/jem.179.4.1317","article-title":"Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes","volume":"179","author":"Casciola-Rosen","year":"1994","journal-title":"J Exp Med"},{"key":"10.1016\/j.autrev.2008.07.041_bib4","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1016\/j.freeradbiomed.2007.02.026","article-title":"Nitric oxide, mitochondrial hyperpolarization, and T cell activation","volume":"42","author":"Nagy","year":"2007","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.autrev.2008.07.041_bib5","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.4049\/jimmunol.162.3.1466","article-title":"Elevation of mitochondrial transmembrane potential and reactive oxygen intermediate levels are early events and occur independently from activation of caspases in Fas signaling","volume":"162","author":"Banki","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2008.07.041_bib6","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1096\/fj.14.10.1352","article-title":"Stimulation of the pentose phosphate pathway and glutathione levels by dehydroascorbate, the oxidized form of vitamin C","volume":"14","author":"Puskas","year":"2000","journal-title":"FASEB J"},{"issue":"26","key":"10.1016\/j.autrev.2008.07.041_bib7","doi-asserted-by":"crossref","first-page":"15294","DOI":"10.1073\/pnas.261560998","article-title":"Different responses of astrocytes and neurons to nitric oxide: the role of glycolytically generated ATP in astrocyte protection","volume":"98","author":"Almeida","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.autrev.2008.07.041_bib8","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/1529-0131(200201)46:1<175::AID-ART10015>3.0.CO;2-H","article-title":"Mitochondrial hyperpolarization and ATP depletion in patients with systemic lupus erythematosus","volume":"46","author":"Gergely","year":"2002","journal-title":"Arth Rheum"},{"key":"10.1016\/j.autrev.2008.07.041_bib9","doi-asserted-by":"crossref","first-page":"4319","DOI":"10.1073\/pnas.261702698","article-title":"FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction","volume":"99","author":"Desai","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"9","key":"10.1016\/j.autrev.2008.07.041_bib10","doi-asserted-by":"crossref","first-page":"2983","DOI":"10.1002\/art.22085","article-title":"Rapamycin reduces disease activity and normalizes T-cell activation-induced calcium fluxing in patients with systemic lupus erythematosus","volume":"54","author":"Fernandez","year":"2006","journal-title":"Arth Rheum"},{"key":"10.1016\/j.autrev.2008.07.041_bib11","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1007\/s000180050492","article-title":"The role of adapter proteins in T cell activation","volume":"56","author":"Koretzky","year":"1999","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.autrev.2008.07.041_bib12","doi-asserted-by":"crossref","first-page":"13119","DOI":"10.1073\/pnas.93.23.13119","article-title":"Oxidative stress by tumor-derived macrophages suppresses the expression of CD3 zeta chain of T-cell receptor complex and antigen-specific T-cell responses","volume":"93","author":"Otsuji","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.autrev.2008.07.041_bib13","doi-asserted-by":"crossref","first-page":"160","DOI":"10.4049\/jimmunol.157.1.160","article-title":"Sublethal levels of oxidative stress stimulate transcriptional activation of c-jun and suppress IL-2 promoter activation in Jurkat T cells","volume":"157","author":"Beiqing","year":"1996","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2008.07.041_bib14","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.4049\/jimmunol.162.4.1988","article-title":"Fas ligand induction in human NK cells is regulated by redox through a calcineurin-nuclear factors of activated T cell-dependent pathway","volume":"162","author":"Furuke","year":"1999","journal-title":"J Immunol"},{"issue":"6","key":"10.1016\/j.autrev.2008.07.041_bib15","doi-asserted-by":"crossref","first-page":"3676","DOI":"10.4049\/jimmunol.173.6.3676","article-title":"Nitric oxide-dependent mitochondrial biogenesis generates Ca2+ signaling profile of lupus T cells","volume":"173","author":"Nagy","year":"2004","journal-title":"J