{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T03:14:35Z","timestamp":1784776475490,"version":"3.55.0"},"reference-count":19,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Autoimmunity Reviews"],"published-print":{"date-parts":[[2009,1]]},"DOI":"10.1016\/j.autrev.2008.07.043","type":"journal-article","created":{"date-parts":[[2008,9,7]],"date-time":"2008-09-07T19:12:45Z","timestamp":1220814765000},"page":"196-198","source":"Crossref","is-referenced-by-count":38,"title":["Aberrant T cell ERK pathway signaling and chromatin structure in lupus"],"prefix":"10.1016","volume":"8","author":[{"given":"Gabriela","family":"Gorelik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Richardson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.autrev.2008.07.043_bib1","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0092-8674(00)81108-3","article-title":"Systemic lupus erythematosus","volume":"85","author":"Kotzin","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.autrev.2008.07.043_bib2","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1002\/art.10192","article-title":"Abnormal T cell signal transduction in systemic lupus erythematosus","volume":"46","author":"Kammer","year":"2002","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.autrev.2008.07.043_bib3","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/ncprheum0573","article-title":"Primer: epigenetics of autoimmunity","volume":"3","author":"Richardson","year":"2007","journal-title":"Nat Clin Pract Rheumatol"},{"key":"10.1016\/j.autrev.2008.07.043_bib4","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.4049\/jimmunol.159.3.1303","article-title":"Effect of mitogenic stimulation and DNA methylation on human T cell DNA methyltransferase expression and activity","volume":"159","author":"Yang","year":"1997","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2008.07.043_bib5","doi-asserted-by":"crossref","first-page":"11327","DOI":"10.1074\/jbc.270.19.11327","article-title":"Regulation of DNA methylation by the Ras signaling pathway","volume":"270","author":"MacLeod","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/j.autrev.2008.07.043_bib6","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1002\/art.1780350608","article-title":"Phenotypic and functional similarities between 5-azacytidine-treated T cells and a T cell subset in patients with active systemic lupus erythematosus","volume":"35","author":"Richardson","year":"1992","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.autrev.2008.07.043_bib7","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1002\/art.10234","article-title":"Demethylation of ITGAL (CD11a) regulatory sequences in systemic lupus erythematosus","volume":"46","author":"Lu","year":"2002","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.autrev.2008.07.043_bib8","doi-asserted-by":"crossref","first-page":"2866","DOI":"10.1172\/JCI118743","article-title":"Mechanisms of drug-induced lupus. II. T cells overexpressing lymphocyte function-associated antigen 1 become autoreactive and cause a lupus-like disease in syngeneic mice","volume":"97","author":"Yung","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1016\/j.autrev.2008.07.043_bib9","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.4049\/jimmunol.176.4.2095","article-title":"Accelerated macrophage apoptosis induces autoantibody formation and organ damage in systemic lupus erythematosus","volume":"176","author":"Denny","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2008.07.043_bib10","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0889-857X(21)00226-X","article-title":"Drug-induced lupus","volume":"20","author":"Yung","year":"1994","journal-title":"Rheum Dis Clin North Am"},{"key":"10.1016\/j.autrev.2008.07.043_bib11","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.4049\/jimmunol.140.7.2197","article-title":"Hydralazine and procainamide inhibit T cell DNA methylation and induce autoreactivity","volume":"140","author":"Cornacchia","year":"1988","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2008.07.043_bib12","doi-asserted-by":"crossref","first-page":"40749","DOI":"10.1074\/jbc.M505593200","article-title":"Procainamide is a specific inhibitor of DNA methyltransferase 1","volume":"280","author":"Lee","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.autrev.2008.07.043_bib13","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1002\/art.10833","article-title":"Hydralazine may induce autoimmunity by inhibiting extracellular signal-regulated kinase pathway signaling","volume":"48","author":"Deng","year":"2003","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.autrev.2008.07.043_bib14","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1002\/art.1780331109","article-title":"Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis","volume":"33","author":"Richardson","year":"1990","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.autrev.2008.07.043_bib15","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1002\/1529-0131(200102)44:2<397::AID-ANR59>3.0.CO;2-N","article-title":"Decreased Ras-mitogen-activated protein kinase signaling may cause DNA hypomethylation in T lymphocytes from lupus patients","volume":"44","author":"Deng","year":"2001","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.autrev.2008.07.043_bib16","doi-asserted-by":"crossref","first-page":"6212","DOI":"10.4049\/jimmunol.174.10.6212","article-title":"Demethylation of the same promoter sequence increases CD70 expression in lupus T cells and T cells treated with lupus-inducing drugs","volume":"174","author":"Lu","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2008.07.043_bib17","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1002\/art.20255","article-title":"Overexpression of CD70 and overstimulation of IgG synthesis by lupus T cells and T cells treated with DNA methylation inhibitors","volume":"50","author":"Oelke","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.autrev.2008.07.043_bib18","doi-asserted-by":"crossref","first-page":"5553","DOI":"10.4049\/jimmunol.179.8.5553","article-title":"Impaired T cell protein kinase C delta activation decreases ERK pathway signaling in idiopathic and hydralazine-induced lupus","volume":"179","author":"Gorelik","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2008.07.043_bib19","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/416865a","article-title":"Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta","volume":"416","author":"Miyamoto","year":"2002","journal-title":"Nature"}],"container-title":["Autoimmunity Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568997208001560?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568997208001560?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T21:46:00Z","timestamp":1684532760000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568997208001560"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,1]]}},"alternative-id":["S1568997208001560"],"URL":"https:\/\/doi.org\/10.1016\/j.autrev.2008.07.043","relation":{},"ISSN":["1568-9972"],"issn-type":[{"value":"1568-9972","type":"print"}],"subject":[],"published":{"date-parts":[[2009,1]]}}}