Immunol"},{"issue":"4","key":"10.1016\/j.autrev.2008.07.041_bib16","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.4049\/jimmunol.155.4.2269","article-title":"TCR\/CD3 complex-mediated signal transduction pathway in T cells and T cell lines from patients with systemic lupus erythematosus","volume":"155","author":"Vassilopoulos","year":"1995","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2008.07.041_bib17","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/hep.510300111","article-title":"CD95-mediated murine hepatic apoptosis requires an intact glutathione status","volume":"30","author":"Hentze","year":"1999","journal-title":"Hepatology"},{"key":"10.1016\/j.autrev.2008.07.041_bib18","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1084\/jem.185.8.1481","article-title":"Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosis","volume":"185","author":"Leist","year":"1997","journal-title":"J Exp Med"},{"issue":"Suppl.2","key":"10.1016\/j.autrev.2008.07.041_bib19","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1038\/sj.cdd.4401780","article-title":"Macroautophagy versus mitochondrial autophagy: a question of fate?","volume":"12","author":"Kundu","year":"2005","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.autrev.2008.07.041_bib20","doi-asserted-by":"crossref","first-page":"7719","DOI":"10.1038\/sj.onc.1203249","article-title":"More than one way to die: apoptosis, necrosis and reactive oxygen damage","volume":"18","author":"Fiers","year":"1999","journal-title":"Oncogene"},{"issue":"4","key":"10.1016\/j.autrev.2008.07.041_bib21","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1046\/j.1440-1827.2000.01052.x","article-title":"Reactive follicular hyperplasia in the lymph node lesions from systemic lupus erythematosus patients: a clinicopathological and immunohistological study of 21 cases","volume":"50","author":"Kojima","year":"2000","journal-title":"Pathol Int"},{"issue":"3","key":"10.1016\/j.autrev.2008.07.041_bib22","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1084\/jem.191.3.423","article-title":"Consequences of cell death: exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells","volume":"191","author":"Sauter","year":"2000","journal-title":"J Exp Med"},{"issue":"5","key":"10.1016\/j.autrev.2008.07.041_bib23","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1097\/00002281-200309000-00005","article-title":"The central role of dendritic cells and interferon-alpha in SLE","volume":"15","author":"Pascual","year":"2003","journal-title":"Curr Opin Rheumatol"},{"issue":"13","key":"10.1016\/j.autrev.2008.07.041_bib24","doi-asserted-by":"crossref","first-page":"7631","DOI":"10.1073\/pnas.95.13.7631","article-title":"Persistent inhibition of cell respiration by nitric oxide: crucial role of S-nitrosylation of mitochondrial complex I and protective action of glutathione","volume":"95","author":"Clementi","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"10.1016\/j.autrev.2008.07.041_bib25","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1089\/15230860260196227","article-title":"Metabolic switches of T-cell activation and apoptosis","volume":"4","author":"Perl","year":"2002","journal-title":"Antiox Redox Signal"},{"issue":"4","key":"10.1016\/j.autrev.2008.07.041_bib26","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1191\/096120301680416940","article-title":"Antioxidants suppress mortality in the female NZB\u00d7NZW F1 mouse model of systemic lupus erythematosus (SLE)","volume":"10","author":"Suwannaroj","year":"2001","journal-title":"Lupus"},{"key":"10.1016\/j.autrev.2008.07.041_bib27","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1056\/NEJMoa042976","article-title":"High-dose acetylcysteine in idiopathic pulmonary fibrosis","volume":"353","author":"Demedts","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.autrev.2008.07.041_bib28","doi-asserted-by":"crossref","first-page":"5188","DOI":"10.4049\/jimmunol.171.10.5188","article-title":"T cell activation-induced mitochondrial hyperpolarization is mediated by Ca2+- and redox-dependent production of nitric oxide","volume":"171","author":"Nagy","year":"2003","journal-title":"J Immunol"},{"issue":"6","key":"10.1016\/j.autrev.2008.07.041_bib29","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.immuni.2006.04.006","article-title":"Endothelial nitric oxide synthase regulates T cell receptor signaling at the immunological synapse","volume":"24","author":"Ibiza","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.autrev.2008.07.041_bib30","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1084\/jem.179.2.651","volume":"179","author":"Weinberg","year":"1994","journal-title":"J Exp Med"},{"key":"10.1016\/j.autrev.2008.07.041_bib31","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1084\/jem.186.3.365","article-title":"Clinical and serologic manifestations of autoimmune disease in MRL-lpr\/lpr mice lacking nitric oxide synthase type 2","volume":"186","author":"Gilkeson","year":"1997","journal-title":"J Exp Med"},{"key":"10.1016\/j.autrev.2008.07.041_bib32","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/art.1780370219","article-title":"Rapamycin prolongs survival and arrests pathophysiologic changes in murine systemic lupus erythematosus","volume":"37","author":"Warner","year":"1994","journal-title":"Arth Rheum"},{"issue":"12","key":"10.1016\/j.autrev.2008.07.041_bib33","doi-asserted-by":"crossref","first-page":"8338","DOI":"10.4049\/jimmunol.177.12.8338","article-title":"Rapamycin promotes expansion of functional CD4+CD25+FOXP3+ regulatory T cells of both healthy subjects and type 1 diabetic patients","volume":"177","author":"Battaglia","year":"2006","journal-title":"J Immunol"},{"issue":"4","key":"10.1016\/j.autrev.2008.07.041_bib34","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.4049\/jimmunol.178.4.2579","article-title":"Deficient CD4+CD25high T regulatory cell function in patients with active systemic lupus erythematosus","volume":"178","author":"Valencia","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2008.07.041_bib35","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1006\/clin.1996.0192","article-title":"Defective CD3-mediated cell death in activated T cells from patients with systemic lupus erythematosus: role of decreased intracellular TNF-alpha","volume":"81","author":"Kovacs","year":"1996","journal-title":"Clin Immunol Immunopathol"},{"key":"10.1016\/j.autrev.2008.07.041_bib36","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.4049\/jimmunol.169.2.1092","article-title":"Persistent mitochondrial hyperpolarization, increased reactive oxygen intermediate production, and cytoplasmic alkalinization characterize altered IL-10 signaling in patients with systemic lupus erythematosus","volume":"169","author":"Gergely","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2008.07.041_bib37","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.1172\/JCI119806","article-title":"Interleukin-10 promotes activation-induced cell death of SLE lymphocytes mediated by Fas ligand","volume":"100","author":"Georgescu","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1016\/j.autrev.2008.07.041_bib38","doi-asserted-by":"crossref","first-page":"32994","DOI":"10.1074\/jbc.271.51.32994","article-title":"Glutathione levels and sensitivity to apoptosis are regulated by changes in transaldolase expression","volume":"271","author":"Banki","year":"1996","journal-title":"J Biol Chem"},{"issue":"14","key":"10.1016\/j.autrev.2008.07.041_bib39","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1242\/jcs.03062","article-title":"Nitric oxide and mitochondrial biogenesis","volume":"119","author":"Nisoli","year":"2006","journal-title":"J Cell Sci"},{"key":"10.1016\/j.autrev.2008.07.041_bib40","doi-asserted-by":"crossref","first-page":"5443","DOI":"10.1242\/jcs.02657","article-title":"In smooth muscle, FK506- binding protein modulates IP3 receptor-evoked Ca2+ release by mTOR and calcineurin","volume":"23","author":"MacMillan","year":"2005","journal-title":"J Cell Sci"}],"container-title":["Autoimmunity Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568997208001547?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568997208001547?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T21:46:00Z","timestamp":1684532760000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568997208001547"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,1]]}},"alternative-id":["S1568997208001547"],"URL":"https:\/\/doi.org\/10.1016\/j.autrev.2008.07.041","relation":{},"ISSN":["1568-9972"],"issn-type":[{"value":"1568-9972","type":"print"}],"subject":[],"published":{"date-parts":[[2009,1]]}}}